Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound
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Publication Date: | 2016 |
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Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNIFESP |
Download full: | https://repositorio.unifesp.br/handle/11600/56536 http://dx.doi.org/10.3389/fendo.2016.00163 |
Summary: | Sleep homeostasis depends on the length and quality (occurrence of stressful events, for instance) of the preceding waking time. Forced wakefulness (sleep deprivation or sleep restriction) is one of the main tools used for the understanding of mechanisms that play a role in homeostatic processes involved in sleep regulation and their interrelations. Interestingly, forced wakefulness for periods longer than 24 h activates stress response systems, whereas stressful events impact on sleep pattern. Hypothalamic peptides (corticotropin-releasing hormone, prolactin, and the CLIP/ACTH (18-39)) play an important role in the expression of stress-induced sleep effects, essentially by modulating rapid eye movement sleep, which has been claimed to affect the organism resilience to the deleterious effects of stress. Some of the mechanisms involved in the generation and regulation of sleep and the main peptides/hypothalamic hormones involved in these responses will be discussed in this review. |
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Machado, Ricardo Borges [UNIFESP]Suchecki, Deborah [UNIFESP]2020-07-31T12:47:02Z2020-07-31T12:47:02Z2016Frontiers In Endocrinology. Lausanne, v. 7, p. -, 2016.1664-2392https://repositorio.unifesp.br/handle/11600/56536http://dx.doi.org/10.3389/fendo.2016.00163WOS000390233700001.pdf10.3389/fendo.2016.00163WOS:000390233700001Sleep homeostasis depends on the length and quality (occurrence of stressful events, for instance) of the preceding waking time. Forced wakefulness (sleep deprivation or sleep restriction) is one of the main tools used for the understanding of mechanisms that play a role in homeostatic processes involved in sleep regulation and their interrelations. Interestingly, forced wakefulness for periods longer than 24 h activates stress response systems, whereas stressful events impact on sleep pattern. Hypothalamic peptides (corticotropin-releasing hormone, prolactin, and the CLIP/ACTH (18-39)) play an important role in the expression of stress-induced sleep effects, essentially by modulating rapid eye movement sleep, which has been claimed to affect the organism resilience to the deleterious effects of stress. Some of the mechanisms involved in the generation and regulation of sleep and the main peptides/hypothalamic hormones involved in these responses will be discussed in this review.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)/Centros de Pesquisa, Inovação e Difusão (CEPID)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Ibirapuera, Psychosomat Res Grp, Dept Psychol, Sao Paulo, BrazilUniv Ibirapuera, Psychosomat Res Grp, Dept Pharm, Sao Paulo, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Psychobiol, Sao Paulo, BrazilDepartment of Psychobiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, BrazilFAPESP/CEPID: 98/14303-3CNPq: 486769/2013-5FAPESP: 2010/09087-3CNPq: 302294/2012-0FAPESP: 2015/26364-4Web of Science-engFrontiers Media SaFrontiers In EndocrinologysleepstressprolactinCLIPserotoninCRHhomeostasisREM sleepNeuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Reboundinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLausanne7info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000390233700001.pdfapplication/pdf871764${dspace.ui.url}/bitstream/11600/56536/1/WOS000390233700001.pdf6e6194bc49d6e54332b997270e554721MD51open accessTEXTWOS000390233700001.pdf.txtWOS000390233700001.pdf.txtExtracted texttext/plain53019${dspace.ui.url}/bitstream/11600/56536/2/WOS000390233700001.pdf.txtb54c990e4f51f0a163c2ee50b413b7b7MD52open accessTHUMBNAILWOS000390233700001.pdf.jpgWOS000390233700001.pdf.jpgIM Thumbnailimage/jpeg6264${dspace.ui.url}/bitstream/11600/56536/4/WOS000390233700001.pdf.jpg05dc0131d205c8df613b6ef0f4f2a9d5MD54open access11600/565362022-07-31 23:52:55.647open accessoai:repositorio.unifesp.br:11600/56536Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-08-01T02:52:55Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound |
title |
Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound |
spellingShingle |
Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound Machado, Ricardo Borges [UNIFESP] sleep stress prolactin CLIP serotonin CRH homeostasis REM sleep |
title_short |
Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound |
title_full |
Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound |
title_fullStr |
Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound |
title_full_unstemmed |
Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound |
title_sort |
Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound |
author |
Machado, Ricardo Borges [UNIFESP] |
author_facet |
Machado, Ricardo Borges [UNIFESP] Suchecki, Deborah [UNIFESP] |
author_role |
author |
author2 |
Suchecki, Deborah [UNIFESP] |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Machado, Ricardo Borges [UNIFESP] Suchecki, Deborah [UNIFESP] |
dc.subject.eng.fl_str_mv |
sleep stress prolactin CLIP serotonin CRH homeostasis REM sleep |
topic |
sleep stress prolactin CLIP serotonin CRH homeostasis REM sleep |
description |
Sleep homeostasis depends on the length and quality (occurrence of stressful events, for instance) of the preceding waking time. Forced wakefulness (sleep deprivation or sleep restriction) is one of the main tools used for the understanding of mechanisms that play a role in homeostatic processes involved in sleep regulation and their interrelations. Interestingly, forced wakefulness for periods longer than 24 h activates stress response systems, whereas stressful events impact on sleep pattern. Hypothalamic peptides (corticotropin-releasing hormone, prolactin, and the CLIP/ACTH (18-39)) play an important role in the expression of stress-induced sleep effects, essentially by modulating rapid eye movement sleep, which has been claimed to affect the organism resilience to the deleterious effects of stress. Some of the mechanisms involved in the generation and regulation of sleep and the main peptides/hypothalamic hormones involved in these responses will be discussed in this review. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2020-07-31T12:47:02Z |
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2020-07-31T12:47:02Z |
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dc.identifier.citation.fl_str_mv |
Frontiers In Endocrinology. Lausanne, v. 7, p. -, 2016. |
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https://repositorio.unifesp.br/handle/11600/56536 http://dx.doi.org/10.3389/fendo.2016.00163 |
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1664-2392 |
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WOS000390233700001.pdf |
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10.3389/fendo.2016.00163 |
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WOS:000390233700001 |
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Frontiers In Endocrinology. Lausanne, v. 7, p. -, 2016. 1664-2392 WOS000390233700001.pdf 10.3389/fendo.2016.00163 WOS:000390233700001 |
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https://repositorio.unifesp.br/handle/11600/56536 http://dx.doi.org/10.3389/fendo.2016.00163 |
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