Structure-function Relationships Using the Cirrus Spectral Domain Optical Coherence Tomograph and Standard Automated Perimetry
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/34346 http://dx.doi.org/10.1097/IJG.0b013e31822af27a |
Resumo: | Purpose: To evaluate the relationship between glaucomatous structural damage assessed by the Cirrus Spectral Domain OCT (SDOCT) and functional loss as measured by standard automated perimetry (SAP).Methods: Four hundred twenty-two eyes (78 healthy, 210 suspects, 134 glaucomatous) of 250 patients were recruited from the longitudinal Diagnostic Innovations in Glaucoma Study and from the African Descent and Glaucoma Evaluation Study. All eyes underwent testing with the Cirrus SDOCT and SAP within a 6-month period. the relationship between parapapillary retinal nerve fiber layer thickness (RNFL) sectors and corresponding topographic SAP locations was evaluated using locally weighted scatterplot smoothing and regression analysis. SAP sensitivity values were evaluated using both linear as well as logarithmic scales. We also tested the fit of a model (Hood) for structure-function relationship in glaucoma.Results: Structure was significantly related to function for all but the nasal thickness sector. the relationship was strongest for superotemporal RNFL thickness and inferonasal sensitivity (R(2) = 0.314, P < 0.001). the Hood model fitted the data relatively well with 88% of the eyes inside the 95% confidence interval predicted by the model.Conclusions: RNFL thinning measured by the Cirrus SDOCT was associated with correspondent visual field loss in glaucoma. |
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Leite, Mauro T. [UNIFESP]Zangwill, Linda M.Weinreb, Robert N.Rao, Harsha L.Alencar, Luciana M.Medeiros, Felipe A. [UNIFESP]Univ Calif San DiegoUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)LV Prasad Eye Inst2016-01-24T14:17:35Z2016-01-24T14:17:35Z2012-01-01Journal of Glaucoma. Philadelphia: Lippincott Williams & Wilkins, v. 21, n. 1, p. 49-54, 2012.1057-0829http://repositorio.unifesp.br/handle/11600/34346http://dx.doi.org/10.1097/IJG.0b013e31822af27a10.1097/IJG.0b013e31822af27aWOS:000299108600010Purpose: To evaluate the relationship between glaucomatous structural damage assessed by the Cirrus Spectral Domain OCT (SDOCT) and functional loss as measured by standard automated perimetry (SAP).Methods: Four hundred twenty-two eyes (78 healthy, 210 suspects, 134 glaucomatous) of 250 patients were recruited from the longitudinal Diagnostic Innovations in Glaucoma Study and from the African Descent and Glaucoma Evaluation Study. All eyes underwent testing with the Cirrus SDOCT and SAP within a 6-month period. the relationship between parapapillary retinal nerve fiber layer thickness (RNFL) sectors and corresponding topographic SAP locations was evaluated using locally weighted scatterplot smoothing and regression analysis. SAP sensitivity values were evaluated using both linear as well as logarithmic scales. We also tested the fit of a model (Hood) for structure-function relationship in glaucoma.Results: Structure was significantly related to function for all but the nasal thickness sector. the relationship was strongest for superotemporal RNFL thickness and inferonasal sensitivity (R(2) = 0.314, P < 0.001). the Hood model fitted the data relatively well with 88% of the eyes inside the 95% confidence interval predicted by the model.Conclusions: RNFL thinning measured by the Cirrus SDOCT was associated with correspondent visual field loss in glaucoma.Optovue IncTopconHeidelberg EngineeringCarl Zeiss MeditecCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Alcon Laboratories Inc.AllerganPfizer Inc.SANTEN Inc.NEIUniv Calif San Diego, Hamilton Glaucoma Ctr, Dept Ophthalmol, La Jolla, CA 92093 USAUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, BrazilUniv São Paulo, Dept Ophthalmol, São Paulo, BrazilLV Prasad Eye Inst, Hyderabad, Andhra Pradesh, IndiaUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, BrazilCAPES: BEX1327/09-7NEI: EY08208NEI: EY11008Web of Science49-54engLippincott Williams & WilkinsJournal of Glaucomastructure-functionretinal nerve fiber layerspectral-domain OCTstandard automated perimetryglaucomaCirrusStructure-function Relationships Using the Cirrus Spectral Domain Optical Coherence Tomograph and Standard Automated Perimetryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/343462022-09-27 09:38:18.071metadata only accessoai:repositorio.unifesp.br:11600/34346Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-09-27T12:38:18Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Structure-function Relationships Using the Cirrus Spectral Domain Optical Coherence Tomograph and Standard Automated Perimetry |
title |
Structure-function Relationships Using the Cirrus Spectral Domain Optical Coherence Tomograph and Standard Automated Perimetry |
spellingShingle |
Structure-function Relationships Using the Cirrus Spectral Domain Optical Coherence Tomograph and Standard Automated Perimetry Leite, Mauro T. [UNIFESP] structure-function retinal nerve fiber layer spectral-domain OCT standard automated perimetry glaucoma Cirrus |
title_short |
Structure-function Relationships Using the Cirrus Spectral Domain Optical Coherence Tomograph and Standard Automated Perimetry |
title_full |
Structure-function Relationships Using the Cirrus Spectral Domain Optical Coherence Tomograph and Standard Automated Perimetry |
title_fullStr |
Structure-function Relationships Using the Cirrus Spectral Domain Optical Coherence Tomograph and Standard Automated Perimetry |
title_full_unstemmed |
Structure-function Relationships Using the Cirrus Spectral Domain Optical Coherence Tomograph and Standard Automated Perimetry |
title_sort |
Structure-function Relationships Using the Cirrus Spectral Domain Optical Coherence Tomograph and Standard Automated Perimetry |
author |
Leite, Mauro T. [UNIFESP] |
author_facet |
Leite, Mauro T. [UNIFESP] Zangwill, Linda M. Weinreb, Robert N. Rao, Harsha L. Alencar, Luciana M. Medeiros, Felipe A. [UNIFESP] |
author_role |
author |
author2 |
Zangwill, Linda M. Weinreb, Robert N. Rao, Harsha L. Alencar, Luciana M. Medeiros, Felipe A. [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Univ Calif San Diego Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) LV Prasad Eye Inst |
dc.contributor.author.fl_str_mv |
Leite, Mauro T. [UNIFESP] Zangwill, Linda M. Weinreb, Robert N. Rao, Harsha L. Alencar, Luciana M. Medeiros, Felipe A. [UNIFESP] |
dc.subject.eng.fl_str_mv |
structure-function retinal nerve fiber layer spectral-domain OCT standard automated perimetry glaucoma Cirrus |
topic |
structure-function retinal nerve fiber layer spectral-domain OCT standard automated perimetry glaucoma Cirrus |
description |
Purpose: To evaluate the relationship between glaucomatous structural damage assessed by the Cirrus Spectral Domain OCT (SDOCT) and functional loss as measured by standard automated perimetry (SAP).Methods: Four hundred twenty-two eyes (78 healthy, 210 suspects, 134 glaucomatous) of 250 patients were recruited from the longitudinal Diagnostic Innovations in Glaucoma Study and from the African Descent and Glaucoma Evaluation Study. All eyes underwent testing with the Cirrus SDOCT and SAP within a 6-month period. the relationship between parapapillary retinal nerve fiber layer thickness (RNFL) sectors and corresponding topographic SAP locations was evaluated using locally weighted scatterplot smoothing and regression analysis. SAP sensitivity values were evaluated using both linear as well as logarithmic scales. We also tested the fit of a model (Hood) for structure-function relationship in glaucoma.Results: Structure was significantly related to function for all but the nasal thickness sector. the relationship was strongest for superotemporal RNFL thickness and inferonasal sensitivity (R(2) = 0.314, P < 0.001). the Hood model fitted the data relatively well with 88% of the eyes inside the 95% confidence interval predicted by the model.Conclusions: RNFL thinning measured by the Cirrus SDOCT was associated with correspondent visual field loss in glaucoma. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:17:35Z |
dc.date.available.fl_str_mv |
2016-01-24T14:17:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Journal of Glaucoma. Philadelphia: Lippincott Williams & Wilkins, v. 21, n. 1, p. 49-54, 2012. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/34346 http://dx.doi.org/10.1097/IJG.0b013e31822af27a |
dc.identifier.issn.none.fl_str_mv |
1057-0829 |
dc.identifier.doi.none.fl_str_mv |
10.1097/IJG.0b013e31822af27a |
dc.identifier.wos.none.fl_str_mv |
WOS:000299108600010 |
identifier_str_mv |
Journal of Glaucoma. Philadelphia: Lippincott Williams & Wilkins, v. 21, n. 1, p. 49-54, 2012. 1057-0829 10.1097/IJG.0b013e31822af27a WOS:000299108600010 |
url |
http://repositorio.unifesp.br/handle/11600/34346 http://dx.doi.org/10.1097/IJG.0b013e31822af27a |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Journal of Glaucoma |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
49-54 |
dc.publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1802764162374303744 |