Efeito de Diferentes Terapias no Reparo e na Microestrutura do Tecido Ósseo.
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFU |
Texto Completo: | https://repositorio.ufu.br/handle/123456789/31247 http://doi.org/10.14393/ufu.te.2020.858 |
Resumo: | The bone structure has a complex physiological process of regeneration, since this tissue has many particular characteristics in addition to undergoing continuous remodeling throughout life. However, there are acquired clinical conditions where bone repair process is compromised. Bone morphology and constitution are altered when associated with some specific use of medication or ionizing radiation, essential medical therapies for the treatment of some pathologies. Radiotherapy is currently used to control cancer, however, high doses of radiation cause metabolic damage to healthy tissues. In bone tissue, ionizing radiation promotes changes in its chemical and physical composition, resulting in immediate collapse of bone quality, producing serious effects such as mandibular osteoradionecrosis (ORN), increased risk of fractures and tissue hypovascularization, resulting in a reduced healing capacity. Osteoradionecrosis affects patients who receive ionizing radiation as therapeutic treatment for head and neck cancer. The affected area by radiotherapy has the process of restoring bone tissue impaired due to hypovascular, hypocellular and hypoxic tissue changes. The use of bisphosphonates is regularly indicated for conditions related to cancer and metabolic bone diseases, acting mainly in inhibiting osteoclastic activity and consequently inhibiting bone resorption. Jaw osteonecrosis related to the use of bisphosphonate is a common complication that adversely affects quality of life, producing significant morbidity in patients affected injuring the metabolism of bone repair. Hyperbaric oxygenation (OH) has been used as an efficient strategy to minimize the damage related to osteoradionecrosis and osteonecrosis associated with the use of bisphosphonates. In this context, the present phd dissertation proposed an study on the effect of OH on bone regeneration through systematic review and through experiments in rats submited to ionization and medication protocols. In conclusion, the analyzes indicated that OH favored the bone repair process once compromised, through beneficial effects such as: percentage of new bone formation, increased angiogenic response, as well as activities related to osteogenesis and bone remodeling. |
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Efeito de Diferentes Terapias no Reparo e na Microestrutura do Tecido Ósseo.Effect of different therapies on Bone Tissue Repair and Microstructure.Regeneração ósseaOxigenação hiperbárica.Radiação IonizanteOsteorradionecroseBone regenerationBisphosphonate-Associated Osteonecrosis of the Jaw,OsteoradionecrosisIonizing radiationHyperbaric oxygenationCNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA::CLINICA ODONTOLOGICAOdontologiaThe bone structure has a complex physiological process of regeneration, since this tissue has many particular characteristics in addition to undergoing continuous remodeling throughout life. However, there are acquired clinical conditions where bone repair process is compromised. Bone morphology and constitution are altered when associated with some specific use of medication or ionizing radiation, essential medical therapies for the treatment of some pathologies. Radiotherapy is currently used to control cancer, however, high doses of radiation cause metabolic damage to healthy tissues. In bone tissue, ionizing radiation promotes changes in its chemical and physical composition, resulting in immediate collapse of bone quality, producing serious effects such as mandibular osteoradionecrosis (ORN), increased risk of fractures and tissue hypovascularization, resulting in a reduced healing capacity. Osteoradionecrosis affects patients who receive ionizing radiation as therapeutic treatment for head and neck cancer. The affected area by radiotherapy has the process of restoring bone tissue impaired due to hypovascular, hypocellular and hypoxic tissue changes. The use of bisphosphonates is regularly indicated for conditions related to cancer and metabolic bone diseases, acting mainly in inhibiting osteoclastic activity and consequently inhibiting bone resorption. Jaw osteonecrosis related to the use of bisphosphonate is a common complication that adversely affects quality of life, producing significant morbidity in patients affected injuring the metabolism of bone repair. Hyperbaric oxygenation (OH) has been used as an efficient strategy to minimize the damage related to osteoradionecrosis and osteonecrosis associated with the use of bisphosphonates. In this context, the present phd dissertation proposed an study on the effect of OH on bone regeneration through systematic review and through experiments in rats submited to ionization and medication protocols. In conclusion, the analyzes indicated that OH favored the bone repair process once compromised, through beneficial effects such as: percentage of new bone formation, increased angiogenic response, as well as activities related to osteogenesis and bone remodeling.Tese (Doutorado)A estrutura óssea possui um processo fisiológico de regeneração complexo, visto que este tecido possui inúmeras particularidades estruturais além de sofrer remodelação contínua ao longo da vida. No entanto, existem condições clínicas adquiridas em que o processo de reparo ósseo é comprometido. A morfologia e a constituição óssea são alteradas quando associadas a determinados medicamentos ou à radiação ionizante, terapias médicas essenciais para tratamento de algumas patologias. A radioterapia é usualmente empregada para tratamentos de câncer, no entanto, altas doses de radiação provocam danos metabólicos em tecidos sadios. No tecido ósseo, a radiação ionizante promove alterações em sua composição química e física, resultando em um colapso imediato da qualidade óssea, produzindo efeitos colaterais graves como a osteorradionecrose mandibular (ORN), o aumento do risco de fraturas e a hipovascularização do tecido, resultando em uma capacidade de cicatrização reduzida. A osteorradionecrose acomete pacientes que recebem radiação terapêutica para o tratamento do câncer da cabeça e pescoço. A área afetada pela radioterapia possui o processo de renovação do tecido ósseo prejudicado devido a alterações teciduais hipovasculares, hipocelulares e hipóxicas. O uso de bifosfonatos é regularmente indicado para condições relacionadas ao câncer e para o manejo de doenças ósseas metabólicas, atuando sobretudo na inibição da atividade osteoclástica e consequentemente inibindo a reabsorção óssea. A osteonecrose dos maxilares relacionada ao bisfosfonato é uma comum complicação que afeta adversamente a qualidade de vida, produzindo morbidade significativa em pacientes afetados prejudicando o metabolismo de renovação óssea. A oxigenação hiperbárica (OH) tem sido utilizada como uma estratégia eficiente para minimizar os prejuízos relacionados a osteorradionecrose e a osteonecrose associada ao uso de bifosfonatos. Considerando esse contexto, a presente tese de doutorado propôs investigar o efeito do OH na regeneração óssea através de revisão sistemática e por meio de experimentação em ratos submetidos a radiação ionizante e a protocolos medicamentosos. Em conclusão as análises indicaram que a OH favorece o processo de reparo ósseo comprometido, através de efeitos benéficos como: porcentagem de neoformação óssea, resposta angiogênica aumentada, assim como atividades relacionadas à osteogênese e remodelação óssea.2022-11-15Universidade Federal de UberlândiaBrasilPrograma de Pós-graduação em OdontologiaFilici, Leticia de Souza Castrohttp://lattes.cnpq.br/9213076488588229Macedo, Sérgio Bruzadellihttp://lattes.cnpq.br/0546585585808007Barbar, Paula Dechichihttp://lattes.cnpq.br/0316757832048240Rocha, Flaviana Soareshttp://lattes.cnpq.br/8388874546877102Oliveira, Pedro Henrique Justinohttp://lattes.cnpq.br/8169625019841581Henriques, Joao Cesar Guimaraeshttp://lattes.cnpq.br/5357433616713642Ferreira Junior, Luiz Henrique2021-02-10T14:39:27Z2021-02-10T14:39:27Z2020-12-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdfFERREIRA JUNIOR, Luiz Henrique, Efeito de Diferentes Terapias no Reparo e na Microestrutura do Tecido Ósseo. 2020. 85 f. Tese (Doutorado em Odontologia) - Universidade Federal de Uberlândia. Uberlândia, 2021. DOI http://doi.org/10.14393/ufu.te.2020.858https://repositorio.ufu.br/handle/123456789/31247http://doi.org/10.14393/ufu.te.2020.858porinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFUinstname:Universidade Federal de Uberlândia (UFU)instacron:UFU2023-12-14T15:57:24Zoai:repositorio.ufu.br:123456789/31247Repositório InstitucionalONGhttp://repositorio.ufu.br/oai/requestdiinf@dirbi.ufu.bropendoar:2023-12-14T15:57:24Repositório Institucional da UFU - Universidade Federal de Uberlândia (UFU)false |
dc.title.none.fl_str_mv |
Efeito de Diferentes Terapias no Reparo e na Microestrutura do Tecido Ósseo. Effect of different therapies on Bone Tissue Repair and Microstructure. |
title |
Efeito de Diferentes Terapias no Reparo e na Microestrutura do Tecido Ósseo. |
spellingShingle |
Efeito de Diferentes Terapias no Reparo e na Microestrutura do Tecido Ósseo. Ferreira Junior, Luiz Henrique Regeneração óssea Oxigenação hiperbárica. Radiação Ionizante Osteorradionecrose Bone regeneration Bisphosphonate-Associated Osteonecrosis of the Jaw, Osteoradionecrosis Ionizing radiation Hyperbaric oxygenation CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA::CLINICA ODONTOLOGICA Odontologia |
title_short |
Efeito de Diferentes Terapias no Reparo e na Microestrutura do Tecido Ósseo. |
title_full |
Efeito de Diferentes Terapias no Reparo e na Microestrutura do Tecido Ósseo. |
title_fullStr |
Efeito de Diferentes Terapias no Reparo e na Microestrutura do Tecido Ósseo. |
title_full_unstemmed |
Efeito de Diferentes Terapias no Reparo e na Microestrutura do Tecido Ósseo. |
title_sort |
Efeito de Diferentes Terapias no Reparo e na Microestrutura do Tecido Ósseo. |
author |
Ferreira Junior, Luiz Henrique |
author_facet |
Ferreira Junior, Luiz Henrique |
author_role |
author |
dc.contributor.none.fl_str_mv |
Filici, Leticia de Souza Castro http://lattes.cnpq.br/9213076488588229 Macedo, Sérgio Bruzadelli http://lattes.cnpq.br/0546585585808007 Barbar, Paula Dechichi http://lattes.cnpq.br/0316757832048240 Rocha, Flaviana Soares http://lattes.cnpq.br/8388874546877102 Oliveira, Pedro Henrique Justino http://lattes.cnpq.br/8169625019841581 Henriques, Joao Cesar Guimaraes http://lattes.cnpq.br/5357433616713642 |
dc.contributor.author.fl_str_mv |
Ferreira Junior, Luiz Henrique |
dc.subject.por.fl_str_mv |
Regeneração óssea Oxigenação hiperbárica. Radiação Ionizante Osteorradionecrose Bone regeneration Bisphosphonate-Associated Osteonecrosis of the Jaw, Osteoradionecrosis Ionizing radiation Hyperbaric oxygenation CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA::CLINICA ODONTOLOGICA Odontologia |
topic |
Regeneração óssea Oxigenação hiperbárica. Radiação Ionizante Osteorradionecrose Bone regeneration Bisphosphonate-Associated Osteonecrosis of the Jaw, Osteoradionecrosis Ionizing radiation Hyperbaric oxygenation CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA::CLINICA ODONTOLOGICA Odontologia |
description |
The bone structure has a complex physiological process of regeneration, since this tissue has many particular characteristics in addition to undergoing continuous remodeling throughout life. However, there are acquired clinical conditions where bone repair process is compromised. Bone morphology and constitution are altered when associated with some specific use of medication or ionizing radiation, essential medical therapies for the treatment of some pathologies. Radiotherapy is currently used to control cancer, however, high doses of radiation cause metabolic damage to healthy tissues. In bone tissue, ionizing radiation promotes changes in its chemical and physical composition, resulting in immediate collapse of bone quality, producing serious effects such as mandibular osteoradionecrosis (ORN), increased risk of fractures and tissue hypovascularization, resulting in a reduced healing capacity. Osteoradionecrosis affects patients who receive ionizing radiation as therapeutic treatment for head and neck cancer. The affected area by radiotherapy has the process of restoring bone tissue impaired due to hypovascular, hypocellular and hypoxic tissue changes. The use of bisphosphonates is regularly indicated for conditions related to cancer and metabolic bone diseases, acting mainly in inhibiting osteoclastic activity and consequently inhibiting bone resorption. Jaw osteonecrosis related to the use of bisphosphonate is a common complication that adversely affects quality of life, producing significant morbidity in patients affected injuring the metabolism of bone repair. Hyperbaric oxygenation (OH) has been used as an efficient strategy to minimize the damage related to osteoradionecrosis and osteonecrosis associated with the use of bisphosphonates. In this context, the present phd dissertation proposed an study on the effect of OH on bone regeneration through systematic review and through experiments in rats submited to ionization and medication protocols. In conclusion, the analyzes indicated that OH favored the bone repair process once compromised, through beneficial effects such as: percentage of new bone formation, increased angiogenic response, as well as activities related to osteogenesis and bone remodeling. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-21 2021-02-10T14:39:27Z 2021-02-10T14:39:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
FERREIRA JUNIOR, Luiz Henrique, Efeito de Diferentes Terapias no Reparo e na Microestrutura do Tecido Ósseo. 2020. 85 f. Tese (Doutorado em Odontologia) - Universidade Federal de Uberlândia. Uberlândia, 2021. DOI http://doi.org/10.14393/ufu.te.2020.858 https://repositorio.ufu.br/handle/123456789/31247 http://doi.org/10.14393/ufu.te.2020.858 |
identifier_str_mv |
FERREIRA JUNIOR, Luiz Henrique, Efeito de Diferentes Terapias no Reparo e na Microestrutura do Tecido Ósseo. 2020. 85 f. Tese (Doutorado em Odontologia) - Universidade Federal de Uberlândia. Uberlândia, 2021. DOI http://doi.org/10.14393/ufu.te.2020.858 |
url |
https://repositorio.ufu.br/handle/123456789/31247 http://doi.org/10.14393/ufu.te.2020.858 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Uberlândia Brasil Programa de Pós-graduação em Odontologia |
publisher.none.fl_str_mv |
Universidade Federal de Uberlândia Brasil Programa de Pós-graduação em Odontologia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFU instname:Universidade Federal de Uberlândia (UFU) instacron:UFU |
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Universidade Federal de Uberlândia (UFU) |
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UFU |
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UFU |
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Repositório Institucional da UFU |
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Repositório Institucional da UFU |
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Repositório Institucional da UFU - Universidade Federal de Uberlândia (UFU) |
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diinf@dirbi.ufu.br |
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1805569668082040832 |