Resting energy expenditure and its determinants in hemodialysis patients
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/29515 http://dx.doi.org/10.1038/sj.ejcn.1602516 |
Resumo: | Objective: Chronic kidney disease is associated with several metabolic disturbances that can affect energy metabolism. As resting energy expenditure (REE) is scarcely investigated in patients on hemodialysis (HD) therapy, we aimed to evaluate the REE and its determinants in HD patients.Design: Cross-sectional study.Setting: Dialysis Unit of the Nephrology Division, Federal University of São Paulo, Brazil.Subjects: the study included 55 patients ( 28 male, 41.4 +/- 12.6 years old) undergoing HD therapy thrice weekly for at least 2 months, and 55 healthy individuals pair matched for age and gender. Subjects underwent fasting blood tests, as well as nutritional assessment, and the REE was assessed by indirect calorimetry.Results: REE of HD patients was similar to that of pair-matched controls (1379 +/- 7272 and 1440 +/- 7259 kcal/day, respectively), even when adjusted for fat-free mass (P = 0.24). REE of HD patients correlated positively with fat-free mass (r = 0.74; P < 0.001) and body mass index (r = 0.37; P < 0.01), and negatively with dialysis adequacy (r = -0.46; P < 0.001). No significant univariate correlation was found between REE and age, dialysis vintage, serum creatinine, urea, albumin, bicarbonate, parathyroid hormone (PTH) or high-sensitivity C-reactive protein (CRP). in the multiple linear regression analysis, using REE as dependent variable, the final model showed that besides the well-recognized determinants of REE such as fat-free mass and age, PTH and CRP were the independent determinants of REE in HD patients (R-2 = 0.64).Conclusions: in this study, the REE of HD patients was similar to that of healthy individuals, even with the positive effect of secondary hyperparathyroidism and inflammation on REE of these patients. |
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Kamimura, Maria Ayako [UNIFESP]Draibe, Sergio Antonio [UNIFESP]Avesani, Carla Maria [UNIFESP]Canziani, Maria Eugênia Fernandes [UNIFESP]Colugnati, Fernando Antonio Basile [UNIFESP]Cuppari, Lilian [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T12:41:53Z2016-01-24T12:41:53Z2007-03-01European Journal of Clinical Nutrition. London: Nature Publishing Group, v. 61, n. 3, p. 362-367, 2007.0954-3007http://repositorio.unifesp.br/handle/11600/29515http://dx.doi.org/10.1038/sj.ejcn.160251610.1038/sj.ejcn.1602516WOS:000244570600009Objective: Chronic kidney disease is associated with several metabolic disturbances that can affect energy metabolism. As resting energy expenditure (REE) is scarcely investigated in patients on hemodialysis (HD) therapy, we aimed to evaluate the REE and its determinants in HD patients.Design: Cross-sectional study.Setting: Dialysis Unit of the Nephrology Division, Federal University of São Paulo, Brazil.Subjects: the study included 55 patients ( 28 male, 41.4 +/- 12.6 years old) undergoing HD therapy thrice weekly for at least 2 months, and 55 healthy individuals pair matched for age and gender. Subjects underwent fasting blood tests, as well as nutritional assessment, and the REE was assessed by indirect calorimetry.Results: REE of HD patients was similar to that of pair-matched controls (1379 +/- 7272 and 1440 +/- 7259 kcal/day, respectively), even when adjusted for fat-free mass (P = 0.24). REE of HD patients correlated positively with fat-free mass (r = 0.74; P < 0.001) and body mass index (r = 0.37; P < 0.01), and negatively with dialysis adequacy (r = -0.46; P < 0.001). No significant univariate correlation was found between REE and age, dialysis vintage, serum creatinine, urea, albumin, bicarbonate, parathyroid hormone (PTH) or high-sensitivity C-reactive protein (CRP). in the multiple linear regression analysis, using REE as dependent variable, the final model showed that besides the well-recognized determinants of REE such as fat-free mass and age, PTH and CRP were the independent determinants of REE in HD patients (R-2 = 0.64).Conclusions: in this study, the REE of HD patients was similar to that of healthy individuals, even with the positive effect of secondary hyperparathyroidism and inflammation on REE of these patients.Universidade Federal de São Paulo, Div Nephrol, BR-04039000 São Paulo, BrazilUniversidade Federal de São Paulo, Nutr Program, São Paulo, BrazilUniversidade Federal de São Paulo, Div Nephrol, BR-04039000 São Paulo, BrazilUniversidade Federal de São Paulo, Nutr Program, São Paulo, BrazilWeb of Science362-367engNature Publishing GroupEuropean Journal of Clinical Nutritionhemodialysisenergy metabolismhyperparathyroidisminflammationResting energy expenditure and its determinants in hemodialysis patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/295152023-01-12 21:52:29.694metadata only accessoai:repositorio.unifesp.br:11600/29515Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-01-13T00:52:29Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Resting energy expenditure and its determinants in hemodialysis patients |
title |
Resting energy expenditure and its determinants in hemodialysis patients |
spellingShingle |
Resting energy expenditure and its determinants in hemodialysis patients Kamimura, Maria Ayako [UNIFESP] hemodialysis energy metabolism hyperparathyroidism inflammation |
title_short |
Resting energy expenditure and its determinants in hemodialysis patients |
title_full |
Resting energy expenditure and its determinants in hemodialysis patients |
title_fullStr |
Resting energy expenditure and its determinants in hemodialysis patients |
title_full_unstemmed |
Resting energy expenditure and its determinants in hemodialysis patients |
title_sort |
Resting energy expenditure and its determinants in hemodialysis patients |
author |
Kamimura, Maria Ayako [UNIFESP] |
author_facet |
Kamimura, Maria Ayako [UNIFESP] Draibe, Sergio Antonio [UNIFESP] Avesani, Carla Maria [UNIFESP] Canziani, Maria Eugênia Fernandes [UNIFESP] Colugnati, Fernando Antonio Basile [UNIFESP] Cuppari, Lilian [UNIFESP] |
author_role |
author |
author2 |
Draibe, Sergio Antonio [UNIFESP] Avesani, Carla Maria [UNIFESP] Canziani, Maria Eugênia Fernandes [UNIFESP] Colugnati, Fernando Antonio Basile [UNIFESP] Cuppari, Lilian [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Kamimura, Maria Ayako [UNIFESP] Draibe, Sergio Antonio [UNIFESP] Avesani, Carla Maria [UNIFESP] Canziani, Maria Eugênia Fernandes [UNIFESP] Colugnati, Fernando Antonio Basile [UNIFESP] Cuppari, Lilian [UNIFESP] |
dc.subject.eng.fl_str_mv |
hemodialysis energy metabolism hyperparathyroidism inflammation |
topic |
hemodialysis energy metabolism hyperparathyroidism inflammation |
description |
Objective: Chronic kidney disease is associated with several metabolic disturbances that can affect energy metabolism. As resting energy expenditure (REE) is scarcely investigated in patients on hemodialysis (HD) therapy, we aimed to evaluate the REE and its determinants in HD patients.Design: Cross-sectional study.Setting: Dialysis Unit of the Nephrology Division, Federal University of São Paulo, Brazil.Subjects: the study included 55 patients ( 28 male, 41.4 +/- 12.6 years old) undergoing HD therapy thrice weekly for at least 2 months, and 55 healthy individuals pair matched for age and gender. Subjects underwent fasting blood tests, as well as nutritional assessment, and the REE was assessed by indirect calorimetry.Results: REE of HD patients was similar to that of pair-matched controls (1379 +/- 7272 and 1440 +/- 7259 kcal/day, respectively), even when adjusted for fat-free mass (P = 0.24). REE of HD patients correlated positively with fat-free mass (r = 0.74; P < 0.001) and body mass index (r = 0.37; P < 0.01), and negatively with dialysis adequacy (r = -0.46; P < 0.001). No significant univariate correlation was found between REE and age, dialysis vintage, serum creatinine, urea, albumin, bicarbonate, parathyroid hormone (PTH) or high-sensitivity C-reactive protein (CRP). in the multiple linear regression analysis, using REE as dependent variable, the final model showed that besides the well-recognized determinants of REE such as fat-free mass and age, PTH and CRP were the independent determinants of REE in HD patients (R-2 = 0.64).Conclusions: in this study, the REE of HD patients was similar to that of healthy individuals, even with the positive effect of secondary hyperparathyroidism and inflammation on REE of these patients. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007-03-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:41:53Z |
dc.date.available.fl_str_mv |
2016-01-24T12:41:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
European Journal of Clinical Nutrition. London: Nature Publishing Group, v. 61, n. 3, p. 362-367, 2007. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/29515 http://dx.doi.org/10.1038/sj.ejcn.1602516 |
dc.identifier.issn.none.fl_str_mv |
0954-3007 |
dc.identifier.doi.none.fl_str_mv |
10.1038/sj.ejcn.1602516 |
dc.identifier.wos.none.fl_str_mv |
WOS:000244570600009 |
identifier_str_mv |
European Journal of Clinical Nutrition. London: Nature Publishing Group, v. 61, n. 3, p. 362-367, 2007. 0954-3007 10.1038/sj.ejcn.1602516 WOS:000244570600009 |
url |
http://repositorio.unifesp.br/handle/11600/29515 http://dx.doi.org/10.1038/sj.ejcn.1602516 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
European Journal of Clinical Nutrition |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
362-367 |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1802764118572138496 |