Associação entre mediadores inflamatórios, dislipidêmicos, índice de massa corporal e nível de atividade física em crianças

Detalhes bibliográficos
Autor(a) principal: GUEDES, Juliano Magalhães
Data de Publicação: 2014
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFTM
Texto Completo: http://bdtd.uftm.edu.br/handle/tede/192
Resumo: O objetivo do presente estudo foi investigar a associação entre mediadores inflamatórios (MI), dislipidêmicos, índice de massa corporal (IMC) e nível de atividade física em crianças de 10 anos de idade. Foram avaliadas 94 crianças, distribuídas nos grupos eutróficas (n = 19 meninas; n = 17 meninos); com sobrepeso (n = 18 meninas; n = 16 meninos) e obesidade (n = 13 meninas; n = 11 meninos). Massa corporal (kg), estatura (cm) e dobras cutâneas (mm) foram mensuradas para cálculo do IMC e % de gordura, respectivamente. Amostras de sangue foram coletadas após jejum de 12 a 14 h para dosagem da glicemia, triglicerídeos, HDL-c e IL-6, TNF- α e CCL-2. O nível de atividade física foi calculado pela média de passos/dia em sete dias consecutivos mensurados por pedômetro. A normalidade dos dados foi checada pelo teste Shapiro-Wilk e ANOVA one way com post-hoc de Tukey para comparações múltiplas entre grupos. Associações entre marcadores inflamatórios, IMC e nível de atividade física foram testadas pela correlação de Pearson. O intervalo de confiança (IC) foi de 95% e nível de significância α ≤ 5%. IL-6, TNF- α e CCL-2 apresentaram correlação negativa moderada com HDL-c log (r = - 0,486, r = - 0,470, r = - 0,428; p < 0,05, respectivamente) e correlação positiva moderada com triglicerídeos-log (r = 0,568, r = 0,543, r = 0,530; p < 0,05, respectivamente), IMC-log (r = 0,686, r = 0,662, r = 0,608; p < 0,05, respectivamente) e % de gordura (r = 0,620, r = 0,593, r = 0,592; p < 0,05, respectivamente). Os MI não apresentaram correlação com o número de passos/dia (IL-6, r = 0,084; TNF- α, r = 0,090; CCL-2, r = 0,086; p > 0,05). IL-6, TNF– α, CCL-2 e triglicerídeos-log foram maiores (p < 0,05) entre crianças obesas em relação às eutróficas, mas não em relação aquelas com sobrepeso (p > 0,05). HDL-c log foi maior entre crianças eutróficas em relação aquelas com sobrepeso e obesidade (45,5 mg/dL vs. 40 mg/dL vs. 36 mg/dL, p < 0,05, respectivamente). A classificação do IMC parece não interferir o nível de atividade física, mas sobrepeso e obesidade desencadeiam respostas inflamatórias de crianças de 10 anos de idade e sinaliza o desenvolvimento de doenças cardiovasculares como diabetes, aterosclerose, hipertensão arterial sistêmica e infarto agudo do miocárdio.
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spelling Associação entre mediadores inflamatórios, dislipidêmicos, índice de massa corporal e nível de atividade física em criançasCriançaMediadores inflamatóriosNível de atividade físicaMassa corporalChildInflammatory markersPhysical activity levelBody massEducação FísicaO objetivo do presente estudo foi investigar a associação entre mediadores inflamatórios (MI), dislipidêmicos, índice de massa corporal (IMC) e nível de atividade física em crianças de 10 anos de idade. Foram avaliadas 94 crianças, distribuídas nos grupos eutróficas (n = 19 meninas; n = 17 meninos); com sobrepeso (n = 18 meninas; n = 16 meninos) e obesidade (n = 13 meninas; n = 11 meninos). Massa corporal (kg), estatura (cm) e dobras cutâneas (mm) foram mensuradas para cálculo do IMC e % de gordura, respectivamente. Amostras de sangue foram coletadas após jejum de 12 a 14 h para dosagem da glicemia, triglicerídeos, HDL-c e IL-6, TNF- α e CCL-2. O nível de atividade física foi calculado pela média de passos/dia em sete dias consecutivos mensurados por pedômetro. A normalidade dos dados foi checada pelo teste Shapiro-Wilk e ANOVA one way com post-hoc de Tukey para comparações múltiplas entre grupos. Associações entre marcadores inflamatórios, IMC e nível de atividade física foram testadas pela correlação de Pearson. O intervalo de confiança (IC) foi de 95% e nível de significância α ≤ 5%. IL-6, TNF- α e CCL-2 apresentaram correlação negativa moderada com HDL-c log (r = - 0,486, r = - 0,470, r = - 0,428; p < 0,05, respectivamente) e correlação positiva moderada com triglicerídeos-log (r = 0,568, r = 0,543, r = 0,530; p < 0,05, respectivamente), IMC-log (r = 0,686, r = 0,662, r = 0,608; p < 0,05, respectivamente) e % de gordura (r = 0,620, r = 0,593, r = 0,592; p < 0,05, respectivamente). Os MI não apresentaram correlação com o número de passos/dia (IL-6, r = 0,084; TNF- α, r = 0,090; CCL-2, r = 0,086; p > 0,05). IL-6, TNF– α, CCL-2 e triglicerídeos-log foram maiores (p < 0,05) entre crianças obesas em relação às eutróficas, mas não em relação aquelas com sobrepeso (p > 0,05). HDL-c log foi maior entre crianças eutróficas em relação aquelas com sobrepeso e obesidade (45,5 mg/dL vs. 40 mg/dL vs. 36 mg/dL, p < 0,05, respectivamente). A classificação do IMC parece não interferir o nível de atividade física, mas sobrepeso e obesidade desencadeiam respostas inflamatórias de crianças de 10 anos de idade e sinaliza o desenvolvimento de doenças cardiovasculares como diabetes, aterosclerose, hipertensão arterial sistêmica e infarto agudo do miocárdio.The purpose of this study was to investigate association among inflammatory markers, dyslipidemic, body mass index (BMI) and physical activity level in children of 10 years age. It was evaluated 94 children, being n = 19 girls and 17 boys eutrophic, n = 18 girls and 16 boys overweight and n = 13 girls and 11 boys obese. Body mass (kg), height (cm) and skinfolds (mm) were measured to calculate BMI and body fat%, respectively. Blood samples were collected after 12 to 14 hours of fasting for measurement of glucose, triglycerides, HDL-c log and inflammation markers (IM) IL-6, TNF-α and CCL-2. The physical activity level was calculated by steps/day average in 7 consecutive days measured by pedometer. The normality of the data was checked by Shapiro-Wilk test and one-way ANOVA with post-hoc Tukey's for multiple comparisons among groups. Associations among inflammatory markers, BMI and physical activity were tested by Pearson correlation. The confidence interval (CI) was 95% and significance level of α ≤ 5%. IL-6, TNF-α and CCL-2 showed moderate negative correlation with HDL-c log (r = - 0.486, r = -0.470, r = - 0.428, p <0.05, respectively) and moderate positive correlation with triglyceride-log (r = 0.568, r = 0.543, r = 0.530, p <0.05, respectively), IMC-log (r = 0.686, r = 0.662, r = 0.608, p <0.05, respectively) and % fat (r = 0.620, r = 0.593, r = 0.592, p <0.05, respectively). The IM did not correlate with the steps / day number (IL-6, r = 0.084, TNF-α, r = 0.090, CCL-2, r = 0.086, p> 0.05). IL-6, TNF-α, CCL-2 and log-triglycerides were higher (p <0.05) in obese children compared to eutrophic, but not those related to overweight (p> 0.05). HDL-c-log was higher among eutrophic children related to overweight and obese (45.5 mg / dL vs. 40 mg / dL vs. 36 mg / dL, p <0.05, respectively). BMI classification seems not to interfere the physical activity level, but overweight and obesity trigger inflammation responses in children of 10 years age and signals the development of cardiovascular diseases such as diabetes, atherosclerosis, hypertension and acute myocardial infarction.Universidade Federal do Triângulo MineiroInstituto de Ciências da Saúde - ICS::Curso de Graduação em Educação FísicaBrasilUFTMPrograma de Pós-Graduação em Educação FísicaMENDES, Edmar Lacerda00103654518GUEDES, Juliano Magalhães2015-12-15T12:05:06Z2014-04-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdfGUEDES, Juliano Magalhães. Associação entre mediadores inflamatórios, dislipidêmicos, índice de massa corporal e nível de atividade física em crianças. 2014. 71F. 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Circulating tumor necrosis factor-alpha concentrations in a native Canadian population with high rates of type 2 diabetes mellitus. J Clin Endocrinol Metab, v. 84, n. 1, p. 272-8, Jan 1999.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFTMinstname:Universidade Federal do Triangulo Mineiro (UFTM)instacron:UFTM2018-03-23T18:43:45Zoai:bdtd.uftm.edu.br:tede/192Biblioteca Digital de Teses e Dissertaçõeshttp://bdtd.uftm.edu.br/PUBhttp://bdtd.uftm.edu.br/oai/requestbdtd@uftm.edu.br||bdtd@uftm.edu.bropendoar:2018-03-23T18:43:45Biblioteca Digital de Teses e Dissertações da UFTM - Universidade Federal do Triangulo Mineiro (UFTM)false
dc.title.none.fl_str_mv Associação entre mediadores inflamatórios, dislipidêmicos, índice de massa corporal e nível de atividade física em crianças
title Associação entre mediadores inflamatórios, dislipidêmicos, índice de massa corporal e nível de atividade física em crianças
spellingShingle Associação entre mediadores inflamatórios, dislipidêmicos, índice de massa corporal e nível de atividade física em crianças
GUEDES, Juliano Magalhães
Criança
Mediadores inflamatórios
Nível de atividade física
Massa corporal
Child
Inflammatory markers
Physical activity level
Body mass
Educação Física
title_short Associação entre mediadores inflamatórios, dislipidêmicos, índice de massa corporal e nível de atividade física em crianças
title_full Associação entre mediadores inflamatórios, dislipidêmicos, índice de massa corporal e nível de atividade física em crianças
title_fullStr Associação entre mediadores inflamatórios, dislipidêmicos, índice de massa corporal e nível de atividade física em crianças
title_full_unstemmed Associação entre mediadores inflamatórios, dislipidêmicos, índice de massa corporal e nível de atividade física em crianças
title_sort Associação entre mediadores inflamatórios, dislipidêmicos, índice de massa corporal e nível de atividade física em crianças
author GUEDES, Juliano Magalhães
author_facet GUEDES, Juliano Magalhães
author_role author
dc.contributor.none.fl_str_mv MENDES, Edmar Lacerda
00103654518
dc.contributor.author.fl_str_mv GUEDES, Juliano Magalhães
dc.subject.por.fl_str_mv Criança
Mediadores inflamatórios
Nível de atividade física
Massa corporal
Child
Inflammatory markers
Physical activity level
Body mass
Educação Física
topic Criança
Mediadores inflamatórios
Nível de atividade física
Massa corporal
Child
Inflammatory markers
Physical activity level
Body mass
Educação Física
description O objetivo do presente estudo foi investigar a associação entre mediadores inflamatórios (MI), dislipidêmicos, índice de massa corporal (IMC) e nível de atividade física em crianças de 10 anos de idade. Foram avaliadas 94 crianças, distribuídas nos grupos eutróficas (n = 19 meninas; n = 17 meninos); com sobrepeso (n = 18 meninas; n = 16 meninos) e obesidade (n = 13 meninas; n = 11 meninos). Massa corporal (kg), estatura (cm) e dobras cutâneas (mm) foram mensuradas para cálculo do IMC e % de gordura, respectivamente. Amostras de sangue foram coletadas após jejum de 12 a 14 h para dosagem da glicemia, triglicerídeos, HDL-c e IL-6, TNF- α e CCL-2. O nível de atividade física foi calculado pela média de passos/dia em sete dias consecutivos mensurados por pedômetro. A normalidade dos dados foi checada pelo teste Shapiro-Wilk e ANOVA one way com post-hoc de Tukey para comparações múltiplas entre grupos. Associações entre marcadores inflamatórios, IMC e nível de atividade física foram testadas pela correlação de Pearson. O intervalo de confiança (IC) foi de 95% e nível de significância α ≤ 5%. IL-6, TNF- α e CCL-2 apresentaram correlação negativa moderada com HDL-c log (r = - 0,486, r = - 0,470, r = - 0,428; p < 0,05, respectivamente) e correlação positiva moderada com triglicerídeos-log (r = 0,568, r = 0,543, r = 0,530; p < 0,05, respectivamente), IMC-log (r = 0,686, r = 0,662, r = 0,608; p < 0,05, respectivamente) e % de gordura (r = 0,620, r = 0,593, r = 0,592; p < 0,05, respectivamente). Os MI não apresentaram correlação com o número de passos/dia (IL-6, r = 0,084; TNF- α, r = 0,090; CCL-2, r = 0,086; p > 0,05). IL-6, TNF– α, CCL-2 e triglicerídeos-log foram maiores (p < 0,05) entre crianças obesas em relação às eutróficas, mas não em relação aquelas com sobrepeso (p > 0,05). HDL-c log foi maior entre crianças eutróficas em relação aquelas com sobrepeso e obesidade (45,5 mg/dL vs. 40 mg/dL vs. 36 mg/dL, p < 0,05, respectivamente). A classificação do IMC parece não interferir o nível de atividade física, mas sobrepeso e obesidade desencadeiam respostas inflamatórias de crianças de 10 anos de idade e sinaliza o desenvolvimento de doenças cardiovasculares como diabetes, aterosclerose, hipertensão arterial sistêmica e infarto agudo do miocárdio.
publishDate 2014
dc.date.none.fl_str_mv 2014-04-04
2015-12-15T12:05:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv GUEDES, Juliano Magalhães. Associação entre mediadores inflamatórios, dislipidêmicos, índice de massa corporal e nível de atividade física em crianças. 2014. 71F. Dissertação(Mestrado em Educação Física) - Programa de Pós-Graduação em Educação Física, Universidade Federal do Triângulo Mineiro, Uberaba, 2015.
http://bdtd.uftm.edu.br/handle/tede/192
identifier_str_mv GUEDES, Juliano Magalhães. Associação entre mediadores inflamatórios, dislipidêmicos, índice de massa corporal e nível de atividade física em crianças. 2014. 71F. Dissertação(Mestrado em Educação Física) - Programa de Pós-Graduação em Educação Física, Universidade Federal do Triângulo Mineiro, Uberaba, 2015.
url http://bdtd.uftm.edu.br/handle/tede/192
dc.language.iso.fl_str_mv por
language por
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Instituto de Ciências da Saúde - ICS::Curso de Graduação em Educação Física
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Programa de Pós-Graduação em Educação Física
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