Clinicopathologic study and Ki-67 proliferative marker evaluation in human osteosarcomas
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio.unb.br/handle/10482/26549 https://dx.doi.org/10.1590/S1676-24442005000600008 |
Resumo: | BACKGROUND: Osteosarcoma is a relatively uncommon malignant neoplasm and little information has been reported on its cell proliferation using Ki-67. OBJECTIVES: Evaluate histological, clinical and immunohistochemical parameters using Ki-67 labeling index (LI), correlate one to another and with follow-up. MATERIAL AND METHOD: Fifty-seven patients with available clinicopathological data submitted to the study of cell proliferation as determined by Ki-67 expression measured by immunohistochemistry (IHC) staining using formalin-fixed paraffin embedded sections. In each sample, positive cells were quantified on at least a thousand nuclei and expressed as Ki-67 LI according to median value. RESULTS AND DISCUSSION: Non-significant correlations were observed in metastatic and non-metastatic cases when variables as surgery, tumor size, death and relapse were compared with Ki-67 LI values (cut-off of 45%). In the group of non-metastatic cases there was a direct correlation between higher values of Ki-67 index and better overall survival. Metastatic patients overall survival curve and LI high and low Ki-67 did not show significant differences. CONCLUSION: Based on our results the Ki-67 LI could be useful as a prognostic marker in patients without metastasis at diagnosis. |
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Clinicopathologic study and Ki-67 proliferative marker evaluation in human osteosarcomasEstudo clinicopatológico com avaliação do índice de proliferação celular avaliado pelo Ki-67 em osteossarcomas humanosOsteossarcomaKi-67Imuno-histoquímicaPrognósticoBACKGROUND: Osteosarcoma is a relatively uncommon malignant neoplasm and little information has been reported on its cell proliferation using Ki-67. OBJECTIVES: Evaluate histological, clinical and immunohistochemical parameters using Ki-67 labeling index (LI), correlate one to another and with follow-up. MATERIAL AND METHOD: Fifty-seven patients with available clinicopathological data submitted to the study of cell proliferation as determined by Ki-67 expression measured by immunohistochemistry (IHC) staining using formalin-fixed paraffin embedded sections. In each sample, positive cells were quantified on at least a thousand nuclei and expressed as Ki-67 LI according to median value. RESULTS AND DISCUSSION: Non-significant correlations were observed in metastatic and non-metastatic cases when variables as surgery, tumor size, death and relapse were compared with Ki-67 LI values (cut-off of 45%). In the group of non-metastatic cases there was a direct correlation between higher values of Ki-67 index and better overall survival. Metastatic patients overall survival curve and LI high and low Ki-67 did not show significant differences. CONCLUSION: Based on our results the Ki-67 LI could be useful as a prognostic marker in patients without metastasis at diagnosis.INTRODUÇÃO: Osteossarcoma é uma neoplasia rara do tecido ósseo, tendo sido publicados poucos trabalhos na literatura que avaliaram o índice de proliferação celular Ki-67 (IPC-Ki-67) nesse tipo de sarcoma. OBJETIVO: Avaliação e comparação dos parâmetros clínicos, histológicos e de imunoexpressão do Ki-67 com a evolução clínica dos pacientes. MATERIAL E MÉTODO: Blocos de parafina de 57 casos de osteossarcomas, cujos pacientes apresentavam dados clinicopatológicos fidedignos, foram submetidos a estudo da proliferação celular através da técnica de imuno-histoquímica. Em cada amostra o IPC foi determinado pela contagem de núcleos marcados em pelo menos mil células neoplásicas. Em cada grupo de pacientes o IPC-Ki-67 foi considerado alto ou baixo, tendo como referência a mediana dos valores do Ki-67. RESULTADOS E DISCUSSÃO: Não houve correlação estatística significativa entre os valores do IPC-Ki-67 (valor de corte = 45%) dos osteossarcomas dos pacientes com ou sem metástases ao diagnóstico, em relação às variáveis óbito, recaída tumoral, tamanho do tumor e tipo de cirurgia. No grupo de pacientes sem metástases houve correlação direta entre o tempo de sobrevida e o índice de proliferação celular (isto é, o IPC-Ki-67 > 45% correlacionou-se com maior tempo de sobrevida). Nos casos de pacientes com metástases ao diagnóstico, os valores do IPC-Ki-67 não apresentaram correlação significativa com a sobrevida. CONCLUSÃO: Com base nos nossos resultados, o IPC-Ki-67 pode ser utilizado para avaliação prognóstica em pacientes com osteossarcoma sem metástases ao diagnóstico.Em processamentoSociedade Brasileira de Patologia ClínicaSociedade Brasileira de PatologiaSociedade Brasileira de Citopatologia2017-12-07T04:43:44Z2017-12-07T04:43:44Z2005info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfJ. Bras. Patol. Med. Lab.,v.41,n.6,p.419-424,2005http://repositorio.unb.br/handle/10482/26549https://dx.doi.org/10.1590/S1676-24442005000600008Marinho, Larissa CardosoPatrício, Francy Reis da SilvaJesus-Garcia Filho, ReynaldoPetrilli, Antônio SérgioOdashiro, Luciana NakaoMacedo, CarlaAlves, Maria Teresa Seixasinfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2024-08-27T21:14:18Zoai:repositorio.unb.br:10482/26549Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2024-08-27T21:14:18Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.none.fl_str_mv |
Clinicopathologic study and Ki-67 proliferative marker evaluation in human osteosarcomas Estudo clinicopatológico com avaliação do índice de proliferação celular avaliado pelo Ki-67 em osteossarcomas humanos |
title |
Clinicopathologic study and Ki-67 proliferative marker evaluation in human osteosarcomas |
spellingShingle |
Clinicopathologic study and Ki-67 proliferative marker evaluation in human osteosarcomas Marinho, Larissa Cardoso Osteossarcoma Ki-67 Imuno-histoquímica Prognóstico |
title_short |
Clinicopathologic study and Ki-67 proliferative marker evaluation in human osteosarcomas |
title_full |
Clinicopathologic study and Ki-67 proliferative marker evaluation in human osteosarcomas |
title_fullStr |
Clinicopathologic study and Ki-67 proliferative marker evaluation in human osteosarcomas |
title_full_unstemmed |
Clinicopathologic study and Ki-67 proliferative marker evaluation in human osteosarcomas |
title_sort |
Clinicopathologic study and Ki-67 proliferative marker evaluation in human osteosarcomas |
author |
Marinho, Larissa Cardoso |
author_facet |
Marinho, Larissa Cardoso Patrício, Francy Reis da Silva Jesus-Garcia Filho, Reynaldo Petrilli, Antônio Sérgio Odashiro, Luciana Nakao Macedo, Carla Alves, Maria Teresa Seixas |
author_role |
author |
author2 |
Patrício, Francy Reis da Silva Jesus-Garcia Filho, Reynaldo Petrilli, Antônio Sérgio Odashiro, Luciana Nakao Macedo, Carla Alves, Maria Teresa Seixas |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Marinho, Larissa Cardoso Patrício, Francy Reis da Silva Jesus-Garcia Filho, Reynaldo Petrilli, Antônio Sérgio Odashiro, Luciana Nakao Macedo, Carla Alves, Maria Teresa Seixas |
dc.subject.por.fl_str_mv |
Osteossarcoma Ki-67 Imuno-histoquímica Prognóstico |
topic |
Osteossarcoma Ki-67 Imuno-histoquímica Prognóstico |
description |
BACKGROUND: Osteosarcoma is a relatively uncommon malignant neoplasm and little information has been reported on its cell proliferation using Ki-67. OBJECTIVES: Evaluate histological, clinical and immunohistochemical parameters using Ki-67 labeling index (LI), correlate one to another and with follow-up. MATERIAL AND METHOD: Fifty-seven patients with available clinicopathological data submitted to the study of cell proliferation as determined by Ki-67 expression measured by immunohistochemistry (IHC) staining using formalin-fixed paraffin embedded sections. In each sample, positive cells were quantified on at least a thousand nuclei and expressed as Ki-67 LI according to median value. RESULTS AND DISCUSSION: Non-significant correlations were observed in metastatic and non-metastatic cases when variables as surgery, tumor size, death and relapse were compared with Ki-67 LI values (cut-off of 45%). In the group of non-metastatic cases there was a direct correlation between higher values of Ki-67 index and better overall survival. Metastatic patients overall survival curve and LI high and low Ki-67 did not show significant differences. CONCLUSION: Based on our results the Ki-67 LI could be useful as a prognostic marker in patients without metastasis at diagnosis. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005 2017-12-07T04:43:44Z 2017-12-07T04:43:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
J. Bras. Patol. Med. Lab.,v.41,n.6,p.419-424,2005 http://repositorio.unb.br/handle/10482/26549 https://dx.doi.org/10.1590/S1676-24442005000600008 |
identifier_str_mv |
J. Bras. Patol. Med. Lab.,v.41,n.6,p.419-424,2005 |
url |
http://repositorio.unb.br/handle/10482/26549 https://dx.doi.org/10.1590/S1676-24442005000600008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia ClínicaSociedade Brasileira de PatologiaSociedade Brasileira de Citopatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia ClínicaSociedade Brasileira de PatologiaSociedade Brasileira de Citopatologia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
instname_str |
Universidade de Brasília (UnB) |
instacron_str |
UNB |
institution |
UNB |
reponame_str |
Repositório Institucional da UnB |
collection |
Repositório Institucional da UnB |
repository.name.fl_str_mv |
Repositório Institucional da UnB - Universidade de Brasília (UnB) |
repository.mail.fl_str_mv |
repositorio@unb.br |
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1810580710367428608 |