COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/38894 http://dx.doi.org/10.1371/journal.pone.0119592 |
Resumo: | ObjectiveObsessive-compulsive disorder (OCD) is a common and debilitating psychiatric illness. Although a genetic component contributes to its etiology, no single gene or mechanism has been identified to the OCD susceptibility. the catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAO-A) genes have been investigated in previous OCD studies, but the results are still unclear. More recently, Taylor (2013) in a comprehensive meta-analysis of genetic association studies has identified COMT and MAO-A polymorphisms involved with OCD. in an effort to clarify the role of these two genes in OCD vulnerability, a family-based association investigation was performed as an alternative strategy to the classical case-control design.MethodsTransmission disequilibrium analyses were performed after genotyping 13 single-nucleotide polymorphisms (eight in COMT and five in MAO-A) in 783 OCD trios (probands and their parents). Four different OCD phenotypes (from narrow to broad OCD definitions) and a SNP x SNP epistasis were also analyzed.ResultsOCD, broad and narrow phenotypes, were not associated with any of the investigated COMT and MAO-A polymorphisms. in addition, the analyses of gene-gene interaction did not show significant epistatic influences on phenotype between COMT and MAO-A.ConclusionsThe findings do not support an association between DSM-IV OCD and the variants of COMT or MAO-A. However, results from this study cannot exclude the contribution of these genes in the manifestation of OCD. the evaluation of broader spectrum phenotypes could help to understand the role of these and other genes in the pathophysiology of OCD and its spectrum disorders. |
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Sampaio, Aline SantosHounie, Ana GabrielaPetribu, KatiaCappi, CarolinaMorais, IvanilVallada, HomeroRosario, Maria Conceição do [UNIFESP]Stewart, S. EvelynFargeness, JesenMathews, CarolArnold, PaulHanna, Gregory L.Richter, MargaretKennedy, JamesFontenelle, LeonardoBraganca Pereira, Carlos Alberto dePauls, David L.Miguel, Euripedes ConstantinoUniversidade de São Paulo (USP)Universidade Federal da Bahia (UFBA)Univ PernambucoUniversidade Federal de São Paulo (UNIFESP)British Columbia Mental Hlth & Addict Res InstMassachusetts Gen HospUniv Calif San FranciscoHosp Sick ChildrenUniv MichiganSunnybrook Hlth Sci CtrUniv TorontoUniversidade Federal do Rio de Janeiro (UFRJ)2016-01-24T14:40:15Z2016-01-24T14:40:15Z2015-03-20Plos One. San Francisco: Public Library Science, v. 10, n. 3, 14 p., 2015.1932-6203http://repositorio.unifesp.br/handle/11600/38894http://dx.doi.org/10.1371/journal.pone.0119592WOS000352084200098.pdf10.1371/journal.pone.0119592WOS:000352084200098ObjectiveObsessive-compulsive disorder (OCD) is a common and debilitating psychiatric illness. Although a genetic component contributes to its etiology, no single gene or mechanism has been identified to the OCD susceptibility. the catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAO-A) genes have been investigated in previous OCD studies, but the results are still unclear. More recently, Taylor (2013) in a comprehensive meta-analysis of genetic association studies has identified COMT and MAO-A polymorphisms involved with OCD. in an effort to clarify the role of these two genes in OCD vulnerability, a family-based association investigation was performed as an alternative strategy to the classical case-control design.MethodsTransmission disequilibrium analyses were performed after genotyping 13 single-nucleotide polymorphisms (eight in COMT and five in MAO-A) in 783 OCD trios (probands and their parents). Four different OCD phenotypes (from narrow to broad OCD definitions) and a SNP x SNP epistasis were also analyzed.ResultsOCD, broad and narrow phenotypes, were not associated with any of the investigated COMT and MAO-A polymorphisms. in addition, the analyses of gene-gene interaction did not show significant epistatic influences on phenotype between COMT and MAO-A.ConclusionsThe findings do not support an association between DSM-IV OCD and the variants of COMT or MAO-A. However, results from this study cannot exclude the contribution of these genes in the manifestation of OCD. the evaluation of broader spectrum phenotypes could help to understand the role of these and other genes in the pathophysiology of OCD and its spectrum disorders.Brazilian governmental agenciesConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundo de Aprimoramento Academico (FUAA-Grant for Academic Improvement)Department of Psychiatry University of São Paulo School of MedicineUniv São Paulo, Fac Med, Dept & Inst Psychiat, São Paulo, SP, BrazilUniv Fed Bahia, Serv Med Univ, Salvador, BA, BrazilUniv Pernambuco, Fac Ciencias Med, Recife, PE, BrazilUniversidade Federal de São Paulo, São Paulo, SP, BrazilBritish Columbia Mental Hlth & Addict Res Inst, Vancouver, BC, CanadaMassachusetts Gen Hosp, PNGU, Boston, MA 02114 USAMassachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USAUniv Calif San Francisco, Dept Psychiat, San Francisco, CA USAHosp Sick Children, Program Genet & Genome Biol, Toronto, ON M5G 1X8, CanadaUniv Michigan, Dept Psychiat, Ann Arbor, MI 48109 USASunnybrook Hlth Sci Ctr, Frederick W Thompson Anxiety Disorders Ctr, Toronto, ON M4N 3M5, CanadaUniv Toronto, Ctr Addict & Mental Hlth, Toronto, ON, CanadaUniv Fed Rio de Janeiro, Inst Psiquiatria, IPUB, Programa Ansiedade & Depressao, Rio de Janeiro, BrazilUniv São Paulo, Inst Math & Stat, Dept Stat, São Paulo, SP, BrazilUniversidade Federal de São Paulo, EPM, São Paulo, SP, BrazilCNPq: 573974/2008-0FAPESP: 2005/55628-08FAPESP: 2008/57896-8Web of Science14engPublic Library SciencePlos OneCOMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000352084200098.pdfapplication/pdf1128759${dspace.ui.url}/bitstream/11600/38894/1/WOS000352084200098.pdf3c78f5bfd987d05181b659b7707bbe44MD51open accessTEXTWOS000352084200098.pdf.txtWOS000352084200098.pdf.txtExtracted texttext/plain49945${dspace.ui.url}/bitstream/11600/38894/2/WOS000352084200098.pdf.txtf24031184def60983be21a2ea860e1fdMD52open access11600/388942022-11-03 15:00:28.137open accessoai:repositorio.unifesp.br:11600/38894Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-11-03T18:00:28Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study |
title |
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study |
spellingShingle |
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study Sampaio, Aline Santos |
title_short |
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study |
title_full |
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study |
title_fullStr |
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study |
title_full_unstemmed |
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study |
title_sort |
COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study |
author |
Sampaio, Aline Santos |
author_facet |
Sampaio, Aline Santos Hounie, Ana Gabriela Petribu, Katia Cappi, Carolina Morais, Ivanil Vallada, Homero Rosario, Maria Conceição do [UNIFESP] Stewart, S. Evelyn Fargeness, Jesen Mathews, Carol Arnold, Paul Hanna, Gregory L. Richter, Margaret Kennedy, James Fontenelle, Leonardo Braganca Pereira, Carlos Alberto de Pauls, David L. Miguel, Euripedes Constantino |
author_role |
author |
author2 |
Hounie, Ana Gabriela Petribu, Katia Cappi, Carolina Morais, Ivanil Vallada, Homero Rosario, Maria Conceição do [UNIFESP] Stewart, S. Evelyn Fargeness, Jesen Mathews, Carol Arnold, Paul Hanna, Gregory L. Richter, Margaret Kennedy, James Fontenelle, Leonardo Braganca Pereira, Carlos Alberto de Pauls, David L. Miguel, Euripedes Constantino |
author2_role |
author author author author author author author author author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal da Bahia (UFBA) Univ Pernambuco Universidade Federal de São Paulo (UNIFESP) British Columbia Mental Hlth & Addict Res Inst Massachusetts Gen Hosp Univ Calif San Francisco Hosp Sick Children Univ Michigan Sunnybrook Hlth Sci Ctr Univ Toronto Universidade Federal do Rio de Janeiro (UFRJ) |
dc.contributor.author.fl_str_mv |
Sampaio, Aline Santos Hounie, Ana Gabriela Petribu, Katia Cappi, Carolina Morais, Ivanil Vallada, Homero Rosario, Maria Conceição do [UNIFESP] Stewart, S. Evelyn Fargeness, Jesen Mathews, Carol Arnold, Paul Hanna, Gregory L. Richter, Margaret Kennedy, James Fontenelle, Leonardo Braganca Pereira, Carlos Alberto de Pauls, David L. Miguel, Euripedes Constantino |
description |
ObjectiveObsessive-compulsive disorder (OCD) is a common and debilitating psychiatric illness. Although a genetic component contributes to its etiology, no single gene or mechanism has been identified to the OCD susceptibility. the catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAO-A) genes have been investigated in previous OCD studies, but the results are still unclear. More recently, Taylor (2013) in a comprehensive meta-analysis of genetic association studies has identified COMT and MAO-A polymorphisms involved with OCD. in an effort to clarify the role of these two genes in OCD vulnerability, a family-based association investigation was performed as an alternative strategy to the classical case-control design.MethodsTransmission disequilibrium analyses were performed after genotyping 13 single-nucleotide polymorphisms (eight in COMT and five in MAO-A) in 783 OCD trios (probands and their parents). Four different OCD phenotypes (from narrow to broad OCD definitions) and a SNP x SNP epistasis were also analyzed.ResultsOCD, broad and narrow phenotypes, were not associated with any of the investigated COMT and MAO-A polymorphisms. in addition, the analyses of gene-gene interaction did not show significant epistatic influences on phenotype between COMT and MAO-A.ConclusionsThe findings do not support an association between DSM-IV OCD and the variants of COMT or MAO-A. However, results from this study cannot exclude the contribution of these genes in the manifestation of OCD. the evaluation of broader spectrum phenotypes could help to understand the role of these and other genes in the pathophysiology of OCD and its spectrum disorders. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-03-20 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:40:15Z |
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2016-01-24T14:40:15Z |
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Plos One. San Francisco: Public Library Science, v. 10, n. 3, 14 p., 2015. |
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http://repositorio.unifesp.br/handle/11600/38894 http://dx.doi.org/10.1371/journal.pone.0119592 |
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1932-6203 |
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WOS000352084200098.pdf |
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10.1371/journal.pone.0119592 |
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WOS:000352084200098 |
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Plos One. San Francisco: Public Library Science, v. 10, n. 3, 14 p., 2015. 1932-6203 WOS000352084200098.pdf 10.1371/journal.pone.0119592 WOS:000352084200098 |
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http://repositorio.unifesp.br/handle/11600/38894 http://dx.doi.org/10.1371/journal.pone.0119592 |
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