Association of increased levels of homocysteine and peripheral arterial disease in a Japanese-Brazilian population
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/29827 http://dx.doi.org/10.1016/j.ejvs.2007.02.008 |
Resumo: | Objectives. Our aim was to evaluate the possible association between homocysteine levels and peripheral arterial disease (PAD) in a population-based study of Japanese-Brazilians.Materials and methods. This cross-sectional study was derived from a population-based survey on the prevalence of diabetes and associated diseases conducted in Japanese-Brazilians. A total of 1330 male and female subjects aged >= 30 years were submitted to clinical examination and laboratory procedures including homocysteine measurement. the ankle-brachial index (ABI) was calculated, subjects with ABI values <0.9 were diagnosed with PAD. the evaluable population included 1008 subjects. Logistic regression was used taking PAD as the dependent variable.Results. Mean age of the population was 56.5 years and overall prevalence of PAD was 20%. A worse cardiovascular profile was found in male patients, including significantly higher homocysteine levels (11.9 +/- 1.8 vs. 9.1 +/- 1.1 mu mol/L, p < 0.001). Men with PAD had higher prevalence rates of hyperhomocysteinemia compared to women (22.7% vs 7.6%). Univariate analysis showed an odds ratio of hyperhomocysteinemia for PAD of 1.51 [1.02-2.25] in men and 1. 69 [1.06-2.68] in women. After adjustment for other cardiovascular risk factors, higher levels of homocysteine were only significantly related to PAD in men.Conclusion. in a Japanese-Brazilian population, elevated levels of homocysteine are associated with PAD in men. Prospective studies are necessary to confirm this finding. |
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Garofolo, Luciana [UNIFESP]Barros, Newton [UNIFESP]Miranda Junior, Fausto [UNIFESP]D'Almeida, Vânia [UNIFESP]Cardien, L. C. [UNIFESP]Ferreira, S. R.Universidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)2016-01-24T13:48:49Z2016-01-24T13:48:49Z2007-07-01European Journal of Vascular and Endovascular Surgery. London: W B Saunders Co Ltd, v. 34, n. 1, p. 23-28, 2007.1078-5884http://repositorio.unifesp.br/handle/11600/29827http://dx.doi.org/10.1016/j.ejvs.2007.02.008WOS000247908200004.pdf10.1016/j.ejvs.2007.02.008WOS:000247908200004Objectives. Our aim was to evaluate the possible association between homocysteine levels and peripheral arterial disease (PAD) in a population-based study of Japanese-Brazilians.Materials and methods. This cross-sectional study was derived from a population-based survey on the prevalence of diabetes and associated diseases conducted in Japanese-Brazilians. A total of 1330 male and female subjects aged >= 30 years were submitted to clinical examination and laboratory procedures including homocysteine measurement. the ankle-brachial index (ABI) was calculated, subjects with ABI values <0.9 were diagnosed with PAD. the evaluable population included 1008 subjects. Logistic regression was used taking PAD as the dependent variable.Results. Mean age of the population was 56.5 years and overall prevalence of PAD was 20%. A worse cardiovascular profile was found in male patients, including significantly higher homocysteine levels (11.9 +/- 1.8 vs. 9.1 +/- 1.1 mu mol/L, p < 0.001). Men with PAD had higher prevalence rates of hyperhomocysteinemia compared to women (22.7% vs 7.6%). Univariate analysis showed an odds ratio of hyperhomocysteinemia for PAD of 1.51 [1.02-2.25] in men and 1. 69 [1.06-2.68] in women. After adjustment for other cardiovascular risk factors, higher levels of homocysteine were only significantly related to PAD in men.Conclusion. in a Japanese-Brazilian population, elevated levels of homocysteine are associated with PAD in men. Prospective studies are necessary to confirm this finding.Universidade Federal de São Paulo, Dept Surg, Postgrad Course Cardiac Vasc & Thorac Surg, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Surg, Div Vasc Surg, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pediat, São Paulo, BrazilUniv São Paulo, Sch Publ Hlth, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Surg, Postgrad Course Cardiac Vasc & Thorac Surg, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Surg, Div Vasc Surg, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pediat, São Paulo, BrazilWeb of Science23-28engW B Saunders Co LtdEuropean Journal of Vascular and Endovascular Surgeryperipheral arterial diseasehomocysteinerisk factorAssociation of increased levels of homocysteine and peripheral arterial disease in a Japanese-Brazilian populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000247908200004.pdfapplication/pdf114822${dspace.ui.url}/bitstream/11600/29827/1/WOS000247908200004.pdf39b7e94c00eee8ff4f14310a03811e10MD51open accessTEXTWOS000247908200004.pdf.txtWOS000247908200004.pdf.txtExtracted texttext/plain28676${dspace.ui.url}/bitstream/11600/29827/2/WOS000247908200004.pdf.txt7c741f2b79ade7fc870b58bea8706178MD52open access11600/298272022-02-18 12:05:32.383open accessoai:repositorio.unifesp.br:11600/29827Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-02-18T15:05:32Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Association of increased levels of homocysteine and peripheral arterial disease in a Japanese-Brazilian population |
title |
Association of increased levels of homocysteine and peripheral arterial disease in a Japanese-Brazilian population |
spellingShingle |
Association of increased levels of homocysteine and peripheral arterial disease in a Japanese-Brazilian population Garofolo, Luciana [UNIFESP] peripheral arterial disease homocysteine risk factor |
title_short |
Association of increased levels of homocysteine and peripheral arterial disease in a Japanese-Brazilian population |
title_full |
Association of increased levels of homocysteine and peripheral arterial disease in a Japanese-Brazilian population |
title_fullStr |
Association of increased levels of homocysteine and peripheral arterial disease in a Japanese-Brazilian population |
title_full_unstemmed |
Association of increased levels of homocysteine and peripheral arterial disease in a Japanese-Brazilian population |
title_sort |
Association of increased levels of homocysteine and peripheral arterial disease in a Japanese-Brazilian population |
author |
Garofolo, Luciana [UNIFESP] |
author_facet |
Garofolo, Luciana [UNIFESP] Barros, Newton [UNIFESP] Miranda Junior, Fausto [UNIFESP] D'Almeida, Vânia [UNIFESP] Cardien, L. C. [UNIFESP] Ferreira, S. R. |
author_role |
author |
author2 |
Barros, Newton [UNIFESP] Miranda Junior, Fausto [UNIFESP] D'Almeida, Vânia [UNIFESP] Cardien, L. C. [UNIFESP] Ferreira, S. R. |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Garofolo, Luciana [UNIFESP] Barros, Newton [UNIFESP] Miranda Junior, Fausto [UNIFESP] D'Almeida, Vânia [UNIFESP] Cardien, L. C. [UNIFESP] Ferreira, S. R. |
dc.subject.eng.fl_str_mv |
peripheral arterial disease homocysteine risk factor |
topic |
peripheral arterial disease homocysteine risk factor |
description |
Objectives. Our aim was to evaluate the possible association between homocysteine levels and peripheral arterial disease (PAD) in a population-based study of Japanese-Brazilians.Materials and methods. This cross-sectional study was derived from a population-based survey on the prevalence of diabetes and associated diseases conducted in Japanese-Brazilians. A total of 1330 male and female subjects aged >= 30 years were submitted to clinical examination and laboratory procedures including homocysteine measurement. the ankle-brachial index (ABI) was calculated, subjects with ABI values <0.9 were diagnosed with PAD. the evaluable population included 1008 subjects. Logistic regression was used taking PAD as the dependent variable.Results. Mean age of the population was 56.5 years and overall prevalence of PAD was 20%. A worse cardiovascular profile was found in male patients, including significantly higher homocysteine levels (11.9 +/- 1.8 vs. 9.1 +/- 1.1 mu mol/L, p < 0.001). Men with PAD had higher prevalence rates of hyperhomocysteinemia compared to women (22.7% vs 7.6%). Univariate analysis showed an odds ratio of hyperhomocysteinemia for PAD of 1.51 [1.02-2.25] in men and 1. 69 [1.06-2.68] in women. After adjustment for other cardiovascular risk factors, higher levels of homocysteine were only significantly related to PAD in men.Conclusion. in a Japanese-Brazilian population, elevated levels of homocysteine are associated with PAD in men. Prospective studies are necessary to confirm this finding. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007-07-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T13:48:49Z |
dc.date.available.fl_str_mv |
2016-01-24T13:48:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
European Journal of Vascular and Endovascular Surgery. London: W B Saunders Co Ltd, v. 34, n. 1, p. 23-28, 2007. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/29827 http://dx.doi.org/10.1016/j.ejvs.2007.02.008 |
dc.identifier.issn.none.fl_str_mv |
1078-5884 |
dc.identifier.file.none.fl_str_mv |
WOS000247908200004.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.ejvs.2007.02.008 |
dc.identifier.wos.none.fl_str_mv |
WOS:000247908200004 |
identifier_str_mv |
European Journal of Vascular and Endovascular Surgery. London: W B Saunders Co Ltd, v. 34, n. 1, p. 23-28, 2007. 1078-5884 WOS000247908200004.pdf 10.1016/j.ejvs.2007.02.008 WOS:000247908200004 |
url |
http://repositorio.unifesp.br/handle/11600/29827 http://dx.doi.org/10.1016/j.ejvs.2007.02.008 |
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eng |
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eng |
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European Journal of Vascular and Endovascular Surgery |
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openAccess |
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23-28 |
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W B Saunders Co Ltd |
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W B Saunders Co Ltd |
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