Challenges of the intensive insulin therapy in experimental models of extensive burn injury
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/31036 |
Resumo: | Burn injuries (BI) above 40% of total body surface area (TBSA) are considered extensive and associated to systemic responses. The intensive insulin therapy (IIT) has been chosen as treatment because of its anabolic and anti-inflammatory properties, and by glycemic control. Several experimental models of extensive BI with IIT has just been studied, however they have many variables and challenges. Thus, this review aims to investigate the animal models of extensive BI with IIT, in order to better understanding benefits and limitations of this therapy. The review of papers published on the literature and indexed on the PubMed database was conducted by searching the keywords predetermined. Insulin administration after BI is able to revert hyperglycemia state, accelerate wound healing, decrease the mRNA expression of some pro-inflammatory cytokines, attenuate acute lung injuries, decrease inflammation in intestinal epithelium and attenuate the muscle loss. We can conclude, although there are limitations related to burn standard or insulin administration, the systemic benefits of ITT overcome limitations |
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Quintana, Hananiah TardivoBaptista, Vivianne Izabelle de AraújoLazzarin, Mariana CruzOliveira, Flavia de2020-12-17T14:11:58Z2020-12-17T14:11:58Z2020-08-30QUINTANA, Hananiah Tardivo; BAPTISTA, Vivianne Izabelle de Araújo; LAZZARIN, Mariana Cruz; OLIVEIRA, Flavia de. Challenges of the intensive insulin therapy in experimental models of extensive burn injury. World Journal Of Advanced Research And Reviews, [s. l.], v. 7, n. 2, p. 34-44, 30 ago. 2020. Disponível em: https://wjarr.com/content/challenges-intensive-insulin-therapy-experimental-models-extensive-burn-injury. Acesso em: 03 nov. 2020. http://dx.doi.org/10.30574/wjarr.2020.7.2.02772581-9615https://repositorio.ufrn.br/handle/123456789/3103610.30574/wjarr.2020.7.2.0277World Journal SeriesAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessBurnInsulinMetabolismIntensive insulin therapyInsulin resistanceChallenges of the intensive insulin therapy in experimental models of extensive burn injuryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBurn injuries (BI) above 40% of total body surface area (TBSA) are considered extensive and associated to systemic responses. The intensive insulin therapy (IIT) has been chosen as treatment because of its anabolic and anti-inflammatory properties, and by glycemic control. Several experimental models of extensive BI with IIT has just been studied, however they have many variables and challenges. Thus, this review aims to investigate the animal models of extensive BI with IIT, in order to better understanding benefits and limitations of this therapy. The review of papers published on the literature and indexed on the PubMed database was conducted by searching the keywords predetermined. Insulin administration after BI is able to revert hyperglycemia state, accelerate wound healing, decrease the mRNA expression of some pro-inflammatory cytokines, attenuate acute lung injuries, decrease inflammation in intestinal epithelium and attenuate the muscle loss. We can conclude, although there are limitations related to burn standard or insulin administration, the systemic benefits of ITT overcome limitationsengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALIntensiveInsulinTherapy_Baptista_2020.pdfIntensiveInsulinTherapy_Baptista_2020.pdfapplication/pdf772936https://repositorio.ufrn.br/bitstream/123456789/31036/1/IntensiveInsulinTherapy_Baptista_2020.pdf7f1d21dbbca9f7c03ab6faa171a1c11dMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/31036/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/31036/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53TEXTIntensiveInsulinTherapy_Baptista_2020.pdf.txtIntensiveInsulinTherapy_Baptista_2020.pdf.txtExtracted texttext/plain40090https://repositorio.ufrn.br/bitstream/123456789/31036/4/IntensiveInsulinTherapy_Baptista_2020.pdf.txt3aa102420ea114c607dbb310f534d572MD54THUMBNAILIntensiveInsulinTherapy_Baptista_2020.pdf.jpgIntensiveInsulinTherapy_Baptista_2020.pdf.jpgGenerated Thumbnailimage/jpeg1710https://repositorio.ufrn.br/bitstream/123456789/31036/5/IntensiveInsulinTherapy_Baptista_2020.pdf.jpg4e8c2872c19326612a9ef5519e4438acMD55123456789/310362020-12-20 04:59:32.509oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2020-12-20T07:59:32Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Challenges of the intensive insulin therapy in experimental models of extensive burn injury |
title |
Challenges of the intensive insulin therapy in experimental models of extensive burn injury |
spellingShingle |
Challenges of the intensive insulin therapy in experimental models of extensive burn injury Quintana, Hananiah Tardivo Burn Insulin Metabolism Intensive insulin therapy Insulin resistance |
title_short |
Challenges of the intensive insulin therapy in experimental models of extensive burn injury |
title_full |
Challenges of the intensive insulin therapy in experimental models of extensive burn injury |
title_fullStr |
Challenges of the intensive insulin therapy in experimental models of extensive burn injury |
title_full_unstemmed |
Challenges of the intensive insulin therapy in experimental models of extensive burn injury |
title_sort |
Challenges of the intensive insulin therapy in experimental models of extensive burn injury |
author |
Quintana, Hananiah Tardivo |
author_facet |
Quintana, Hananiah Tardivo Baptista, Vivianne Izabelle de Araújo Lazzarin, Mariana Cruz Oliveira, Flavia de |
author_role |
author |
author2 |
Baptista, Vivianne Izabelle de Araújo Lazzarin, Mariana Cruz Oliveira, Flavia de |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Quintana, Hananiah Tardivo Baptista, Vivianne Izabelle de Araújo Lazzarin, Mariana Cruz Oliveira, Flavia de |
dc.subject.por.fl_str_mv |
Burn Insulin Metabolism Intensive insulin therapy Insulin resistance |
topic |
Burn Insulin Metabolism Intensive insulin therapy Insulin resistance |
description |
Burn injuries (BI) above 40% of total body surface area (TBSA) are considered extensive and associated to systemic responses. The intensive insulin therapy (IIT) has been chosen as treatment because of its anabolic and anti-inflammatory properties, and by glycemic control. Several experimental models of extensive BI with IIT has just been studied, however they have many variables and challenges. Thus, this review aims to investigate the animal models of extensive BI with IIT, in order to better understanding benefits and limitations of this therapy. The review of papers published on the literature and indexed on the PubMed database was conducted by searching the keywords predetermined. Insulin administration after BI is able to revert hyperglycemia state, accelerate wound healing, decrease the mRNA expression of some pro-inflammatory cytokines, attenuate acute lung injuries, decrease inflammation in intestinal epithelium and attenuate the muscle loss. We can conclude, although there are limitations related to burn standard or insulin administration, the systemic benefits of ITT overcome limitations |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-12-17T14:11:58Z |
dc.date.available.fl_str_mv |
2020-12-17T14:11:58Z |
dc.date.issued.fl_str_mv |
2020-08-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
QUINTANA, Hananiah Tardivo; BAPTISTA, Vivianne Izabelle de Araújo; LAZZARIN, Mariana Cruz; OLIVEIRA, Flavia de. Challenges of the intensive insulin therapy in experimental models of extensive burn injury. World Journal Of Advanced Research And Reviews, [s. l.], v. 7, n. 2, p. 34-44, 30 ago. 2020. Disponível em: https://wjarr.com/content/challenges-intensive-insulin-therapy-experimental-models-extensive-burn-injury. Acesso em: 03 nov. 2020. http://dx.doi.org/10.30574/wjarr.2020.7.2.0277 |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/31036 |
dc.identifier.issn.none.fl_str_mv |
2581-9615 |
dc.identifier.doi.none.fl_str_mv |
10.30574/wjarr.2020.7.2.0277 |
identifier_str_mv |
QUINTANA, Hananiah Tardivo; BAPTISTA, Vivianne Izabelle de Araújo; LAZZARIN, Mariana Cruz; OLIVEIRA, Flavia de. Challenges of the intensive insulin therapy in experimental models of extensive burn injury. World Journal Of Advanced Research And Reviews, [s. l.], v. 7, n. 2, p. 34-44, 30 ago. 2020. Disponível em: https://wjarr.com/content/challenges-intensive-insulin-therapy-experimental-models-extensive-burn-injury. Acesso em: 03 nov. 2020. http://dx.doi.org/10.30574/wjarr.2020.7.2.0277 2581-9615 10.30574/wjarr.2020.7.2.0277 |
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https://repositorio.ufrn.br/handle/123456789/31036 |
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eng |
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eng |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ info:eu-repo/semantics/openAccess |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ |
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openAccess |
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World Journal Series |
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World Journal Series |
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