Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/54504 https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492017000300154 |
Resumo: | Purpose: To assess the efficacy of monotherapy using tacrolimus eye drops versus sodium cromoglycate for the treatment of vernal keratoconjunctivitis (VKC). Methods: Randomized double-masked controlled trial comparing the efficacy of tacrolimus 0.03% eye drops t.i.d. (Group 1) with sodium cromoglycate 4% eye drops t.i.d. (Group 2) for the symptomatic control of VKC at days 0, 15, 30, 45, and 90 of follow-up. Visual acuity, intraocular pressure, and other complications were evaluated to assess safety and side effects. Results: In total, 16 patients were included, with 8 enrolled in each group. Two patients from Group 2 were excluded from the analysis at days 45 and 90 because of corticosteroid use. Most patients were male (81.8%) and presented with limbal VKC (56.3%). There were statistically significant differences in favor of tacrolimus in the following severity scores: itching at day 90 (p = 0.001) |
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Mueller, Eduardo Gayger [UNIFESP]dos Santos, Myrna Serapiao [UNIFESP]Freitas, Denise [UNIFESP]Pereira Gomes, Jose Alvaro [UNIFESP]Belfort, Rubens, Jr. [UNIFESP]2020-07-13T11:53:16Z2020-07-13T11:53:16Z2017Arquivos Brasileiros De Oftalmologia. Sao Paulo, v. 80, n. 3, p. 154-158, 2017.0004-2749https://repositorio.unifesp.br/handle/11600/54504https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492017000300154S0004-27492017000300154.pdfS0004-2749201700030015410.5935/0004-2749.20170038WOS:000408254100004Purpose: To assess the efficacy of monotherapy using tacrolimus eye drops versus sodium cromoglycate for the treatment of vernal keratoconjunctivitis (VKC). Methods: Randomized double-masked controlled trial comparing the efficacy of tacrolimus 0.03% eye drops t.i.d. (Group 1) with sodium cromoglycate 4% eye drops t.i.d. (Group 2) for the symptomatic control of VKC at days 0, 15, 30, 45, and 90 of follow-up. Visual acuity, intraocular pressure, and other complications were evaluated to assess safety and side effects. Results: In total, 16 patients were included, with 8 enrolled in each group. Two patients from Group 2 were excluded from the analysis at days 45 and 90 because of corticosteroid use. Most patients were male (81.8%) and presented with limbal VKC (56.3%). There were statistically significant differences in favor of tacrolimus in the following severity scores: itching at day 90 (p = 0.001)foreign body sensation at day 15 (p = 0.042)photophobia at day 30 (p = 0.041)keratitis at day 30 (p = 0.048)and limbal activity at days 15 (p = 0.011), 30 (p = 0.007), and 45 (p = 0.015). No relevant adverse effects were reported, except for a burning sensation with tacrolimus, though this did not compromise treatment compliance. Conclusion: Treatment with tacrolimus was superior to sodium cromoglycate when comparing severity scores for symptoms of itching, foreign body sensation, and photophobia, as well as for signs of limbal inflammatory activity and keratitis.Instituto da Visao (IPEPO), Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Ophthalmol & Visual Sci, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Ophthalmol & Visual Sci, Sao Paulo, BrazilWeb of Science154-158engConsel Brasil OftalmologiaArquivos Brasileiros De OftalmologiaConjunctivitisAllergicAnti-allergic agentsTacrolimusOphthalmic solutionsCromolyn sodiumTacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSao Paulo803info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0004-27492017000300154.pdfapplication/pdf332815${dspace.ui.url}/bitstream/11600/54504/1/S0004-27492017000300154.pdfc1b5cedcc4364fc84e39b9c5f633dd5cMD51open accessTEXTS0004-27492017000300154.pdf.txtS0004-27492017000300154.pdf.txtExtracted texttext/plain31883${dspace.ui.url}/bitstream/11600/54504/2/S0004-27492017000300154.pdf.txt9336fb9fd8182bfb4c12c028de96667bMD52open accessTHUMBNAILS0004-27492017000300154.pdf.jpgS0004-27492017000300154.pdf.jpgIM Thumbnailimage/jpeg5981${dspace.ui.url}/bitstream/11600/54504/4/S0004-27492017000300154.pdf.jpgbf3130e7d396dc3caeb8c102399e400eMD54open access11600/545042022-08-01 06:46:42.842open accessoai:repositorio.unifesp.br:11600/54504Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-08-01T09:46:42Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial |
title |
Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial |
spellingShingle |
Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial Mueller, Eduardo Gayger [UNIFESP] Conjunctivitis Allergic Anti-allergic agents Tacrolimus Ophthalmic solutions Cromolyn sodium |
title_short |
Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial |
title_full |
Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial |
title_fullStr |
Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial |
title_full_unstemmed |
Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial |
title_sort |
Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial |
author |
Mueller, Eduardo Gayger [UNIFESP] |
author_facet |
Mueller, Eduardo Gayger [UNIFESP] dos Santos, Myrna Serapiao [UNIFESP] Freitas, Denise [UNIFESP] Pereira Gomes, Jose Alvaro [UNIFESP] Belfort, Rubens, Jr. [UNIFESP] |
author_role |
author |
author2 |
dos Santos, Myrna Serapiao [UNIFESP] Freitas, Denise [UNIFESP] Pereira Gomes, Jose Alvaro [UNIFESP] Belfort, Rubens, Jr. [UNIFESP] |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Mueller, Eduardo Gayger [UNIFESP] dos Santos, Myrna Serapiao [UNIFESP] Freitas, Denise [UNIFESP] Pereira Gomes, Jose Alvaro [UNIFESP] Belfort, Rubens, Jr. [UNIFESP] |
dc.subject.eng.fl_str_mv |
Conjunctivitis Allergic Anti-allergic agents Tacrolimus Ophthalmic solutions Cromolyn sodium |
topic |
Conjunctivitis Allergic Anti-allergic agents Tacrolimus Ophthalmic solutions Cromolyn sodium |
description |
Purpose: To assess the efficacy of monotherapy using tacrolimus eye drops versus sodium cromoglycate for the treatment of vernal keratoconjunctivitis (VKC). Methods: Randomized double-masked controlled trial comparing the efficacy of tacrolimus 0.03% eye drops t.i.d. (Group 1) with sodium cromoglycate 4% eye drops t.i.d. (Group 2) for the symptomatic control of VKC at days 0, 15, 30, 45, and 90 of follow-up. Visual acuity, intraocular pressure, and other complications were evaluated to assess safety and side effects. Results: In total, 16 patients were included, with 8 enrolled in each group. Two patients from Group 2 were excluded from the analysis at days 45 and 90 because of corticosteroid use. Most patients were male (81.8%) and presented with limbal VKC (56.3%). There were statistically significant differences in favor of tacrolimus in the following severity scores: itching at day 90 (p = 0.001) |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2020-07-13T11:53:16Z |
dc.date.available.fl_str_mv |
2020-07-13T11:53:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Arquivos Brasileiros De Oftalmologia. Sao Paulo, v. 80, n. 3, p. 154-158, 2017. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/54504 https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492017000300154 |
dc.identifier.issn.none.fl_str_mv |
0004-2749 |
dc.identifier.file.none.fl_str_mv |
S0004-27492017000300154.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0004-27492017000300154 |
dc.identifier.doi.none.fl_str_mv |
10.5935/0004-2749.20170038 |
dc.identifier.wos.none.fl_str_mv |
WOS:000408254100004 |
identifier_str_mv |
Arquivos Brasileiros De Oftalmologia. Sao Paulo, v. 80, n. 3, p. 154-158, 2017. 0004-2749 S0004-27492017000300154.pdf S0004-27492017000300154 10.5935/0004-2749.20170038 WOS:000408254100004 |
url |
https://repositorio.unifesp.br/handle/11600/54504 https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492017000300154 |
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eng |
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Arquivos Brasileiros De Oftalmologia |
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openAccess |
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154-158 |
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Sao Paulo |
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Consel Brasil Oftalmologia |
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Consel Brasil Oftalmologia |
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