Atividade Leishmanicida de novos complexos de rutênio(II) contendo dppm e ligantes N-S, N-O ou O-O doadores

• Main Author: Silva, Paulo Adão Braga da
• Publication Date: 2017
• Format: Master thesis
• Language: por
• Source: Repositório Institucional da UFU
• Download full: https://repositorio.ufu.br/handle/123456789/22525; http://dx.doi.org/10.14393/ufu.di.2018.1209
• topic: Complexos de Rutênio(II); Ruthenium (II) complexes; Leishmania amazonensis; Atividade Leishmanicida; Leishmanicidal activity; Dppm; Hidroxinicotinatos; Hydroxynicotinates; Mercaptonicotinatos; Mercaptonicotinates; Química; Leishmaniose - Tratamento; Compostos de rutênio; CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA INORGANICA::QUIMICA BIO-INORGANICA

"The present work describes the synthesis, characterization and leishmanicidal activity of four new ruthenium(II) complexes, with general formulas cis-[Ru (N-S) (dppm)2]PF6, cis-[Ru (N-O) (dppm)2] PF6 and cis-[Ru (O-O) (dppm)2] PF6, where dppm = 1,1-bis (diphenylphosphine) methane, N-S = 6-mercaptonicotinic acid and 2-mercaptonicotinic acid, N-O = 2-hydroxynicotinic acid, O-O = 6-hydroxynicotinic acid. The complexes were obtained in methanolic solution, with precipitation being obtained with the addition of a counter ion in aqueous solution and the resuktant solid separated by filtration. Complexes were characterized by elemental analysis (CHNS), infrared spectroscopy (ATR-FTIR), ultraviolet-visible (UV-Vis) and nuclear magnetic ressonance (phosphorus and proton) spectroscopies. The four compounds and also the precursor were submitted to leishmanicidal activity assays against the species Leishmania (L.) amazonensis. The results showed that the compound cis-[Ru(2-Hnc)(dppm)2]PF6 had and IC50 of 0.86 μM and the cis-[Ru(6-Hcp)(dppm)2]PF6 a 1.25 μM IC50 value, these values were better than the obtained for the precursor complex and even lower than that found for the leishmaniasis drug pentamidine."