Heterogeneous individual motility biases group composition in a model of aggregating cells
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/254242 |
Resumo: | Aggregative life cycles are characterized by alternating phases of unicellular growth and multicellular development. Their multiple, independent evolutionary emergence suggests that they may have coopted pervasive properties of single-celled ancestors. Primitive multicellular aggregates, where coordination mechanisms were less efficient than in extant aggregative microbes, must have faced high levels of conflict between different co-aggregating populations. Such conflicts within a multicellular body manifest in the differential reproductive output of cells of different types. Here, we study how heterogeneity in cell motility affects the aggregation process and creates a mismatch between the composition of the population and that of self-organized groups of active adhesive particles. We model cells as self-propelled particles and describe aggregation in a plane starting from a dispersed configuration. Inspired by the life cycle of aggregative model organisms such as Dictyostelium discoideum or Myxococcus xanthus, whose cells interact for a fixed duration before the onset of chimeric multicellular development, we study finite-time configurations for identical particles and in binary mixes. We show that co-aggregation results in three different types of frequency-dependent biases, one of which is associated to evolutionarily stable coexistence of particles with different motility. We propose a heuristic explanation of such observations, based on the competition between delayed aggregation of slower particles and detachment of faster particles. Unexpectedly, despite the complexity and non-linearity of the system, biases can be largely predicted from the behavior of the two corresponding homogenous populations. This model points to differential motility as a possibly important factor in driving the evolutionary emergence of facultatively multicellular life-cycles. |
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Forget, MathieuAdiba, SandrineBrunnet, Leonardo GregoryDe Monte, Silvia2023-02-07T05:02:10Z20222296-701Xhttp://hdl.handle.net/10183/254242001160356Aggregative life cycles are characterized by alternating phases of unicellular growth and multicellular development. Their multiple, independent evolutionary emergence suggests that they may have coopted pervasive properties of single-celled ancestors. Primitive multicellular aggregates, where coordination mechanisms were less efficient than in extant aggregative microbes, must have faced high levels of conflict between different co-aggregating populations. Such conflicts within a multicellular body manifest in the differential reproductive output of cells of different types. Here, we study how heterogeneity in cell motility affects the aggregation process and creates a mismatch between the composition of the population and that of self-organized groups of active adhesive particles. We model cells as self-propelled particles and describe aggregation in a plane starting from a dispersed configuration. Inspired by the life cycle of aggregative model organisms such as Dictyostelium discoideum or Myxococcus xanthus, whose cells interact for a fixed duration before the onset of chimeric multicellular development, we study finite-time configurations for identical particles and in binary mixes. We show that co-aggregation results in three different types of frequency-dependent biases, one of which is associated to evolutionarily stable coexistence of particles with different motility. We propose a heuristic explanation of such observations, based on the competition between delayed aggregation of slower particles and detachment of faster particles. Unexpectedly, despite the complexity and non-linearity of the system, biases can be largely predicted from the behavior of the two corresponding homogenous populations. This model points to differential motility as a possibly important factor in driving the evolutionary emergence of facultatively multicellular life-cycles.application/pdfengFrontiers in Ecology and Evolution. Lausanne. Vol. 10 (Dec. 2022), 1052309, 18 p.Biologia evolutivaAgregacaoSimulação computacionalDinâmica populacionalMulticellularityEvolutionSelf-propelled particle systemsAggregationMotilityHeterogeneityHeterogeneous individual motility biases group composition in a model of aggregating cellsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001160356.pdf.txt001160356.pdf.txtExtracted Texttext/plain85006http://www.lume.ufrgs.br/bitstream/10183/254242/2/001160356.pdf.txt965fa1f89119bd78cad5cd1c2776a1afMD52ORIGINAL001160356.pdfTexto completo (inglês)application/pdf2542686http://www.lume.ufrgs.br/bitstream/10183/254242/1/001160356.pdfaa81b9e6d7731e7b4bb3f46987c58803MD5110183/2542422024-05-18 06:24:24.717793oai:www.lume.ufrgs.br:10183/254242Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-05-18T09:24:24Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Heterogeneous individual motility biases group composition in a model of aggregating cells |
title |
Heterogeneous individual motility biases group composition in a model of aggregating cells |
spellingShingle |
Heterogeneous individual motility biases group composition in a model of aggregating cells Forget, Mathieu Biologia evolutiva Agregacao Simulação computacional Dinâmica populacional Multicellularity Evolution Self-propelled particle systems Aggregation Motility Heterogeneity |
title_short |
Heterogeneous individual motility biases group composition in a model of aggregating cells |
title_full |
Heterogeneous individual motility biases group composition in a model of aggregating cells |
title_fullStr |
Heterogeneous individual motility biases group composition in a model of aggregating cells |
title_full_unstemmed |
Heterogeneous individual motility biases group composition in a model of aggregating cells |
title_sort |
Heterogeneous individual motility biases group composition in a model of aggregating cells |
author |
Forget, Mathieu |
author_facet |
Forget, Mathieu Adiba, Sandrine Brunnet, Leonardo Gregory De Monte, Silvia |
author_role |
author |
author2 |
Adiba, Sandrine Brunnet, Leonardo Gregory De Monte, Silvia |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Forget, Mathieu Adiba, Sandrine Brunnet, Leonardo Gregory De Monte, Silvia |
dc.subject.por.fl_str_mv |
Biologia evolutiva Agregacao Simulação computacional Dinâmica populacional |
topic |
Biologia evolutiva Agregacao Simulação computacional Dinâmica populacional Multicellularity Evolution Self-propelled particle systems Aggregation Motility Heterogeneity |
dc.subject.eng.fl_str_mv |
Multicellularity Evolution Self-propelled particle systems Aggregation Motility Heterogeneity |
description |
Aggregative life cycles are characterized by alternating phases of unicellular growth and multicellular development. Their multiple, independent evolutionary emergence suggests that they may have coopted pervasive properties of single-celled ancestors. Primitive multicellular aggregates, where coordination mechanisms were less efficient than in extant aggregative microbes, must have faced high levels of conflict between different co-aggregating populations. Such conflicts within a multicellular body manifest in the differential reproductive output of cells of different types. Here, we study how heterogeneity in cell motility affects the aggregation process and creates a mismatch between the composition of the population and that of self-organized groups of active adhesive particles. We model cells as self-propelled particles and describe aggregation in a plane starting from a dispersed configuration. Inspired by the life cycle of aggregative model organisms such as Dictyostelium discoideum or Myxococcus xanthus, whose cells interact for a fixed duration before the onset of chimeric multicellular development, we study finite-time configurations for identical particles and in binary mixes. We show that co-aggregation results in three different types of frequency-dependent biases, one of which is associated to evolutionarily stable coexistence of particles with different motility. We propose a heuristic explanation of such observations, based on the competition between delayed aggregation of slower particles and detachment of faster particles. Unexpectedly, despite the complexity and non-linearity of the system, biases can be largely predicted from the behavior of the two corresponding homogenous populations. This model points to differential motility as a possibly important factor in driving the evolutionary emergence of facultatively multicellular life-cycles. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-02-07T05:02:10Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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http://hdl.handle.net/10183/254242 |
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001160356 |
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http://hdl.handle.net/10183/254242 |
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eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Frontiers in Ecology and Evolution. Lausanne. Vol. 10 (Dec. 2022), 1052309, 18 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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