Lyophilization of ImunoparvumR° as an alternative to reduce its side-effects

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Onaldo G.
Data de Publicação: 2009
Outros Autores: de Araújo, Gilmar T., Rolim, Hercília M. L., Nascimento, Silene C., Coelho, Luana C. B. B.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Ciências Exatas e Naturais (Online)
Texto Completo: https://revistas.unicentro.br/index.php/RECEN/article/view/469
Resumo: In Brazil, Imunoparvum R° is used as an immunomodulator. It is commercialized in 2 ml ampoules containing 2 mg of Propionebacterium acnes (formerly known as Corynebacterium parvum)/ml, in a 0.5 % phenol and 0.85% sodium chloride solution. High therapeutic power associated to minimum side effects is a great challenge to the pharmaceuticalindustry. Research results have shown that Imunoparvum R° induces side effects in humans and animals, probably because of its phenol content (SOUSA, 1993; RODRIGUES, 2001). The objective of this study was to determine the phenol content of lyophilized and non-lyophilized Imunoparvum R° and to compare their side effects in mice. It was demonstrated that the lyophilization process reduces the phenol content and the side effects of Imunoparvum R°, when compared to the commercialized Propionebacterium acnes suspension.
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spelling Lyophilization of ImunoparvumR° as an alternative to reduce its side-effectsCiências da SaúdeImunoparvum; hipersensitividade; câncer; fenol; adjuvanteIn Brazil, Imunoparvum R° is used as an immunomodulator. It is commercialized in 2 ml ampoules containing 2 mg of Propionebacterium acnes (formerly known as Corynebacterium parvum)/ml, in a 0.5 % phenol and 0.85% sodium chloride solution. High therapeutic power associated to minimum side effects is a great challenge to the pharmaceuticalindustry. Research results have shown that Imunoparvum R° induces side effects in humans and animals, probably because of its phenol content (SOUSA, 1993; RODRIGUES, 2001). The objective of this study was to determine the phenol content of lyophilized and non-lyophilized Imunoparvum R° and to compare their side effects in mice. It was demonstrated that the lyophilization process reduces the phenol content and the side effects of Imunoparvum R°, when compared to the commercialized Propionebacterium acnes suspension.UNICENTRORodrigues, Onaldo G.de Araújo, Gilmar T.Rolim, Hercília M. L.Nascimento, Silene C.Coelho, Luana C. B. B.2009-12-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigoapplication/pdfhttps://revistas.unicentro.br/index.php/RECEN/article/view/469RECEN-Revista de Ciências Naturais e Exatas; v. 4, n. 1 (2002); 73-78RECEN - Revista Ciências Exatas e Naturais; v. 4, n. 1 (2002); 73-782175-56201518-0352reponame:Revista Ciências Exatas e Naturais (Online)instname:Universidade Estadual do Centro-Oeste (UNICENTRO)instacron:UNENTROporhttps://revistas.unicentro.br/index.php/RECEN/article/view/469/626info:eu-repo/semantics/openAccess2009-12-16T19:37:12Zoai:ojs.revistas.unicentro.br:article/469Revistahttps://revistas.unicentro.br/index.php/RECENPUBhttps://revistas.unicentro.br/index.php/RECEN/oai||recen@unicentro.br2175-56201518-0352opendoar:2009-12-16T19:37:12Revista Ciências Exatas e Naturais (Online) - Universidade Estadual do Centro-Oeste (UNICENTRO)false
dc.title.none.fl_str_mv Lyophilization of ImunoparvumR° as an alternative to reduce its side-effects
title Lyophilization of ImunoparvumR° as an alternative to reduce its side-effects
spellingShingle Lyophilization of ImunoparvumR° as an alternative to reduce its side-effects
Rodrigues, Onaldo G.
Ciências da Saúde
Imunoparvum; hipersensitividade; câncer; fenol; adjuvante
title_short Lyophilization of ImunoparvumR° as an alternative to reduce its side-effects
title_full Lyophilization of ImunoparvumR° as an alternative to reduce its side-effects
title_fullStr Lyophilization of ImunoparvumR° as an alternative to reduce its side-effects
title_full_unstemmed Lyophilization of ImunoparvumR° as an alternative to reduce its side-effects
title_sort Lyophilization of ImunoparvumR° as an alternative to reduce its side-effects
author Rodrigues, Onaldo G.
author_facet Rodrigues, Onaldo G.
de Araújo, Gilmar T.
Rolim, Hercília M. L.
Nascimento, Silene C.
Coelho, Luana C. B. B.
author_role author
author2 de Araújo, Gilmar T.
Rolim, Hercília M. L.
Nascimento, Silene C.
Coelho, Luana C. B. B.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv
dc.contributor.author.fl_str_mv Rodrigues, Onaldo G.
de Araújo, Gilmar T.
Rolim, Hercília M. L.
Nascimento, Silene C.
Coelho, Luana C. B. B.
dc.subject.por.fl_str_mv Ciências da Saúde
Imunoparvum; hipersensitividade; câncer; fenol; adjuvante
topic Ciências da Saúde
Imunoparvum; hipersensitividade; câncer; fenol; adjuvante
description In Brazil, Imunoparvum R° is used as an immunomodulator. It is commercialized in 2 ml ampoules containing 2 mg of Propionebacterium acnes (formerly known as Corynebacterium parvum)/ml, in a 0.5 % phenol and 0.85% sodium chloride solution. High therapeutic power associated to minimum side effects is a great challenge to the pharmaceuticalindustry. Research results have shown that Imunoparvum R° induces side effects in humans and animals, probably because of its phenol content (SOUSA, 1993; RODRIGUES, 2001). The objective of this study was to determine the phenol content of lyophilized and non-lyophilized Imunoparvum R° and to compare their side effects in mice. It was demonstrated that the lyophilization process reduces the phenol content and the side effects of Imunoparvum R°, when compared to the commercialized Propionebacterium acnes suspension.
publishDate 2009
dc.date.none.fl_str_mv 2009-12-16
dc.type.none.fl_str_mv
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigo
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistas.unicentro.br/index.php/RECEN/article/view/469
url https://revistas.unicentro.br/index.php/RECEN/article/view/469
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistas.unicentro.br/index.php/RECEN/article/view/469/626
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv UNICENTRO
publisher.none.fl_str_mv UNICENTRO
dc.source.none.fl_str_mv RECEN-Revista de Ciências Naturais e Exatas; v. 4, n. 1 (2002); 73-78
RECEN - Revista Ciências Exatas e Naturais; v. 4, n. 1 (2002); 73-78
2175-5620
1518-0352
reponame:Revista Ciências Exatas e Naturais (Online)
instname:Universidade Estadual do Centro-Oeste (UNICENTRO)
instacron:UNENTRO
instname_str Universidade Estadual do Centro-Oeste (UNICENTRO)
instacron_str UNENTRO
institution UNENTRO
reponame_str Revista Ciências Exatas e Naturais (Online)
collection Revista Ciências Exatas e Naturais (Online)
repository.name.fl_str_mv Revista Ciências Exatas e Naturais (Online) - Universidade Estadual do Centro-Oeste (UNICENTRO)
repository.mail.fl_str_mv ||recen@unicentro.br
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