Development of a magnetic system for the treatment of Helicobacter pylori infections
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/29312 |
Resumo: | We report a study to develop a magnetic system for local delivery of amoxicillin. Magnetite microparticles produced by coprecipitation were coated with a solution of amoxicillin and Eudragit®S100 by spray drying. Scanning electron microscopy, optical microscopy, X-ray powder diffraction and vibrating sample magnetometry revealed that the particles were superparamagnetic, with an average diameter of 17.2 μm, and an initial susceptibility controllable by the magnetite content in the suspension feeding the sprayer. Our results suggest a possible way to treat Helicobacter pylori infections, using an oral drug delivery system, and open prospects to coat magnetic microparticles by spray drying for biomedical applications |
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Araújo, José Humberto deSilva, Érica LiraCarvalho, Juliana FernandesPontes, Thales Renan FerreiraOliveira, Elquio EleamenFrancelino, Bárbara L.Medeiros, Aldo da CunhaCarriço, Arthur da SilvaEgito, Eryvaldo Sócrates Tabosa do2020-06-19T18:29:19Z2020-06-19T18:29:19Z2010-03-05SILVA, Érica L.; CARVALHO, Juliana F.; PONTES, Thales R.F.; OLIVEIRA, Elquio E.; FRANCELINO, Bárbara L.; MEDEIROS, Aldo C.; EGITO, E. Sócrates T.; ARAÚJO, José H. ; Carriço, Artur S.. Development of a magnetic system for the treatment of Helicobacter pylori infections. Journal of Magnetism and Magnetic Materials, v. 321, p. 1566-1570, 2009. Disponível em: https://www.sciencedirect.com/science/article/pii/S0304885309001553?via%3Dihub#!. Acesso em: 18 jun 2020. https://doi.org/10.1016/j.jmmm.2009.02.087.0304-8853https://repositorio.ufrn.br/jspui/handle/123456789/2931210.1016/j.jmmm.2009.02.087ElsevierAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessMagnetic vectorizationHelicobacter pyloriMagnetite microparticlePray drying coatingSuperparamagnetic particleDevelopment of a magnetic system for the treatment of Helicobacter pylori infectionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleWe report a study to develop a magnetic system for local delivery of amoxicillin. Magnetite microparticles produced by coprecipitation were coated with a solution of amoxicillin and Eudragit®S100 by spray drying. Scanning electron microscopy, optical microscopy, X-ray powder diffraction and vibrating sample magnetometry revealed that the particles were superparamagnetic, with an average diameter of 17.2 μm, and an initial susceptibility controllable by the magnetite content in the suspension feeding the sprayer. Our results suggest a possible way to treat Helicobacter pylori infections, using an oral drug delivery system, and open prospects to coat magnetic microparticles by spray drying for biomedical applicationsengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/29312/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/29312/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53TEXTDevelopmentofamagnetic_Araujo_2009.pdf.txtDevelopmentofamagnetic_Araujo_2009.pdf.txtExtracted texttext/plain24580https://repositorio.ufrn.br/bitstream/123456789/29312/4/Developmentofamagnetic_Araujo_2009.pdf.txtdf5b40220fd02483e1f67e2a653098a9MD54THUMBNAILDevelopmentofamagnetic_Araujo_2009.pdf.jpgDevelopmentofamagnetic_Araujo_2009.pdf.jpgGenerated Thumbnailimage/jpeg1732https://repositorio.ufrn.br/bitstream/123456789/29312/5/Developmentofamagnetic_Araujo_2009.pdf.jpg9355efe9ed3454f3f7d2ecd1e06ab056MD55ORIGINALDevelopmentofamagnetic_Araujo_2009.pdfDevelopmentofamagnetic_Araujo_2009.pdfapplication/pdf1039280https://repositorio.ufrn.br/bitstream/123456789/29312/1/Developmentofamagnetic_Araujo_2009.pdf12cfa3d0a9b4aae19aae84235e71d812MD51123456789/293122020-06-21 04:45:32.406oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2020-06-21T07:45:32Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Development of a magnetic system for the treatment of Helicobacter pylori infections |
title |
Development of a magnetic system for the treatment of Helicobacter pylori infections |
spellingShingle |
Development of a magnetic system for the treatment of Helicobacter pylori infections Araújo, José Humberto de Magnetic vectorization Helicobacter pylori Magnetite microparticle Pray drying coating Superparamagnetic particle |
title_short |
Development of a magnetic system for the treatment of Helicobacter pylori infections |
title_full |
Development of a magnetic system for the treatment of Helicobacter pylori infections |
title_fullStr |
Development of a magnetic system for the treatment of Helicobacter pylori infections |
title_full_unstemmed |
Development of a magnetic system for the treatment of Helicobacter pylori infections |
title_sort |
Development of a magnetic system for the treatment of Helicobacter pylori infections |
author |
Araújo, José Humberto de |
author_facet |
Araújo, José Humberto de Silva, Érica Lira Carvalho, Juliana Fernandes Pontes, Thales Renan Ferreira Oliveira, Elquio Eleamen Francelino, Bárbara L. Medeiros, Aldo da Cunha Carriço, Arthur da Silva Egito, Eryvaldo Sócrates Tabosa do |
author_role |
author |
author2 |
Silva, Érica Lira Carvalho, Juliana Fernandes Pontes, Thales Renan Ferreira Oliveira, Elquio Eleamen Francelino, Bárbara L. Medeiros, Aldo da Cunha Carriço, Arthur da Silva Egito, Eryvaldo Sócrates Tabosa do |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Araújo, José Humberto de Silva, Érica Lira Carvalho, Juliana Fernandes Pontes, Thales Renan Ferreira Oliveira, Elquio Eleamen Francelino, Bárbara L. Medeiros, Aldo da Cunha Carriço, Arthur da Silva Egito, Eryvaldo Sócrates Tabosa do |
dc.subject.por.fl_str_mv |
Magnetic vectorization Helicobacter pylori Magnetite microparticle Pray drying coating Superparamagnetic particle |
topic |
Magnetic vectorization Helicobacter pylori Magnetite microparticle Pray drying coating Superparamagnetic particle |
description |
We report a study to develop a magnetic system for local delivery of amoxicillin. Magnetite microparticles produced by coprecipitation were coated with a solution of amoxicillin and Eudragit®S100 by spray drying. Scanning electron microscopy, optical microscopy, X-ray powder diffraction and vibrating sample magnetometry revealed that the particles were superparamagnetic, with an average diameter of 17.2 μm, and an initial susceptibility controllable by the magnetite content in the suspension feeding the sprayer. Our results suggest a possible way to treat Helicobacter pylori infections, using an oral drug delivery system, and open prospects to coat magnetic microparticles by spray drying for biomedical applications |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010-03-05 |
dc.date.accessioned.fl_str_mv |
2020-06-19T18:29:19Z |
dc.date.available.fl_str_mv |
2020-06-19T18:29:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, Érica L.; CARVALHO, Juliana F.; PONTES, Thales R.F.; OLIVEIRA, Elquio E.; FRANCELINO, Bárbara L.; MEDEIROS, Aldo C.; EGITO, E. Sócrates T.; ARAÚJO, José H. ; Carriço, Artur S.. Development of a magnetic system for the treatment of Helicobacter pylori infections. Journal of Magnetism and Magnetic Materials, v. 321, p. 1566-1570, 2009. Disponível em: https://www.sciencedirect.com/science/article/pii/S0304885309001553?via%3Dihub#!. Acesso em: 18 jun 2020. https://doi.org/10.1016/j.jmmm.2009.02.087. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/29312 |
dc.identifier.issn.none.fl_str_mv |
0304-8853 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.jmmm.2009.02.087 |
identifier_str_mv |
SILVA, Érica L.; CARVALHO, Juliana F.; PONTES, Thales R.F.; OLIVEIRA, Elquio E.; FRANCELINO, Bárbara L.; MEDEIROS, Aldo C.; EGITO, E. Sócrates T.; ARAÚJO, José H. ; Carriço, Artur S.. Development of a magnetic system for the treatment of Helicobacter pylori infections. Journal of Magnetism and Magnetic Materials, v. 321, p. 1566-1570, 2009. Disponível em: https://www.sciencedirect.com/science/article/pii/S0304885309001553?via%3Dihub#!. Acesso em: 18 jun 2020. https://doi.org/10.1016/j.jmmm.2009.02.087. 0304-8853 10.1016/j.jmmm.2009.02.087 |
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https://repositorio.ufrn.br/jspui/handle/123456789/29312 |
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eng |
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eng |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ |
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openAccess |
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Elsevier |
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Elsevier |
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