alpha-Pinene isolated from Schinus terebintinfolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/33892 http://dx.doi.org/10.1016/j.bbrc.2011.06.176 |
Resumo: | Malignant melanoma is one the most aggressive types of cancer and its incidence has gradually increased in the last years, accounting for about 75% of skin cancer deaths. This poor prognosis results from the tumor resistance to conventional drugs mainly by deregulation of apoptotic pathways. the aim of this work was to investigate the cell death mechanism induced by alpha-pinene and its therapeutic application. Our results demonstrated that alpha-pinene was able to induce apoptosis evidenced by early disruption of the mitochondrial potential, production of reactive oxygen species, increase in caspase-3 activity, heterochromatin aggregation, DNA fragmentation and exposure of phosphatidyl serine on the cell surface. Most importantly, this molecule was very effective in the treatment of experimental metastatic melanoma reducing the number of lung tumor nodules. This is the first report on the apoptotic and antimetastatic activity of isolated alpha-pinene. (C) 2011 Elsevier Inc. All rights reserved. |
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Matsuo, Alisson Leonardo [UNIFESP]Figueiredo, Carlos Rogerio [UNIFESP]Arruda, Denise Costa [UNIFESP]Pereira, Felipe Valença [UNIFESP]Scutti, Jorge Augusto Borin [UNIFESP]Massaoka, Mariana Hiromi [UNIFESP]Travassos, Luiz Rodolpho [UNIFESP]Sartorelli, Patricia [UNIFESP]Lago, Joao Henrique Ghilardi [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:17:00Z2016-01-24T14:17:00Z2011-07-29Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc Elsevier Science, v. 411, n. 2, p. 449-454, 2011.0006-291Xhttp://repositorio.unifesp.br/handle/11600/33892http://dx.doi.org/10.1016/j.bbrc.2011.06.176WOS000293809900039.pdf10.1016/j.bbrc.2011.06.176WOS:000293809900039Malignant melanoma is one the most aggressive types of cancer and its incidence has gradually increased in the last years, accounting for about 75% of skin cancer deaths. This poor prognosis results from the tumor resistance to conventional drugs mainly by deregulation of apoptotic pathways. the aim of this work was to investigate the cell death mechanism induced by alpha-pinene and its therapeutic application. Our results demonstrated that alpha-pinene was able to induce apoptosis evidenced by early disruption of the mitochondrial potential, production of reactive oxygen species, increase in caspase-3 activity, heterochromatin aggregation, DNA fragmentation and exposure of phosphatidyl serine on the cell surface. Most importantly, this molecule was very effective in the treatment of experimental metastatic melanoma reducing the number of lung tumor nodules. This is the first report on the apoptotic and antimetastatic activity of isolated alpha-pinene. (C) 2011 Elsevier Inc. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo, Dept Micro Imuno & Parasitol, Disciplina Biol Celular, São Paulo, BrazilUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Micro Imuno & Parasitol, Disciplina Biol Celular, São Paulo, BrazilUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, BrazilWeb of Science449-454engElsevier B.V.Biochemical and Biophysical Research Communicationshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessalpha-PineneMelanomaApoptosisalpha-Pinene isolated from Schinus terebintinfolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000293809900039.pdfapplication/pdf649946${dspace.ui.url}/bitstream/11600/33892/1/WOS000293809900039.pdf79b96dec42a7d9d16613087e97a57728MD51open accessTEXTWOS000293809900039.pdf.txtWOS000293809900039.pdf.txtExtracted texttext/plain28648${dspace.ui.url}/bitstream/11600/33892/9/WOS000293809900039.pdf.txt29fa7acbcfa266b13c14b5f5d7f6e46aMD59open accessTHUMBNAILWOS000293809900039.pdf.jpgWOS000293809900039.pdf.jpgIM Thumbnailimage/jpeg7330${dspace.ui.url}/bitstream/11600/33892/11/WOS000293809900039.pdf.jpga8d0b66d938db6d3db43f8d873bdb400MD511open access11600/338922023-06-05 19:26:44.036open accessoai:repositorio.unifesp.br:11600/33892Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:26:44Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
alpha-Pinene isolated from Schinus terebintinfolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model |
title |
alpha-Pinene isolated from Schinus terebintinfolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model |
spellingShingle |
alpha-Pinene isolated from Schinus terebintinfolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model Matsuo, Alisson Leonardo [UNIFESP] alpha-Pinene Melanoma Apoptosis |
title_short |
alpha-Pinene isolated from Schinus terebintinfolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model |
title_full |
alpha-Pinene isolated from Schinus terebintinfolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model |
title_fullStr |
alpha-Pinene isolated from Schinus terebintinfolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model |
title_full_unstemmed |
alpha-Pinene isolated from Schinus terebintinfolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model |
title_sort |
alpha-Pinene isolated from Schinus terebintinfolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model |
author |
Matsuo, Alisson Leonardo [UNIFESP] |
author_facet |
Matsuo, Alisson Leonardo [UNIFESP] Figueiredo, Carlos Rogerio [UNIFESP] Arruda, Denise Costa [UNIFESP] Pereira, Felipe Valença [UNIFESP] Scutti, Jorge Augusto Borin [UNIFESP] Massaoka, Mariana Hiromi [UNIFESP] Travassos, Luiz Rodolpho [UNIFESP] Sartorelli, Patricia [UNIFESP] Lago, Joao Henrique Ghilardi [UNIFESP] |
author_role |
author |
author2 |
Figueiredo, Carlos Rogerio [UNIFESP] Arruda, Denise Costa [UNIFESP] Pereira, Felipe Valença [UNIFESP] Scutti, Jorge Augusto Borin [UNIFESP] Massaoka, Mariana Hiromi [UNIFESP] Travassos, Luiz Rodolpho [UNIFESP] Sartorelli, Patricia [UNIFESP] Lago, Joao Henrique Ghilardi [UNIFESP] |
author2_role |
author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Matsuo, Alisson Leonardo [UNIFESP] Figueiredo, Carlos Rogerio [UNIFESP] Arruda, Denise Costa [UNIFESP] Pereira, Felipe Valença [UNIFESP] Scutti, Jorge Augusto Borin [UNIFESP] Massaoka, Mariana Hiromi [UNIFESP] Travassos, Luiz Rodolpho [UNIFESP] Sartorelli, Patricia [UNIFESP] Lago, Joao Henrique Ghilardi [UNIFESP] |
dc.subject.eng.fl_str_mv |
alpha-Pinene Melanoma Apoptosis |
topic |
alpha-Pinene Melanoma Apoptosis |
description |
Malignant melanoma is one the most aggressive types of cancer and its incidence has gradually increased in the last years, accounting for about 75% of skin cancer deaths. This poor prognosis results from the tumor resistance to conventional drugs mainly by deregulation of apoptotic pathways. the aim of this work was to investigate the cell death mechanism induced by alpha-pinene and its therapeutic application. Our results demonstrated that alpha-pinene was able to induce apoptosis evidenced by early disruption of the mitochondrial potential, production of reactive oxygen species, increase in caspase-3 activity, heterochromatin aggregation, DNA fragmentation and exposure of phosphatidyl serine on the cell surface. Most importantly, this molecule was very effective in the treatment of experimental metastatic melanoma reducing the number of lung tumor nodules. This is the first report on the apoptotic and antimetastatic activity of isolated alpha-pinene. (C) 2011 Elsevier Inc. All rights reserved. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-07-29 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:17:00Z |
dc.date.available.fl_str_mv |
2016-01-24T14:17:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc Elsevier Science, v. 411, n. 2, p. 449-454, 2011. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/33892 http://dx.doi.org/10.1016/j.bbrc.2011.06.176 |
dc.identifier.issn.none.fl_str_mv |
0006-291X |
dc.identifier.file.none.fl_str_mv |
WOS000293809900039.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.bbrc.2011.06.176 |
dc.identifier.wos.none.fl_str_mv |
WOS:000293809900039 |
identifier_str_mv |
Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc Elsevier Science, v. 411, n. 2, p. 449-454, 2011. 0006-291X WOS000293809900039.pdf 10.1016/j.bbrc.2011.06.176 WOS:000293809900039 |
url |
http://repositorio.unifesp.br/handle/11600/33892 http://dx.doi.org/10.1016/j.bbrc.2011.06.176 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Biochemical and Biophysical Research Communications |
dc.rights.driver.fl_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
449-454 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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