Antimicrobial effect and modulator of the hydroalcoholic extract of Genipa americana (Jenipapo)

• Autor(a) principal: Sousa Júnior, Dárcio Luiz de
• Data de Publicação: 2019
• Outros Autores: Benjamim, Ítalo Mykaell da Silva, Teotônio, Luiz Eduardo Oliveira, Gonçalves, Filipe Joaquim, Salviano, Carla Morgana Tôrres, Leandro, Renata Correia, Lopes, Maria Janice Pereira, Aquino, Pedro Everson Alexandre de, Leite, Nadghia Figueiredo
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Saúde (Santa Maria)
• Texto Completo: https://periodicos.ufsm.br/revistasaude/article/view/33472
• topic: Antimicrobials; Modulation; Genipa americana; Antimicrobianos; Modulação; Genipa americana

Genipa americana, belonging to the family Rubiaceae, a large tree that is found in several areas of Brazil, popularly known as Jenipapeiro being used to combat liver and inflammatory diseases, and reduce cholesterol This study has as main objective to evaluate the phytochemical, antibacterial and modulatory prospection of the hydroalcoholic extract of the stem bark of Genipa americana against strains of standard and multiresistant bacteria. For the analysis of the antibacterial activity of the hydroalcoholic extract, the broth microdilution test was carried out to determine the minimum inhibitory concentration (MIC), and the antimicrobial modulation by means of gentamicin, amikacin and clindamycin. The results obtained from the MIC by the bacteria Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa were ≥ 1024 μg / mL. In the modulation modulation of the concentration of two antibiotics for each bacterial strain. Thus, it is a fact to conclude that this extract has remarkable modulatory activity, especially when tested against bacteria of clinical interest, such as P. aeruginosa, opportunistic bacteria, stressing that more research should be done on the potential of this species, which has important phytochemical compounds capable to reduce antimicrobial resistance.