Single nucleotide polymorphisms in immune system genes and their association with clinical symptoms persistence in dengue-infected persons
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/31559 |
Resumo: | This study was undertaken to determine the prevalence of dengue clinical symptom persistence during 60 days of disease follow up, in patients of Espírito Santo state (ES)-Brazil and to evaluate the relation of single nucleotide polymorphisms (SNPs) in FccRIIa, CD209, VDR, TNF-a, IL-4, IL-6 and IFN-c genes with symptom persistence. During 2012–2013, 96 blood samples from individuals diagnosed with symptomatic dengue were collected. Clinical symptom persistence in 60 days of follow-up was assessed by a clinical and epidemiological questionnaire filled in 4 interviews. SNP genotyping was performed by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). In two months of monitoring the dengue infection, we observed that symptoms persisted in 38.5% (37/96) of dengue patients at the end of the first month (D30) and in 11.5% (11/96) of dengue patients at the end of the second month (D60). Our results show an association between FccRIIa, TNF-a and IL-6 gene SNPs and symptom persistence and an association trend with CD209, IL-4 and IFN-c gene SNPs. Our findings may increase the knowledge on the pathophysiological mechanisms of persistent symptoms of infection with the dengue virus (DENV) and thus help the clinical management of patients |
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Dettogni, Raquel SpinasséTristão-Sá, RicardoSantos, Marcelo dosSilva, Franciane Figueiredo daLouro, Iúri Drumond2021-02-19T10:18:14Z2021-02-19T10:18:14Z2015DETTOGNI, Raquel Spinassé; TRISTAO-SA, Ricardo; SANTOS, Marcelo dos; SILVA, Franciane Figueiredo da; LOURO, Iúri Drumond. Single nucleotide polymorphisms in immune system genes and their association with clinical symptoms persistence in dengue-infected persons. Human Immunology, [s. l.], v. 76, n. 10, p. 717-723, 2015. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0198885915004632?via%3Dihub. Acesso em: 07 jul. 2020. https://doi.org/10.1016/j.humimm.2015.09.0260198-8859 (print)https://repositorio.ufrn.br/handle/123456789/3155910.1016/j.humimm.2015.09.026ElsevierImmune system SNPsReceptorsCytokinesDengueSymptoms persistentSingle nucleotide polymorphisms in immune system genes and their association with clinical symptoms persistence in dengue-infected personsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThis study was undertaken to determine the prevalence of dengue clinical symptom persistence during 60 days of disease follow up, in patients of Espírito Santo state (ES)-Brazil and to evaluate the relation of single nucleotide polymorphisms (SNPs) in FccRIIa, CD209, VDR, TNF-a, IL-4, IL-6 and IFN-c genes with symptom persistence. During 2012–2013, 96 blood samples from individuals diagnosed with symptomatic dengue were collected. Clinical symptom persistence in 60 days of follow-up was assessed by a clinical and epidemiological questionnaire filled in 4 interviews. SNP genotyping was performed by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). In two months of monitoring the dengue infection, we observed that symptoms persisted in 38.5% (37/96) of dengue patients at the end of the first month (D30) and in 11.5% (11/96) of dengue patients at the end of the second month (D60). Our results show an association between FccRIIa, TNF-a and IL-6 gene SNPs and symptom persistence and an association trend with CD209, IL-4 and IFN-c gene SNPs. Our findings may increase the knowledge on the pathophysiological mechanisms of persistent symptoms of infection with the dengue virus (DENV) and thus help the clinical management of patientsengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/31559/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/31559/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53TEXTSingleNucleotidePolymorphisms_Santos_2015.pdf.txtSingleNucleotidePolymorphisms_Santos_2015.pdf.txtExtracted texttext/plain44900https://repositorio.ufrn.br/bitstream/123456789/31559/4/SingleNucleotidePolymorphisms_Santos_2015.pdf.txt9b8219920210eab4db3468484e9b8e1bMD54THUMBNAILSingleNucleotidePolymorphisms_Santos_2015.pdf.jpgSingleNucleotidePolymorphisms_Santos_2015.pdf.jpgGenerated Thumbnailimage/jpeg1721https://repositorio.ufrn.br/bitstream/123456789/31559/5/SingleNucleotidePolymorphisms_Santos_2015.pdf.jpgdf6b8f79b82fec197778e88277930938MD55123456789/315592023-02-07 16:14:11.346oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-02-07T19:14:11Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Single nucleotide polymorphisms in immune system genes and their association with clinical symptoms persistence in dengue-infected persons |
title |
Single nucleotide polymorphisms in immune system genes and their association with clinical symptoms persistence in dengue-infected persons |
spellingShingle |
Single nucleotide polymorphisms in immune system genes and their association with clinical symptoms persistence in dengue-infected persons Dettogni, Raquel Spinassé Immune system SNPs Receptors Cytokines Dengue Symptoms persistent |
title_short |
Single nucleotide polymorphisms in immune system genes and their association with clinical symptoms persistence in dengue-infected persons |
title_full |
Single nucleotide polymorphisms in immune system genes and their association with clinical symptoms persistence in dengue-infected persons |
title_fullStr |
Single nucleotide polymorphisms in immune system genes and their association with clinical symptoms persistence in dengue-infected persons |
title_full_unstemmed |
Single nucleotide polymorphisms in immune system genes and their association with clinical symptoms persistence in dengue-infected persons |
title_sort |
Single nucleotide polymorphisms in immune system genes and their association with clinical symptoms persistence in dengue-infected persons |
author |
Dettogni, Raquel Spinassé |
author_facet |
Dettogni, Raquel Spinassé Tristão-Sá, Ricardo Santos, Marcelo dos Silva, Franciane Figueiredo da Louro, Iúri Drumond |
author_role |
author |
author2 |
Tristão-Sá, Ricardo Santos, Marcelo dos Silva, Franciane Figueiredo da Louro, Iúri Drumond |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Dettogni, Raquel Spinassé Tristão-Sá, Ricardo Santos, Marcelo dos Silva, Franciane Figueiredo da Louro, Iúri Drumond |
dc.subject.por.fl_str_mv |
Immune system SNPs Receptors Cytokines Dengue Symptoms persistent |
topic |
Immune system SNPs Receptors Cytokines Dengue Symptoms persistent |
description |
This study was undertaken to determine the prevalence of dengue clinical symptom persistence during 60 days of disease follow up, in patients of Espírito Santo state (ES)-Brazil and to evaluate the relation of single nucleotide polymorphisms (SNPs) in FccRIIa, CD209, VDR, TNF-a, IL-4, IL-6 and IFN-c genes with symptom persistence. During 2012–2013, 96 blood samples from individuals diagnosed with symptomatic dengue were collected. Clinical symptom persistence in 60 days of follow-up was assessed by a clinical and epidemiological questionnaire filled in 4 interviews. SNP genotyping was performed by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). In two months of monitoring the dengue infection, we observed that symptoms persisted in 38.5% (37/96) of dengue patients at the end of the first month (D30) and in 11.5% (11/96) of dengue patients at the end of the second month (D60). Our results show an association between FccRIIa, TNF-a and IL-6 gene SNPs and symptom persistence and an association trend with CD209, IL-4 and IFN-c gene SNPs. Our findings may increase the knowledge on the pathophysiological mechanisms of persistent symptoms of infection with the dengue virus (DENV) and thus help the clinical management of patients |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2021-02-19T10:18:14Z |
dc.date.available.fl_str_mv |
2021-02-19T10:18:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
DETTOGNI, Raquel Spinassé; TRISTAO-SA, Ricardo; SANTOS, Marcelo dos; SILVA, Franciane Figueiredo da; LOURO, Iúri Drumond. Single nucleotide polymorphisms in immune system genes and their association with clinical symptoms persistence in dengue-infected persons. Human Immunology, [s. l.], v. 76, n. 10, p. 717-723, 2015. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0198885915004632?via%3Dihub. Acesso em: 07 jul. 2020. https://doi.org/10.1016/j.humimm.2015.09.026 |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/31559 |
dc.identifier.issn.none.fl_str_mv |
0198-8859 (print) |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.humimm.2015.09.026 |
identifier_str_mv |
DETTOGNI, Raquel Spinassé; TRISTAO-SA, Ricardo; SANTOS, Marcelo dos; SILVA, Franciane Figueiredo da; LOURO, Iúri Drumond. Single nucleotide polymorphisms in immune system genes and their association with clinical symptoms persistence in dengue-infected persons. Human Immunology, [s. l.], v. 76, n. 10, p. 717-723, 2015. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0198885915004632?via%3Dihub. Acesso em: 07 jul. 2020. https://doi.org/10.1016/j.humimm.2015.09.026 0198-8859 (print) 10.1016/j.humimm.2015.09.026 |
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eng |
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eng |
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Elsevier |
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Elsevier |
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