Graduação histológica e aspectos clínico-patológicos relacionados em meningiomas de cães
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/11268 |
Resumo: | Meningioma is the primary neoplasm of the central nervous system (CNS) most commonly reported in dogs and is the most frequently diagnosed primary tumor in the CNS of dogs in the Laboratory of Veterinary Pathology (LPV) of the Federal University of Santa Maria (UFSM). In this study, twenty two cases of meningiomas in dogs, diagnosed in about 18 years, were analyzed. The neoplasms were histologicaly classified and graded according to the World and Health Organization (WHO of 2007) for human meningiomas, adapted for dogs, in Grade I (G-I; beningn), Grade II (G-II; atypical), and Grade III (G-III; anaplastic or malignant). Aditional data about gender, age, breed, skull conformation, clinical course and signs, anatomic localization, gross and histological findings were obtained from the necropsy reports. Intracranial and supratentorial meningiomas were the most frequent in relation to the other intracranial or intraspinal sites. The intracranial ones were characterized mainly by clinical signs of thalamic-cortical alteration. Intraspinal ones were mainly characterized by ataxia. G-I meningiomas were the most frequent in dogs, followed by G-III and G-II. GI were characterized by having the psammomatous subtype as the most frequent, more than one morphological pattern in the same tumor, one third presenting areas of invasion of nervous tissue, 71.4% of cases involving females, a mean age of 11 years, pure breed dogs as the most affected and for having the longest survival time after the manifestation of clinical signs. G-II meningiomas were characterized by having the chordoid subtype as the most frequent, invasion of nervous tissue in one third of cases, only females affected, a mean age of 12 years, two-thirds of the dogs affected were mongrels and the maximum survival time of 20 days. The G-III meningiomas were characterized by having the papillary subtype as the most frequent, invasion of the nervous tissue in 80% of the cases, 60% of the cases involving females, a mean age of 8 years, 80% of dogs affected were Boxers and the maximum survival time of 90 days. In conclusion, this study allowed to establish a relationship between the three histological grades observed in 22 cases of meningiomas in dogs with various clinical-epidemiological and pathological parameters, providing useful information for a better understanding of the correlation between the histological grading and the clinical evolution of these neoplasms. |
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Graduação histológica e aspectos clínico-patológicos relacionados em meningiomas de cãesHistological grading and related clinical and pathological aspects of canine meningiomaMeningiomasNeoplasmas encefálicosGraduação histológicaDoenças de cãesBrain neoplasmsHistological gradingDog diseasesCNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIAMeningioma is the primary neoplasm of the central nervous system (CNS) most commonly reported in dogs and is the most frequently diagnosed primary tumor in the CNS of dogs in the Laboratory of Veterinary Pathology (LPV) of the Federal University of Santa Maria (UFSM). In this study, twenty two cases of meningiomas in dogs, diagnosed in about 18 years, were analyzed. The neoplasms were histologicaly classified and graded according to the World and Health Organization (WHO of 2007) for human meningiomas, adapted for dogs, in Grade I (G-I; beningn), Grade II (G-II; atypical), and Grade III (G-III; anaplastic or malignant). Aditional data about gender, age, breed, skull conformation, clinical course and signs, anatomic localization, gross and histological findings were obtained from the necropsy reports. Intracranial and supratentorial meningiomas were the most frequent in relation to the other intracranial or intraspinal sites. The intracranial ones were characterized mainly by clinical signs of thalamic-cortical alteration. Intraspinal ones were mainly characterized by ataxia. G-I meningiomas were the most frequent in dogs, followed by G-III and G-II. GI were characterized by having the psammomatous subtype as the most frequent, more than one morphological pattern in the same tumor, one third presenting areas of invasion of nervous tissue, 71.4% of cases involving females, a mean age of 11 years, pure breed dogs as the most affected and for having the longest survival time after the manifestation of clinical signs. G-II meningiomas were characterized by having the chordoid subtype as the most frequent, invasion of nervous tissue in one third of cases, only females affected, a mean age of 12 years, two-thirds of the dogs affected were mongrels and the maximum survival time of 20 days. The G-III meningiomas were characterized by having the papillary subtype as the most frequent, invasion of the nervous tissue in 80% of the cases, 60% of the cases involving females, a mean age of 8 years, 80% of dogs affected were Boxers and the maximum survival time of 90 days. In conclusion, this study allowed to establish a relationship between the three histological grades observed in 22 cases of meningiomas in dogs with various clinical-epidemiological and pathological parameters, providing useful information for a better understanding of the correlation between the histological grading and the clinical evolution of these neoplasms.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESO meningioma é o neoplasma primário do sistema nervoso central (SNC) mais comumente reportado em cães e é o tumor primário mais frequentemente diagnosticado no SNC de cães no Laboratório de Patologia Veterinária (LPV) da Universidade Federal de Santa Maria (UFSM). Neste estudo, vinte e dois casos de meningiomas em cães, diagnosticados num período de cerca de 18 anos no LPV-UFSM, foram revisados. Os neoplasmas foram graduados e classificados histologicamente de acordo com os critérios da Organização Mundial da Saúde (OMS de 2007) para meningiomas em humanos adaptados para cães, em Grau I (G-I; benignos), Grau II (G-II; atípicos) e Grau III (G-III; anaplásico ou maligno). Dos protocolos de necropsias foram retiradas adicionalmente informações referentes ao sexo, idade, raça, evolução clínica, sinais clínicos, localização anatômica e achados macroscópicos. Os meningiomas intracranianos supratentoriais foram os mais frequentes em relação às demais localizações intracranianas ou intraespinhais. Os intracranianos caracterizaram-se principalmente por sinais clínicos de alteração tálamo-cortical. Os intraespinhais caracterizaram-se principalmente causarem por ataxia. Meningiomas G-I foram os mais frequentes em cães, seguidos pelos G-III e G-II. Os G-I caracterizaram-se por ter o subtipo psammomatoso como o mais frequente, mais de um padrão morfológico num mesmo tumor, um terço apresentando áreas de invasão do tecido nervoso, 71,4% dos casos acometendo fêmeas, uma média de idade de 11 anos, cães com raça definida como os mais acometidos e por ter o maior tempo de sobrevivência após a manifestação dos sinais clínicos. Os meningiomas G-II caracterizaram-se por ter o subtipo cordoide como o mais frequente, invasão do tecido nervoso em um terço dos casos, somente fêmeas acometidas, uma média de idade de 12 anos, dois terços dos cães acometidos sem raça definida e o tempo máximo de sobrevivência de 20 dias. Os meningiomas G-III caracterizaram-se por ter o subtipo papilar como o mais frequente, invasão do tecido nervoso em 80% dos casos, 60% dos casos acometendo fêmeas, uma média de idade de 8 anos, 80% dos cães acometidos da raça Boxer e o tempo máximo de sobrevivência de 90 dias. Concluindo, este estudo permitiu estabelecer uma relação entre os três graus histológicos observados em 22 casos de meningiomas em cães com vários parâmetros clínico-epidemiológicos e patológicos, fornecendo informações úteis para um melhor conhecimento da correlação entre a graduação histológica e a evolução clínica desses neoplasmas.Universidade Federal de Santa MariaBrasilMedicina VeterináriaUFSMPrograma de Pós-Graduação em Medicina VeterináriaCentro de Ciências RuraisKommers, Glaucia Denisehttp://lattes.cnpq.br/5818649889964582Fernandes, Cristina Gevehrhttp://lattes.cnpq.br/4498627593892325Fighera, Rafael Almeidahttp://lattes.cnpq.br/6223365736139655Areco, Walter Vicente Cardozo2017-07-28T13:43:02Z2017-07-28T13:43:02Z2016-12-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://repositorio.ufsm.br/handle/1/11268porAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM2017-08-03T02:15:09Zoai:repositorio.ufsm.br:1/11268Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2017-08-03T02:15:09Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.none.fl_str_mv |
Graduação histológica e aspectos clínico-patológicos relacionados em meningiomas de cães Histological grading and related clinical and pathological aspects of canine meningioma |
title |
Graduação histológica e aspectos clínico-patológicos relacionados em meningiomas de cães |
spellingShingle |
Graduação histológica e aspectos clínico-patológicos relacionados em meningiomas de cães Areco, Walter Vicente Cardozo Meningiomas Neoplasmas encefálicos Graduação histológica Doenças de cães Brain neoplasms Histological grading Dog diseases CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
title_short |
Graduação histológica e aspectos clínico-patológicos relacionados em meningiomas de cães |
title_full |
Graduação histológica e aspectos clínico-patológicos relacionados em meningiomas de cães |
title_fullStr |
Graduação histológica e aspectos clínico-patológicos relacionados em meningiomas de cães |
title_full_unstemmed |
Graduação histológica e aspectos clínico-patológicos relacionados em meningiomas de cães |
title_sort |
Graduação histológica e aspectos clínico-patológicos relacionados em meningiomas de cães |
author |
Areco, Walter Vicente Cardozo |
author_facet |
Areco, Walter Vicente Cardozo |
author_role |
author |
dc.contributor.none.fl_str_mv |
Kommers, Glaucia Denise http://lattes.cnpq.br/5818649889964582 Fernandes, Cristina Gevehr http://lattes.cnpq.br/4498627593892325 Fighera, Rafael Almeida http://lattes.cnpq.br/6223365736139655 |
dc.contributor.author.fl_str_mv |
Areco, Walter Vicente Cardozo |
dc.subject.por.fl_str_mv |
Meningiomas Neoplasmas encefálicos Graduação histológica Doenças de cães Brain neoplasms Histological grading Dog diseases CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
topic |
Meningiomas Neoplasmas encefálicos Graduação histológica Doenças de cães Brain neoplasms Histological grading Dog diseases CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
description |
Meningioma is the primary neoplasm of the central nervous system (CNS) most commonly reported in dogs and is the most frequently diagnosed primary tumor in the CNS of dogs in the Laboratory of Veterinary Pathology (LPV) of the Federal University of Santa Maria (UFSM). In this study, twenty two cases of meningiomas in dogs, diagnosed in about 18 years, were analyzed. The neoplasms were histologicaly classified and graded according to the World and Health Organization (WHO of 2007) for human meningiomas, adapted for dogs, in Grade I (G-I; beningn), Grade II (G-II; atypical), and Grade III (G-III; anaplastic or malignant). Aditional data about gender, age, breed, skull conformation, clinical course and signs, anatomic localization, gross and histological findings were obtained from the necropsy reports. Intracranial and supratentorial meningiomas were the most frequent in relation to the other intracranial or intraspinal sites. The intracranial ones were characterized mainly by clinical signs of thalamic-cortical alteration. Intraspinal ones were mainly characterized by ataxia. G-I meningiomas were the most frequent in dogs, followed by G-III and G-II. GI were characterized by having the psammomatous subtype as the most frequent, more than one morphological pattern in the same tumor, one third presenting areas of invasion of nervous tissue, 71.4% of cases involving females, a mean age of 11 years, pure breed dogs as the most affected and for having the longest survival time after the manifestation of clinical signs. G-II meningiomas were characterized by having the chordoid subtype as the most frequent, invasion of nervous tissue in one third of cases, only females affected, a mean age of 12 years, two-thirds of the dogs affected were mongrels and the maximum survival time of 20 days. The G-III meningiomas were characterized by having the papillary subtype as the most frequent, invasion of the nervous tissue in 80% of the cases, 60% of the cases involving females, a mean age of 8 years, 80% of dogs affected were Boxers and the maximum survival time of 90 days. In conclusion, this study allowed to establish a relationship between the three histological grades observed in 22 cases of meningiomas in dogs with various clinical-epidemiological and pathological parameters, providing useful information for a better understanding of the correlation between the histological grading and the clinical evolution of these neoplasms. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12-19 2017-07-28T13:43:02Z 2017-07-28T13:43:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/11268 |
url |
http://repositorio.ufsm.br/handle/1/11268 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Brasil Medicina Veterinária UFSM Programa de Pós-Graduação em Medicina Veterinária Centro de Ciências Rurais |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Brasil Medicina Veterinária UFSM Programa de Pós-Graduação em Medicina Veterinária Centro de Ciências Rurais |
dc.source.none.fl_str_mv |
reponame:Manancial - Repositório Digital da UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Manancial - Repositório Digital da UFSM |
collection |
Manancial - Repositório Digital da UFSM |
repository.name.fl_str_mv |
Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
_version_ |
1805922015167643648 |