Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/36572 http://dx.doi.org/10.3390/md11082722 |
Resumo: | Fucan is a term that defines a family of homo-and hetero-polysaccharides containing sulfated L-fucose in its structure. in this work, a heterofucan (F2.0v) from the seaweed, Dictyota menstrualis, was evaluated as an antinociceptive and anti-inflammatory agent. F2.0v (20.0 mg/kg) inhibits 100% of leukocyte migration into the peritoneal cavity after chemical stimulation. However, F2.0v does not alter the expression of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6), as well as tumor necrosis factor alpha (TNF-alpha). F2.0v (20.0 mg/kg) has peripheral antinociceptive activity with potency similar to dipyrone. On the other hand, it had no effect on pain response on the hot plate test. Confocal microscopy analysis and flow cytometry showed that F2.0v binds to the surface of leucocytes, which leads us to suggest that the mechanism of action of anti-inflammatory and antinociceptive F2.0v is related to its ability to inhibit the migration of leukocytes to the site of tissue injury. in summary, the data show that F2.0v compound has great potential as an antinociceptive and anti-inflammatory, and future studies will be performed to further characterize the mechanism of action of F2.0v. |
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Lopes Albuquerque, Ivan RuiCordeiro, Sara LimaGomes, Dayanne LopesDreyfuss, Juliana Luporini [UNIFESP]Alves Filgueira, Luciana GuimaraesLeite, Edda LisboaNader, Helena Bonciani [UNIFESP]Oliveira Rocha, Hugo AlexandreFed Univ Rio Grande Norte UFRNUniversidade Federal de São Paulo (UNIFESP)2016-01-24T14:32:02Z2016-01-24T14:32:02Z2013-08-01Marine Drugs. Basel: Mdpi Ag, v. 11, n. 8, p. 2722-2740, 2013.1660-3397http://repositorio.unifesp.br/handle/11600/36572http://dx.doi.org/10.3390/md11082722WOS000330521300003.pdf10.3390/md11082722WOS:000330521300003Fucan is a term that defines a family of homo-and hetero-polysaccharides containing sulfated L-fucose in its structure. in this work, a heterofucan (F2.0v) from the seaweed, Dictyota menstrualis, was evaluated as an antinociceptive and anti-inflammatory agent. F2.0v (20.0 mg/kg) inhibits 100% of leukocyte migration into the peritoneal cavity after chemical stimulation. However, F2.0v does not alter the expression of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6), as well as tumor necrosis factor alpha (TNF-alpha). F2.0v (20.0 mg/kg) has peripheral antinociceptive activity with potency similar to dipyrone. On the other hand, it had no effect on pain response on the hot plate test. Confocal microscopy analysis and flow cytometry showed that F2.0v binds to the surface of leucocytes, which leads us to suggest that the mechanism of action of anti-inflammatory and antinociceptive F2.0v is related to its ability to inhibit the migration of leukocytes to the site of tissue injury. in summary, the data show that F2.0v compound has great potential as an antinociceptive and anti-inflammatory, and future studies will be performed to further characterize the mechanism of action of F2.0v.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundacao de Apoio a Pesquisa do Estado do Rio Grande do Norte-FAPERNCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Ministerio de Ciencia, Tecnologia e Inovacao-MCTIFed Univ Rio Grande Norte UFRN, Dept Biochem, Lab Biotechnol Nat Polymers BIOPOL, BR-59078970 Natal, RN, BrazilFed Univ Rio Grande Norte UFRN, Grad Program Hlth Sci, BR-59078970 Natal, RN, BrazilFed Univ São Paulo UNIFESP, Dept Biochem, BR-04044020 São Paulo, BrazilFed Univ São Paulo UNIFESP, Dept Biochem, BR-04044020 São Paulo, BrazilWeb of Science2722-2740engMdpi AgMarine Drugsfucanbrown seaweedpainanalgesicdictyotalesEvaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000330521300003.pdfapplication/pdf884037${dspace.ui.url}/bitstream/11600/36572/1/WOS000330521300003.pdf210de6b97858ed8bb7f7ac52b6895b7bMD51open accessTEXTWOS000330521300003.pdf.txtWOS000330521300003.pdf.txtExtracted texttext/plain46009${dspace.ui.url}/bitstream/11600/36572/2/WOS000330521300003.pdf.txtedb30579d48f9a4795584da1a50e1119MD52open access11600/365722021-09-29 14:54:12.303open accessoai:repositorio.unifesp.br:11600/36572Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-09-29T17:54:12Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis |
title |
Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis |
spellingShingle |
Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis Lopes Albuquerque, Ivan Rui fucan brown seaweed pain analgesic dictyotales |
title_short |
Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis |
title_full |
Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis |
title_fullStr |
Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis |
title_full_unstemmed |
Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis |
title_sort |
Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis |
author |
Lopes Albuquerque, Ivan Rui |
author_facet |
Lopes Albuquerque, Ivan Rui Cordeiro, Sara Lima Gomes, Dayanne Lopes Dreyfuss, Juliana Luporini [UNIFESP] Alves Filgueira, Luciana Guimaraes Leite, Edda Lisboa Nader, Helena Bonciani [UNIFESP] Oliveira Rocha, Hugo Alexandre |
author_role |
author |
author2 |
Cordeiro, Sara Lima Gomes, Dayanne Lopes Dreyfuss, Juliana Luporini [UNIFESP] Alves Filgueira, Luciana Guimaraes Leite, Edda Lisboa Nader, Helena Bonciani [UNIFESP] Oliveira Rocha, Hugo Alexandre |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Fed Univ Rio Grande Norte UFRN Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Lopes Albuquerque, Ivan Rui Cordeiro, Sara Lima Gomes, Dayanne Lopes Dreyfuss, Juliana Luporini [UNIFESP] Alves Filgueira, Luciana Guimaraes Leite, Edda Lisboa Nader, Helena Bonciani [UNIFESP] Oliveira Rocha, Hugo Alexandre |
dc.subject.eng.fl_str_mv |
fucan brown seaweed pain analgesic dictyotales |
topic |
fucan brown seaweed pain analgesic dictyotales |
description |
Fucan is a term that defines a family of homo-and hetero-polysaccharides containing sulfated L-fucose in its structure. in this work, a heterofucan (F2.0v) from the seaweed, Dictyota menstrualis, was evaluated as an antinociceptive and anti-inflammatory agent. F2.0v (20.0 mg/kg) inhibits 100% of leukocyte migration into the peritoneal cavity after chemical stimulation. However, F2.0v does not alter the expression of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6), as well as tumor necrosis factor alpha (TNF-alpha). F2.0v (20.0 mg/kg) has peripheral antinociceptive activity with potency similar to dipyrone. On the other hand, it had no effect on pain response on the hot plate test. Confocal microscopy analysis and flow cytometry showed that F2.0v binds to the surface of leucocytes, which leads us to suggest that the mechanism of action of anti-inflammatory and antinociceptive F2.0v is related to its ability to inhibit the migration of leukocytes to the site of tissue injury. in summary, the data show that F2.0v compound has great potential as an antinociceptive and anti-inflammatory, and future studies will be performed to further characterize the mechanism of action of F2.0v. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-08-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:32:02Z |
dc.date.available.fl_str_mv |
2016-01-24T14:32:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Marine Drugs. Basel: Mdpi Ag, v. 11, n. 8, p. 2722-2740, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/36572 http://dx.doi.org/10.3390/md11082722 |
dc.identifier.issn.none.fl_str_mv |
1660-3397 |
dc.identifier.file.none.fl_str_mv |
WOS000330521300003.pdf |
dc.identifier.doi.none.fl_str_mv |
10.3390/md11082722 |
dc.identifier.wos.none.fl_str_mv |
WOS:000330521300003 |
identifier_str_mv |
Marine Drugs. Basel: Mdpi Ag, v. 11, n. 8, p. 2722-2740, 2013. 1660-3397 WOS000330521300003.pdf 10.3390/md11082722 WOS:000330521300003 |
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http://repositorio.unifesp.br/handle/11600/36572 http://dx.doi.org/10.3390/md11082722 |
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eng |
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Mdpi Ag |
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Mdpi Ag |
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