Neuronal Assembly Detection and Cell Membership Specification by Principal Component Analysis

Detalhes bibliográficos
Autor(a) principal: Lopes-dos-Santos, Vítor
Data de Publicação: 2011
Outros Autores: Conde-Ocazionez, Sergio, Nicolelis, Miguel A. L., Ribeiro, Sidarta Tollendal Gomes, Tort, Adriano Bretanha Lopes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/1/6194
Resumo: LOPES-DOS-SANTOS, V. , CONDE-OCAZIONEZ, S. ; NICOLELIS, M. A. L. , RIBEIRO, S. T. , TORT, A. B. L. . Neuronal assembly detection and cell membership specification by principal component analysis. Plos One, v. 6, p. e20996, 2011.
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spelling Lopes-dos-Santos, VítorConde-Ocazionez, SergioNicolelis, Miguel A. L.Ribeiro, Sidarta Tollendal GomesTort, Adriano Bretanha Lopes2013-02-18T19:43:30Z2013-02-18T19:43:30Z2011Lopes-dos-Santos V., Conde-Ocazionez S., Nicolelis, M. A. L., Ribeiro, S. T., Tort, A. B. L. (2011)https://repositorio.ufrn.br/jspui/handle/1/6194LOPES-DOS-SANTOS, V. , CONDE-OCAZIONEZ, S. ; NICOLELIS, M. A. L. , RIBEIRO, S. T. , TORT, A. B. L. . Neuronal assembly detection and cell membership specification by principal component analysis. Plos One, v. 6, p. e20996, 2011.In 1949, Donald Hebb postulated that assemblies of synchronously activated neurons are the elementary units of information processing in the brain. Despite being one of the most influential theories in neuroscience, Hebb’s cell assembly hypothesis only started to become testable in the past two decades due to technological advances. However, while the technology for the simultaneous recording of large neuronal populations undergoes fast development, there is still a paucity of analytical methods that can properly detect and track the activity of cell assemblies. Here we describe a principal component-based method that is able to (1) identify all cell assemblies present in the neuronal population investigated, (2) determine the number of neurons involved in ensemble activity, (3) specify the precise identity of the neurons pertaining to each cell assembly, and (4) unravel the time course of the individual activity of multiple assemblies. Application of the method to multielectrode recordings of awake and behaving rats revealed that assemblies detected in the cerebral cortex and hippocampus typically contain overlapping neurons. The results indicate that the PCA method presented here is able to properly detect, track and specify neuronal assemblies, irrespective of overlapping membership.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, e Associação Alberto Santos Dumont para Apoio à Pesquisa.engNeuronal Assembly Detection and Cell Membership Specification by Principal Component Analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALAdrianoBLTort_ICE_Neuronal2011.pdfAdrianoBLTort_ICE_Neuronal2011.pdfapplication/pdf1524625https://repositorio.ufrn.br/bitstream/1/6194/1/AdrianoBLTort_ICE_Neuronal2011.pdfbb1021444bbb13ab5408b3847ac1eb1eMD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-852https://repositorio.ufrn.br/bitstream/1/6194/2/license_url3d480ae6c91e310daba2020f8787d6f9MD52license_textlicense_texttext/html; charset=utf-80https://repositorio.ufrn.br/bitstream/1/6194/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-823898https://repositorio.ufrn.br/bitstream/1/6194/4/license_rdfe363e809996cf46ada20da1accfcd9c7MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/1/6194/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD55TEXTAdrianoBLTort_ICE_Neuronal2011.pdf.txtAdrianoBLTort_ICE_Neuronal2011.pdf.txtExtracted texttext/plain78945https://repositorio.ufrn.br/bitstream/1/6194/10/AdrianoBLTort_ICE_Neuronal2011.pdf.txte54a80b994dbf2f8e4ac7495cc86c319MD510THUMBNAILAdrianoBLTort_ICE_Neuronal2011.pdf.jpgAdrianoBLTort_ICE_Neuronal2011.pdf.jpgIM Thumbnailimage/jpeg13142https://repositorio.ufrn.br/bitstream/1/6194/11/AdrianoBLTort_ICE_Neuronal2011.pdf.jpg51e1fd1c2c0be18edaac6a0ff98c5b60MD5111/61942021-07-09 20:09:57.966oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-09T23:09:57Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Neuronal Assembly Detection and Cell Membership Specification by Principal Component Analysis
title Neuronal Assembly Detection and Cell Membership Specification by Principal Component Analysis
spellingShingle Neuronal Assembly Detection and Cell Membership Specification by Principal Component Analysis
Lopes-dos-Santos, Vítor
title_short Neuronal Assembly Detection and Cell Membership Specification by Principal Component Analysis
title_full Neuronal Assembly Detection and Cell Membership Specification by Principal Component Analysis
title_fullStr Neuronal Assembly Detection and Cell Membership Specification by Principal Component Analysis
title_full_unstemmed Neuronal Assembly Detection and Cell Membership Specification by Principal Component Analysis
title_sort Neuronal Assembly Detection and Cell Membership Specification by Principal Component Analysis
author Lopes-dos-Santos, Vítor
author_facet Lopes-dos-Santos, Vítor
Conde-Ocazionez, Sergio
Nicolelis, Miguel A. L.
Ribeiro, Sidarta Tollendal Gomes
Tort, Adriano Bretanha Lopes
author_role author
author2 Conde-Ocazionez, Sergio
Nicolelis, Miguel A. L.
Ribeiro, Sidarta Tollendal Gomes
Tort, Adriano Bretanha Lopes
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Lopes-dos-Santos, Vítor
Conde-Ocazionez, Sergio
Nicolelis, Miguel A. L.
Ribeiro, Sidarta Tollendal Gomes
Tort, Adriano Bretanha Lopes
description LOPES-DOS-SANTOS, V. , CONDE-OCAZIONEZ, S. ; NICOLELIS, M. A. L. , RIBEIRO, S. T. , TORT, A. B. L. . Neuronal assembly detection and cell membership specification by principal component analysis. Plos One, v. 6, p. e20996, 2011.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2013-02-18T19:43:30Z
dc.date.available.fl_str_mv 2013-02-18T19:43:30Z
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dc.identifier.citation.fl_str_mv Lopes-dos-Santos V., Conde-Ocazionez S., Nicolelis, M. A. L., Ribeiro, S. T., Tort, A. B. L. (2011)
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/1/6194
identifier_str_mv Lopes-dos-Santos V., Conde-Ocazionez S., Nicolelis, M. A. L., Ribeiro, S. T., Tort, A. B. L. (2011)
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