Effect of fish oil intake on glucose levels in rat prefrontal cortex, as measured by microdialysis

Detalhes bibliográficos
Autor(a) principal: Sousa, Isy Faria de [UNIFESP]
Data de Publicação: 2013
Outros Autores: Souza, Adriana Pereira de [UNIFESP], Andrade, Iracema Senna de [UNIFESP], Boldarine, Valter Tadeu [UNIFESP], Nascimento, Claudia Maria da Penha Oller do [UNIFESP], Oyama, Lila Missae [UNIFESP], Telles, Monica Marques [UNIFESP], Ribeiro, Eliane Beraldi [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://repositorio.unifesp.br/handle/11600/37090
https://dx.doi.org/10.1186/1476-511X-12-188
Resumo: Background: Brain glucose sensing may contribute to energy homeostasis control. the prefrontal cortex (PFC) participates in the hedonic component of feeding control. As high-fat diets may disrupt energy homeostasis, we evaluated in male Wistar rats whether intake of high-fat fish-oil diet modified cortical glucose extracellular levels and the feeding induced by intracerebroventricular glucose or PFC glucoprivation.Methods: Glucose levels in PFC microdialysates were measured before and after a 30-min meal. Food intake was measured in animals receiving intracerebroventricular glucose followed, 30-min. later, by 2-deoxy-D-glucose injected into the PFC.Results: the fish-oil group showed normal body weight and serum insulin while fat pads weight and glucose levels were increased. Baseline PFC glucose and 30-min. carbohydrates intake were similar between the groups. Feeding-induced PFC glucose levels increased earlier and more pronouncedly in fish-oil than in control rats. Intracerebroventricular glucose inhibited feeding consistently in the control but not in the fish-oil group. Local PFC glucoprivation with 2-DG attenuated glucose-induced hypophagia.Conclusions: the present experiments have shown that, following food intake, more glucose reached the prefrontal cortex of the rats fed the high-fat fish-oil diet than of the rats fed the control diet. However, when administered directly into the lateral cerebral ventricle, glucose was able to consistently inhibit feeding only in the control rats. the findings indicate that, an impairment of glucose transport into the brain does not contribute to the disturbances induced by the high-fat fish-oil feeding.
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spelling Sousa, Isy Faria de [UNIFESP]Souza, Adriana Pereira de [UNIFESP]Andrade, Iracema Senna de [UNIFESP]Boldarine, Valter Tadeu [UNIFESP]Nascimento, Claudia Maria da Penha Oller do [UNIFESP]Oyama, Lila Missae [UNIFESP]Telles, Monica Marques [UNIFESP]Ribeiro, Eliane Beraldi [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:34:52Z2016-01-24T14:34:52Z2013-12-26Lipids in Health and Disease. London: Biomed Central Ltd, v. 12, 9 p., 2013.1476-511Xhttps://repositorio.unifesp.br/handle/11600/37090https://dx.doi.org/10.1186/1476-511X-12-188WOS000329391600001.pdf10.1186/1476-511X-12-188WOS:000329391600001Background: Brain glucose sensing may contribute to energy homeostasis control. the prefrontal cortex (PFC) participates in the hedonic component of feeding control. As high-fat diets may disrupt energy homeostasis, we evaluated in male Wistar rats whether intake of high-fat fish-oil diet modified cortical glucose extracellular levels and the feeding induced by intracerebroventricular glucose or PFC glucoprivation.Methods: Glucose levels in PFC microdialysates were measured before and after a 30-min meal. Food intake was measured in animals receiving intracerebroventricular glucose followed, 30-min. later, by 2-deoxy-D-glucose injected into the PFC.Results: the fish-oil group showed normal body weight and serum insulin while fat pads weight and glucose levels were increased. Baseline PFC glucose and 30-min. carbohydrates intake were similar between the groups. Feeding-induced PFC glucose levels increased earlier and more pronouncedly in fish-oil than in control rats. Intracerebroventricular glucose inhibited feeding consistently in the control but not in the fish-oil group. Local PFC glucoprivation with 2-DG attenuated glucose-induced hypophagia.Conclusions: the present experiments have shown that, following food intake, more glucose reached the prefrontal cortex of the rats fed the high-fat fish-oil diet than of the rats fed the control diet. However, when administered directly into the lateral cerebral ventricle, glucose was able to consistently inhibit feeding only in the control rats. the findings indicate that, an impairment of glucose transport into the brain does not contribute to the disturbances induced by the high-fat fish-oil feeding.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal de São Paulo Unifesp, Dept Fisiol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo Unifesp, Dept Fisiol, BR-04023062 São Paulo, BrazilWeb of Science9engBiomed Central LtdLipids in Health and DiseaseFood intakeObesityLong-chain omega-3 fatty acidsBrain microdialysisEffect of fish oil intake on glucose levels in rat prefrontal cortex, as measured by microdialysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000329391600001.pdfapplication/pdf486774${dspace.ui.url}/bitstream/11600/37090/1/WOS000329391600001.pdf018bb4140af22fdfef0597805d442f44MD51open accessTEXTWOS000329391600001.pdf.txtWOS000329391600001.pdf.txtExtracted texttext/plain43754${dspace.ui.url}/bitstream/11600/37090/2/WOS000329391600001.pdf.txtdf8757114d85317211e54212bd611324MD52open access11600/370902021-09-30 17:26:55.8open accessoai:repositorio.unifesp.br:11600/37090Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:21:18.189660Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Effect of fish oil intake on glucose levels in rat prefrontal cortex, as measured by microdialysis
title Effect of fish oil intake on glucose levels in rat prefrontal cortex, as measured by microdialysis
spellingShingle Effect of fish oil intake on glucose levels in rat prefrontal cortex, as measured by microdialysis
Sousa, Isy Faria de [UNIFESP]
Food intake
Obesity
Long-chain omega-3 fatty acids
Brain microdialysis
title_short Effect of fish oil intake on glucose levels in rat prefrontal cortex, as measured by microdialysis
title_full Effect of fish oil intake on glucose levels in rat prefrontal cortex, as measured by microdialysis
title_fullStr Effect of fish oil intake on glucose levels in rat prefrontal cortex, as measured by microdialysis
title_full_unstemmed Effect of fish oil intake on glucose levels in rat prefrontal cortex, as measured by microdialysis
title_sort Effect of fish oil intake on glucose levels in rat prefrontal cortex, as measured by microdialysis
author Sousa, Isy Faria de [UNIFESP]
author_facet Sousa, Isy Faria de [UNIFESP]
Souza, Adriana Pereira de [UNIFESP]
Andrade, Iracema Senna de [UNIFESP]
Boldarine, Valter Tadeu [UNIFESP]
Nascimento, Claudia Maria da Penha Oller do [UNIFESP]
Oyama, Lila Missae [UNIFESP]
Telles, Monica Marques [UNIFESP]
Ribeiro, Eliane Beraldi [UNIFESP]
author_role author
author2 Souza, Adriana Pereira de [UNIFESP]
Andrade, Iracema Senna de [UNIFESP]
Boldarine, Valter Tadeu [UNIFESP]
Nascimento, Claudia Maria da Penha Oller do [UNIFESP]
Oyama, Lila Missae [UNIFESP]
Telles, Monica Marques [UNIFESP]
Ribeiro, Eliane Beraldi [UNIFESP]
author2_role author
author
author
author
author
author
author
dc.contributor.institution.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Sousa, Isy Faria de [UNIFESP]
Souza, Adriana Pereira de [UNIFESP]
Andrade, Iracema Senna de [UNIFESP]
Boldarine, Valter Tadeu [UNIFESP]
Nascimento, Claudia Maria da Penha Oller do [UNIFESP]
Oyama, Lila Missae [UNIFESP]
Telles, Monica Marques [UNIFESP]
Ribeiro, Eliane Beraldi [UNIFESP]
dc.subject.eng.fl_str_mv Food intake
Obesity
Long-chain omega-3 fatty acids
Brain microdialysis
topic Food intake
Obesity
Long-chain omega-3 fatty acids
Brain microdialysis
description Background: Brain glucose sensing may contribute to energy homeostasis control. the prefrontal cortex (PFC) participates in the hedonic component of feeding control. As high-fat diets may disrupt energy homeostasis, we evaluated in male Wistar rats whether intake of high-fat fish-oil diet modified cortical glucose extracellular levels and the feeding induced by intracerebroventricular glucose or PFC glucoprivation.Methods: Glucose levels in PFC microdialysates were measured before and after a 30-min meal. Food intake was measured in animals receiving intracerebroventricular glucose followed, 30-min. later, by 2-deoxy-D-glucose injected into the PFC.Results: the fish-oil group showed normal body weight and serum insulin while fat pads weight and glucose levels were increased. Baseline PFC glucose and 30-min. carbohydrates intake were similar between the groups. Feeding-induced PFC glucose levels increased earlier and more pronouncedly in fish-oil than in control rats. Intracerebroventricular glucose inhibited feeding consistently in the control but not in the fish-oil group. Local PFC glucoprivation with 2-DG attenuated glucose-induced hypophagia.Conclusions: the present experiments have shown that, following food intake, more glucose reached the prefrontal cortex of the rats fed the high-fat fish-oil diet than of the rats fed the control diet. However, when administered directly into the lateral cerebral ventricle, glucose was able to consistently inhibit feeding only in the control rats. the findings indicate that, an impairment of glucose transport into the brain does not contribute to the disturbances induced by the high-fat fish-oil feeding.
publishDate 2013
dc.date.issued.fl_str_mv 2013-12-26
dc.date.accessioned.fl_str_mv 2016-01-24T14:34:52Z
dc.date.available.fl_str_mv 2016-01-24T14:34:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv Lipids in Health and Disease. London: Biomed Central Ltd, v. 12, 9 p., 2013.
dc.identifier.uri.fl_str_mv https://repositorio.unifesp.br/handle/11600/37090
https://dx.doi.org/10.1186/1476-511X-12-188
dc.identifier.issn.none.fl_str_mv 1476-511X
dc.identifier.file.none.fl_str_mv WOS000329391600001.pdf
dc.identifier.doi.none.fl_str_mv 10.1186/1476-511X-12-188
dc.identifier.wos.none.fl_str_mv WOS:000329391600001
identifier_str_mv Lipids in Health and Disease. London: Biomed Central Ltd, v. 12, 9 p., 2013.
1476-511X
WOS000329391600001.pdf
10.1186/1476-511X-12-188
WOS:000329391600001
url https://repositorio.unifesp.br/handle/11600/37090
https://dx.doi.org/10.1186/1476-511X-12-188
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Lipids in Health and Disease
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dc.publisher.none.fl_str_mv Biomed Central Ltd
publisher.none.fl_str_mv Biomed Central Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
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