Consciousness Regained: Disentangling Mechanisms, Brain Systems, and Behavioral Responses
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/58178 http://dx.doi.org/10.1523/JNEUROSCI.1838-17.2017 |
Resumo: | How consciousness (experience) arises from and relates to material brain processes (the "mind-body problem") has been pondered by thinkers for centuries, and is regarded as among the deepest unsolved problems in science, with wide-ranging theoretical, clinical, and ethical implications. Until the last few decades, this was largely seen as a philosophical topic, but not widely accepted in mainstream neuroscience. Since the 1980s, however, novel methods and theoretical advances have yielded remarkable results, opening up the field for scientific and clinical progress. Since a seminal paper by Crick and Koch (1998) claimed that a science of consciousness should first search for its neural correlates (NCC), a variety of correlates have been suggested, including both content-specific NCCs, determining particular phenomenal components within an experience, and the full NCC, the neural substrates supporting entire conscious experiences. In this review, we present recent progress on theoretical, experimental, and clinical issues. Specifically, we (1) review methodological advances that are important for dissociating conscious experience from related enabling and executive functions, (2) suggest how critically reconsidering the role of the frontal cortex may further delineate NCCs, (3) advocate the need for general, objective, brain-based measures of the capacity for consciousness that are independent of sensory processing and executive functions, and (4) show how animal studies can reveal population and network phenomena of relevance for understanding mechanisms of consciousness. |
id |
UFSP_61803558dc2cc0658436afd792378db7 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/58178 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Storm, Johan F.Boly, MelanieCasali, Adenauer G. [UNIFESP]Massimini, MarcelloOlcese, UmbertoPennartz, Cyriel M. A.Wilke, Melanie2020-09-01T13:21:17Z2020-09-01T13:21:17Z2017Journal Of Neuroscience. Washington, v. 37, n. 45, p. 10882-10893, 2017.0270-6474https://repositorio.unifesp.br/handle/11600/58178http://dx.doi.org/10.1523/JNEUROSCI.1838-17.2017WOS000414662100014.pdf10.1523/JNEUROSCI.1838-17.2017WOS:000414662100014How consciousness (experience) arises from and relates to material brain processes (the "mind-body problem") has been pondered by thinkers for centuries, and is regarded as among the deepest unsolved problems in science, with wide-ranging theoretical, clinical, and ethical implications. Until the last few decades, this was largely seen as a philosophical topic, but not widely accepted in mainstream neuroscience. Since the 1980s, however, novel methods and theoretical advances have yielded remarkable results, opening up the field for scientific and clinical progress. Since a seminal paper by Crick and Koch (1998) claimed that a science of consciousness should first search for its neural correlates (NCC), a variety of correlates have been suggested, including both content-specific NCCs, determining particular phenomenal components within an experience, and the full NCC, the neural substrates supporting entire conscious experiences. In this review, we present recent progress on theoretical, experimental, and clinical issues. Specifically, we (1) review methodological advances that are important for dissociating conscious experience from related enabling and executive functions, (2) suggest how critically reconsidering the role of the frontal cortex may further delineate NCCs, (3) advocate the need for general, objective, brain-based measures of the capacity for consciousness that are independent of sensory processing and executive functions, and (4) show how animal studies can reveal population and network phenomena of relevance for understanding mechanisms of consciousness.European Union's Horizon 2020 Research and Innovation ProgrammeHermann and Lilly Schilling FoundationGerman Research FoundationCenter for Nanoscale Microscopy and Molecular Physiology of the BrainNational Institutes of Health/National Institute of Neurological Disorders and StrokeSao Paulo Research FoundationJames S. McDonnell Foundation Scholar AwardEU Grant H2020-FETOPENCanadian Institute for Advanced ResearchAzrieli Program in Brain, Mind and ConsciousnessFLAG-ERA JTC project CANONNorwegian Research CouncilNetherlands Organization for Scientific ResearchUniv Oslo, Inst Basal Med Sci, Div Physiol, Dept Mol Med, POB 1103 Blindern, N-0317 Oslo, NorwayUniv Wisconsin, Dept Neurol, Madison, WI 53705 USAUniv Wisconsin, Dept Psychiat, Madison, WI 53719 USAUniv Fed Sao Paulo, Inst Sci & Technol, BR-12231280 Sao Jose Dos Campos, SP, BrazilUniv Milan, Dept Biomed & Clin Sci Luigi Sacco, I-20157 Milan, ItalyFdn Don Carlo Gnocchi ONLUS, Ist Ricovero & Cura Carattere Sci, I-20162 Milan, ItalyUniv Amsterdam, Swammerdam Inst Life Sci, Cognit & Syst Neurosci Grp, NL-1098 XH Amsterdam, NetherlandsUniv Amsterdam, Res Prior Program Brain & Cognit, NL-1098 XH Amsterdam, NetherlandsUniv Med Goettingen, Dept Cognit Neurol, D-37075 Gottingen, GermanyLeibniz Inst Primate Res, German Primate Ctr, D-37077 Gottingen, GermanyLeibniz Sci Campus Primate Cognit, D-37077 Gottingen, GermanyUniv Fed Sao Paulo, Inst Sci & Technol, BR-12231280 Sao Jose Dos Campos, SP, BrazilEuropean Union's Horizon 2020 Research and Innovation Programme: 720270German Research Foundation: WI 4046/1-1National Institutes of Health/National Institute of Neurological Disorders and Stroke: 1R03NS096379FAPESP: 2016/08263-9EU Grant H2020-FETOPEN: RIA 686764Web of Science10882-10893engSoc NeuroscienceJournal Of Neurosciencebrain complexityconsciousnesscontent-specific NCCfunctional connectivityneural correlates of consciousnessno-report paradigmPerturbational Complexity Indexunresponsive wakefulnessvegetative stateConsciousness Regained: Disentangling Mechanisms, Brain Systems, and Behavioral Responsesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleWashington3745info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000414662100014.pdfapplication/pdf983370${dspace.ui.url}/bitstream/11600/58178/1/WOS000414662100014.pdf95b44142ffab0110bcdfa5e75b2f19b3MD51open accessTEXTWOS000414662100014.pdf.txtWOS000414662100014.pdf.txtExtracted texttext/plain85233${dspace.ui.url}/bitstream/11600/58178/8/WOS000414662100014.pdf.txt6cf5aebba2e6991bc566020e16858ba1MD58open accessTHUMBNAILWOS000414662100014.pdf.jpgWOS000414662100014.pdf.jpgIM Thumbnailimage/jpeg7871${dspace.ui.url}/bitstream/11600/58178/10/WOS000414662100014.pdf.jpg91f341ce82d7fc6e26ff9c5812fdb639MD510open access11600/581782023-06-05 19:10:33.165open accessoai:repositorio.unifesp.br:11600/58178Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:10:33Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Consciousness Regained: Disentangling Mechanisms, Brain Systems, and Behavioral Responses |
title |
Consciousness Regained: Disentangling Mechanisms, Brain Systems, and Behavioral Responses |
spellingShingle |
Consciousness Regained: Disentangling Mechanisms, Brain Systems, and Behavioral Responses Storm, Johan F. brain complexity consciousness content-specific NCC functional connectivity neural correlates of consciousness no-report paradigm Perturbational Complexity Index unresponsive wakefulness vegetative state |
title_short |
Consciousness Regained: Disentangling Mechanisms, Brain Systems, and Behavioral Responses |
title_full |
Consciousness Regained: Disentangling Mechanisms, Brain Systems, and Behavioral Responses |
title_fullStr |
Consciousness Regained: Disentangling Mechanisms, Brain Systems, and Behavioral Responses |
title_full_unstemmed |
Consciousness Regained: Disentangling Mechanisms, Brain Systems, and Behavioral Responses |
title_sort |
Consciousness Regained: Disentangling Mechanisms, Brain Systems, and Behavioral Responses |
author |
Storm, Johan F. |
author_facet |
Storm, Johan F. Boly, Melanie Casali, Adenauer G. [UNIFESP] Massimini, Marcello Olcese, Umberto Pennartz, Cyriel M. A. Wilke, Melanie |
author_role |
author |
author2 |
Boly, Melanie Casali, Adenauer G. [UNIFESP] Massimini, Marcello Olcese, Umberto Pennartz, Cyriel M. A. Wilke, Melanie |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Storm, Johan F. Boly, Melanie Casali, Adenauer G. [UNIFESP] Massimini, Marcello Olcese, Umberto Pennartz, Cyriel M. A. Wilke, Melanie |
dc.subject.eng.fl_str_mv |
brain complexity consciousness content-specific NCC functional connectivity neural correlates of consciousness no-report paradigm Perturbational Complexity Index unresponsive wakefulness vegetative state |
topic |
brain complexity consciousness content-specific NCC functional connectivity neural correlates of consciousness no-report paradigm Perturbational Complexity Index unresponsive wakefulness vegetative state |
description |
How consciousness (experience) arises from and relates to material brain processes (the "mind-body problem") has been pondered by thinkers for centuries, and is regarded as among the deepest unsolved problems in science, with wide-ranging theoretical, clinical, and ethical implications. Until the last few decades, this was largely seen as a philosophical topic, but not widely accepted in mainstream neuroscience. Since the 1980s, however, novel methods and theoretical advances have yielded remarkable results, opening up the field for scientific and clinical progress. Since a seminal paper by Crick and Koch (1998) claimed that a science of consciousness should first search for its neural correlates (NCC), a variety of correlates have been suggested, including both content-specific NCCs, determining particular phenomenal components within an experience, and the full NCC, the neural substrates supporting entire conscious experiences. In this review, we present recent progress on theoretical, experimental, and clinical issues. Specifically, we (1) review methodological advances that are important for dissociating conscious experience from related enabling and executive functions, (2) suggest how critically reconsidering the role of the frontal cortex may further delineate NCCs, (3) advocate the need for general, objective, brain-based measures of the capacity for consciousness that are independent of sensory processing and executive functions, and (4) show how animal studies can reveal population and network phenomena of relevance for understanding mechanisms of consciousness. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2020-09-01T13:21:17Z |
dc.date.available.fl_str_mv |
2020-09-01T13:21:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Journal Of Neuroscience. Washington, v. 37, n. 45, p. 10882-10893, 2017. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/58178 http://dx.doi.org/10.1523/JNEUROSCI.1838-17.2017 |
dc.identifier.issn.none.fl_str_mv |
0270-6474 |
dc.identifier.file.none.fl_str_mv |
WOS000414662100014.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1523/JNEUROSCI.1838-17.2017 |
dc.identifier.wos.none.fl_str_mv |
WOS:000414662100014 |
identifier_str_mv |
Journal Of Neuroscience. Washington, v. 37, n. 45, p. 10882-10893, 2017. 0270-6474 WOS000414662100014.pdf 10.1523/JNEUROSCI.1838-17.2017 WOS:000414662100014 |
url |
https://repositorio.unifesp.br/handle/11600/58178 http://dx.doi.org/10.1523/JNEUROSCI.1838-17.2017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Journal Of Neuroscience |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
10882-10893 |
dc.coverage.none.fl_str_mv |
Washington |
dc.publisher.none.fl_str_mv |
Soc Neuroscience |
publisher.none.fl_str_mv |
Soc Neuroscience |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
${dspace.ui.url}/bitstream/11600/58178/1/WOS000414662100014.pdf ${dspace.ui.url}/bitstream/11600/58178/8/WOS000414662100014.pdf.txt ${dspace.ui.url}/bitstream/11600/58178/10/WOS000414662100014.pdf.jpg |
bitstream.checksum.fl_str_mv |
95b44142ffab0110bcdfa5e75b2f19b3 6cf5aebba2e6991bc566020e16858ba1 91f341ce82d7fc6e26ff9c5812fdb639 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764270331494400 |