A motilidade esofágica na esclerose sistêmica e suas relações com as alterações cutâneas e pulmonares

• Autor(a) principal: Markus, Juliana
• Data de Publicação: 2017
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFU
• Texto Completo: https://repositorio.ufu.br/handle/123456789/21422; http://dx.doi.org/10.14393/ufu.di.2018.149
• topic: Ciências médicas; Medical sciences; Escleroderma sistêmico; Systemic scleroderma; Esôfago; Esophagus; Pulmões; Lungs; Esclerose sistêmica; Systemic sclerosis; Doenças pulmonares intersticiais; Interstitial lung diseases; CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA::REUMATOLOGIA

Introduction Systemic Sclerosis (SS) is an autoimmune disorder that affects several systems and organs, of unknown etiology, characterized by vascular damage and fibrosis of the skin and organs. Among the organs involved are the esophagus and the lung. Objectives To relate the profile of changes in esophageal manometry (EM), the type of skin involvement, interstitial lung disease (ILD) as well as esophageal symptoms in SS patients. Method This is an observational, cross-sectional study carried out at the outpatient clinic of the Hospital of the Federal University of Uberlândia. After approval by the Ethics Committee and signed the terms of consent, 50 patients were initially included, between 04/12/2014 to 06/25/2015. They were submitted to the usual investigations for the condition and according to clinical complaints. The statistical analysis was descriptive in percentage, means and standard deviation. The Chi-square test was used to evaluate the relationship between EM, high resolution tomography and oesophageal symptoms. Results 91.9% of the patients had some manometric alterations. 37.8% had involvement of the esophageal body and lower esophageal sphincter. 37.8% presented ILD. 24.3% presented the diffuse form of SS. Conclusion This study did not demonstrate a pattern of distribution of esophageal changes related to the type of cutaneous involvement. There was no relation of a specific manometric standard with the presence of ILD. Not even the presence of gastrointestinal clinical symptoms was associated with a cutaneous pattern or with manometric changes of the esophagus or with the presence of ILD. Key words: Systemic sclerosis, Esophagus, Interstitial lung disease.