A study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone?
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/xmlui/handle/11600/62159 https://doi.org/10.1093/ijnp/pyaa050 |
Resumo: | Background Our previous studies showed increased angiotensin I-converting enzyme (ACE) activity in chronic schizophrenia patients compared with healthy control (HC) volunteers, and the relevance of combining ACE genotype and activity for predicting schizophrenia was suggested. Methods ACE activity was measured in plasma of ACE insertion/deletion (I/D) genotyped HC volunteers (n = 53) and antipsychotic-naïve first-episode psychosis (FEP) patients (n = 45) assessed at baseline (FEB-B) and also after 2 months (FEP-2M) of treatment with the atypical antipsychotic risperidone. Results ACE activity measurements showed significant differences among HC, FEP-B, and FEP-2M groups (F = 5.356, df = 2, P = .005) as well as between HC and FEP-2M (post-hoc Tukey’s multiple comparisons test, P = .004). No correlation was observed for ACE activity increases and symptom severity reductions in FEP as assessed by total Positive and Negative Syndrome Scale (r = −0.131, P = .434). FEP subgrouped by ACE I/D genotype showed significant ACE activity increases, mainly in the DD genotype subgroup. No correlation between ACE activity and age was observed in FEP or HC groups separately (r = 0.210, P = .392), but ACE activity level differences observed between these groups were influenced by age. Conclusions The importance of measuring the ACE activity in blood plasma, associated with ACE I/D genotyping to support the follow-up of FEP patients, did not show correlation with general symptom amelioration in the present study. However, new insights into the influence of age and I/D genotype for ACE activity changes in FEP individuals upon treatment was demonstrated. |
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Repositório Institucional da UNIFESP |
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Nani, João Victor [UNIFESP]Dal Mas, Caroline [UNIFESP]Yonamine, Camila M. [UNIFESP]Ota, Vanessa K. [UNIFESP]Noto, Cristiano [UNIFESP]Belangero, Sintia I. [UNIFESP]Mari, Jair J. [UNIFESP]Bressan, Rodrigo [UNIFESP]Cordeiro, Quirino [UNIFESP]Gadelha, Ary [UNIFESP]Hayashi, Mirian A. F. [UNIFESP]http://lattes.cnpq.br/55593093952321472021-10-29T15:06:40Z2021-10-29T15:06:40Z2020-07-22The International Journal of Neuropsychopharmacology, Oxford, v. 23, n. 11, p. 721-730. 22 July 2020.1469-5111https://repositorio.unifesp.br/xmlui/handle/11600/62159https://doi.org/10.1093/ijnp/pyaa05010.1093/ijnp/pyaa050Background Our previous studies showed increased angiotensin I-converting enzyme (ACE) activity in chronic schizophrenia patients compared with healthy control (HC) volunteers, and the relevance of combining ACE genotype and activity for predicting schizophrenia was suggested. Methods ACE activity was measured in plasma of ACE insertion/deletion (I/D) genotyped HC volunteers (n = 53) and antipsychotic-naïve first-episode psychosis (FEP) patients (n = 45) assessed at baseline (FEB-B) and also after 2 months (FEP-2M) of treatment with the atypical antipsychotic risperidone. Results ACE activity measurements showed significant differences among HC, FEP-B, and FEP-2M groups (F = 5.356, df = 2, P = .005) as well as between HC and FEP-2M (post-hoc Tukey’s multiple comparisons test, P = .004). No correlation was observed for ACE activity increases and symptom severity reductions in FEP as assessed by total Positive and Negative Syndrome Scale (r = −0.131, P = .434). FEP subgrouped by ACE I/D genotype showed significant ACE activity increases, mainly in the DD genotype subgroup. No correlation between ACE activity and age was observed in FEP or HC groups separately (r = 0.210, P = .392), but ACE activity level differences observed between these groups were influenced by age. Conclusions The importance of measuring the ACE activity in blood plasma, associated with ACE I/D genotyping to support the follow-up of FEP patients, did not show correlation with general symptom amelioration in the present study. However, new insights into the influence of age and I/D genotype for ACE activity changes in FEP individuals upon treatment was demonstrated.p. 721-730engOxford University PressInternational Journal of NeuropsychopharmacologyAngiotensin-converting enzyme (ACE)first-episode psychosis (FEP)risperidonegenotypeenzyme activityA study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleOxfordinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPEscola Paulista de Medicina (EPM)FarmacologiaOutraFarmacologiaORIGINALpyaa050.pdfpyaa050.pdfapplication/pdf650449${dspace.ui.url}/bitstream/11600/62159/1/pyaa050.pdf6af6dfab125f3c4f2518b471dba0a37fMD51open 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InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-23T05:21:14Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.pt_BR.fl_str_mv |
A study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone? |
title |
A study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone? |
spellingShingle |
A study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone? Nani, João Victor [UNIFESP] Angiotensin-converting enzyme (ACE) first-episode psychosis (FEP) risperidone genotype enzyme activity |
title_short |
A study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone? |
title_full |
A study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone? |
title_fullStr |
A study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone? |
title_full_unstemmed |
A study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone? |
title_sort |
A study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone? |
author |
Nani, João Victor [UNIFESP] |
author_facet |
Nani, João Victor [UNIFESP] Dal Mas, Caroline [UNIFESP] Yonamine, Camila M. [UNIFESP] Ota, Vanessa K. [UNIFESP] Noto, Cristiano [UNIFESP] Belangero, Sintia I. [UNIFESP] Mari, Jair J. [UNIFESP] Bressan, Rodrigo [UNIFESP] Cordeiro, Quirino [UNIFESP] Gadelha, Ary [UNIFESP] Hayashi, Mirian A. F. [UNIFESP] |
author_role |
author |
author2 |
Dal Mas, Caroline [UNIFESP] Yonamine, Camila M. [UNIFESP] Ota, Vanessa K. [UNIFESP] Noto, Cristiano [UNIFESP] Belangero, Sintia I. [UNIFESP] Mari, Jair J. [UNIFESP] Bressan, Rodrigo [UNIFESP] Cordeiro, Quirino [UNIFESP] Gadelha, Ary [UNIFESP] Hayashi, Mirian A. F. [UNIFESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.authorLattes.pt_BR.fl_str_mv |
http://lattes.cnpq.br/5559309395232147 |
dc.contributor.author.fl_str_mv |
Nani, João Victor [UNIFESP] Dal Mas, Caroline [UNIFESP] Yonamine, Camila M. [UNIFESP] Ota, Vanessa K. [UNIFESP] Noto, Cristiano [UNIFESP] Belangero, Sintia I. [UNIFESP] Mari, Jair J. [UNIFESP] Bressan, Rodrigo [UNIFESP] Cordeiro, Quirino [UNIFESP] Gadelha, Ary [UNIFESP] Hayashi, Mirian A. F. [UNIFESP] |
dc.subject.por.fl_str_mv |
Angiotensin-converting enzyme (ACE) first-episode psychosis (FEP) risperidone genotype enzyme activity |
topic |
Angiotensin-converting enzyme (ACE) first-episode psychosis (FEP) risperidone genotype enzyme activity |
description |
Background Our previous studies showed increased angiotensin I-converting enzyme (ACE) activity in chronic schizophrenia patients compared with healthy control (HC) volunteers, and the relevance of combining ACE genotype and activity for predicting schizophrenia was suggested. Methods ACE activity was measured in plasma of ACE insertion/deletion (I/D) genotyped HC volunteers (n = 53) and antipsychotic-naïve first-episode psychosis (FEP) patients (n = 45) assessed at baseline (FEB-B) and also after 2 months (FEP-2M) of treatment with the atypical antipsychotic risperidone. Results ACE activity measurements showed significant differences among HC, FEP-B, and FEP-2M groups (F = 5.356, df = 2, P = .005) as well as between HC and FEP-2M (post-hoc Tukey’s multiple comparisons test, P = .004). No correlation was observed for ACE activity increases and symptom severity reductions in FEP as assessed by total Positive and Negative Syndrome Scale (r = −0.131, P = .434). FEP subgrouped by ACE I/D genotype showed significant ACE activity increases, mainly in the DD genotype subgroup. No correlation between ACE activity and age was observed in FEP or HC groups separately (r = 0.210, P = .392), but ACE activity level differences observed between these groups were influenced by age. Conclusions The importance of measuring the ACE activity in blood plasma, associated with ACE I/D genotyping to support the follow-up of FEP patients, did not show correlation with general symptom amelioration in the present study. However, new insights into the influence of age and I/D genotype for ACE activity changes in FEP individuals upon treatment was demonstrated. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-07-22 |
dc.date.accessioned.fl_str_mv |
2021-10-29T15:06:40Z |
dc.date.available.fl_str_mv |
2021-10-29T15:06:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
The International Journal of Neuropsychopharmacology, Oxford, v. 23, n. 11, p. 721-730. 22 July 2020. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/xmlui/handle/11600/62159 https://doi.org/10.1093/ijnp/pyaa050 |
dc.identifier.issn.none.fl_str_mv |
1469-5111 |
dc.identifier.doi.none.fl_str_mv |
10.1093/ijnp/pyaa050 |
identifier_str_mv |
The International Journal of Neuropsychopharmacology, Oxford, v. 23, n. 11, p. 721-730. 22 July 2020. 1469-5111 10.1093/ijnp/pyaa050 |
url |
https://repositorio.unifesp.br/xmlui/handle/11600/62159 https://doi.org/10.1093/ijnp/pyaa050 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
International Journal of Neuropsychopharmacology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
p. 721-730 |
dc.coverage.none.fl_str_mv |
Oxford |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
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