Development of a magnetic system for the treatment of Helicobacter pylori infections

Detalhes bibliográficos
Autor(a) principal: Araújo, José Humberto de
Data de Publicação: 2010
Outros Autores: Silva, Érica Lira, Carvalho, Juliana Fernandes, Pontes, Thales Renan Ferreira, Oliveira, Elquio Eleamen, Francelino, Bárbara L., Medeiros, Aldo da Cunha, Carriço, Arthur da Silva, Egito, Eryvaldo Sócrates Tabosa do
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/29312
Resumo: We report a study to develop a magnetic system for local delivery of amoxicillin. Magnetite microparticles produced by coprecipitation were coated with a solution of amoxicillin and Eudragit®S100 by spray drying. Scanning electron microscopy, optical microscopy, X-ray powder diffraction and vibrating sample magnetometry revealed that the particles were superparamagnetic, with an average diameter of 17.2 μm, and an initial susceptibility controllable by the magnetite content in the suspension feeding the sprayer. Our results suggest a possible way to treat Helicobacter pylori infections, using an oral drug delivery system, and open prospects to coat magnetic microparticles by spray drying for biomedical applications
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spelling Araújo, José Humberto deSilva, Érica LiraCarvalho, Juliana FernandesPontes, Thales Renan FerreiraOliveira, Elquio EleamenFrancelino, Bárbara L.Medeiros, Aldo da CunhaCarriço, Arthur da SilvaEgito, Eryvaldo Sócrates Tabosa do2020-06-19T18:29:19Z2020-06-19T18:29:19Z2010-03-05SILVA, Érica L.; CARVALHO, Juliana F.; PONTES, Thales R.F.; OLIVEIRA, Elquio E.; FRANCELINO, Bárbara L.; MEDEIROS, Aldo C.; EGITO, E. Sócrates T.; ARAÚJO, José H. ; Carriço, Artur S.. Development of a magnetic system for the treatment of Helicobacter pylori infections. Journal of Magnetism and Magnetic Materials, v. 321, p. 1566-1570, 2009. Disponível em: https://www.sciencedirect.com/science/article/pii/S0304885309001553?via%3Dihub#!. Acesso em: 18 jun 2020. https://doi.org/10.1016/j.jmmm.2009.02.087.0304-8853https://repositorio.ufrn.br/jspui/handle/123456789/2931210.1016/j.jmmm.2009.02.087ElsevierAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessMagnetic vectorizationHelicobacter pyloriMagnetite microparticlePray drying coatingSuperparamagnetic particleDevelopment of a magnetic system for the treatment of Helicobacter pylori infectionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleWe report a study to develop a magnetic system for local delivery of amoxicillin. Magnetite microparticles produced by coprecipitation were coated with a solution of amoxicillin and Eudragit®S100 by spray drying. Scanning electron microscopy, optical microscopy, X-ray powder diffraction and vibrating sample magnetometry revealed that the particles were superparamagnetic, with an average diameter of 17.2 μm, and an initial susceptibility controllable by the magnetite content in the suspension feeding the sprayer. Our results suggest a possible way to treat Helicobacter pylori infections, using an oral drug delivery system, and open prospects to coat magnetic microparticles by spray drying for biomedical applicationsengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/29312/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/29312/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53TEXTDevelopmentofamagnetic_Araujo_2009.pdf.txtDevelopmentofamagnetic_Araujo_2009.pdf.txtExtracted texttext/plain24580https://repositorio.ufrn.br/bitstream/123456789/29312/4/Developmentofamagnetic_Araujo_2009.pdf.txtdf5b40220fd02483e1f67e2a653098a9MD54THUMBNAILDevelopmentofamagnetic_Araujo_2009.pdf.jpgDevelopmentofamagnetic_Araujo_2009.pdf.jpgGenerated Thumbnailimage/jpeg1732https://repositorio.ufrn.br/bitstream/123456789/29312/5/Developmentofamagnetic_Araujo_2009.pdf.jpg9355efe9ed3454f3f7d2ecd1e06ab056MD55ORIGINALDevelopmentofamagnetic_Araujo_2009.pdfDevelopmentofamagnetic_Araujo_2009.pdfapplication/pdf1039280https://repositorio.ufrn.br/bitstream/123456789/29312/1/Developmentofamagnetic_Araujo_2009.pdf12cfa3d0a9b4aae19aae84235e71d812MD51123456789/293122020-06-21 04:45:32.406oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2020-06-21T07:45:32Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Development of a magnetic system for the treatment of Helicobacter pylori infections
title Development of a magnetic system for the treatment of Helicobacter pylori infections
spellingShingle Development of a magnetic system for the treatment of Helicobacter pylori infections
Araújo, José Humberto de
Magnetic vectorization
Helicobacter pylori
Magnetite microparticle
Pray drying coating
Superparamagnetic particle
title_short Development of a magnetic system for the treatment of Helicobacter pylori infections
title_full Development of a magnetic system for the treatment of Helicobacter pylori infections
title_fullStr Development of a magnetic system for the treatment of Helicobacter pylori infections
title_full_unstemmed Development of a magnetic system for the treatment of Helicobacter pylori infections
title_sort Development of a magnetic system for the treatment of Helicobacter pylori infections
author Araújo, José Humberto de
author_facet Araújo, José Humberto de
Silva, Érica Lira
Carvalho, Juliana Fernandes
Pontes, Thales Renan Ferreira
Oliveira, Elquio Eleamen
Francelino, Bárbara L.
Medeiros, Aldo da Cunha
Carriço, Arthur da Silva
Egito, Eryvaldo Sócrates Tabosa do
author_role author
author2 Silva, Érica Lira
Carvalho, Juliana Fernandes
Pontes, Thales Renan Ferreira
Oliveira, Elquio Eleamen
Francelino, Bárbara L.
Medeiros, Aldo da Cunha
Carriço, Arthur da Silva
Egito, Eryvaldo Sócrates Tabosa do
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Araújo, José Humberto de
Silva, Érica Lira
Carvalho, Juliana Fernandes
Pontes, Thales Renan Ferreira
Oliveira, Elquio Eleamen
Francelino, Bárbara L.
Medeiros, Aldo da Cunha
Carriço, Arthur da Silva
Egito, Eryvaldo Sócrates Tabosa do
dc.subject.por.fl_str_mv Magnetic vectorization
Helicobacter pylori
Magnetite microparticle
Pray drying coating
Superparamagnetic particle
topic Magnetic vectorization
Helicobacter pylori
Magnetite microparticle
Pray drying coating
Superparamagnetic particle
description We report a study to develop a magnetic system for local delivery of amoxicillin. Magnetite microparticles produced by coprecipitation were coated with a solution of amoxicillin and Eudragit®S100 by spray drying. Scanning electron microscopy, optical microscopy, X-ray powder diffraction and vibrating sample magnetometry revealed that the particles were superparamagnetic, with an average diameter of 17.2 μm, and an initial susceptibility controllable by the magnetite content in the suspension feeding the sprayer. Our results suggest a possible way to treat Helicobacter pylori infections, using an oral drug delivery system, and open prospects to coat magnetic microparticles by spray drying for biomedical applications
publishDate 2010
dc.date.issued.fl_str_mv 2010-03-05
dc.date.accessioned.fl_str_mv 2020-06-19T18:29:19Z
dc.date.available.fl_str_mv 2020-06-19T18:29:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv SILVA, Érica L.; CARVALHO, Juliana F.; PONTES, Thales R.F.; OLIVEIRA, Elquio E.; FRANCELINO, Bárbara L.; MEDEIROS, Aldo C.; EGITO, E. Sócrates T.; ARAÚJO, José H. ; Carriço, Artur S.. Development of a magnetic system for the treatment of Helicobacter pylori infections. Journal of Magnetism and Magnetic Materials, v. 321, p. 1566-1570, 2009. Disponível em: https://www.sciencedirect.com/science/article/pii/S0304885309001553?via%3Dihub#!. Acesso em: 18 jun 2020. https://doi.org/10.1016/j.jmmm.2009.02.087.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/123456789/29312
dc.identifier.issn.none.fl_str_mv 0304-8853
dc.identifier.doi.none.fl_str_mv 10.1016/j.jmmm.2009.02.087
identifier_str_mv SILVA, Érica L.; CARVALHO, Juliana F.; PONTES, Thales R.F.; OLIVEIRA, Elquio E.; FRANCELINO, Bárbara L.; MEDEIROS, Aldo C.; EGITO, E. Sócrates T.; ARAÚJO, José H. ; Carriço, Artur S.. Development of a magnetic system for the treatment of Helicobacter pylori infections. Journal of Magnetism and Magnetic Materials, v. 321, p. 1566-1570, 2009. Disponível em: https://www.sciencedirect.com/science/article/pii/S0304885309001553?via%3Dihub#!. Acesso em: 18 jun 2020. https://doi.org/10.1016/j.jmmm.2009.02.087.
0304-8853
10.1016/j.jmmm.2009.02.087
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http://creativecommons.org/licenses/by/3.0/br/
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