Experimental model of cultured skin graft

Detalhes bibliográficos
Autor(a) principal: Gragnani, Alfredo [UNIFESP]
Data de Publicação: 2004
Outros Autores: Morgan, Jeffrey R., Ferreira, Lydia Masako [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0102-86502004000700003
http://repositorio.unifesp.br/handle/11600/2304
Resumo: One of the most used animal models of cultured keratinocytes autografting is based on xenografting of human keratinocytes to the rat or athymic mice, immunological neutral recipient that acts as biological carrier. It could be studied in this model many facts that occur after transplant without the ethical aspect in the clinical study. The proposition of the experimental model is related to the sequence of the total or partial skin transplant, as autografting or xenografting, cultured or not, to the back of athymic mice. The model presents the possibility of study in vivo athymic animal, when the in vivo study in anima nobili is not ethical. It permits the xenografting evaluation of cultured cells graft or of the genetically modified cells and of the association of the cultured cells and the dermal substitutes, the composite grafts, and of the autografting.
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spelling Experimental model of cultured skin graftModelo experimental de enxerto de pele cultivadoKeratinocytesDermisSkin transplantationCells, CulturedAthymic miceQueratinócitosDermeTransplante de peleCélulas cultivadasRato atímicoOne of the most used animal models of cultured keratinocytes autografting is based on xenografting of human keratinocytes to the rat or athymic mice, immunological neutral recipient that acts as biological carrier. It could be studied in this model many facts that occur after transplant without the ethical aspect in the clinical study. The proposition of the experimental model is related to the sequence of the total or partial skin transplant, as autografting or xenografting, cultured or not, to the back of athymic mice. The model presents the possibility of study in vivo athymic animal, when the in vivo study in anima nobili is not ethical. It permits the xenografting evaluation of cultured cells graft or of the genetically modified cells and of the association of the cultured cells and the dermal substitutes, the composite grafts, and of the autografting.Um dos modelos animais mais utilizados de auto-enxertia de queratinócitos cultivados é baseado em xeno-enxerto de queratinócitos humanos em rato atímico, um receptor imunologicamente neutro que atua como carreador biológico. Muitos fatos podem ser estudados nesse modelo que acontecem após o transplante sem os aspectos éticos do estudo clínico. A proposição do modelo experimental esta relacionada a sequência do transplante de pele parcial ou total como auto-enxerto ou xeno-enxerto, cultivado ou não, no dorso do rato atímico. O modelo apresenta a possibilidade do estudo in vivo do animal atímico, quando o estudo in vivo em anima nobili não é considerado ético. Isso permite a avaliação do xeno-enxerto de células humanas normais ou modificadas geneticamente modificadas cultivadas e a associação de células cultivadas e substitutes dérmicos, de enxertos compostos e de auto-enxerto.UNIFESP-EPM Post-Graduation Program of Plastic SurgeryShriners Hospital for ChildrenHarvard Medical SchoolUNIFESP-EPM Plastic Surgery Division of Surgery DepartmentUNIFESP, EPM, Post-Graduation Program of Plastic SurgeryUNIFESP, EPM Plastic Surgery Division of Surgery DepartmentSciELOSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaUniversidade Federal de São Paulo (UNIFESP)Shriners Hospital for ChildrenHarvard Medical SchoolGragnani, Alfredo [UNIFESP]Morgan, Jeffrey R.Ferreira, Lydia Masako [UNIFESP]2015-06-14T13:31:21Z2015-06-14T13:31:21Z2004-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion4-10application/pdfhttp://dx.doi.org/10.1590/S0102-86502004000700003Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 19, p. 4-10, 2004.10.1590/S0102-86502004000700003S0102-86502004000700003.pdf0102-8650S0102-86502004000700003http://repositorio.unifesp.br/handle/11600/2304engActa Cirurgica Brasileirainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-04T13:35:22Zoai:repositorio.unifesp.br/:11600/2304Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T13:35:22Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Experimental model of cultured skin graft
Modelo experimental de enxerto de pele cultivado
title Experimental model of cultured skin graft
spellingShingle Experimental model of cultured skin graft
Gragnani, Alfredo [UNIFESP]
Keratinocytes
Dermis
Skin transplantation
Cells, Cultured
Athymic mice
Queratinócitos
Derme
Transplante de pele
Células cultivadas
Rato atímico
title_short Experimental model of cultured skin graft
title_full Experimental model of cultured skin graft
title_fullStr Experimental model of cultured skin graft
title_full_unstemmed Experimental model of cultured skin graft
title_sort Experimental model of cultured skin graft
author Gragnani, Alfredo [UNIFESP]
author_facet Gragnani, Alfredo [UNIFESP]
Morgan, Jeffrey R.
Ferreira, Lydia Masako [UNIFESP]
author_role author
author2 Morgan, Jeffrey R.
Ferreira, Lydia Masako [UNIFESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Shriners Hospital for Children
Harvard Medical School
dc.contributor.author.fl_str_mv Gragnani, Alfredo [UNIFESP]
Morgan, Jeffrey R.
Ferreira, Lydia Masako [UNIFESP]
dc.subject.por.fl_str_mv Keratinocytes
Dermis
Skin transplantation
Cells, Cultured
Athymic mice
Queratinócitos
Derme
Transplante de pele
Células cultivadas
Rato atímico
topic Keratinocytes
Dermis
Skin transplantation
Cells, Cultured
Athymic mice
Queratinócitos
Derme
Transplante de pele
Células cultivadas
Rato atímico
description One of the most used animal models of cultured keratinocytes autografting is based on xenografting of human keratinocytes to the rat or athymic mice, immunological neutral recipient that acts as biological carrier. It could be studied in this model many facts that occur after transplant without the ethical aspect in the clinical study. The proposition of the experimental model is related to the sequence of the total or partial skin transplant, as autografting or xenografting, cultured or not, to the back of athymic mice. The model presents the possibility of study in vivo athymic animal, when the in vivo study in anima nobili is not ethical. It permits the xenografting evaluation of cultured cells graft or of the genetically modified cells and of the association of the cultured cells and the dermal substitutes, the composite grafts, and of the autografting.
publishDate 2004
dc.date.none.fl_str_mv 2004-12-01
2015-06-14T13:31:21Z
2015-06-14T13:31:21Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0102-86502004000700003
Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 19, p. 4-10, 2004.
10.1590/S0102-86502004000700003
S0102-86502004000700003.pdf
0102-8650
S0102-86502004000700003
http://repositorio.unifesp.br/handle/11600/2304
url http://dx.doi.org/10.1590/S0102-86502004000700003
http://repositorio.unifesp.br/handle/11600/2304
identifier_str_mv Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 19, p. 4-10, 2004.
10.1590/S0102-86502004000700003
S0102-86502004000700003.pdf
0102-8650
S0102-86502004000700003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Cirurgica Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 4-10
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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