Genetic Variation among Major Human Geographic Groups Supports a Peculiar Evolutionary Trend in PAX9
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/33362 http://dx.doi.org/10.1371/journal.pone.0015656 |
Resumo: | A total of 172 persons from nine South Amerindian, three African and one Eskimo populations were studied in relation to the Paired box gene 9 (PAX9) exon 3 (138 base pairs) as well as its 5' and 3' flanking intronic segments (232 bp and 220 bp, respectively) and integrated with the information available for the same genetic region from individuals of different geographical origins. Nine mutations were scored in exon 3 and six in its flanking regions; four of them are new South American tribe-specific singletons. Exon3 nucleotide diversity is several orders of magnitude higher than its intronic regions. Additionally, a set of variants in the PAX9 and 101 other genes related with dentition can define at least some dental morphological differences between Sub-Saharan Africans and non-Africans, probably associated with adaptations after the modern human exodus from Africa. Exon 3 of PAX9 could be a good molecular example of how evolvability works. |
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Paixao-Cortes, Vanessa R.Meyer, DiogoPereira, Tiago da Veiga [UNIFESP]Mazieres, StephaneElion, JacquesKrishnamoorthy, RajagopalZago, Marco A.Silva, Wilson A.Salzano, Francisco M.Bortolini, Maria CatiraUniv Fed Rio Grande do SulUniversidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)CNRSFac MedUniv Paris Diderot2016-01-24T14:06:04Z2016-01-24T14:06:04Z2011-01-27Plos One. San Francisco: Public Library Science, v. 6, n. 1, 7 p., 2011.1932-6203http://repositorio.unifesp.br/handle/11600/33362http://dx.doi.org/10.1371/journal.pone.0015656WOS000286663900016.pdf10.1371/journal.pone.0015656WOS:000286663900016A total of 172 persons from nine South Amerindian, three African and one Eskimo populations were studied in relation to the Paired box gene 9 (PAX9) exon 3 (138 base pairs) as well as its 5' and 3' flanking intronic segments (232 bp and 220 bp, respectively) and integrated with the information available for the same genetic region from individuals of different geographical origins. Nine mutations were scored in exon 3 and six in its flanking regions; four of them are new South American tribe-specific singletons. Exon3 nucleotide diversity is several orders of magnitude higher than its intronic regions. Additionally, a set of variants in the PAX9 and 101 other genes related with dentition can define at least some dental morphological differences between Sub-Saharan Africans and non-Africans, probably associated with adaptations after the modern human exodus from Africa. Exon 3 of PAX9 could be a good molecular example of how evolvability works.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Institutos do Milenio and Programa de Apoio a Nucleos de Excelencia ProgramsFundacao de Amparo a Pesquisa do Estado do Rio Grande do SulFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Fed Rio Grande do Sul, Inst Biociencias, Dept Genet, BR-90049 Porto Alegre, RS, BrazilUniv São Paulo, Inst Biociencias, Dept Genet & Biol Evolut, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Bioquim, São Paulo, BrazilCNRS, Lab Anthropobiol, FRE2960, Toulouse, FranceFac Med, CS80011, Marseille, FranceUniv Paris Diderot, Hop Robert Debre, Insern, UMR 763, Paris, FranceUniv São Paulo, Fac Med, Dept Clin Med, São Paulo, BrazilUniv São Paulo, Fac Med Ribeirao Preto, Dept Genet, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Bioquim, São Paulo, BrazilWeb of Science7engPublic Library SciencePlos OneGenetic Variation among Major Human Geographic Groups Supports a Peculiar Evolutionary Trend in PAX9info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000286663900016.pdfapplication/pdf123454${dspace.ui.url}/bitstream/11600/33362/1/WOS000286663900016.pdfd60226825215342d1e88594bd5dab869MD51open accessTEXTWOS000286663900016.pdf.txtWOS000286663900016.pdf.txtExtracted texttext/plain39188${dspace.ui.url}/bitstream/11600/33362/2/WOS000286663900016.pdf.txt4e2d4f5658e842adc0ba0d6252b5abbbMD52open access11600/333622022-09-27 14:45:04.336open accessoai:repositorio.unifesp.br:11600/33362Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-09-27T17:45:04Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Genetic Variation among Major Human Geographic Groups Supports a Peculiar Evolutionary Trend in PAX9 |
title |
Genetic Variation among Major Human Geographic Groups Supports a Peculiar Evolutionary Trend in PAX9 |
spellingShingle |
Genetic Variation among Major Human Geographic Groups Supports a Peculiar Evolutionary Trend in PAX9 Paixao-Cortes, Vanessa R. |
title_short |
Genetic Variation among Major Human Geographic Groups Supports a Peculiar Evolutionary Trend in PAX9 |
title_full |
Genetic Variation among Major Human Geographic Groups Supports a Peculiar Evolutionary Trend in PAX9 |
title_fullStr |
Genetic Variation among Major Human Geographic Groups Supports a Peculiar Evolutionary Trend in PAX9 |
title_full_unstemmed |
Genetic Variation among Major Human Geographic Groups Supports a Peculiar Evolutionary Trend in PAX9 |
title_sort |
Genetic Variation among Major Human Geographic Groups Supports a Peculiar Evolutionary Trend in PAX9 |
author |
Paixao-Cortes, Vanessa R. |
author_facet |
Paixao-Cortes, Vanessa R. Meyer, Diogo Pereira, Tiago da Veiga [UNIFESP] Mazieres, Stephane Elion, Jacques Krishnamoorthy, Rajagopal Zago, Marco A. Silva, Wilson A. Salzano, Francisco M. Bortolini, Maria Catira |
author_role |
author |
author2 |
Meyer, Diogo Pereira, Tiago da Veiga [UNIFESP] Mazieres, Stephane Elion, Jacques Krishnamoorthy, Rajagopal Zago, Marco A. Silva, Wilson A. Salzano, Francisco M. Bortolini, Maria Catira |
author2_role |
author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Univ Fed Rio Grande do Sul Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) CNRS Fac Med Univ Paris Diderot |
dc.contributor.author.fl_str_mv |
Paixao-Cortes, Vanessa R. Meyer, Diogo Pereira, Tiago da Veiga [UNIFESP] Mazieres, Stephane Elion, Jacques Krishnamoorthy, Rajagopal Zago, Marco A. Silva, Wilson A. Salzano, Francisco M. Bortolini, Maria Catira |
description |
A total of 172 persons from nine South Amerindian, three African and one Eskimo populations were studied in relation to the Paired box gene 9 (PAX9) exon 3 (138 base pairs) as well as its 5' and 3' flanking intronic segments (232 bp and 220 bp, respectively) and integrated with the information available for the same genetic region from individuals of different geographical origins. Nine mutations were scored in exon 3 and six in its flanking regions; four of them are new South American tribe-specific singletons. Exon3 nucleotide diversity is several orders of magnitude higher than its intronic regions. Additionally, a set of variants in the PAX9 and 101 other genes related with dentition can define at least some dental morphological differences between Sub-Saharan Africans and non-Africans, probably associated with adaptations after the modern human exodus from Africa. Exon 3 of PAX9 could be a good molecular example of how evolvability works. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-01-27 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:06:04Z |
dc.date.available.fl_str_mv |
2016-01-24T14:06:04Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Plos One. San Francisco: Public Library Science, v. 6, n. 1, 7 p., 2011. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/33362 http://dx.doi.org/10.1371/journal.pone.0015656 |
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1932-6203 |
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WOS000286663900016.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0015656 |
dc.identifier.wos.none.fl_str_mv |
WOS:000286663900016 |
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Plos One. San Francisco: Public Library Science, v. 6, n. 1, 7 p., 2011. 1932-6203 WOS000286663900016.pdf 10.1371/journal.pone.0015656 WOS:000286663900016 |
url |
http://repositorio.unifesp.br/handle/11600/33362 http://dx.doi.org/10.1371/journal.pone.0015656 |
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Public Library Science |
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Public Library Science |
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