Congenital hepatic fibrosis associated with ascites in a nellore calf

• Autor(a) principal: Gois,Daniela Dantas de
• Data de Publicação: 2020
• Outros Autores: Sousa,Isabelle Vieira de, Barbosa,Francisca Maria Sousa, Silva Neto,José Ferreira da, Sampaio,Rubia Avlade Guedes, Simões,Sara Vilar Dantas, Dantas,Igor Mariz, Lucena,Ricardo Barbosa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Ciência Rural
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782020000500552
• topic: Bos primigenius indicus; genetic factors; malformation; perinatal mortality

ABSTRACT: Congenital hepatic fibrosis (CHF) is an autosomal recessive malformation characterized by a variable degree of fibrosis and bile duct proliferation, mainly described in people and rarely reported in bovine European breeds. In addition to liver fibrosis, this syndrome has been associated with ascites and subcutaneous edema in calves. This paper described the pathological findings of the first report of CHF in a Nelore bovine fetus. A stillborn calf was removed by cesarean section because of dystocia. At necropsy, characteristic changes of CHF were observed, such as a large increase in abdominal volume associated with hepatic fibrosis and marked subcutaneous edema. Histological examination of liver revealed periportal and port-portal islands of fibrosis separating the parenchyma into nodules of variable sizes and containing numerous abnormally shaped bile ducts. The CHF should be considered in the differential diagnosis in young calves that present with ascites.