Analysis of the biocompatibility of a biocelulose and a poly L- lactic acid membrane
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian journal of oral sciences (Online) |
Texto Completo: | https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8670616 |
Resumo: | The use of selective barriers as resorbable membranes has become a routine clinical procedure for guided bone regeneration. Therefore, the production of membranes with a low inflammatory potential during their resorption process has become the goal of a considerable number of researches. Aim: The purpose of the present study was to evaluate the biocompatibility of poly (L- lactic acid) (PLLA) and biocelulose membranes (BC) inserted in the subcutaneous tissue on the dorsum of rats. Methods: Fifteen animals underwent surgical procedures for the insertion of 4 types of membranes: COL (Collagen membrane) – Control Group; BC (Biocellulose membrane); BCAg (Biocellulose membrane impregnated with Silver); PLLA (Poly (L-lactic acid) membrane). All membrane types were inserted into each animal. Animals were euthanized after 3, 7, and 15 days of the surgical procedure. Descriptive histological analyses were carried out to investigate host tissue reaction to membrane presence by assessing the anti-inflammatory process composition associated with the membrane resorption and the presence of foreign-body reaction or encapsulation. Results: The BC membranes showed a higher degree of inflammation and poor pattern of integration with the surrounding tissues than the PLLA and COL membranes. Conclusion: The PLLA and COL membranes present better biocompatibility than the BC membranes. |
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UNICAMP-8 |
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Brazilian journal of oral sciences (Online) |
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Analysis of the biocompatibility of a biocelulose and a poly L- lactic acid membraneBiocompatible materialsInflammationMembranesCelulosePolyestersThe use of selective barriers as resorbable membranes has become a routine clinical procedure for guided bone regeneration. Therefore, the production of membranes with a low inflammatory potential during their resorption process has become the goal of a considerable number of researches. Aim: The purpose of the present study was to evaluate the biocompatibility of poly (L- lactic acid) (PLLA) and biocelulose membranes (BC) inserted in the subcutaneous tissue on the dorsum of rats. Methods: Fifteen animals underwent surgical procedures for the insertion of 4 types of membranes: COL (Collagen membrane) – Control Group; BC (Biocellulose membrane); BCAg (Biocellulose membrane impregnated with Silver); PLLA (Poly (L-lactic acid) membrane). All membrane types were inserted into each animal. Animals were euthanized after 3, 7, and 15 days of the surgical procedure. Descriptive histological analyses were carried out to investigate host tissue reaction to membrane presence by assessing the anti-inflammatory process composition associated with the membrane resorption and the presence of foreign-body reaction or encapsulation. Results: The BC membranes showed a higher degree of inflammation and poor pattern of integration with the surrounding tissues than the PLLA and COL membranes. Conclusion: The PLLA and COL membranes present better biocompatibility than the BC membranes.Universidade Estadual de Campinas2022-08-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/867061610.20396/bjos.v21i00.8670616Brazilian Journal of Oral Sciences; v. 21 (2022): Continuous Publication; e220616Brazilian Journal of Oral Sciences; Vol. 21 (2022): Continuous Publication; e2206161677-3225reponame:Brazilian journal of oral sciences (Online)instname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPenghttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8670616/29880Brazil; ContemporaryCopyright (c) 2021 José Doval Neto, Rodrigo Fernando Costa Marques, Adriana Cristina Motta, Eliana Aparecida de Rezende Duek, Guilherme José Pimentel Lopes de Oliveira, Cláudio Marcantoniohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessDoval Neto, José Marques, Rodrigo Fernando Costa Motta, Adriana Cristina Duek, Eliana Aparecida de Rezende Oliveira, Guilherme José Pimentel Lopes de Marcantonio, Cláudio 2022-08-23T12:05:17Zoai:ojs.periodicos.sbu.unicamp.br:article/8670616Revistahttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/PUBhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/oaibrjorals@fop.unicamp.br||brjorals@fop.unicamp.br1677-32251677-3217opendoar:2022-08-23T12:05:17Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP)false |
dc.title.none.fl_str_mv |
Analysis of the biocompatibility of a biocelulose and a poly L- lactic acid membrane |
title |
Analysis of the biocompatibility of a biocelulose and a poly L- lactic acid membrane |
spellingShingle |
Analysis of the biocompatibility of a biocelulose and a poly L- lactic acid membrane Doval Neto, José Biocompatible materials Inflammation Membranes Celulose Polyesters |
title_short |
Analysis of the biocompatibility of a biocelulose and a poly L- lactic acid membrane |
title_full |
Analysis of the biocompatibility of a biocelulose and a poly L- lactic acid membrane |
title_fullStr |
Analysis of the biocompatibility of a biocelulose and a poly L- lactic acid membrane |
title_full_unstemmed |
Analysis of the biocompatibility of a biocelulose and a poly L- lactic acid membrane |
title_sort |
Analysis of the biocompatibility of a biocelulose and a poly L- lactic acid membrane |
author |
Doval Neto, José |
author_facet |
Doval Neto, José Marques, Rodrigo Fernando Costa Motta, Adriana Cristina Duek, Eliana Aparecida de Rezende Oliveira, Guilherme José Pimentel Lopes de Marcantonio, Cláudio |
author_role |
author |
author2 |
Marques, Rodrigo Fernando Costa Motta, Adriana Cristina Duek, Eliana Aparecida de Rezende Oliveira, Guilherme José Pimentel Lopes de Marcantonio, Cláudio |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Doval Neto, José Marques, Rodrigo Fernando Costa Motta, Adriana Cristina Duek, Eliana Aparecida de Rezende Oliveira, Guilherme José Pimentel Lopes de Marcantonio, Cláudio |
dc.subject.por.fl_str_mv |
Biocompatible materials Inflammation Membranes Celulose Polyesters |
topic |
Biocompatible materials Inflammation Membranes Celulose Polyesters |
description |
The use of selective barriers as resorbable membranes has become a routine clinical procedure for guided bone regeneration. Therefore, the production of membranes with a low inflammatory potential during their resorption process has become the goal of a considerable number of researches. Aim: The purpose of the present study was to evaluate the biocompatibility of poly (L- lactic acid) (PLLA) and biocelulose membranes (BC) inserted in the subcutaneous tissue on the dorsum of rats. Methods: Fifteen animals underwent surgical procedures for the insertion of 4 types of membranes: COL (Collagen membrane) – Control Group; BC (Biocellulose membrane); BCAg (Biocellulose membrane impregnated with Silver); PLLA (Poly (L-lactic acid) membrane). All membrane types were inserted into each animal. Animals were euthanized after 3, 7, and 15 days of the surgical procedure. Descriptive histological analyses were carried out to investigate host tissue reaction to membrane presence by assessing the anti-inflammatory process composition associated with the membrane resorption and the presence of foreign-body reaction or encapsulation. Results: The BC membranes showed a higher degree of inflammation and poor pattern of integration with the surrounding tissues than the PLLA and COL membranes. Conclusion: The PLLA and COL membranes present better biocompatibility than the BC membranes. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08-22 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/other |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8670616 10.20396/bjos.v21i00.8670616 |
url |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8670616 |
identifier_str_mv |
10.20396/bjos.v21i00.8670616 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8670616/29880 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
Brazil; Contemporary |
dc.publisher.none.fl_str_mv |
Universidade Estadual de Campinas |
publisher.none.fl_str_mv |
Universidade Estadual de Campinas |
dc.source.none.fl_str_mv |
Brazilian Journal of Oral Sciences; v. 21 (2022): Continuous Publication; e220616 Brazilian Journal of Oral Sciences; Vol. 21 (2022): Continuous Publication; e220616 1677-3225 reponame:Brazilian journal of oral sciences (Online) instname:Universidade Estadual de Campinas (UNICAMP) instacron:UNICAMP |
instname_str |
Universidade Estadual de Campinas (UNICAMP) |
instacron_str |
UNICAMP |
institution |
UNICAMP |
reponame_str |
Brazilian journal of oral sciences (Online) |
collection |
Brazilian journal of oral sciences (Online) |
repository.name.fl_str_mv |
Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP) |
repository.mail.fl_str_mv |
brjorals@fop.unicamp.br||brjorals@fop.unicamp.br |
_version_ |
1800216404174045184 |