Parental age is related to the occurrence of cleft lip and palate in Brazilian populations
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian journal of oral sciences (Online) |
Texto Completo: | https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8648758 |
Resumo: | Aim: To evaluate the association of environmental risk factors, particularly paternal and maternal age, with gender and type of oral cleft in newborn with nonsyndromic cleft lip with or without cleft palate (NSCL/P). Methods: This study included 1,346 children with NSCL/P of two Brazilian Services for treatment of craniofacial deformities. Parental ages were classified into the following groups: maternal age <35, 36-39, and ≥40 years; paternal age <39 and ≥40 years. The data was analyzed with chi-square test and multinomial logistic regression analysis. The odds ratios were estimated with a 95% confidence interval. Results: Of the 1,346 children included in this study, CLP was the type of NSCL/P with highest prevalence, followed by, respectively, CL and CP. There was a greater occurrence of NSCL/P in males compared to females (55.8% versus 44.2%). CLP was more common in men, while the CL and CP were more prevalent in women (p=0.000). No association between maternal age and clefts was observed (p=0.747). However, there was evidence of association between father’s aged ≥40 years old and NSCL/P (p=0.031). When patients with CP were analyzed separately, no association between the father’s age and the child’s gender (p=0.728) was observed, i.e. the female gender prevails among patients with CP, regardless of the father’s age. Conclusions: This study showed that there were differences in the distribution of the non-syndromic cleft lip and/or palate and the gender, and fathers aged ≥40 years old may have increased risk of oral cleft. Further studies involving different populations are needed for a better understanding of the effect of maternal and paternal ages as a risk factor for the occurrence of oral clefts. |
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oai:ojs.periodicos.sbu.unicamp.br:article/8648758 |
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UNICAMP-8 |
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Brazilian journal of oral sciences (Online) |
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|
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Parental age is related to the occurrence of cleft lip and palate in Brazilian populationsCleft palate. Cleft lip. Paternal age. Maternal age. Risk factors.Fatores de risco ambientaisAim: To evaluate the association of environmental risk factors, particularly paternal and maternal age, with gender and type of oral cleft in newborn with nonsyndromic cleft lip with or without cleft palate (NSCL/P). Methods: This study included 1,346 children with NSCL/P of two Brazilian Services for treatment of craniofacial deformities. Parental ages were classified into the following groups: maternal age <35, 36-39, and ≥40 years; paternal age <39 and ≥40 years. The data was analyzed with chi-square test and multinomial logistic regression analysis. The odds ratios were estimated with a 95% confidence interval. Results: Of the 1,346 children included in this study, CLP was the type of NSCL/P with highest prevalence, followed by, respectively, CL and CP. There was a greater occurrence of NSCL/P in males compared to females (55.8% versus 44.2%). CLP was more common in men, while the CL and CP were more prevalent in women (p=0.000). No association between maternal age and clefts was observed (p=0.747). However, there was evidence of association between father’s aged ≥40 years old and NSCL/P (p=0.031). When patients with CP were analyzed separately, no association between the father’s age and the child’s gender (p=0.728) was observed, i.e. the female gender prevails among patients with CP, regardless of the father’s age. Conclusions: This study showed that there were differences in the distribution of the non-syndromic cleft lip and/or palate and the gender, and fathers aged ≥40 years old may have increased risk of oral cleft. Further studies involving different populations are needed for a better understanding of the effect of maternal and paternal ages as a risk factor for the occurrence of oral clefts.Universidade Estadual de Campinas2017-04-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/864875810.20396/bjos.v15i2.8648758Brazilian Journal of Oral Sciences; v. 15 n. 2 (2016): Apr./Jun.; 167-170Brazilian Journal of Oral Sciences; Vol. 15 No. 2 (2016): Apr./Jun.; 167-1701677-3225reponame:Brazilian journal of oral sciences (Online)instname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPenghttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8648758/15794Carvalho, Paulo Henrique Pimenta deMachado, Renato AssisReis, Silvia Regina de AlmeidaMartelli, Daniella Reis BarbosaDias, Verônica OliveiraMartelli Júnior, Hercílioinfo:eu-repo/semantics/openAccess2018-04-03T11:18:06Zoai:ojs.periodicos.sbu.unicamp.br:article/8648758Revistahttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/PUBhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/oaibrjorals@fop.unicamp.br||brjorals@fop.unicamp.br1677-32251677-3217opendoar:2018-04-03T11:18:06Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP)false |
dc.title.none.fl_str_mv |
Parental age is related to the occurrence of cleft lip and palate in Brazilian populations |
title |
Parental age is related to the occurrence of cleft lip and palate in Brazilian populations |
spellingShingle |
Parental age is related to the occurrence of cleft lip and palate in Brazilian populations Carvalho, Paulo Henrique Pimenta de Cleft palate. Cleft lip. Paternal age. Maternal age. Risk factors. Fatores de risco ambientais |
title_short |
Parental age is related to the occurrence of cleft lip and palate in Brazilian populations |
title_full |
Parental age is related to the occurrence of cleft lip and palate in Brazilian populations |
title_fullStr |
Parental age is related to the occurrence of cleft lip and palate in Brazilian populations |
title_full_unstemmed |
Parental age is related to the occurrence of cleft lip and palate in Brazilian populations |
title_sort |
Parental age is related to the occurrence of cleft lip and palate in Brazilian populations |
author |
Carvalho, Paulo Henrique Pimenta de |
author_facet |
Carvalho, Paulo Henrique Pimenta de Machado, Renato Assis Reis, Silvia Regina de Almeida Martelli, Daniella Reis Barbosa Dias, Verônica Oliveira Martelli Júnior, Hercílio |
author_role |
author |
author2 |
Machado, Renato Assis Reis, Silvia Regina de Almeida Martelli, Daniella Reis Barbosa Dias, Verônica Oliveira Martelli Júnior, Hercílio |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho, Paulo Henrique Pimenta de Machado, Renato Assis Reis, Silvia Regina de Almeida Martelli, Daniella Reis Barbosa Dias, Verônica Oliveira Martelli Júnior, Hercílio |
dc.subject.por.fl_str_mv |
Cleft palate. Cleft lip. Paternal age. Maternal age. Risk factors. Fatores de risco ambientais |
topic |
Cleft palate. Cleft lip. Paternal age. Maternal age. Risk factors. Fatores de risco ambientais |
description |
Aim: To evaluate the association of environmental risk factors, particularly paternal and maternal age, with gender and type of oral cleft in newborn with nonsyndromic cleft lip with or without cleft palate (NSCL/P). Methods: This study included 1,346 children with NSCL/P of two Brazilian Services for treatment of craniofacial deformities. Parental ages were classified into the following groups: maternal age <35, 36-39, and ≥40 years; paternal age <39 and ≥40 years. The data was analyzed with chi-square test and multinomial logistic regression analysis. The odds ratios were estimated with a 95% confidence interval. Results: Of the 1,346 children included in this study, CLP was the type of NSCL/P with highest prevalence, followed by, respectively, CL and CP. There was a greater occurrence of NSCL/P in males compared to females (55.8% versus 44.2%). CLP was more common in men, while the CL and CP were more prevalent in women (p=0.000). No association between maternal age and clefts was observed (p=0.747). However, there was evidence of association between father’s aged ≥40 years old and NSCL/P (p=0.031). When patients with CP were analyzed separately, no association between the father’s age and the child’s gender (p=0.728) was observed, i.e. the female gender prevails among patients with CP, regardless of the father’s age. Conclusions: This study showed that there were differences in the distribution of the non-syndromic cleft lip and/or palate and the gender, and fathers aged ≥40 years old may have increased risk of oral cleft. Further studies involving different populations are needed for a better understanding of the effect of maternal and paternal ages as a risk factor for the occurrence of oral clefts. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-04-20 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/other |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8648758 10.20396/bjos.v15i2.8648758 |
url |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8648758 |
identifier_str_mv |
10.20396/bjos.v15i2.8648758 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8648758/15794 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual de Campinas |
publisher.none.fl_str_mv |
Universidade Estadual de Campinas |
dc.source.none.fl_str_mv |
Brazilian Journal of Oral Sciences; v. 15 n. 2 (2016): Apr./Jun.; 167-170 Brazilian Journal of Oral Sciences; Vol. 15 No. 2 (2016): Apr./Jun.; 167-170 1677-3225 reponame:Brazilian journal of oral sciences (Online) instname:Universidade Estadual de Campinas (UNICAMP) instacron:UNICAMP |
instname_str |
Universidade Estadual de Campinas (UNICAMP) |
instacron_str |
UNICAMP |
institution |
UNICAMP |
reponame_str |
Brazilian journal of oral sciences (Online) |
collection |
Brazilian journal of oral sciences (Online) |
repository.name.fl_str_mv |
Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP) |
repository.mail.fl_str_mv |
brjorals@fop.unicamp.br||brjorals@fop.unicamp.br |
_version_ |
1800216401700454400 |