Antioxidant, Antinociceptive, and Anti-inflammatory Properties of the Ethanolic Extract of Combretum duarteanum in Rodents
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFS |
| Texto Completo: | https://ri.ufs.br/handle/riufs/612 |
Resumo: | This is a copy of an article published in the Journal of Medicinal Food© 2011 - copyright Mary Ann Liebert, Inc.; Journal of Medicinal Food is available online at: http://online.liebertpub.com |
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Gouveia, Marcos Guilherme de SouzaXavier, Maria AldeniseBarreto, André SalesGelain, Daniel PensSantos, João Paulo Almeida dosAraújo, Adriano Antunes de SouzaSilva, Francilene Amaral daQuintans, Jullyana de Souza SiqueiraAgra, Maria de FátimaCabral, Analúcia G. S.Tavares, Josean F.Silva, Marcelo S.Quintans-Júnior, Lucindo José2013-06-11T21:35:52Z2013-06-11T21:35:52Z2011-11GOUVEIA, M. G. S. et al. Antioxidant, antinociceptive, and anti-inflammatory properties of the ethanolic extract of combretum duarteanum in rodents. Journal of Medicinal Food, San Diego, v. 14, n. 11, p. 1389-1396, nov. 2011. Disponível em: <http://online.liebertpub.com/doi/full/10.1089/jmf.2010.0212>. Acesso em: 11 jun. 2013.1557-7600https://ri.ufs.br/handle/riufs/612Copyright Mary Ann Liebert, Inc.This is a copy of an article published in the Journal of Medicinal Food© 2011 - copyright Mary Ann Liebert, Inc.; Journal of Medicinal Food is available online at: http://online.liebertpub.comThe antioxidant, antinociceptive, and anti-inflammatory activities of the ethanolic extract from leaves of Combretum duarteanum (EEC) were assessed in rodents through in vitro tests. The antioxidant activity was investigated by using thiobarbituric acid reactive species (TBARS), hydroxyl radical–scavenging, and scavenging activity of nitric oxide assays. The antinociceptive activity was investigated by using acetic acid–induced writhing, formalin, and hot-plate tests in mice. The anti-inflammatory activity was assessed in rats by using the carrageenan-induced hind-paw edema test and arachidonic acid–induced paw edema test. EEC possesses a strong antioxidant potential according to the TBARS, nitric oxide, and hydroxyl radical–scavenging assays; it also presented scavenger activity in all in vitro tests. After intraperitoneal injection, EEC (100, 200, and 400 mg/kg) significantly reduced the number of writhes (38.1%, 90.6%, and 97.8%, respectively) in a writhing test and the number of paw licks during phase 1 (30.5% and 69.5%, higher doses) and phase 2 (38.1%, 90.6%, and 97.8%, all doses) of a formalin test when compared with the control group. Naloxone (1.5 mg/kg, intraperito- neally) antagonized the antinociceptive action of EEC (400 mg/kg), and this finding suggests participation of the opioid system. Administration of 200 and 400 mg/kg (intraperitoneally) of EEC exhibited an anti-inflammatory activity in the carrageenin test, which was based on interference with prostaglandin synthesis. This finding was confirmed by the arachidonic acid test. Together, these results indicate that properties of EEC might be further explored in the search for newer tools to treat painful inflammatory conditions, including those related to pro-oxidant states.Mary Ann Liebert, Inc.Anti-inflamatórioAtividade antioxidanteAtividade antinociceptivaPlantas medicinaisCombretum duarteanumAntioxidant, Antinociceptive, and Anti-inflammatory Properties of the Ethanolic Extract of Combretum duarteanum in Rodentsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTHUMBNAILAntioxidantCombretumDuarteanum.pdf.jpgAntioxidantCombretumDuarteanum.pdf.jpgGenerated Thumbnailimage/jpeg1670https://ri.ufs.br/jspui/bitstream/riufs/612/4/AntioxidantCombretumDuarteanum.pdf.jpg6006b54d8ae26d85de5bf79f355529b6MD54ORIGINALAntioxidantCombretumDuarteanum.pdfAntioxidantCombretumDuarteanum.pdfapplication/pdf186118https://ri.ufs.br/jspui/bitstream/riufs/612/1/AntioxidantCombretumDuarteanum.pdf1f8e2c17482994ff712d4a8695b0b71dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://ri.ufs.br/jspui/bitstream/riufs/612/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTAntioxidantCombretumDuarteanum.pdf.txtAntioxidantCombretumDuarteanum.pdf.txtExtracted texttext/plain38457https://ri.ufs.br/jspui/bitstream/riufs/612/3/AntioxidantCombretumDuarteanum.pdf.txtf18ba0747e3cdcabdc9b2d2b0bfe05bbMD53riufs/6122013-06-12 02:00:07.429oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2013-06-12T05:00:07Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
| dc.title.pt_BR.fl_str_mv |
Antioxidant, Antinociceptive, and Anti-inflammatory Properties of the Ethanolic Extract of Combretum duarteanum in Rodents |
| title |
Antioxidant, Antinociceptive, and Anti-inflammatory Properties of the Ethanolic Extract of Combretum duarteanum in Rodents |
| spellingShingle |
Antioxidant, Antinociceptive, and Anti-inflammatory Properties of the Ethanolic Extract of Combretum duarteanum in Rodents Gouveia, Marcos Guilherme de Souza Anti-inflamatório Atividade antioxidante Atividade antinociceptiva Plantas medicinais Combretum duarteanum |
| title_short |
Antioxidant, Antinociceptive, and Anti-inflammatory Properties of the Ethanolic Extract of Combretum duarteanum in Rodents |
| title_full |
Antioxidant, Antinociceptive, and Anti-inflammatory Properties of the Ethanolic Extract of Combretum duarteanum in Rodents |
| title_fullStr |
Antioxidant, Antinociceptive, and Anti-inflammatory Properties of the Ethanolic Extract of Combretum duarteanum in Rodents |
| title_full_unstemmed |
Antioxidant, Antinociceptive, and Anti-inflammatory Properties of the Ethanolic Extract of Combretum duarteanum in Rodents |
| title_sort |
Antioxidant, Antinociceptive, and Anti-inflammatory Properties of the Ethanolic Extract of Combretum duarteanum in Rodents |
| author |
Gouveia, Marcos Guilherme de Souza |
| author_facet |
Gouveia, Marcos Guilherme de Souza Xavier, Maria Aldenise Barreto, André Sales Gelain, Daniel Pens Santos, João Paulo Almeida dos Araújo, Adriano Antunes de Souza Silva, Francilene Amaral da Quintans, Jullyana de Souza Siqueira Agra, Maria de Fátima Cabral, Analúcia G. S. Tavares, Josean F. Silva, Marcelo S. Quintans-Júnior, Lucindo José |
| author_role |
author |
| author2 |
Xavier, Maria Aldenise Barreto, André Sales Gelain, Daniel Pens Santos, João Paulo Almeida dos Araújo, Adriano Antunes de Souza Silva, Francilene Amaral da Quintans, Jullyana de Souza Siqueira Agra, Maria de Fátima Cabral, Analúcia G. S. Tavares, Josean F. Silva, Marcelo S. Quintans-Júnior, Lucindo José |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gouveia, Marcos Guilherme de Souza Xavier, Maria Aldenise Barreto, André Sales Gelain, Daniel Pens Santos, João Paulo Almeida dos Araújo, Adriano Antunes de Souza Silva, Francilene Amaral da Quintans, Jullyana de Souza Siqueira Agra, Maria de Fátima Cabral, Analúcia G. S. Tavares, Josean F. Silva, Marcelo S. Quintans-Júnior, Lucindo José |
| dc.subject.por.fl_str_mv |
Anti-inflamatório Atividade antioxidante Atividade antinociceptiva Plantas medicinais Combretum duarteanum |
| topic |
Anti-inflamatório Atividade antioxidante Atividade antinociceptiva Plantas medicinais Combretum duarteanum |
| description |
This is a copy of an article published in the Journal of Medicinal Food© 2011 - copyright Mary Ann Liebert, Inc.; Journal of Medicinal Food is available online at: http://online.liebertpub.com |
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2011 |
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2011-11 |
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2013-06-11T21:35:52Z |
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2013-06-11T21:35:52Z |
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info:eu-repo/semantics/publishedVersion |
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GOUVEIA, M. G. S. et al. Antioxidant, antinociceptive, and anti-inflammatory properties of the ethanolic extract of combretum duarteanum in rodents. Journal of Medicinal Food, San Diego, v. 14, n. 11, p. 1389-1396, nov. 2011. Disponível em: <http://online.liebertpub.com/doi/full/10.1089/jmf.2010.0212>. Acesso em: 11 jun. 2013. |
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https://ri.ufs.br/handle/riufs/612 |
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1557-7600 |
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Copyright Mary Ann Liebert, Inc. |
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GOUVEIA, M. G. S. et al. Antioxidant, antinociceptive, and anti-inflammatory properties of the ethanolic extract of combretum duarteanum in rodents. Journal of Medicinal Food, San Diego, v. 14, n. 11, p. 1389-1396, nov. 2011. Disponível em: <http://online.liebertpub.com/doi/full/10.1089/jmf.2010.0212>. Acesso em: 11 jun. 2013. 1557-7600 Copyright Mary Ann Liebert, Inc. |
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Mary Ann Liebert, Inc. |
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Mary Ann Liebert, Inc. |
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reponame:Repositório Institucional da UFS instname:Universidade Federal de Sergipe (UFS) instacron:UFS |
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