The use of stem cells for the treatment of autoimmune diseases
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Publication Date: | 2007 |
Other Authors: | , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UFRGS |
Download full: | http://hdl.handle.net/10183/21211 |
Summary: | Autoimmune diseases constitute a heterogeneous group of conditions commonly treated with anti-inflammatory, immunosuppressant and immunomodulating drugs, with satisfactory results in most cases. Nevertheless, some patients become resistant to conventional therapy. The use of high doses of drugs in such cases results in the need for bone marrow reconstitution, a situation which has stimulated research into the use of hematopoietic stem cells in autoimmune disease therapy. Stem cell transplantation in such diseases aims to destroy the self-reacting immune cells and produce a new functional immune system, as well as substitute cells for tissue damaged in the course of the disease. Significant results, such as the reestablishment of tolerance and a decrease in the recurrence of autoimmune disease, have been reported following stem cell transplantation in patients with autoimmune disease in Brazil and throughout the world. These results suggest that stem cell transplantation has the potential to become an important therapeutic approach to the treatment of various autoimmune diseases including rheumatoid arthritis, juvenile idiopathic arthritis, systemic lupus erythematosus, multiple sclerosis, systemic sclerosis, Crohn’s disease, autoimmune blood cytopenias, and type I diabetes mellitus. |
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Rosa, Sílvia BarcellosVoltarelli, Júlio CesarChies, Jose Artur BogoPranke, Patricia Helena Lucas2010-04-24T04:15:45Z20070100-879Xhttp://hdl.handle.net/10183/21211000611364Autoimmune diseases constitute a heterogeneous group of conditions commonly treated with anti-inflammatory, immunosuppressant and immunomodulating drugs, with satisfactory results in most cases. Nevertheless, some patients become resistant to conventional therapy. The use of high doses of drugs in such cases results in the need for bone marrow reconstitution, a situation which has stimulated research into the use of hematopoietic stem cells in autoimmune disease therapy. Stem cell transplantation in such diseases aims to destroy the self-reacting immune cells and produce a new functional immune system, as well as substitute cells for tissue damaged in the course of the disease. Significant results, such as the reestablishment of tolerance and a decrease in the recurrence of autoimmune disease, have been reported following stem cell transplantation in patients with autoimmune disease in Brazil and throughout the world. These results suggest that stem cell transplantation has the potential to become an important therapeutic approach to the treatment of various autoimmune diseases including rheumatoid arthritis, juvenile idiopathic arthritis, systemic lupus erythematosus, multiple sclerosis, systemic sclerosis, Crohn’s disease, autoimmune blood cytopenias, and type I diabetes mellitus.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto. Vol. 40, n. 12/ind (dez. 2007), p. 1579-1597Doencas auto-imunesTransplanteLupus eritematosoArtriteDiabetes mellitus tipo 1Células-troncoAutoimmune diseaseStem cellsTransplantationLupus erythematosusArthritisType I diabetes mellitusThe use of stem cells for the treatment of autoimmune diseasesinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000611364.pdf000611364.pdfTexto completo (inglês)application/pdf655132http://www.lume.ufrgs.br/bitstream/10183/21211/1/000611364.pdf567cbcb5f1f7c7ec4ee5fd48f67fdbefMD51TEXT000611364.pdf.txt000611364.pdf.txtExtracted Texttext/plain75758http://www.lume.ufrgs.br/bitstream/10183/21211/2/000611364.pdf.txtbe878e80df1269696c2bd750f3883a52MD52THUMBNAIL000611364.pdf.jpg000611364.pdf.jpgGenerated Thumbnailimage/jpeg1742http://www.lume.ufrgs.br/bitstream/10183/21211/3/000611364.pdf.jpg0d3cc415012efebdc083eac8da167b51MD5310183/212112018-10-08 08:03:16.21oai:www.lume.ufrgs.br:10183/21211Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-08T11:03:16Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
The use of stem cells for the treatment of autoimmune diseases |
title |
The use of stem cells for the treatment of autoimmune diseases |
spellingShingle |
The use of stem cells for the treatment of autoimmune diseases Rosa, Sílvia Barcellos Doencas auto-imunes Transplante Lupus eritematoso Artrite Diabetes mellitus tipo 1 Células-tronco Autoimmune disease Stem cells Transplantation Lupus erythematosus Arthritis Type I diabetes mellitus |
title_short |
The use of stem cells for the treatment of autoimmune diseases |
title_full |
The use of stem cells for the treatment of autoimmune diseases |
title_fullStr |
The use of stem cells for the treatment of autoimmune diseases |
title_full_unstemmed |
The use of stem cells for the treatment of autoimmune diseases |
title_sort |
The use of stem cells for the treatment of autoimmune diseases |
author |
Rosa, Sílvia Barcellos |
author_facet |
Rosa, Sílvia Barcellos Voltarelli, Júlio Cesar Chies, Jose Artur Bogo Pranke, Patricia Helena Lucas |
author_role |
author |
author2 |
Voltarelli, Júlio Cesar Chies, Jose Artur Bogo Pranke, Patricia Helena Lucas |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Rosa, Sílvia Barcellos Voltarelli, Júlio Cesar Chies, Jose Artur Bogo Pranke, Patricia Helena Lucas |
dc.subject.por.fl_str_mv |
Doencas auto-imunes Transplante Lupus eritematoso Artrite Diabetes mellitus tipo 1 Células-tronco |
topic |
Doencas auto-imunes Transplante Lupus eritematoso Artrite Diabetes mellitus tipo 1 Células-tronco Autoimmune disease Stem cells Transplantation Lupus erythematosus Arthritis Type I diabetes mellitus |
dc.subject.eng.fl_str_mv |
Autoimmune disease Stem cells Transplantation Lupus erythematosus Arthritis Type I diabetes mellitus |
description |
Autoimmune diseases constitute a heterogeneous group of conditions commonly treated with anti-inflammatory, immunosuppressant and immunomodulating drugs, with satisfactory results in most cases. Nevertheless, some patients become resistant to conventional therapy. The use of high doses of drugs in such cases results in the need for bone marrow reconstitution, a situation which has stimulated research into the use of hematopoietic stem cells in autoimmune disease therapy. Stem cell transplantation in such diseases aims to destroy the self-reacting immune cells and produce a new functional immune system, as well as substitute cells for tissue damaged in the course of the disease. Significant results, such as the reestablishment of tolerance and a decrease in the recurrence of autoimmune disease, have been reported following stem cell transplantation in patients with autoimmune disease in Brazil and throughout the world. These results suggest that stem cell transplantation has the potential to become an important therapeutic approach to the treatment of various autoimmune diseases including rheumatoid arthritis, juvenile idiopathic arthritis, systemic lupus erythematosus, multiple sclerosis, systemic sclerosis, Crohn’s disease, autoimmune blood cytopenias, and type I diabetes mellitus. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007 |
dc.date.accessioned.fl_str_mv |
2010-04-24T04:15:45Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
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0100-879X |
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000611364 |
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eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto. Vol. 40, n. 12/ind (dez. 2007), p. 1579-1597 |
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openAccess |
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