Mood disorders induced by maternal overnutrition : the role of the gut-brain axis on the development of depression and anxiety
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/238326 |
Resumo: | Since the first evidence suggesting that maternal nutrition can impact the development of diseases in the offspring, much has been elucidated about its effects on the offspring’s nervous system. Animal studies demonstrated that maternal obesity can predispose the offspring to greater chances of metabolic and neurodevelopmental diseases. However, the mechanisms underlying these responses are not well established. In recent years, the role of the gut-brain axis in the development of anxiety and depression in people with obesity has emerged. Studies investigating changes in the maternal microbiota during pregnancy and also in the offspring demonstrate that conditions such as maternal obesity can modulate the microbiota, leading to long-term outcomes in the offspring. Considering that maternal obesity has also been linked to the development of psychiatric conditions (anxiety and depression), the gut-brain axis is a promising target to be further explored in these neuropsychiatric contexts. In the present study, we review the relationship between maternal obesity and anxious and depressive features, exploring the gut-brain axis as a potential mechanism underlying this relationship. |
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Jantsch, JefersonTassinari, Isadora D'ÁvilaGiovenardi, MárciaBambini Júnior, VictorioGuedes, Renata PadilhaFraga, Luciano Sturmer de2022-05-07T04:51:09Z20222296-634Xhttp://hdl.handle.net/10183/238326001140137Since the first evidence suggesting that maternal nutrition can impact the development of diseases in the offspring, much has been elucidated about its effects on the offspring’s nervous system. Animal studies demonstrated that maternal obesity can predispose the offspring to greater chances of metabolic and neurodevelopmental diseases. However, the mechanisms underlying these responses are not well established. In recent years, the role of the gut-brain axis in the development of anxiety and depression in people with obesity has emerged. Studies investigating changes in the maternal microbiota during pregnancy and also in the offspring demonstrate that conditions such as maternal obesity can modulate the microbiota, leading to long-term outcomes in the offspring. Considering that maternal obesity has also been linked to the development of psychiatric conditions (anxiety and depression), the gut-brain axis is a promising target to be further explored in these neuropsychiatric contexts. In the present study, we review the relationship between maternal obesity and anxious and depressive features, exploring the gut-brain axis as a potential mechanism underlying this relationship.application/pdfengFrontiers in cell and developmental biology. Lausanne. Vol. 10 (Jan. 2022), 795384, 8 p.Fenômenos fisiológicos da nutrição maternaObesidade maternaDepressãoAnsiedadeMicrobioma gastrointestinalMaternal obesityGut-brain axisAnxietyDepressionMicrobiotaMood disorders induced by maternal overnutrition : the role of the gut-brain axis on the development of depression and anxietyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001140137.pdf.txt001140137.pdf.txtExtracted Texttext/plain50127http://www.lume.ufrgs.br/bitstream/10183/238326/2/001140137.pdf.txt89d24d0438e9952a80a1f399eb175872MD52ORIGINAL001140137.pdfTexto completo (inglês)application/pdf870778http://www.lume.ufrgs.br/bitstream/10183/238326/1/001140137.pdf580e0fddb826505508ca02f3db78e198MD5110183/2383262022-05-08 04:48:09.616194oai:www.lume.ufrgs.br:10183/238326Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-05-08T07:48:09Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Mood disorders induced by maternal overnutrition : the role of the gut-brain axis on the development of depression and anxiety |
title |
Mood disorders induced by maternal overnutrition : the role of the gut-brain axis on the development of depression and anxiety |
spellingShingle |
Mood disorders induced by maternal overnutrition : the role of the gut-brain axis on the development of depression and anxiety Jantsch, Jeferson Fenômenos fisiológicos da nutrição materna Obesidade materna Depressão Ansiedade Microbioma gastrointestinal Maternal obesity Gut-brain axis Anxiety Depression Microbiota |
title_short |
Mood disorders induced by maternal overnutrition : the role of the gut-brain axis on the development of depression and anxiety |
title_full |
Mood disorders induced by maternal overnutrition : the role of the gut-brain axis on the development of depression and anxiety |
title_fullStr |
Mood disorders induced by maternal overnutrition : the role of the gut-brain axis on the development of depression and anxiety |
title_full_unstemmed |
Mood disorders induced by maternal overnutrition : the role of the gut-brain axis on the development of depression and anxiety |
title_sort |
Mood disorders induced by maternal overnutrition : the role of the gut-brain axis on the development of depression and anxiety |
author |
Jantsch, Jeferson |
author_facet |
Jantsch, Jeferson Tassinari, Isadora D'Ávila Giovenardi, Márcia Bambini Júnior, Victorio Guedes, Renata Padilha Fraga, Luciano Sturmer de |
author_role |
author |
author2 |
Tassinari, Isadora D'Ávila Giovenardi, Márcia Bambini Júnior, Victorio Guedes, Renata Padilha Fraga, Luciano Sturmer de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Jantsch, Jeferson Tassinari, Isadora D'Ávila Giovenardi, Márcia Bambini Júnior, Victorio Guedes, Renata Padilha Fraga, Luciano Sturmer de |
dc.subject.por.fl_str_mv |
Fenômenos fisiológicos da nutrição materna Obesidade materna Depressão Ansiedade Microbioma gastrointestinal |
topic |
Fenômenos fisiológicos da nutrição materna Obesidade materna Depressão Ansiedade Microbioma gastrointestinal Maternal obesity Gut-brain axis Anxiety Depression Microbiota |
dc.subject.eng.fl_str_mv |
Maternal obesity Gut-brain axis Anxiety Depression Microbiota |
description |
Since the first evidence suggesting that maternal nutrition can impact the development of diseases in the offspring, much has been elucidated about its effects on the offspring’s nervous system. Animal studies demonstrated that maternal obesity can predispose the offspring to greater chances of metabolic and neurodevelopmental diseases. However, the mechanisms underlying these responses are not well established. In recent years, the role of the gut-brain axis in the development of anxiety and depression in people with obesity has emerged. Studies investigating changes in the maternal microbiota during pregnancy and also in the offspring demonstrate that conditions such as maternal obesity can modulate the microbiota, leading to long-term outcomes in the offspring. Considering that maternal obesity has also been linked to the development of psychiatric conditions (anxiety and depression), the gut-brain axis is a promising target to be further explored in these neuropsychiatric contexts. In the present study, we review the relationship between maternal obesity and anxious and depressive features, exploring the gut-brain axis as a potential mechanism underlying this relationship. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-05-07T04:51:09Z |
dc.date.issued.fl_str_mv |
2022 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/238326 |
dc.identifier.issn.pt_BR.fl_str_mv |
2296-634X |
dc.identifier.nrb.pt_BR.fl_str_mv |
001140137 |
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2296-634X 001140137 |
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http://hdl.handle.net/10183/238326 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Frontiers in cell and developmental biology. Lausanne. Vol. 10 (Jan. 2022), 795384, 8 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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