Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng spa |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/56073 http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S1657-95342016000200003&lng=en&nrm=iso&tlng=en |
Resumo: | Background: Renal function declines according to age and vascular risk factors, whereas few data are available regarding genetically-mediated effects of anti-hypertensives over renal function. Objective: To estimate urea and creatinine variations in dementia due to Alzheimer disease (AD) by way of a pharmacogenetic analysis of the anti-hypertensive effects of angiotensin-converting enzyme inhibitors (ACEis). Methods: Consecutive outpatients older than 60 years-old with AD and no history of kidney transplant or dialytic therapy were recruited for prospective correlations regarding variations in fasting blood levels of urea and creatinine in one year, considering ACE genotypes of rs1800764 and rs4291 and their respective haplotypes, and treatment with ACEis along with blood pressure variations. Results: For 190 patients, 152 had arterial hypertension, and 122 used ACEis. Minor allele frequencies were 0.492 for rs1800764-C and 0.337 for rs4291-T, both in Hardy-Weinberg equilibrium. There were no overall significant yearly variations in levels of urea and creatinine, but their concurrent variations were positively correlated (rho<0.0001). Each A allele of rs4291 led to an yearly urea increase of 3,074 mg/dL, and an yearly creatinine increase of 0.044 mg/dL, while the use of ACEis was protective regarding creatinine variations. The use of ACEis was also protective for carriers of rs1800764-CT/rs4291-AA, while carriers of rs1800764-CT/rs4291-AT had steeper reductions in creatinine levels, particularly when they were treated with ACEis. Conclusions: Effects of ACEis over creatinine variations are genetically mediated and independent of blood pressure variations in older people with AD. |
id |
UFSP_87e238f5665f506b0a887a27865b6bc4 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/56073 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Oliveira, Fabricio Ferreira de [UNIFESP]Berretta, Juliana Marilia [UNIFESP]Chen, Elizabeth Suchi [UNIFESP]Smith, Marilia Cardoso [UNIFESP]Bertolucci, Paulo Henrique Ferreira [UNIFESP]2020-07-22T13:23:11Z2020-07-22T13:23:11Z2016Colombia Medica. Cali, v. 47, n. 2, p. 76-80, 2016.1657-9534https://repositorio.unifesp.br/handle/11600/56073http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S1657-95342016000200003&lng=en&nrm=iso&tlng=enS1657-95342016000200003-en.pdfS1657-95342016000200003-es.pdfS1657-95342016000200003WOS:000384835700003Background: Renal function declines according to age and vascular risk factors, whereas few data are available regarding genetically-mediated effects of anti-hypertensives over renal function. Objective: To estimate urea and creatinine variations in dementia due to Alzheimer disease (AD) by way of a pharmacogenetic analysis of the anti-hypertensive effects of angiotensin-converting enzyme inhibitors (ACEis). Methods: Consecutive outpatients older than 60 years-old with AD and no history of kidney transplant or dialytic therapy were recruited for prospective correlations regarding variations in fasting blood levels of urea and creatinine in one year, considering ACE genotypes of rs1800764 and rs4291 and their respective haplotypes, and treatment with ACEis along with blood pressure variations. Results: For 190 patients, 152 had arterial hypertension, and 122 used ACEis. Minor allele frequencies were 0.492 for rs1800764-C and 0.337 for rs4291-T, both in Hardy-Weinberg equilibrium. There were no overall significant yearly variations in levels of urea and creatinine, but their concurrent variations were positively correlated (rho<0.0001). Each A allele of rs4291 led to an yearly urea increase of 3,074 mg/dL, and an yearly creatinine increase of 0.044 mg/dL, while the use of ACEis was protective regarding creatinine variations. The use of ACEis was also protective for carriers of rs1800764-CT/rs4291-AA, while carriers of rs1800764-CT/rs4291-AT had steeper reductions in creatinine levels, particularly when they were treated with ACEis. Conclusions: Effects of ACEis over creatinine variations are genetically mediated and independent of blood pressure variations in older people with AD.Fed Univ Sao Paulo UNIFESP, Dept Neurol & Neurosurg, Escola Paulista Med, Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Med, Escola Paulista Med, Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Morphol & Genet, Escola Paulista Med, Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Neurol & Neurosurg, Escola Paulista Med, Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Med, Escola Paulista Med, Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Morphol & Genet, Escola Paulista Med, Sao Paulo, SP, BrazilWeb of Science76-80engspaCorporacion Editora Medica ValleColombia MedicaAlzheimer diseasepharmacogeneticsureacreatinineRenin-Angiotensin SystemPharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer diseaseEfectos farmacogenéticos de inhibidores de la enzima convertidora de la angiotensina en variaciones de urea y creatinina asociadas con el envejecimiento en pacientes con demencia de la enfermedad de Alzheimerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCali472info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS1657-95342016000200003-en.pdfapplication/pdf745198${dspace.ui.url}/bitstream/11600/56073/1/S1657-95342016000200003-en.pdf4e7faf4d5c3d4e6a5d8cb051ced86d28MD51open accessS1657-95342016000200003-es.pdfapplication/pdf715744${dspace.ui.url}/bitstream/11600/56073/2/S1657-95342016000200003-es.pdf7e2902a4d6480d7d33d1edcd4510a52eMD52open accessTEXTS1657-95342016000200003-en.pdf.txtS1657-95342016000200003-en.pdf.txtExtracted texttext/plain28983${dspace.ui.url}/bitstream/11600/56073/3/S1657-95342016000200003-en.pdf.txt0a76495ccb0426d355a4bed07a4d9e6fMD53open accessS1657-95342016000200003-es.pdf.txtS1657-95342016000200003-es.pdf.txtExtracted texttext/plain31651${dspace.ui.url}/bitstream/11600/56073/6/S1657-95342016000200003-es.pdf.txtb737c6579e9f7119734a88834c5a6637MD56open accessTHUMBNAILS1657-95342016000200003-en.pdf.jpgS1657-95342016000200003-en.pdf.jpgIM Thumbnailimage/jpeg7414${dspace.ui.url}/bitstream/11600/56073/5/S1657-95342016000200003-en.pdf.jpgce90a140c043caccb48da9b2440bc94aMD55open accessS1657-95342016000200003-es.pdf.jpgS1657-95342016000200003-es.pdf.jpgIM Thumbnailimage/jpeg7451${dspace.ui.url}/bitstream/11600/56073/8/S1657-95342016000200003-es.pdf.jpg63afa7983fa9a03e4d837db05f59345aMD58open access11600/560732022-08-01 01:20:48.279open accessoai:repositorio.unifesp.br:11600/56073Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-08-01T04:20:48Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease |
dc.title.alternative.es.fl_str_mv |
Efectos farmacogenéticos de inhibidores de la enzima convertidora de la angiotensina en variaciones de urea y creatinina asociadas con el envejecimiento en pacientes con demencia de la enfermedad de Alzheimer |
title |
Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease |
spellingShingle |
Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease Oliveira, Fabricio Ferreira de [UNIFESP] Alzheimer disease pharmacogenetics urea creatinine Renin-Angiotensin System |
title_short |
Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease |
title_full |
Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease |
title_fullStr |
Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease |
title_full_unstemmed |
Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease |
title_sort |
Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease |
author |
Oliveira, Fabricio Ferreira de [UNIFESP] |
author_facet |
Oliveira, Fabricio Ferreira de [UNIFESP] Berretta, Juliana Marilia [UNIFESP] Chen, Elizabeth Suchi [UNIFESP] Smith, Marilia Cardoso [UNIFESP] Bertolucci, Paulo Henrique Ferreira [UNIFESP] |
author_role |
author |
author2 |
Berretta, Juliana Marilia [UNIFESP] Chen, Elizabeth Suchi [UNIFESP] Smith, Marilia Cardoso [UNIFESP] Bertolucci, Paulo Henrique Ferreira [UNIFESP] |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Fabricio Ferreira de [UNIFESP] Berretta, Juliana Marilia [UNIFESP] Chen, Elizabeth Suchi [UNIFESP] Smith, Marilia Cardoso [UNIFESP] Bertolucci, Paulo Henrique Ferreira [UNIFESP] |
dc.subject.eng.fl_str_mv |
Alzheimer disease pharmacogenetics urea creatinine Renin-Angiotensin System |
topic |
Alzheimer disease pharmacogenetics urea creatinine Renin-Angiotensin System |
description |
Background: Renal function declines according to age and vascular risk factors, whereas few data are available regarding genetically-mediated effects of anti-hypertensives over renal function. Objective: To estimate urea and creatinine variations in dementia due to Alzheimer disease (AD) by way of a pharmacogenetic analysis of the anti-hypertensive effects of angiotensin-converting enzyme inhibitors (ACEis). Methods: Consecutive outpatients older than 60 years-old with AD and no history of kidney transplant or dialytic therapy were recruited for prospective correlations regarding variations in fasting blood levels of urea and creatinine in one year, considering ACE genotypes of rs1800764 and rs4291 and their respective haplotypes, and treatment with ACEis along with blood pressure variations. Results: For 190 patients, 152 had arterial hypertension, and 122 used ACEis. Minor allele frequencies were 0.492 for rs1800764-C and 0.337 for rs4291-T, both in Hardy-Weinberg equilibrium. There were no overall significant yearly variations in levels of urea and creatinine, but their concurrent variations were positively correlated (rho<0.0001). Each A allele of rs4291 led to an yearly urea increase of 3,074 mg/dL, and an yearly creatinine increase of 0.044 mg/dL, while the use of ACEis was protective regarding creatinine variations. The use of ACEis was also protective for carriers of rs1800764-CT/rs4291-AA, while carriers of rs1800764-CT/rs4291-AT had steeper reductions in creatinine levels, particularly when they were treated with ACEis. Conclusions: Effects of ACEis over creatinine variations are genetically mediated and independent of blood pressure variations in older people with AD. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2020-07-22T13:23:11Z |
dc.date.available.fl_str_mv |
2020-07-22T13:23:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Colombia Medica. Cali, v. 47, n. 2, p. 76-80, 2016. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/56073 http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S1657-95342016000200003&lng=en&nrm=iso&tlng=en |
dc.identifier.issn.none.fl_str_mv |
1657-9534 |
dc.identifier.file.none.fl_str_mv |
S1657-95342016000200003-en.pdf S1657-95342016000200003-es.pdf |
dc.identifier.scielo.none.fl_str_mv |
S1657-95342016000200003 |
dc.identifier.wos.none.fl_str_mv |
WOS:000384835700003 |
identifier_str_mv |
Colombia Medica. Cali, v. 47, n. 2, p. 76-80, 2016. 1657-9534 S1657-95342016000200003-en.pdf S1657-95342016000200003-es.pdf S1657-95342016000200003 WOS:000384835700003 |
url |
https://repositorio.unifesp.br/handle/11600/56073 http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S1657-95342016000200003&lng=en&nrm=iso&tlng=en |
dc.language.iso.fl_str_mv |
eng spa |
language |
eng spa |
dc.relation.ispartof.none.fl_str_mv |
Colombia Medica |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
76-80 |
dc.coverage.none.fl_str_mv |
Cali |
dc.publisher.none.fl_str_mv |
Corporacion Editora Medica Valle |
publisher.none.fl_str_mv |
Corporacion Editora Medica Valle |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
${dspace.ui.url}/bitstream/11600/56073/1/S1657-95342016000200003-en.pdf ${dspace.ui.url}/bitstream/11600/56073/2/S1657-95342016000200003-es.pdf ${dspace.ui.url}/bitstream/11600/56073/3/S1657-95342016000200003-en.pdf.txt ${dspace.ui.url}/bitstream/11600/56073/6/S1657-95342016000200003-es.pdf.txt ${dspace.ui.url}/bitstream/11600/56073/5/S1657-95342016000200003-en.pdf.jpg ${dspace.ui.url}/bitstream/11600/56073/8/S1657-95342016000200003-es.pdf.jpg |
bitstream.checksum.fl_str_mv |
4e7faf4d5c3d4e6a5d8cb051ced86d28 7e2902a4d6480d7d33d1edcd4510a52e 0a76495ccb0426d355a4bed07a4d9e6f b737c6579e9f7119734a88834c5a6637 ce90a140c043caccb48da9b2440bc94a 63afa7983fa9a03e4d837db05f59345a |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764129543389184 |