Clinical and economic impact of Antimicrobial Stewardship Program in a school hospital in Brazil

• Autor(a) principal: Brondani, Luiz Eduardo Bulegon
• Data de Publicação: 2024
• Outros Autores: Helfer, Ana Paula, Krummenauer, Eliane Carlosso, Renner, Jane Dagmar Pollo, Carneiro, Marcelo, Menezes, Rochele Mosmann
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Saúde (Santa Maria)
• Texto Completo: https://periodicos.ufsm.br/revistasaude/article/view/67943
• topic: Agentes Anti-infecciosos; Serviço de Farmácia Clínica; Redução de Custos; Serviços de Controle de Infecção Hospitalar

Antimicrobials are one of the most prescribed drug classes in hospital environments, generating high health costs, in addition to being co-responsible for bacterial resistance. This study aimed to evaluate the clinical and economic impacts of the Antimicrobial Stewardship Program in a school hospital in the hinterland of Rio Grande do Sul, Brazil. Methods: Antimicrobials were analyzed according to their indication, dose, duration of treatment, and route of administration. Whenever needed, interventions with the prescribing physician or nursing staff were performed to optimize the therapy. Results: A total of 1288 medical prescriptions underwent pharmaceutical analysis. It was carried out 71 interventions, including interventions with medical staff and nursing staff, with an acceptance rate of 75% and 100%, respectively. The cost savings achieved during the study period (5 months) was R$ 5,921.84. The vast majority of patients in the intervention group had a positive outcome, progressing to discharge (86.96%). There was an 18.3% reduction in the Daily Defined Dose of intravenous ciprofloxacin between May and July. Conclusion: This study highlights the positive aspects of using the Antimicrobial Stewardship Program as an effective strategy in reducing costs and consuming antimicrobials without negative impacts on patients’ clinical outcomes.