Theta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region

Detalhes bibliográficos
Autor(a) principal: Robson Scheffer-Teixeira
Data de Publicação: 2012
Outros Autores: Hindiael Belchior, Fábio V. Caixeta, Bryan C. Souza, Ribeiro, Sidarta Tollendal Gomes, Tort, Adriano Bretanha Lopes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/23282
Resumo: It was recently proposed that fast gamma oscillations (60--150 Hz) convey spatial information from the medial entorhinal cortex (EC) to the CA1 region of the hippocampus. However, here we describe 2 functionally distinct oscillations within this frequency range, both coupled to the theta rhythm during active exploration and rapid eye movement sleep: an oscillation with peak activity at ~80 Hz and a faster oscillation centered at ~140 Hz. The 2 oscillations are differentially modulated by the phase of theta depending on the CA1 layer; theta-80 Hz coupling is strongest at stratum lacunosum-- moleculare, while theta-140 Hz coupling is strongest at stratum oriens--alveus. This laminar profile suggests that the ~80 Hz oscillation originates from EC inputs to deeper CA1 layers, while the ~140 Hz oscillation reflects CA1 activity in superficial layers. We further show that the ~140 Hz oscillation differs from sharp wave--associated ripple oscillations in several key characteristics. Our results demonstrate the existence of novel theta--associated high-frequency oscillations and suggest a redefinition of fast gamma oscillations.
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spelling Robson Scheffer-TeixeiraHindiael BelchiorFábio V. CaixetaBryan C. SouzaRibeiro, Sidarta Tollendal GomesTort, Adriano Bretanha Lopes2017-05-31T14:45:36Z2017-05-31T14:45:36Z2012-101047-3211https://repositorio.ufrn.br/jspui/handle/123456789/23282engamplitude modulationcross-frequency couplinggammahippocampal oscillationslocal field potentialTheta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Regioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleIt was recently proposed that fast gamma oscillations (60--150 Hz) convey spatial information from the medial entorhinal cortex (EC) to the CA1 region of the hippocampus. However, here we describe 2 functionally distinct oscillations within this frequency range, both coupled to the theta rhythm during active exploration and rapid eye movement sleep: an oscillation with peak activity at ~80 Hz and a faster oscillation centered at ~140 Hz. The 2 oscillations are differentially modulated by the phase of theta depending on the CA1 layer; theta-80 Hz coupling is strongest at stratum lacunosum-- moleculare, while theta-140 Hz coupling is strongest at stratum oriens--alveus. This laminar profile suggests that the ~80 Hz oscillation originates from EC inputs to deeper CA1 layers, while the ~140 Hz oscillation reflects CA1 activity in superficial layers. We further show that the ~140 Hz oscillation differs from sharp wave--associated ripple oscillations in several key characteristics. Our results demonstrate the existence of novel theta--associated high-frequency oscillations and suggest a redefinition of fast gamma oscillations.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/23282/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52ORIGINALTheta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region.pdfTheta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region.pdfArtigo completoapplication/pdf10901377https://repositorio.ufrn.br/bitstream/123456789/23282/1/Theta%20Phase%20Modulates%20Multiple%20Layer-Specific%20Oscillations%20in%20the%20CA1%20Region.pdf24961a61838cdb10227c72ab8263a87fMD51TEXTTheta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region.pdf.txtTheta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region.pdf.txtExtracted texttext/plain57110https://repositorio.ufrn.br/bitstream/123456789/23282/5/Theta%20Phase%20Modulates%20Multiple%20Layer-Specific%20Oscillations%20in%20the%20CA1%20Region.pdf.txtde80021891b3351fc139d4f45728171dMD55THUMBNAILTheta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region.pdf.jpgTheta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region.pdf.jpgIM Thumbnailimage/jpeg14098https://repositorio.ufrn.br/bitstream/123456789/23282/6/Theta%20Phase%20Modulates%20Multiple%20Layer-Specific%20Oscillations%20in%20the%20CA1%20Region.pdf.jpg9f8504992fc7e4129240c85bd9f9eaffMD56123456789/232822021-07-10 19:48:10.728oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-10T22:48:10Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Theta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region
title Theta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region
spellingShingle Theta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region
Robson Scheffer-Teixeira
amplitude modulation
cross-frequency coupling
gamma
hippocampal oscillations
local field potential
title_short Theta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region
title_full Theta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region
title_fullStr Theta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region
title_full_unstemmed Theta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region
title_sort Theta Phase Modulates Multiple Layer-Specific Oscillations in the CA1 Region
author Robson Scheffer-Teixeira
author_facet Robson Scheffer-Teixeira
Hindiael Belchior
Fábio V. Caixeta
Bryan C. Souza
Ribeiro, Sidarta Tollendal Gomes
Tort, Adriano Bretanha Lopes
author_role author
author2 Hindiael Belchior
Fábio V. Caixeta
Bryan C. Souza
Ribeiro, Sidarta Tollendal Gomes
Tort, Adriano Bretanha Lopes
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Robson Scheffer-Teixeira
Hindiael Belchior
Fábio V. Caixeta
Bryan C. Souza
Ribeiro, Sidarta Tollendal Gomes
Tort, Adriano Bretanha Lopes
dc.subject.por.fl_str_mv amplitude modulation
cross-frequency coupling
gamma
hippocampal oscillations
local field potential
topic amplitude modulation
cross-frequency coupling
gamma
hippocampal oscillations
local field potential
description It was recently proposed that fast gamma oscillations (60--150 Hz) convey spatial information from the medial entorhinal cortex (EC) to the CA1 region of the hippocampus. However, here we describe 2 functionally distinct oscillations within this frequency range, both coupled to the theta rhythm during active exploration and rapid eye movement sleep: an oscillation with peak activity at ~80 Hz and a faster oscillation centered at ~140 Hz. The 2 oscillations are differentially modulated by the phase of theta depending on the CA1 layer; theta-80 Hz coupling is strongest at stratum lacunosum-- moleculare, while theta-140 Hz coupling is strongest at stratum oriens--alveus. This laminar profile suggests that the ~80 Hz oscillation originates from EC inputs to deeper CA1 layers, while the ~140 Hz oscillation reflects CA1 activity in superficial layers. We further show that the ~140 Hz oscillation differs from sharp wave--associated ripple oscillations in several key characteristics. Our results demonstrate the existence of novel theta--associated high-frequency oscillations and suggest a redefinition of fast gamma oscillations.
publishDate 2012
dc.date.issued.fl_str_mv 2012-10
dc.date.accessioned.fl_str_mv 2017-05-31T14:45:36Z
dc.date.available.fl_str_mv 2017-05-31T14:45:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/123456789/23282
dc.identifier.issn.none.fl_str_mv 1047-3211
identifier_str_mv 1047-3211
url https://repositorio.ufrn.br/jspui/handle/123456789/23282
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
instname:Universidade Federal do Rio Grande do Norte (UFRN)
instacron:UFRN
instname_str Universidade Federal do Rio Grande do Norte (UFRN)
instacron_str UFRN
institution UFRN
reponame_str Repositório Institucional da UFRN
collection Repositório Institucional da UFRN
bitstream.url.fl_str_mv https://repositorio.ufrn.br/bitstream/123456789/23282/2/license.txt
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