Serum homocysteine and cysteine levels and associated factors in children and adolescents

Detalhes bibliográficos
Autor(a) principal: Costa, Priscila Ribas de Farias
Data de Publicação: 2017
Outros Autores: Kinra, Sanjay, D'Almeida, Vania [UNIFESP], Assis, Ana Marlucia Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://repositorio.unifesp.br/handle/11600/56312
http://dx.doi.org/10.12873/371ribasdefarias
Resumo: Introduction: Studies have identified high serum homocysteine ( Hcy) and cysteine ( Cys) levels as risk factor for cardiovascular diseases, important cause of death in all world. The factors associated with high levels of these biochemistry markers in adults are well known
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spelling Costa, Priscila Ribas de FariasKinra, SanjayD'Almeida, Vania [UNIFESP]Assis, Ana Marlucia Oliveira2020-07-31T12:46:41Z2020-07-31T12:46:41Z2017Nutricion Clinica Y Dietetica Hospitalaria. Madrid, v. 37, n. 1, p. 106-116, 2017.0211-6057https://repositorio.unifesp.br/handle/11600/56312http://dx.doi.org/10.12873/371ribasdefarias10.12873/371ribasdefariasWOS:000400444300013Introduction: Studies have identified high serum homocysteine ( Hcy) and cysteine ( Cys) levels as risk factor for cardiovascular diseases, important cause of death in all world. The factors associated with high levels of these biochemistry markers in adults are well knownhowever, data are sparse on these associations in the pediatric age group. Objective: the objective was to identify factors associated with different concentrations of serum Hcy and Cys in children and adolescents. Methods: a cross-sectional study with 483 individuals of 715 years of age of both sexes, from a municipality of Bahia. Serum Hcy and Cys levels were considered outcome variables, with exposure being evaluated according to sociodemographic, clinical, biochemical and lifestyle variables. Polytomous logistic regression was used to evaluate the association between exposure and outcome. Results: high serum Hcy levels were associated with being male (PR=3.74p<0.01), age =12 years (PR=2.56p<0.01), being overweight (PR=2.32p=0.02), high blood pressure (PR=1.97p<0.01), low HDL-c levels (PR=1.21p=0.03), high triglyceride levels (PR=1.62p=0.03) and poor intake of foods that protect against hyperhomocysteinemia (PR=1.46p=0.02). High serum Cys levels were associated with age =12 years (PR=2.1p=0.03), being overweight (PR=2.52p=0.03)high blood pressure (PR=1.28p=0.03), low HDL-c levels (PR=1.15p=0.01), high triglyceride levels (PR=1.41p=0.02) and poor intake of foods that protect against hyper-cysteinemia (PR=1.46p=0.01). Conclusions: age > 12 years, being overweight, high blood pressure, low HDL-c levels, high triglyceride levels and poor intake of protective foods are common factors found in individuals with increased serum Hcy and Cys levels. Being male was associated with high serum Hcy levels alone. Considering that these factors are already present early in life, measures should be adopted to prevent and control high Hcy and Cys levels, promoting health and preventing chronic non-communicable diseases at this stage of life.Univ Fed Bahia, Publ Hlth Inst ISC, Salvador, BA, BrazilUniv Fed Bahia, Dept Nutr Sci, Salvador, BA, BrazilLondon Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London, EnglandUniv Fed Sao Paulo, Dept Psychobiol, Vila Clementino, Sao Paulo, SP, BrazilDepartment of Psychobiology, Universidade Federal de São Paulo (UNIFESP), Vila Clementino, São Paulo-SP, BrazilWeb of Science106-116engSoc Espanola Dietetica & Ciencias Alimentacion-SedcaNutricion Clinica Y Dietetica HospitalariaHomocysteinecysteineassociated factorsChildrenadolescentsSerum homocysteine and cysteine levels and associated factors in children and adolescentsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMadrid371info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/563122022-09-19 22:29:22.683metadata only accessoai:repositorio.unifesp.br:11600/56312Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-09-20T01:29:22Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Serum homocysteine and cysteine levels and associated factors in children and adolescents
title Serum homocysteine and cysteine levels and associated factors in children and adolescents
spellingShingle Serum homocysteine and cysteine levels and associated factors in children and adolescents
Costa, Priscila Ribas de Farias
Homocysteine
cysteine
associated factors
Children
adolescents
title_short Serum homocysteine and cysteine levels and associated factors in children and adolescents
title_full Serum homocysteine and cysteine levels and associated factors in children and adolescents
title_fullStr Serum homocysteine and cysteine levels and associated factors in children and adolescents
title_full_unstemmed Serum homocysteine and cysteine levels and associated factors in children and adolescents
title_sort Serum homocysteine and cysteine levels and associated factors in children and adolescents
author Costa, Priscila Ribas de Farias
author_facet Costa, Priscila Ribas de Farias
Kinra, Sanjay
D'Almeida, Vania [UNIFESP]
Assis, Ana Marlucia Oliveira
author_role author
author2 Kinra, Sanjay
D'Almeida, Vania [UNIFESP]
Assis, Ana Marlucia Oliveira
author2_role author
author
author
dc.contributor.author.fl_str_mv Costa, Priscila Ribas de Farias
Kinra, Sanjay
D'Almeida, Vania [UNIFESP]
Assis, Ana Marlucia Oliveira
dc.subject.eng.fl_str_mv Homocysteine
cysteine
associated factors
Children
adolescents
topic Homocysteine
cysteine
associated factors
Children
adolescents
description Introduction: Studies have identified high serum homocysteine ( Hcy) and cysteine ( Cys) levels as risk factor for cardiovascular diseases, important cause of death in all world. The factors associated with high levels of these biochemistry markers in adults are well known
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2020-07-31T12:46:41Z
dc.date.available.fl_str_mv 2020-07-31T12:46:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Nutricion Clinica Y Dietetica Hospitalaria. Madrid, v. 37, n. 1, p. 106-116, 2017.
dc.identifier.uri.fl_str_mv https://repositorio.unifesp.br/handle/11600/56312
http://dx.doi.org/10.12873/371ribasdefarias
dc.identifier.issn.none.fl_str_mv 0211-6057
dc.identifier.doi.none.fl_str_mv 10.12873/371ribasdefarias
dc.identifier.wos.none.fl_str_mv WOS:000400444300013
identifier_str_mv Nutricion Clinica Y Dietetica Hospitalaria. Madrid, v. 37, n. 1, p. 106-116, 2017.
0211-6057
10.12873/371ribasdefarias
WOS:000400444300013
url https://repositorio.unifesp.br/handle/11600/56312
http://dx.doi.org/10.12873/371ribasdefarias
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Nutricion Clinica Y Dietetica Hospitalaria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 106-116
dc.coverage.none.fl_str_mv Madrid
dc.publisher.none.fl_str_mv Soc Espanola Dietetica & Ciencias Alimentacion-Sedca
publisher.none.fl_str_mv Soc Espanola Dietetica & Ciencias Alimentacion-Sedca
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv
_version_ 1802764119464476672

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