Behavioral alterations induced by repeated saxitoxin exposure in drinking water
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | The Journal of venomous animals and toxins including tropical diseases (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100314 |
Resumo: | Abstract Background Blooms of the saxitoxin-producing cyanobacterium Cylindrospermopsis raciborskii have been contaminating drinking water reservoirs in Brazil for many years. Although acute effects of saxitoxin intoxication are well known, chronic deleterious outcomes caused by repeated saxitoxin exposure still require further investigation. The aim of the present work is to investigate the effects of consumption of drinking water contaminated with C. raciborskii for 30 days on learning and memory processes in rats. Methods The effects of saxitoxin (3 or 9 μg/L STX equivalents) or cyanobacteria on behavior was determined using the open field habituation task, elevated plus maze anxiety model task, inhibitory avoidance task, and referential Morris water maze task. Results No effects of saxitoxin consumption was observed on anxiety and motor exploratory parameters in the elevated plus maze and open field habituation tasks, respectively. However, groups treated with 9 μg/L STX equivalents displayed a decreased memory performance in the inhibitory avoidance and Morris water maze tasks. Conclusions These results suggest an amnesic effect of saxitoxin on aversive and spatial memories. |
id |
UNESP-11_5490f036f914afbc77cc6263b6dca052 |
---|---|
oai_identifier_str |
oai:scielo:S1678-91992016000100314 |
network_acronym_str |
UNESP-11 |
network_name_str |
The Journal of venomous animals and toxins including tropical diseases (Online) |
repository_id_str |
|
spelling |
Behavioral alterations induced by repeated saxitoxin exposure in drinking waterSaxitoxinDrinking waterBehaviorAversive memorySpatial memoryRatsAbstract Background Blooms of the saxitoxin-producing cyanobacterium Cylindrospermopsis raciborskii have been contaminating drinking water reservoirs in Brazil for many years. Although acute effects of saxitoxin intoxication are well known, chronic deleterious outcomes caused by repeated saxitoxin exposure still require further investigation. The aim of the present work is to investigate the effects of consumption of drinking water contaminated with C. raciborskii for 30 days on learning and memory processes in rats. Methods The effects of saxitoxin (3 or 9 μg/L STX equivalents) or cyanobacteria on behavior was determined using the open field habituation task, elevated plus maze anxiety model task, inhibitory avoidance task, and referential Morris water maze task. Results No effects of saxitoxin consumption was observed on anxiety and motor exploratory parameters in the elevated plus maze and open field habituation tasks, respectively. However, groups treated with 9 μg/L STX equivalents displayed a decreased memory performance in the inhibitory avoidance and Morris water maze tasks. Conclusions These results suggest an amnesic effect of saxitoxin on aversive and spatial memories.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2016-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100314Journal of Venomous Animals and Toxins including Tropical Diseases v.22 2016reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1186/s40409-016-0072-9info:eu-repo/semantics/openAccessDiehl,FelipeRamos,Patricia BaptistaSantos,Juliane Marques dosBarros,Daniela MartíYunes,João Sarkiseng2016-06-09T00:00:00Zoai:scielo:S1678-91992016000100314Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2016-06-09T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Behavioral alterations induced by repeated saxitoxin exposure in drinking water |
title |
Behavioral alterations induced by repeated saxitoxin exposure in drinking water |
spellingShingle |
Behavioral alterations induced by repeated saxitoxin exposure in drinking water Diehl,Felipe Saxitoxin Drinking water Behavior Aversive memory Spatial memory Rats |
title_short |
Behavioral alterations induced by repeated saxitoxin exposure in drinking water |
title_full |
Behavioral alterations induced by repeated saxitoxin exposure in drinking water |
title_fullStr |
Behavioral alterations induced by repeated saxitoxin exposure in drinking water |
title_full_unstemmed |
Behavioral alterations induced by repeated saxitoxin exposure in drinking water |
title_sort |
Behavioral alterations induced by repeated saxitoxin exposure in drinking water |
author |
Diehl,Felipe |
author_facet |
Diehl,Felipe Ramos,Patricia Baptista Santos,Juliane Marques dos Barros,Daniela Martí Yunes,João Sarkis |
author_role |
author |
author2 |
Ramos,Patricia Baptista Santos,Juliane Marques dos Barros,Daniela Martí Yunes,João Sarkis |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Diehl,Felipe Ramos,Patricia Baptista Santos,Juliane Marques dos Barros,Daniela Martí Yunes,João Sarkis |
dc.subject.por.fl_str_mv |
Saxitoxin Drinking water Behavior Aversive memory Spatial memory Rats |
topic |
Saxitoxin Drinking water Behavior Aversive memory Spatial memory Rats |
description |
Abstract Background Blooms of the saxitoxin-producing cyanobacterium Cylindrospermopsis raciborskii have been contaminating drinking water reservoirs in Brazil for many years. Although acute effects of saxitoxin intoxication are well known, chronic deleterious outcomes caused by repeated saxitoxin exposure still require further investigation. The aim of the present work is to investigate the effects of consumption of drinking water contaminated with C. raciborskii for 30 days on learning and memory processes in rats. Methods The effects of saxitoxin (3 or 9 μg/L STX equivalents) or cyanobacteria on behavior was determined using the open field habituation task, elevated plus maze anxiety model task, inhibitory avoidance task, and referential Morris water maze task. Results No effects of saxitoxin consumption was observed on anxiety and motor exploratory parameters in the elevated plus maze and open field habituation tasks, respectively. However, groups treated with 9 μg/L STX equivalents displayed a decreased memory performance in the inhibitory avoidance and Morris water maze tasks. Conclusions These results suggest an amnesic effect of saxitoxin on aversive and spatial memories. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100314 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100314 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1186/s40409-016-0072-9 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
dc.source.none.fl_str_mv |
Journal of Venomous Animals and Toxins including Tropical Diseases v.22 2016 reponame:The Journal of venomous animals and toxins including tropical diseases (Online) instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
The Journal of venomous animals and toxins including tropical diseases (Online) |
collection |
The Journal of venomous animals and toxins including tropical diseases (Online) |
repository.name.fl_str_mv |
The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
||editorial@jvat.org.br |
_version_ |
1748958540064620544 |