Lifestyle and family history influence cancer prognosis in Brazilian individuals
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/25414 https://doi.org/10.1016/j.prp.2013.08.007 |
Resumo: | The aim of this research was to study prognostic parameters of CRC by analyzing clinical and pathological variables associated with cancer patients at a northeastern Brazilian Hospital. This was a retrospective study evaluating CRC-diagnosed patients across a 10-year period (1995–2005) at Dr. Luiz Antônio Hospital in Natal, RN, Brazil. Data were collected from patients’ medical files. A total of 358 patients were included over the 10-year period. The average age at diagnosis was 58.8 years (S.D. = 15.26), 48.3% of the patients were males and 51.7% were females. Alcohol consumption significantly increased the chance of dying (p < 0.023) from colorectal cancer; this increased risk of death was approximately 71%, compared to 52.2% of the non-alcoholics. In addition, tobacco increased the chance of developing high TNM stage tumors (level III, IV; p < 0.001). Another risk factor for increased mortality was a family history for colorectal cancer (p < 0.002). Our analysis found that patients with an unhealthy lifestyle and/or family history of colorectal cancer were more likely to develop advanced stage colorectal cancer and to have a poor disease prognosis compared to patients with healthy lifestyle and/or sporadic colorectal cancer. These data suggest that a mass screening program should be implemented in northeastern Brazil in order to better prevent and treat colorectal cancer. |
id |
UFRN_f7e4d44cb7ee17db6fb5c9eac77cbd9c |
---|---|
oai_identifier_str |
oai:https://repositorio.ufrn.br:123456789/25414 |
network_acronym_str |
UFRN |
network_name_str |
Repositório Institucional da UFRN |
repository_id_str |
|
spelling |
Araújo, Aurigena Antunes deAraújo Jr, Raimundo F.Lira, George A.Guedes, Hugo G.Cardoso, Marília A.Cavalcante, Francisco J.Araújo, Ana Lucia M.Ramos, Carlos César O.2018-06-16T11:31:58Z2018-06-16T11:31:58Z2013ARAÚJO, Aurigena Antunes de et al. Lifestyle and family history influence cancer prognosis in Brazilian individuals. Pathology, Research and Practice, v. 209, p. 753-757, 2013. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0344033813002112>. Acesso em: 14 mar. 2018.1618-0631https://repositorio.ufrn.br/jspui/handle/123456789/25414https://doi.org/10.1016/j.prp.2013.08.007porElsevierColorectal cancerBrazilSurvivalNeoplasm by sitePublic healthLifestyle and family history influence cancer prognosis in Brazilian individualsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThe aim of this research was to study prognostic parameters of CRC by analyzing clinical and pathological variables associated with cancer patients at a northeastern Brazilian Hospital. This was a retrospective study evaluating CRC-diagnosed patients across a 10-year period (1995–2005) at Dr. Luiz Antônio Hospital in Natal, RN, Brazil. Data were collected from patients’ medical files. A total of 358 patients were included over the 10-year period. The average age at diagnosis was 58.8 years (S.D. = 15.26), 48.3% of the patients were males and 51.7% were females. Alcohol consumption significantly increased the chance of dying (p < 0.023) from colorectal cancer; this increased risk of death was approximately 71%, compared to 52.2% of the non-alcoholics. In addition, tobacco increased the chance of developing high TNM stage tumors (level III, IV; p < 0.001). Another risk factor for increased mortality was a family history for colorectal cancer (p < 0.002). Our analysis found that patients with an unhealthy lifestyle and/or family history of colorectal cancer were more likely to develop advanced stage colorectal cancer and to have a poor disease prognosis compared to patients with healthy lifestyle and/or sporadic colorectal cancer. These data suggest that a mass screening program should be implemented in northeastern Brazil in order to better prevent and treat colorectal cancer.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNTEXTLifestyle and family history influence_2013.pdf.txtLifestyle and family history influence_2013.pdf.txtExtracted texttext/plain32166https://repositorio.ufrn.br/bitstream/123456789/25414/3/Lifestyle%20and%20family%20history%20influence_2013.pdf.txt2b4ec524dfec923b0f0222b5531a10c1MD53THUMBNAILLifestyle and family history influence_2013.pdf.jpgLifestyle and family history influence_2013.pdf.jpgIM Thumbnailimage/jpeg10276https://repositorio.ufrn.br/bitstream/123456789/25414/4/Lifestyle%20and%20family%20history%20influence_2013.pdf.jpgc420d3d51c1b5d3bfce630801b66af16MD54TEXTLifestyle and family history influence_2013.pdf.txtLifestyle and family history influence_2013.pdf.txtExtracted texttext/plain32166https://repositorio.ufrn.br/bitstream/123456789/25414/3/Lifestyle%20and%20family%20history%20influence_2013.pdf.txt2b4ec524dfec923b0f0222b5531a10c1MD53THUMBNAILLifestyle and family history influence_2013.pdf.jpgLifestyle and family history influence_2013.pdf.jpgIM Thumbnailimage/jpeg10276https://repositorio.ufrn.br/bitstream/123456789/25414/4/Lifestyle%20and%20family%20history%20influence_2013.pdf.jpgc420d3d51c1b5d3bfce630801b66af16MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/25414/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52ORIGINALLifestyleFamilyHistory_Araujo_2013.pdfLifestyleFamilyHistory_Araujo_2013.pdfapplication/pdf524517https://repositorio.ufrn.br/bitstream/123456789/25414/1/LifestyleFamilyHistory_Araujo_2013.pdff8eb8fca1e137cff7e3c1c13afe965cfMD51123456789/254142021-11-11 17:04:38.344oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-11-11T20:04:38Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Lifestyle and family history influence cancer prognosis in Brazilian individuals |
title |
Lifestyle and family history influence cancer prognosis in Brazilian individuals |
spellingShingle |
Lifestyle and family history influence cancer prognosis in Brazilian individuals Araújo, Aurigena Antunes de Colorectal cancer Brazil Survival Neoplasm by site Public health |
title_short |
Lifestyle and family history influence cancer prognosis in Brazilian individuals |
title_full |
Lifestyle and family history influence cancer prognosis in Brazilian individuals |
title_fullStr |
Lifestyle and family history influence cancer prognosis in Brazilian individuals |
title_full_unstemmed |
Lifestyle and family history influence cancer prognosis in Brazilian individuals |
title_sort |
Lifestyle and family history influence cancer prognosis in Brazilian individuals |
author |
Araújo, Aurigena Antunes de |
author_facet |
Araújo, Aurigena Antunes de Araújo Jr, Raimundo F. Lira, George A. Guedes, Hugo G. Cardoso, Marília A. Cavalcante, Francisco J. Araújo, Ana Lucia M. Ramos, Carlos César O. |
author_role |
author |
author2 |
Araújo Jr, Raimundo F. Lira, George A. Guedes, Hugo G. Cardoso, Marília A. Cavalcante, Francisco J. Araújo, Ana Lucia M. Ramos, Carlos César O. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Araújo, Aurigena Antunes de Araújo Jr, Raimundo F. Lira, George A. Guedes, Hugo G. Cardoso, Marília A. Cavalcante, Francisco J. Araújo, Ana Lucia M. Ramos, Carlos César O. |
dc.subject.por.fl_str_mv |
Colorectal cancer Brazil Survival Neoplasm by site Public health |
topic |
Colorectal cancer Brazil Survival Neoplasm by site Public health |
description |
The aim of this research was to study prognostic parameters of CRC by analyzing clinical and pathological variables associated with cancer patients at a northeastern Brazilian Hospital. This was a retrospective study evaluating CRC-diagnosed patients across a 10-year period (1995–2005) at Dr. Luiz Antônio Hospital in Natal, RN, Brazil. Data were collected from patients’ medical files. A total of 358 patients were included over the 10-year period. The average age at diagnosis was 58.8 years (S.D. = 15.26), 48.3% of the patients were males and 51.7% were females. Alcohol consumption significantly increased the chance of dying (p < 0.023) from colorectal cancer; this increased risk of death was approximately 71%, compared to 52.2% of the non-alcoholics. In addition, tobacco increased the chance of developing high TNM stage tumors (level III, IV; p < 0.001). Another risk factor for increased mortality was a family history for colorectal cancer (p < 0.002). Our analysis found that patients with an unhealthy lifestyle and/or family history of colorectal cancer were more likely to develop advanced stage colorectal cancer and to have a poor disease prognosis compared to patients with healthy lifestyle and/or sporadic colorectal cancer. These data suggest that a mass screening program should be implemented in northeastern Brazil in order to better prevent and treat colorectal cancer. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2018-06-16T11:31:58Z |
dc.date.available.fl_str_mv |
2018-06-16T11:31:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ARAÚJO, Aurigena Antunes de et al. Lifestyle and family history influence cancer prognosis in Brazilian individuals. Pathology, Research and Practice, v. 209, p. 753-757, 2013. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0344033813002112>. Acesso em: 14 mar. 2018. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/25414 |
dc.identifier.issn.none.fl_str_mv |
1618-0631 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.prp.2013.08.007 |
identifier_str_mv |
ARAÚJO, Aurigena Antunes de et al. Lifestyle and family history influence cancer prognosis in Brazilian individuals. Pathology, Research and Practice, v. 209, p. 753-757, 2013. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0344033813002112>. Acesso em: 14 mar. 2018. 1618-0631 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/25414 https://doi.org/10.1016/j.prp.2013.08.007 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
instname_str |
Universidade Federal do Rio Grande do Norte (UFRN) |
instacron_str |
UFRN |
institution |
UFRN |
reponame_str |
Repositório Institucional da UFRN |
collection |
Repositório Institucional da UFRN |
bitstream.url.fl_str_mv |
https://repositorio.ufrn.br/bitstream/123456789/25414/3/Lifestyle%20and%20family%20history%20influence_2013.pdf.txt https://repositorio.ufrn.br/bitstream/123456789/25414/4/Lifestyle%20and%20family%20history%20influence_2013.pdf.jpg https://repositorio.ufrn.br/bitstream/123456789/25414/3/Lifestyle%20and%20family%20history%20influence_2013.pdf.txt https://repositorio.ufrn.br/bitstream/123456789/25414/4/Lifestyle%20and%20family%20history%20influence_2013.pdf.jpg https://repositorio.ufrn.br/bitstream/123456789/25414/2/license.txt https://repositorio.ufrn.br/bitstream/123456789/25414/1/LifestyleFamilyHistory_Araujo_2013.pdf |
bitstream.checksum.fl_str_mv |
2b4ec524dfec923b0f0222b5531a10c1 c420d3d51c1b5d3bfce630801b66af16 2b4ec524dfec923b0f0222b5531a10c1 c420d3d51c1b5d3bfce630801b66af16 8a4605be74aa9ea9d79846c1fba20a33 f8eb8fca1e137cff7e3c1c13afe965cf |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN) |
repository.mail.fl_str_mv |
|
_version_ |
1802117760296157184 |