Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio)
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/24532 |
Resumo: | The zebrafish is an ideal vertebrate model for neurobehavioral studies with translational relevance to humans. Many aspects of sleep have been studied, but we still do not understand how and why sleep deprivation alters behavioral and physiological processes. A number of hypotheses suggest its role in memory consolidation. In this respect, the aim of this study was to analyze the effects of sleep deprivation on memory in zebrafish (Danio rerio), using an object discrimination paradigm. Four treatments were tested: control, partial sleep deprivation, total sleep deprivation by light pulses, and total sleep deprivation by extended light. The control group explored the new object more than the known object, indicating clear discrimination. The partially sleep-deprived group explored the new object more than the other object in the discrimination phase, suggesting a certain degree of discriminative performance. By contrast, both total sleep deprivation groups equally explored all objects, regardless of their novelty. It seems that only one night of sleep deprivation is enough to affect discriminative response in zebrafish, indicating its negative impact on cognitive processes. We suggest that this study could be a useful screening tool for cognitive dysfunction and a better understanding of the effect of sleep-wake cycles on cognition |
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Silva, Jaquelinne Pinheiro daSilva, Priscila FernandesNogueira, Marcelo BorgesLuchiari, Ana Carolina2018-01-08T13:26:19Z2018-01-08T13:26:19Z2016-09-19SILVA, Jaquelinne Pinheiro da; et al. Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio). Animal Cognition, v. 20, p. 159-169, set. 2016. Disponível em:<https://link.springer.com/article/10.1007/s10071-016-1034-x>. Acesso em: 16 out. 2017.1435-9448https://repositorio.ufrn.br/jspui/handle/123456789/24532engSleepFishMemoryDiscriminationBayesian analysisSleep deprivation effects on object discrimination task in zebrafish (Danio rerio)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThe zebrafish is an ideal vertebrate model for neurobehavioral studies with translational relevance to humans. Many aspects of sleep have been studied, but we still do not understand how and why sleep deprivation alters behavioral and physiological processes. A number of hypotheses suggest its role in memory consolidation. In this respect, the aim of this study was to analyze the effects of sleep deprivation on memory in zebrafish (Danio rerio), using an object discrimination paradigm. Four treatments were tested: control, partial sleep deprivation, total sleep deprivation by light pulses, and total sleep deprivation by extended light. The control group explored the new object more than the known object, indicating clear discrimination. The partially sleep-deprived group explored the new object more than the other object in the discrimination phase, suggesting a certain degree of discriminative performance. By contrast, both total sleep deprivation groups equally explored all objects, regardless of their novelty. It seems that only one night of sleep deprivation is enough to affect discriminative response in zebrafish, indicating its negative impact on cognitive processes. We suggest that this study could be a useful screening tool for cognitive dysfunction and a better understanding of the effect of sleep-wake cycles on cognitioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALSleepDeprivationEffects_Silva_2016.pdfSleepDeprivationEffects_Silva_2016.pdfapplication/pdf1926361https://repositorio.ufrn.br/bitstream/123456789/24532/1/SleepDeprivationEffects_Silva_2016.pdfa1326d20fb3d51161f99213f249b6068MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/24532/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTSleepDeprivationEffects_2016.pdf.txtSleepDeprivationEffects_2016.pdf.txtExtracted texttext/plain48914https://repositorio.ufrn.br/bitstream/123456789/24532/3/SleepDeprivationEffects_2016.pdf.txtc6f1ec16c94e44348337918079211cfdMD53THUMBNAILSleepDeprivationEffects_2016.pdf.jpgSleepDeprivationEffects_2016.pdf.jpgIM Thumbnailimage/jpeg8820https://repositorio.ufrn.br/bitstream/123456789/24532/4/SleepDeprivationEffects_2016.pdf.jpg5171b4584618fb7132d62ff7cf9103aaMD54123456789/245322021-11-08 17:08:30.844oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-11-08T20:08:30Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio) |
title |
Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio) |
spellingShingle |
Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio) Silva, Jaquelinne Pinheiro da Sleep Fish Memory Discrimination Bayesian analysis |
title_short |
Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio) |
title_full |
Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio) |
title_fullStr |
Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio) |
title_full_unstemmed |
Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio) |
title_sort |
Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio) |
author |
Silva, Jaquelinne Pinheiro da |
author_facet |
Silva, Jaquelinne Pinheiro da Silva, Priscila Fernandes Nogueira, Marcelo Borges Luchiari, Ana Carolina |
author_role |
author |
author2 |
Silva, Priscila Fernandes Nogueira, Marcelo Borges Luchiari, Ana Carolina |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Silva, Jaquelinne Pinheiro da Silva, Priscila Fernandes Nogueira, Marcelo Borges Luchiari, Ana Carolina |
dc.subject.por.fl_str_mv |
Sleep Fish Memory Discrimination Bayesian analysis |
topic |
Sleep Fish Memory Discrimination Bayesian analysis |
description |
The zebrafish is an ideal vertebrate model for neurobehavioral studies with translational relevance to humans. Many aspects of sleep have been studied, but we still do not understand how and why sleep deprivation alters behavioral and physiological processes. A number of hypotheses suggest its role in memory consolidation. In this respect, the aim of this study was to analyze the effects of sleep deprivation on memory in zebrafish (Danio rerio), using an object discrimination paradigm. Four treatments were tested: control, partial sleep deprivation, total sleep deprivation by light pulses, and total sleep deprivation by extended light. The control group explored the new object more than the known object, indicating clear discrimination. The partially sleep-deprived group explored the new object more than the other object in the discrimination phase, suggesting a certain degree of discriminative performance. By contrast, both total sleep deprivation groups equally explored all objects, regardless of their novelty. It seems that only one night of sleep deprivation is enough to affect discriminative response in zebrafish, indicating its negative impact on cognitive processes. We suggest that this study could be a useful screening tool for cognitive dysfunction and a better understanding of the effect of sleep-wake cycles on cognition |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-09-19 |
dc.date.accessioned.fl_str_mv |
2018-01-08T13:26:19Z |
dc.date.available.fl_str_mv |
2018-01-08T13:26:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, Jaquelinne Pinheiro da; et al. Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio). Animal Cognition, v. 20, p. 159-169, set. 2016. Disponível em:<https://link.springer.com/article/10.1007/s10071-016-1034-x>. Acesso em: 16 out. 2017. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/24532 |
dc.identifier.issn.none.fl_str_mv |
1435-9448 |
identifier_str_mv |
SILVA, Jaquelinne Pinheiro da; et al. Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio). Animal Cognition, v. 20, p. 159-169, set. 2016. Disponível em:<https://link.springer.com/article/10.1007/s10071-016-1034-x>. Acesso em: 16 out. 2017. 1435-9448 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/24532 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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UFRN |
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UFRN |
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Repositório Institucional da UFRN |
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Repositório Institucional da UFRN |
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