Resistance mechanisms of Cryptococcus spp. and plant compounds as tools to combat them
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/12819 |
Resumo: | Cryptococcus is a genus of dimorphic basidiomycete fungi found in the form of yeasts and filaments. Cryptococcosis has as main etiological agents the species Cryptococcus neoformans and Cryptococcus gattii. This disease is considered a public health problem and has becoming more alarming because of the limitations of antimicrobials available to its treatment, in addition to an increase in reports of fungal resistance. In this sense, the present review sought to survey information on the resistance mechanisms of Cryptococcus spp. against the main drugs used in cryptococcosis therapy as well as on the antimicrobial activities of plants against these fungi. Studies have reported that several mechanisms may be involved in fungal resistance to drugs including drug inactivation by enzymes, expression of efflux pumps and others drug transporters, as well as changes in the drug target and/or implementation of alternative metabolic pathways. As an alternative to conventional antimicrobials, substances and molecules extracted from plants have demonstrated potential for controlling these pathogens. These phytochemicals can trigger the inhibition and/or death of Cryptococcus through morphological changes on fungi cells, inhibition of ergosterol synthesis, cell leakage, capsular decrease, interference in cell division, reduction of activity of several enzymes such as laccase and urease, inhibition of biofilm formation, among others. In this sense, plants are an important source of bioactive compounds with antimicrobial activity that can be studied in the search for new drugs that are increasingly effective, specific and less toxic in the control of cryptococcosis. |
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Resistance mechanisms of Cryptococcus spp. and plant compounds as tools to combat themMecanismos de resistencia de Cryptococcus spp. y compuestos vegetales como herramientas para combatirlosMecanismos de resistência de Cryptococcus spp. e compostos de plantas como ferramentas para combatê-losAntimicrobial extractsResistance of Cryptococcus spp.Toxicity of antimicrobial drugsMechanism of action of antimicrobial plants.Extractos antimicrobianosResistencia de Cryptococcus spp.Toxicidad antimicrobianaMecanismo de acción de plantas antimicrobianas.Extratos antimicrobianosResistência de Cryptococcus spp.Toxicidade de antimicrobianosMecanismo de ação de plantas antimicrobianas.Cryptococcus is a genus of dimorphic basidiomycete fungi found in the form of yeasts and filaments. Cryptococcosis has as main etiological agents the species Cryptococcus neoformans and Cryptococcus gattii. This disease is considered a public health problem and has becoming more alarming because of the limitations of antimicrobials available to its treatment, in addition to an increase in reports of fungal resistance. In this sense, the present review sought to survey information on the resistance mechanisms of Cryptococcus spp. against the main drugs used in cryptococcosis therapy as well as on the antimicrobial activities of plants against these fungi. Studies have reported that several mechanisms may be involved in fungal resistance to drugs including drug inactivation by enzymes, expression of efflux pumps and others drug transporters, as well as changes in the drug target and/or implementation of alternative metabolic pathways. As an alternative to conventional antimicrobials, substances and molecules extracted from plants have demonstrated potential for controlling these pathogens. These phytochemicals can trigger the inhibition and/or death of Cryptococcus through morphological changes on fungi cells, inhibition of ergosterol synthesis, cell leakage, capsular decrease, interference in cell division, reduction of activity of several enzymes such as laccase and urease, inhibition of biofilm formation, among others. In this sense, plants are an important source of bioactive compounds with antimicrobial activity that can be studied in the search for new drugs that are increasingly effective, specific and less toxic in the control of cryptococcosis.Cryptococcus es un género de hongos basidiomicetos dimórficos que se encuentran en forma de levaduras y filamentos. La criptococosis tiene como principales agentes etiológicos las especies Cryptococcus neoformans y Cryptococcus gattii. Esta enfermedad es considerada un problema de salud pública y se ha vuelto más alarmante debido a las limitaciones de los antimicrobianos disponibles para su tratamiento, además del aumento de reportes de resistencia microbiana. En este sentido, la presente revisión buscó generar información sobre los mecanismos de resistencia de Cryptococcus spp. contra los principales fármacos utilizados en el tratamiento de la criptococosis, así como sobre las actividades antimicrobianas de las plantas contra estos hongos. Los estudios informan que varios mecanismos pueden estar involucrados en la resistencia de los hongos a los medicamentos antimicrobianos, incluida la inactivación de los medicamentos por las enzimas, la expresión de bombas de eflujo, los cambios en el objetivo del medicamento y/o la implementación de vías metabólicas alternativas. Como alternativa a los antimicrobianos convencionales, las sustancias y moléculas extraídas de plantas han demostrado tener potencial para el control de estos patógenos. Estos fitoquímicos pueden desencadenar la inhibición y/o muerte de los microorganismos del género Cryptococcus a través de: cambios morfológicos en las células fúngicas, extravasación celular, disminución capsular, interferencia en la división celular, reducción de la actividad de diversas enzimas como la lacasa.y ureasa, inhibición de la formación de biofilmes, entre otros. En este sentido, las plantas son fuentes importantes de compuestos bioactivos con actividad antimicrobiana que pueden ser estudiados en la búsqueda de nuevos fármacos cada vez más efectivos, específicos y menos tóxicos en el control de la criptococosis.Cryptococcus é um gênero de fungos basidiomicetos dimórficos encontrados na forma de leveduras e filamentos. A criptococose tem como principais agente etiológicos as espécies Cryptococcus neoformans e Cryptococcus gattii. Essa doença é considerada um problema de saúde pública e tem se tornado mais alarmante devido às limitações dos antimicrobianos disponíveis para o seu tratamento, além do aumento nos relatos de resistência microbiana. Nesse sentido, a presente revisão buscou levantar informações sobre dos mecanismos de resistência de Cryptococcus spp. frente aos principais fármacos utilizados no tratamento da criptococose, bem como sobre as atividades antimicrobianas de plantas contra esses fungos. Estudos reportam que diversos mecanismos podem estar envolvidos na resistência fúngica a fármacos antimicrobianos, incluindo a inativação de drogas por enzimas, expressão de bombas de efluxo, alterações no alvo da droga e/ou implementação de vias metabólicas alternativas. Como alternativa aos antimicrobianos convencionais, substâncias e moléculas extraídas de plantas têm se mostrado potencial para o controle desses patógenos. Esses fitoquímicos podem desencadear a inibição e/ou morte de microrganismos de Cryptococcus através de: alterações morfológicas nas células fúngicas, extravasamento celular, diminuição capsular, interferência na divisão celular, redução da atividade de várias enzimas como lacase e urease, inibição da formação de biofilme, entre outros. Nesse sentido, as plantas são importantes fontes de compostos bioativos com atividade antimicrobiana que podem ser estudadas na busca de novos fármacos cada vez mais eficazes, específicos e menos tóxicos no controle da criptococose.Research, Society and Development2021-02-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1281910.33448/rsd-v10i2.12819Research, Society and Development; Vol. 10 No. 2; e57810212819Research, Society and Development; Vol. 10 Núm. 2; e57810212819Research, Society and Development; v. 10 n. 2; e578102128192525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/12819/11489Copyright (c) 2021 Suéllen Pedrosa da Silva; Clarice Barbosa Lucena da Costa; José Dayvid Ferreira da Silva; Robson Raion de Vasconcelos Alves; Guilherme Antonio de Souza Silva; Anderson Felipe Soares de Freitas; Caio César da Silva Guedes; Amanda de Oliveira Marinho; Patrícia Maria Guedes Paiva; Thiago Henrique Napoleãohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Suéllen Pedrosa da Costa, Clarice Barbosa Lucena da Silva, José Dayvid Ferreira da Alves, Robson Raion de Vasconcelos Silva, Guilherme Antonio de Souza Freitas, Anderson Felipe Soares de Guedes, Caio César da Silva Marinho, Amanda de Oliveira Paiva, Patrícia Maria Guedes Napoleão, Thiago Henrique 2021-03-02T09:32:39Zoai:ojs.pkp.sfu.ca:article/12819Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:34:17.977302Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Resistance mechanisms of Cryptococcus spp. and plant compounds as tools to combat them Mecanismos de resistencia de Cryptococcus spp. y compuestos vegetales como herramientas para combatirlos Mecanismos de resistência de Cryptococcus spp. e compostos de plantas como ferramentas para combatê-los |
title |
Resistance mechanisms of Cryptococcus spp. and plant compounds as tools to combat them |
spellingShingle |
Resistance mechanisms of Cryptococcus spp. and plant compounds as tools to combat them Silva, Suéllen Pedrosa da Antimicrobial extracts Resistance of Cryptococcus spp. Toxicity of antimicrobial drugs Mechanism of action of antimicrobial plants. Extractos antimicrobianos Resistencia de Cryptococcus spp. Toxicidad antimicrobiana Mecanismo de acción de plantas antimicrobianas. Extratos antimicrobianos Resistência de Cryptococcus spp. Toxicidade de antimicrobianos Mecanismo de ação de plantas antimicrobianas. |
title_short |
Resistance mechanisms of Cryptococcus spp. and plant compounds as tools to combat them |
title_full |
Resistance mechanisms of Cryptococcus spp. and plant compounds as tools to combat them |
title_fullStr |
Resistance mechanisms of Cryptococcus spp. and plant compounds as tools to combat them |
title_full_unstemmed |
Resistance mechanisms of Cryptococcus spp. and plant compounds as tools to combat them |
title_sort |
Resistance mechanisms of Cryptococcus spp. and plant compounds as tools to combat them |
author |
Silva, Suéllen Pedrosa da |
author_facet |
Silva, Suéllen Pedrosa da Costa, Clarice Barbosa Lucena da Silva, José Dayvid Ferreira da Alves, Robson Raion de Vasconcelos Silva, Guilherme Antonio de Souza Freitas, Anderson Felipe Soares de Guedes, Caio César da Silva Marinho, Amanda de Oliveira Paiva, Patrícia Maria Guedes Napoleão, Thiago Henrique |
author_role |
author |
author2 |
Costa, Clarice Barbosa Lucena da Silva, José Dayvid Ferreira da Alves, Robson Raion de Vasconcelos Silva, Guilherme Antonio de Souza Freitas, Anderson Felipe Soares de Guedes, Caio César da Silva Marinho, Amanda de Oliveira Paiva, Patrícia Maria Guedes Napoleão, Thiago Henrique |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Suéllen Pedrosa da Costa, Clarice Barbosa Lucena da Silva, José Dayvid Ferreira da Alves, Robson Raion de Vasconcelos Silva, Guilherme Antonio de Souza Freitas, Anderson Felipe Soares de Guedes, Caio César da Silva Marinho, Amanda de Oliveira Paiva, Patrícia Maria Guedes Napoleão, Thiago Henrique |
dc.subject.por.fl_str_mv |
Antimicrobial extracts Resistance of Cryptococcus spp. Toxicity of antimicrobial drugs Mechanism of action of antimicrobial plants. Extractos antimicrobianos Resistencia de Cryptococcus spp. Toxicidad antimicrobiana Mecanismo de acción de plantas antimicrobianas. Extratos antimicrobianos Resistência de Cryptococcus spp. Toxicidade de antimicrobianos Mecanismo de ação de plantas antimicrobianas. |
topic |
Antimicrobial extracts Resistance of Cryptococcus spp. Toxicity of antimicrobial drugs Mechanism of action of antimicrobial plants. Extractos antimicrobianos Resistencia de Cryptococcus spp. Toxicidad antimicrobiana Mecanismo de acción de plantas antimicrobianas. Extratos antimicrobianos Resistência de Cryptococcus spp. Toxicidade de antimicrobianos Mecanismo de ação de plantas antimicrobianas. |
description |
Cryptococcus is a genus of dimorphic basidiomycete fungi found in the form of yeasts and filaments. Cryptococcosis has as main etiological agents the species Cryptococcus neoformans and Cryptococcus gattii. This disease is considered a public health problem and has becoming more alarming because of the limitations of antimicrobials available to its treatment, in addition to an increase in reports of fungal resistance. In this sense, the present review sought to survey information on the resistance mechanisms of Cryptococcus spp. against the main drugs used in cryptococcosis therapy as well as on the antimicrobial activities of plants against these fungi. Studies have reported that several mechanisms may be involved in fungal resistance to drugs including drug inactivation by enzymes, expression of efflux pumps and others drug transporters, as well as changes in the drug target and/or implementation of alternative metabolic pathways. As an alternative to conventional antimicrobials, substances and molecules extracted from plants have demonstrated potential for controlling these pathogens. These phytochemicals can trigger the inhibition and/or death of Cryptococcus through morphological changes on fungi cells, inhibition of ergosterol synthesis, cell leakage, capsular decrease, interference in cell division, reduction of activity of several enzymes such as laccase and urease, inhibition of biofilm formation, among others. In this sense, plants are an important source of bioactive compounds with antimicrobial activity that can be studied in the search for new drugs that are increasingly effective, specific and less toxic in the control of cryptococcosis. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-02-24 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/12819 10.33448/rsd-v10i2.12819 |
url |
https://rsdjournal.org/index.php/rsd/article/view/12819 |
identifier_str_mv |
10.33448/rsd-v10i2.12819 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/12819/11489 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 2; e57810212819 Research, Society and Development; Vol. 10 Núm. 2; e57810212819 Research, Society and Development; v. 10 n. 2; e57810212819 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052671014731776 |