Potency and Bactericidal Activity of Iclaprim against Recent Clinical Gram-Positive Isolates

Detalhes bibliográficos
Autor(a) principal: Sader, Helio S. [UNIFESP]
Data de Publicação: 2009
Outros Autores: Fritsche, Thomas R., Jones, Ronald N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://repositorio.unifesp.br/handle/11600/31479
http://dx.doi.org/10.1128/AAC.00129-09
Resumo: The in vitro activity of iclaprim, a novel diaminopyrimidine derivative, was evaluated against 5,937 recent gram-positive clinical isolates collected in the United States and Europe. Iclaprim demonstrated potent activity against Staphylococcus aureus (including methicillin-resistant S. aureus [MRSA]), beta-hemolytic Streptococcus spp., and Enterococcus faecalis strains tested. in addition, iclaprim exhibited bactericidal activity against all S. aureus strains tested, including MRSA.
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spelling Sader, Helio S. [UNIFESP]Fritsche, Thomas R.Jones, Ronald N.JMI LabsUniversidade Federal de São Paulo (UNIFESP)Tufts Univ2016-01-24T13:52:28Z2016-01-24T13:52:28Z2009-05-01Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 53, n. 5, p. 2171-2175, 2009.0066-4804http://repositorio.unifesp.br/handle/11600/31479http://dx.doi.org/10.1128/AAC.00129-09WOS000265528700066.pdf10.1128/AAC.00129-09WOS:000265528700066The in vitro activity of iclaprim, a novel diaminopyrimidine derivative, was evaluated against 5,937 recent gram-positive clinical isolates collected in the United States and Europe. Iclaprim demonstrated potent activity against Staphylococcus aureus (including methicillin-resistant S. aureus [MRSA]), beta-hemolytic Streptococcus spp., and Enterococcus faecalis strains tested. in addition, iclaprim exhibited bactericidal activity against all S. aureus strains tested, including MRSA.Arpida AG (Reinach, Switzerland)JMI Labs, Beaver Kreek Ctr 345, N Liberty, IA 52317 USAUniversidade Federal de São Paulo, São Paulo, BrazilTufts Univ, Sch Med, Boston, MA 02111 USAUniversidade Federal de São Paulo, São Paulo, BrazilWeb of Science2171-2175engAmer Soc MicrobiologyAntimicrobial Agents and ChemotherapyPotency and Bactericidal Activity of Iclaprim against Recent Clinical Gram-Positive Isolatesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPInfectologiaORIGINALWOS000265528700066.pdfapplication/pdf51726${dspace.ui.url}/bitstream/11600/31479/1/WOS000265528700066.pdf422ca5ef433730ebf8a70df90810f725MD51open accessTEXTWOS000265528700066.pdf.txtWOS000265528700066.pdf.txtExtracted texttext/plain21570${dspace.ui.url}/bitstream/11600/31479/2/WOS000265528700066.pdf.txt356c9cd1023f4b02cb6621b3aef9ce41MD52open access11600/314792023-02-17 20:34:45.089open accessoai:repositorio.unifesp.br:11600/31479Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-02-17T23:34:45Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Potency and Bactericidal Activity of Iclaprim against Recent Clinical Gram-Positive Isolates
title Potency and Bactericidal Activity of Iclaprim against Recent Clinical Gram-Positive Isolates
spellingShingle Potency and Bactericidal Activity of Iclaprim against Recent Clinical Gram-Positive Isolates
Sader, Helio S. [UNIFESP]
title_short Potency and Bactericidal Activity of Iclaprim against Recent Clinical Gram-Positive Isolates
title_full Potency and Bactericidal Activity of Iclaprim against Recent Clinical Gram-Positive Isolates
title_fullStr Potency and Bactericidal Activity of Iclaprim against Recent Clinical Gram-Positive Isolates
title_full_unstemmed Potency and Bactericidal Activity of Iclaprim against Recent Clinical Gram-Positive Isolates
title_sort Potency and Bactericidal Activity of Iclaprim against Recent Clinical Gram-Positive Isolates
author Sader, Helio S. [UNIFESP]
author_facet Sader, Helio S. [UNIFESP]
Fritsche, Thomas R.
Jones, Ronald N.
author_role author
author2 Fritsche, Thomas R.
Jones, Ronald N.
author2_role author
author
dc.contributor.institution.none.fl_str_mv JMI Labs
Universidade Federal de São Paulo (UNIFESP)
Tufts Univ
dc.contributor.author.fl_str_mv Sader, Helio S. [UNIFESP]
Fritsche, Thomas R.
Jones, Ronald N.
description The in vitro activity of iclaprim, a novel diaminopyrimidine derivative, was evaluated against 5,937 recent gram-positive clinical isolates collected in the United States and Europe. Iclaprim demonstrated potent activity against Staphylococcus aureus (including methicillin-resistant S. aureus [MRSA]), beta-hemolytic Streptococcus spp., and Enterococcus faecalis strains tested. in addition, iclaprim exhibited bactericidal activity against all S. aureus strains tested, including MRSA.
publishDate 2009
dc.date.issued.fl_str_mv 2009-05-01
dc.date.accessioned.fl_str_mv 2016-01-24T13:52:28Z
dc.date.available.fl_str_mv 2016-01-24T13:52:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 53, n. 5, p. 2171-2175, 2009.
dc.identifier.uri.fl_str_mv http://repositorio.unifesp.br/handle/11600/31479
http://dx.doi.org/10.1128/AAC.00129-09
dc.identifier.issn.none.fl_str_mv 0066-4804
dc.identifier.file.none.fl_str_mv WOS000265528700066.pdf
dc.identifier.doi.none.fl_str_mv 10.1128/AAC.00129-09
dc.identifier.wos.none.fl_str_mv WOS:000265528700066
identifier_str_mv Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 53, n. 5, p. 2171-2175, 2009.
0066-4804
WOS000265528700066.pdf
10.1128/AAC.00129-09
WOS:000265528700066
url http://repositorio.unifesp.br/handle/11600/31479
http://dx.doi.org/10.1128/AAC.00129-09
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dc.relation.ispartof.none.fl_str_mv Antimicrobial Agents and Chemotherapy
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dc.format.none.fl_str_mv 2171-2175
dc.publisher.none.fl_str_mv Amer Soc Microbiology
publisher.none.fl_str_mv Amer Soc Microbiology
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instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
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institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
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