Experimental model of cultured skin graft
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0102-86502004000700003 http://repositorio.unifesp.br/handle/11600/2304 |
Resumo: | One of the most used animal models of cultured keratinocytes autografting is based on xenografting of human keratinocytes to the rat or athymic mice, immunological neutral recipient that acts as biological carrier. It could be studied in this model many facts that occur after transplant without the ethical aspect in the clinical study. The proposition of the experimental model is related to the sequence of the total or partial skin transplant, as autografting or xenografting, cultured or not, to the back of athymic mice. The model presents the possibility of study in vivo athymic animal, when the in vivo study in anima nobili is not ethical. It permits the xenografting evaluation of cultured cells graft or of the genetically modified cells and of the association of the cultured cells and the dermal substitutes, the composite grafts, and of the autografting. |
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Experimental model of cultured skin graftModelo experimental de enxerto de pele cultivadoKeratinocytesDermisSkin transplantationCells, CulturedAthymic miceQueratinócitosDermeTransplante de peleCélulas cultivadasRato atímicoOne of the most used animal models of cultured keratinocytes autografting is based on xenografting of human keratinocytes to the rat or athymic mice, immunological neutral recipient that acts as biological carrier. It could be studied in this model many facts that occur after transplant without the ethical aspect in the clinical study. The proposition of the experimental model is related to the sequence of the total or partial skin transplant, as autografting or xenografting, cultured or not, to the back of athymic mice. The model presents the possibility of study in vivo athymic animal, when the in vivo study in anima nobili is not ethical. It permits the xenografting evaluation of cultured cells graft or of the genetically modified cells and of the association of the cultured cells and the dermal substitutes, the composite grafts, and of the autografting.Um dos modelos animais mais utilizados de auto-enxertia de queratinócitos cultivados é baseado em xeno-enxerto de queratinócitos humanos em rato atímico, um receptor imunologicamente neutro que atua como carreador biológico. Muitos fatos podem ser estudados nesse modelo que acontecem após o transplante sem os aspectos éticos do estudo clínico. A proposição do modelo experimental esta relacionada a sequência do transplante de pele parcial ou total como auto-enxerto ou xeno-enxerto, cultivado ou não, no dorso do rato atímico. O modelo apresenta a possibilidade do estudo in vivo do animal atímico, quando o estudo in vivo em anima nobili não é considerado ético. Isso permite a avaliação do xeno-enxerto de células humanas normais ou modificadas geneticamente modificadas cultivadas e a associação de células cultivadas e substitutes dérmicos, de enxertos compostos e de auto-enxerto.UNIFESP-EPM Post-Graduation Program of Plastic SurgeryShriners Hospital for ChildrenHarvard Medical SchoolUNIFESP-EPM Plastic Surgery Division of Surgery DepartmentUNIFESP, EPM, Post-Graduation Program of Plastic SurgeryUNIFESP, EPM Plastic Surgery Division of Surgery DepartmentSciELOSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaUniversidade Federal de São Paulo (UNIFESP)Shriners Hospital for ChildrenHarvard Medical SchoolGragnani, Alfredo [UNIFESP]Morgan, Jeffrey R.Ferreira, Lydia Masako [UNIFESP]2015-06-14T13:31:21Z2015-06-14T13:31:21Z2004-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion4-10application/pdfhttp://dx.doi.org/10.1590/S0102-86502004000700003Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 19, p. 4-10, 2004.10.1590/S0102-86502004000700003S0102-86502004000700003.pdf0102-8650S0102-86502004000700003http://repositorio.unifesp.br/handle/11600/2304engActa Cirurgica Brasileirainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-04T13:35:22Zoai:repositorio.unifesp.br/:11600/2304Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T13:35:22Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Experimental model of cultured skin graft Modelo experimental de enxerto de pele cultivado |
title |
Experimental model of cultured skin graft |
spellingShingle |
Experimental model of cultured skin graft Gragnani, Alfredo [UNIFESP] Keratinocytes Dermis Skin transplantation Cells, Cultured Athymic mice Queratinócitos Derme Transplante de pele Células cultivadas Rato atímico |
title_short |
Experimental model of cultured skin graft |
title_full |
Experimental model of cultured skin graft |
title_fullStr |
Experimental model of cultured skin graft |
title_full_unstemmed |
Experimental model of cultured skin graft |
title_sort |
Experimental model of cultured skin graft |
author |
Gragnani, Alfredo [UNIFESP] |
author_facet |
Gragnani, Alfredo [UNIFESP] Morgan, Jeffrey R. Ferreira, Lydia Masako [UNIFESP] |
author_role |
author |
author2 |
Morgan, Jeffrey R. Ferreira, Lydia Masako [UNIFESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Shriners Hospital for Children Harvard Medical School |
dc.contributor.author.fl_str_mv |
Gragnani, Alfredo [UNIFESP] Morgan, Jeffrey R. Ferreira, Lydia Masako [UNIFESP] |
dc.subject.por.fl_str_mv |
Keratinocytes Dermis Skin transplantation Cells, Cultured Athymic mice Queratinócitos Derme Transplante de pele Células cultivadas Rato atímico |
topic |
Keratinocytes Dermis Skin transplantation Cells, Cultured Athymic mice Queratinócitos Derme Transplante de pele Células cultivadas Rato atímico |
description |
One of the most used animal models of cultured keratinocytes autografting is based on xenografting of human keratinocytes to the rat or athymic mice, immunological neutral recipient that acts as biological carrier. It could be studied in this model many facts that occur after transplant without the ethical aspect in the clinical study. The proposition of the experimental model is related to the sequence of the total or partial skin transplant, as autografting or xenografting, cultured or not, to the back of athymic mice. The model presents the possibility of study in vivo athymic animal, when the in vivo study in anima nobili is not ethical. It permits the xenografting evaluation of cultured cells graft or of the genetically modified cells and of the association of the cultured cells and the dermal substitutes, the composite grafts, and of the autografting. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-12-01 2015-06-14T13:31:21Z 2015-06-14T13:31:21Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0102-86502004000700003 Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 19, p. 4-10, 2004. 10.1590/S0102-86502004000700003 S0102-86502004000700003.pdf 0102-8650 S0102-86502004000700003 http://repositorio.unifesp.br/handle/11600/2304 |
url |
http://dx.doi.org/10.1590/S0102-86502004000700003 http://repositorio.unifesp.br/handle/11600/2304 |
identifier_str_mv |
Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 19, p. 4-10, 2004. 10.1590/S0102-86502004000700003 S0102-86502004000700003.pdf 0102-8650 S0102-86502004000700003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Acta Cirurgica Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
4-10 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268380362833920 |