m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals

Detalhes bibliográficos
Autor(a) principal: Cavarsan, Clarissa Fantin
Data de Publicação: 2011
Outros Autores: Avanzi, Renata Della Torre, Queiroz, Claudio Marcos Teixeira de, Xavier, Gilberto Fernando, Mello, Luiz Eugênio, Covolan, Luciene
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/26109
Resumo: n the present study, we investigated the possible additive effects of epilepsy and aging on the expression of m1 muscarinic acetylcholine receptors (AChR) in the rat hippocampus. Young (3 months) and Aged (20 months) male, Wistar rats were treated with pilocarpine to induce status epilepticus (SE). Immunohistochemical procedure for m1 AChR detection was performed 2 months after pilocarpine-induced SE. In the CA1 pyramidal region m1 AChR staining was significantly decreased in aged epileptic animals when compared to young epileptic and aged control rats, indicating that the aging effect is worsened by the epileptic condition. However, the Nissl-stained cell analysis indicated that the number of pyramidal CA1 neurons was similarly reduced in both epileptic groups, young and aged animals. Therefore, our data suggest that the progressive reduction of m1 AChR expression in CA1 pyramidal cells of aged epileptic rats might bear relevance to the associated progressive cognitive impairment.
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spelling Cavarsan, Clarissa FantinAvanzi, Renata Della TorreQueiroz, Claudio Marcos Teixeira deXavier, Gilberto FernandoMello, Luiz EugênioCovolan, Luciene2018-11-13T12:30:13Z2018-11-13T12:30:13Z2011-08CAVARSAN, C. F. et al. m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals. Aging Dis, v. 2, n. 4, p. 301-307, ago./2011.2152-5250https://repositorio.ufrn.br/jspui/handle/123456789/26109engAgingEpilepsyHippocampusPilocarpinem1 ACh receptorm1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animalsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlen the present study, we investigated the possible additive effects of epilepsy and aging on the expression of m1 muscarinic acetylcholine receptors (AChR) in the rat hippocampus. Young (3 months) and Aged (20 months) male, Wistar rats were treated with pilocarpine to induce status epilepticus (SE). Immunohistochemical procedure for m1 AChR detection was performed 2 months after pilocarpine-induced SE. In the CA1 pyramidal region m1 AChR staining was significantly decreased in aged epileptic animals when compared to young epileptic and aged control rats, indicating that the aging effect is worsened by the epileptic condition. However, the Nissl-stained cell analysis indicated that the number of pyramidal CA1 neurons was similarly reduced in both epileptic groups, young and aged animals. Therefore, our data suggest that the progressive reduction of m1 AChR expression in CA1 pyramidal cells of aged epileptic rats might bear relevance to the associated progressive cognitive impairment.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNTEXTClaudioQueiroz_ICe_2011_m1 acetylcholine.pdf.txtClaudioQueiroz_ICe_2011_m1 acetylcholine.pdf.txtExtracted texttext/plain26539https://repositorio.ufrn.br/bitstream/123456789/26109/3/ClaudioQueiroz_ICe_2011_m1%20acetylcholine.pdf.txta62061e1f892612f2fbcc842e7afb728MD53THUMBNAILClaudioQueiroz_ICe_2011_m1 acetylcholine.pdf.jpgClaudioQueiroz_ICe_2011_m1 acetylcholine.pdf.jpgIM Thumbnailimage/jpeg9935https://repositorio.ufrn.br/bitstream/123456789/26109/4/ClaudioQueiroz_ICe_2011_m1%20acetylcholine.pdf.jpg0f9f9ff196490fac3c61d4c122c09173MD54ORIGINALClaudioQueiroz_ICe_2011_m1 acetylcholine.pdfClaudioQueiroz_ICe_2011_m1 acetylcholine.pdfClaudioQueiroz_ICe_2011_m1 acetylcholineapplication/pdf704800https://repositorio.ufrn.br/bitstream/123456789/26109/1/ClaudioQueiroz_ICe_2011_m1%20acetylcholine.pdf9698149240a6b98e6a6e8025aefdaba0MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/26109/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/261092021-07-08 12:37:03.639oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-08T15:37:03Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals
title m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals
spellingShingle m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals
Cavarsan, Clarissa Fantin
Aging
Epilepsy
Hippocampus
Pilocarpine
m1 ACh receptor
title_short m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals
title_full m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals
title_fullStr m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals
title_full_unstemmed m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals
title_sort m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals
author Cavarsan, Clarissa Fantin
author_facet Cavarsan, Clarissa Fantin
Avanzi, Renata Della Torre
Queiroz, Claudio Marcos Teixeira de
Xavier, Gilberto Fernando
Mello, Luiz Eugênio
Covolan, Luciene
author_role author
author2 Avanzi, Renata Della Torre
Queiroz, Claudio Marcos Teixeira de
Xavier, Gilberto Fernando
Mello, Luiz Eugênio
Covolan, Luciene
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cavarsan, Clarissa Fantin
Avanzi, Renata Della Torre
Queiroz, Claudio Marcos Teixeira de
Xavier, Gilberto Fernando
Mello, Luiz Eugênio
Covolan, Luciene
dc.subject.por.fl_str_mv Aging
Epilepsy
Hippocampus
Pilocarpine
m1 ACh receptor
topic Aging
Epilepsy
Hippocampus
Pilocarpine
m1 ACh receptor
description n the present study, we investigated the possible additive effects of epilepsy and aging on the expression of m1 muscarinic acetylcholine receptors (AChR) in the rat hippocampus. Young (3 months) and Aged (20 months) male, Wistar rats were treated with pilocarpine to induce status epilepticus (SE). Immunohistochemical procedure for m1 AChR detection was performed 2 months after pilocarpine-induced SE. In the CA1 pyramidal region m1 AChR staining was significantly decreased in aged epileptic animals when compared to young epileptic and aged control rats, indicating that the aging effect is worsened by the epileptic condition. However, the Nissl-stained cell analysis indicated that the number of pyramidal CA1 neurons was similarly reduced in both epileptic groups, young and aged animals. Therefore, our data suggest that the progressive reduction of m1 AChR expression in CA1 pyramidal cells of aged epileptic rats might bear relevance to the associated progressive cognitive impairment.
publishDate 2011
dc.date.issued.fl_str_mv 2011-08
dc.date.accessioned.fl_str_mv 2018-11-13T12:30:13Z
dc.date.available.fl_str_mv 2018-11-13T12:30:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CAVARSAN, C. F. et al. m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals. Aging Dis, v. 2, n. 4, p. 301-307, ago./2011.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/123456789/26109
dc.identifier.issn.none.fl_str_mv 2152-5250
identifier_str_mv CAVARSAN, C. F. et al. m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals. Aging Dis, v. 2, n. 4, p. 301-307, ago./2011.
2152-5250
url https://repositorio.ufrn.br/jspui/handle/123456789/26109
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
instname:Universidade Federal do Rio Grande do Norte (UFRN)
instacron:UFRN
instname_str Universidade Federal do Rio Grande do Norte (UFRN)
instacron_str UFRN
institution UFRN
reponame_str Repositório Institucional da UFRN
collection Repositório Institucional da UFRN
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