Advances in proteomic and metabolomic profiling of neurodegenerative diseases
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/237210 |
Resumo: | Proteomics and metabolomics are two emerging fields that hold promise to shine light on the molecular mechanisms causing neurodegenerative diseases. Research in this area may reveal and quantify specific metabolites and proteins that can be targeted by therapeutic interventions intended at halting or reversing the neurodegenerative process. This review aims at providing a general overview on the current status of proteomic and metabolomic profiling in neurodegenerative diseases. We focus on the most common neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. We discuss the relevance of state-of-the-art metabolomics and proteomics approaches and their potential for biomarker discovery. We critically review advancements made so far, highlighting how metabolomics and proteomics may have a significant impact in future therapeutic and biomarker development. Finally, we further outline technologies used so far as well as challenges and limitations, placing the current information in a future-facing context. |
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Schuh, Artur Francisco SchumacherBieger, AndreiBorelli, Wyllians José VendraminiPortley, Makayla K.Awad, Paula SaffieCiga, Sara Bandres2022-04-13T04:52:13Z20221664-2295http://hdl.handle.net/10183/237210001138147Proteomics and metabolomics are two emerging fields that hold promise to shine light on the molecular mechanisms causing neurodegenerative diseases. Research in this area may reveal and quantify specific metabolites and proteins that can be targeted by therapeutic interventions intended at halting or reversing the neurodegenerative process. This review aims at providing a general overview on the current status of proteomic and metabolomic profiling in neurodegenerative diseases. We focus on the most common neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. We discuss the relevance of state-of-the-art metabolomics and proteomics approaches and their potential for biomarker discovery. We critically review advancements made so far, highlighting how metabolomics and proteomics may have a significant impact in future therapeutic and biomarker development. Finally, we further outline technologies used so far as well as challenges and limitations, placing the current information in a future-facing context.application/pdfengFrontiers in neurology. Lausanne. Vol. 12 (Jan. 2022), 792227, 14 p.ProteômicaMetabolômicaDoenças neurodegenerativasDoenças neurodegenerativas : MetabolismoBiomarcadoresProteomicsMetabolomicsAlzheimer’s disease,ADParkinson’s diseasePDAmyotrophic lateral sclerosisALSAdvances in proteomic and metabolomic profiling of neurodegenerative diseasesEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001138147.pdf.txt001138147.pdf.txtExtracted Texttext/plain89235http://www.lume.ufrgs.br/bitstream/10183/237210/2/001138147.pdf.txt432966f99f476567058c6d6f635073d8MD52ORIGINAL001138147.pdfTexto completo (inglês)application/pdf678869http://www.lume.ufrgs.br/bitstream/10183/237210/1/001138147.pdfb30819e7ad72beed27ea5de34865c554MD5110183/2372102022-04-20 04:55:53.153567oai:www.lume.ufrgs.br:10183/237210Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-04-20T07:55:53Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Advances in proteomic and metabolomic profiling of neurodegenerative diseases |
title |
Advances in proteomic and metabolomic profiling of neurodegenerative diseases |
spellingShingle |
Advances in proteomic and metabolomic profiling of neurodegenerative diseases Schuh, Artur Francisco Schumacher Proteômica Metabolômica Doenças neurodegenerativas Doenças neurodegenerativas : Metabolismo Biomarcadores Proteomics Metabolomics Alzheimer’s disease, AD Parkinson’s disease PD Amyotrophic lateral sclerosis ALS |
title_short |
Advances in proteomic and metabolomic profiling of neurodegenerative diseases |
title_full |
Advances in proteomic and metabolomic profiling of neurodegenerative diseases |
title_fullStr |
Advances in proteomic and metabolomic profiling of neurodegenerative diseases |
title_full_unstemmed |
Advances in proteomic and metabolomic profiling of neurodegenerative diseases |
title_sort |
Advances in proteomic and metabolomic profiling of neurodegenerative diseases |
author |
Schuh, Artur Francisco Schumacher |
author_facet |
Schuh, Artur Francisco Schumacher Bieger, Andrei Borelli, Wyllians José Vendramini Portley, Makayla K. Awad, Paula Saffie Ciga, Sara Bandres |
author_role |
author |
author2 |
Bieger, Andrei Borelli, Wyllians José Vendramini Portley, Makayla K. Awad, Paula Saffie Ciga, Sara Bandres |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Schuh, Artur Francisco Schumacher Bieger, Andrei Borelli, Wyllians José Vendramini Portley, Makayla K. Awad, Paula Saffie Ciga, Sara Bandres |
dc.subject.por.fl_str_mv |
Proteômica Metabolômica Doenças neurodegenerativas Doenças neurodegenerativas : Metabolismo Biomarcadores |
topic |
Proteômica Metabolômica Doenças neurodegenerativas Doenças neurodegenerativas : Metabolismo Biomarcadores Proteomics Metabolomics Alzheimer’s disease, AD Parkinson’s disease PD Amyotrophic lateral sclerosis ALS |
dc.subject.eng.fl_str_mv |
Proteomics Metabolomics Alzheimer’s disease, AD Parkinson’s disease PD Amyotrophic lateral sclerosis ALS |
description |
Proteomics and metabolomics are two emerging fields that hold promise to shine light on the molecular mechanisms causing neurodegenerative diseases. Research in this area may reveal and quantify specific metabolites and proteins that can be targeted by therapeutic interventions intended at halting or reversing the neurodegenerative process. This review aims at providing a general overview on the current status of proteomic and metabolomic profiling in neurodegenerative diseases. We focus on the most common neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. We discuss the relevance of state-of-the-art metabolomics and proteomics approaches and their potential for biomarker discovery. We critically review advancements made so far, highlighting how metabolomics and proteomics may have a significant impact in future therapeutic and biomarker development. Finally, we further outline technologies used so far as well as challenges and limitations, placing the current information in a future-facing context. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-04-13T04:52:13Z |
dc.date.issued.fl_str_mv |
2022 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/237210 |
dc.identifier.issn.pt_BR.fl_str_mv |
1664-2295 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001138147 |
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1664-2295 001138147 |
url |
http://hdl.handle.net/10183/237210 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Frontiers in neurology. Lausanne. Vol. 12 (Jan. 2022), 792227, 14 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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