Theoretical-practical approach to herpetiform dermatitis as the main cutaneous manifestation of celiac disease: An integrative review
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/15276 |
Resumo: | Introduction: Dermatitis herpetiformis (DH) is a benign, chronic, inflammatory manifestation of the skin. The lesions are erythemato-papular vesicular eruptions, pruritic, symmetrical, herpetiform in shape, and have an affinity for extensor surfaces. It is male-dominant, between the ages of 30 and 40, and is related to abnormalities of the small intestinal mucosa and to IgA deposition in the papillary dermis. It has a multifactorial origin, encompassing genetic, environmental, and immunologic components. Objectives: To analyze the application of knowledge obtained by integrative review addressing dermatitis herpetiformis and celiac disease (CD) to develop a clinical rationale for early diagnosis and effective treatment. Methodology: Scientific and review articles published and referenced in MEDLINE, LILACS, IBECS, BINACIS, LIS, BRISA/RedTESA and MEdCArib were consulted, delimited from 2008 to 2019. The books "Tratado de dermatologia" by Belda Júnior and "Dermatologia" by Sampaio and Rivitti were also included. Results: The diagnosis of DH is clinical, laboratory and immunological. The presentation and eruption activity of the blisters is variable. The classic histopathologic finding is a subepidermal cleft with neutrophils and eosinophils in the dermal papillae, with perivesicular mixed inflammatory infiltrate. Direct immunofluorescence of uninvolved skin is the gold standard. The mainstay of treatment involves a gluten-free diet coupled with the use of medications.Incomplete remission is frequently observed in patients who do not restrict gluten. Conclusion: Knowledge of the clinical and subclinical manifestations of DH and CD as well as laboratory findings is crucial for early diagnosis, helping to rule out misdiagnosis, exacerbations, or complications. |
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Theoretical-practical approach to herpetiform dermatitis as the main cutaneous manifestation of celiac disease: An integrative reviewAbordaje teórico-práctico de la dermatitis herpetiforme como principal manifestación cutánea de la enfermedad celíaca: Una revisión integradoraAbordagem teórico-prática da dermatite herpetiforme como a principal manifestação cutânea da doença celíaca: Revisão integrativaDermatite herpetiformeDoença celíacaLesões cutâneasLesões versículobolhosas.Dermatitis herpetiformeEnfermedad celíacaLesiones cutáneasLesiones versículo-ampollosas.Herpertiformis dermatitesCeliac diseaseSkin lesionsVersiculobullous lesions.Introduction: Dermatitis herpetiformis (DH) is a benign, chronic, inflammatory manifestation of the skin. The lesions are erythemato-papular vesicular eruptions, pruritic, symmetrical, herpetiform in shape, and have an affinity for extensor surfaces. It is male-dominant, between the ages of 30 and 40, and is related to abnormalities of the small intestinal mucosa and to IgA deposition in the papillary dermis. It has a multifactorial origin, encompassing genetic, environmental, and immunologic components. Objectives: To analyze the application of knowledge obtained by integrative review addressing dermatitis herpetiformis and celiac disease (CD) to develop a clinical rationale for early diagnosis and effective treatment. Methodology: Scientific and review articles published and referenced in MEDLINE, LILACS, IBECS, BINACIS, LIS, BRISA/RedTESA and MEdCArib were consulted, delimited from 2008 to 2019. The books "Tratado de dermatologia" by Belda Júnior and "Dermatologia" by Sampaio and Rivitti were also included. Results: The diagnosis of DH is clinical, laboratory and immunological. The presentation and eruption activity of the blisters is variable. The classic histopathologic finding is a subepidermal cleft with neutrophils and eosinophils in the dermal papillae, with perivesicular mixed inflammatory infiltrate. Direct immunofluorescence of uninvolved skin is the gold standard. The mainstay of treatment involves a gluten-free diet coupled with the use of medications.Incomplete remission is frequently observed in patients who do not restrict gluten. Conclusion: Knowledge of the clinical and subclinical manifestations of DH and CD as well as laboratory findings is crucial for early diagnosis, helping to rule out misdiagnosis, exacerbations, or complications.Introducción: La dermatitis herpetiforme (DH) es una manifestación benigna, crónica e inflamatoria de la piel. Las lesiones son erupciones eritematoso-papular-vesiculares, pruriginosas, simétricas, dispuestas en forma herpetiforme, con afinidad por las superficies extensoras. Existe predilección por el sexo masculino, entre 30 y 40 años, y se relaciona con anomalías en la mucosa del intestino delgado y el depósito de IgA en la dermis papilar. Tiene un origen multifactorial, que engloba componentes genéticos, ambientales e inmunológicos. Objetivos: Analizar la aplicación de los conocimientos obtenidos por la revisión integradora que aborda la dermatitis herpetiforme y la enfermedad celíaca (EC) para la elaboración de un razonamiento clínico ante el diagnóstico precoz y el tratamiento eficaz. Metodología: Se consultaron artículos científicos y de revisión publicados y referenciados en MEDLINE, LILACS, IBECS, BINACIS, LIS, BRISA / RedTESA y MEdCArib, delimitados de 2008 a 2019. Los libros “Tratado de dermatología” de Belda Júnior y “Dermatología” de Sampaio y Rivitti también se incluyeron. Resultados: El diagnóstico de HD es clínico, de laboratorio e inmunológico. La actividad de presentación y erupción de las burbujas es variable. El hallazgo histopatológico clásico es una hendidura subepidérmica con neutrófilos y eosinófilos en las papilas dérmicas, con infiltrado inflamatorio perivesicular mixto. La inmunofluorescencia directa de la piel no afectada es el estándar de oro. El pilar del tratamiento implica una dieta libre de gluten asociada al uso de medicamentos, observándose frecuentes remisiones incompletas en pacientes que no restringen el gluten. Conclusión: El conocimiento de las manifestaciones clínicas y subclínicas de la DH y la EC, así como los hallazgos de laboratorio, son cruciales para el diagnóstico precoz, corroborando para descartar diagnósticos erróneos, exacerbaciones o complicaciones.Introdução: A dermatite herpetiforme (DH) é uma manifestação benigna, crônica e inflamatória da pele. As lesões são erupções eritêmato- pápulo- vesiculosa, pruriginosas, simétricas, dispostas de forma herpetiforme, tendo afinidade por superfícies extensoras. Há predileção pelo sexo masculino, entre 30 e 40 anos e está relacionada com anormalidades na mucosa do intestino delgado e ao depósito de IgA na derme papilar. Tem origem multifatorial, abrangendo componentes genéticos, ambientais e imunológicos. Objetivos: Analisar a aplicação dos conhecimentos obtidos pela revisão integrativa abordando a dermatite herpetiforme e doença celíaca (DC) para elaboração de um raciocínio clínico frente ao diagnóstico precoce e tratamento efetivo. Metodologia: Artigos científicos e de revisão publicados e referenciados no MEDLINE, LILACS, IBECS, BINACIS, LIS, BRISA/RedTESA e MEdCArib foram consultados, delimitados de 2008 a 2019. Os livros “Tratado de dermatologia” de Belda Júnior e “Dermatologia” de Sampaio e Rivitti também foram incluídos. Resultados: O diagnóstico da DH é clinico, laboratorial e imunológico. A apresentação e atividade de erupção das bolhas é variável. O achado histopatológico clássico é uma fenda subepidérmica com neutrófilos e eosinófilos nas papilas dérmica, com infiltrado inflamatório misto perivesicular. A imunofluorescência direta da pele não envolvida é padrão ouro.O pilar do tratamento envolve uma dieta livre de glúten associado ao uso de medicamentos, sendo observada a remissão incompleta frequente em pacientes que não restringem o glúten. Conclusão: O conhecimento das manifestações clínicas e subclínicas da DH e DC assim como achados laboratoriais são cruciais ao diagnóstico precoce, corroborando para afastar diagnósticos errôneos, exacerbações ou complicações.Research, Society and Development2021-05-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1527610.33448/rsd-v10i6.15276Research, Society and Development; Vol. 10 No. 6; e18110615276Research, Society and Development; Vol. 10 Núm. 6; e18110615276Research, Society and Development; v. 10 n. 6; e181106152762525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/15276/13998Copyright (c) 2021 Sarah Maria Monteiro Soares Costa de Holanda; Raíssa Martins de Oliveira Nunes ; Larissa Alves dos Santos Silva ; Marianna Mendes de Barros ; Pedro Henrique Freitas Silva ; Anna Joyce Tajra Assunção ; Adhonias Carvalho Moura ; Evandra Marielly Leite Nogueira Freitas Galvão https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessHolanda, Sarah Maria Monteiro Soares Costa de Nunes , Raíssa Martins de OliveiraSilva , Larissa Alves dos SantosBarros , Marianna Mendes deSilva , Pedro Henrique FreitasAssunção , Anna Joyce TajraMoura , Adhonias CarvalhoGalvão , Evandra Marielly Leite Nogueira Freitas2021-06-10T22:51:46Zoai:ojs.pkp.sfu.ca:article/15276Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:36:08.456362Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Theoretical-practical approach to herpetiform dermatitis as the main cutaneous manifestation of celiac disease: An integrative review Abordaje teórico-práctico de la dermatitis herpetiforme como principal manifestación cutánea de la enfermedad celíaca: Una revisión integradora Abordagem teórico-prática da dermatite herpetiforme como a principal manifestação cutânea da doença celíaca: Revisão integrativa |
title |
Theoretical-practical approach to herpetiform dermatitis as the main cutaneous manifestation of celiac disease: An integrative review |
spellingShingle |
Theoretical-practical approach to herpetiform dermatitis as the main cutaneous manifestation of celiac disease: An integrative review Holanda, Sarah Maria Monteiro Soares Costa de Dermatite herpetiforme Doença celíaca Lesões cutâneas Lesões versículobolhosas. Dermatitis herpetiforme Enfermedad celíaca Lesiones cutáneas Lesiones versículo-ampollosas. Herpertiformis dermatites Celiac disease Skin lesions Versiculobullous lesions. |
title_short |
Theoretical-practical approach to herpetiform dermatitis as the main cutaneous manifestation of celiac disease: An integrative review |
title_full |
Theoretical-practical approach to herpetiform dermatitis as the main cutaneous manifestation of celiac disease: An integrative review |
title_fullStr |
Theoretical-practical approach to herpetiform dermatitis as the main cutaneous manifestation of celiac disease: An integrative review |
title_full_unstemmed |
Theoretical-practical approach to herpetiform dermatitis as the main cutaneous manifestation of celiac disease: An integrative review |
title_sort |
Theoretical-practical approach to herpetiform dermatitis as the main cutaneous manifestation of celiac disease: An integrative review |
author |
Holanda, Sarah Maria Monteiro Soares Costa de |
author_facet |
Holanda, Sarah Maria Monteiro Soares Costa de Nunes , Raíssa Martins de Oliveira Silva , Larissa Alves dos Santos Barros , Marianna Mendes de Silva , Pedro Henrique Freitas Assunção , Anna Joyce Tajra Moura , Adhonias Carvalho Galvão , Evandra Marielly Leite Nogueira Freitas |
author_role |
author |
author2 |
Nunes , Raíssa Martins de Oliveira Silva , Larissa Alves dos Santos Barros , Marianna Mendes de Silva , Pedro Henrique Freitas Assunção , Anna Joyce Tajra Moura , Adhonias Carvalho Galvão , Evandra Marielly Leite Nogueira Freitas |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Holanda, Sarah Maria Monteiro Soares Costa de Nunes , Raíssa Martins de Oliveira Silva , Larissa Alves dos Santos Barros , Marianna Mendes de Silva , Pedro Henrique Freitas Assunção , Anna Joyce Tajra Moura , Adhonias Carvalho Galvão , Evandra Marielly Leite Nogueira Freitas |
dc.subject.por.fl_str_mv |
Dermatite herpetiforme Doença celíaca Lesões cutâneas Lesões versículobolhosas. Dermatitis herpetiforme Enfermedad celíaca Lesiones cutáneas Lesiones versículo-ampollosas. Herpertiformis dermatites Celiac disease Skin lesions Versiculobullous lesions. |
topic |
Dermatite herpetiforme Doença celíaca Lesões cutâneas Lesões versículobolhosas. Dermatitis herpetiforme Enfermedad celíaca Lesiones cutáneas Lesiones versículo-ampollosas. Herpertiformis dermatites Celiac disease Skin lesions Versiculobullous lesions. |
description |
Introduction: Dermatitis herpetiformis (DH) is a benign, chronic, inflammatory manifestation of the skin. The lesions are erythemato-papular vesicular eruptions, pruritic, symmetrical, herpetiform in shape, and have an affinity for extensor surfaces. It is male-dominant, between the ages of 30 and 40, and is related to abnormalities of the small intestinal mucosa and to IgA deposition in the papillary dermis. It has a multifactorial origin, encompassing genetic, environmental, and immunologic components. Objectives: To analyze the application of knowledge obtained by integrative review addressing dermatitis herpetiformis and celiac disease (CD) to develop a clinical rationale for early diagnosis and effective treatment. Methodology: Scientific and review articles published and referenced in MEDLINE, LILACS, IBECS, BINACIS, LIS, BRISA/RedTESA and MEdCArib were consulted, delimited from 2008 to 2019. The books "Tratado de dermatologia" by Belda Júnior and "Dermatologia" by Sampaio and Rivitti were also included. Results: The diagnosis of DH is clinical, laboratory and immunological. The presentation and eruption activity of the blisters is variable. The classic histopathologic finding is a subepidermal cleft with neutrophils and eosinophils in the dermal papillae, with perivesicular mixed inflammatory infiltrate. Direct immunofluorescence of uninvolved skin is the gold standard. The mainstay of treatment involves a gluten-free diet coupled with the use of medications.Incomplete remission is frequently observed in patients who do not restrict gluten. Conclusion: Knowledge of the clinical and subclinical manifestations of DH and CD as well as laboratory findings is crucial for early diagnosis, helping to rule out misdiagnosis, exacerbations, or complications. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/15276 10.33448/rsd-v10i6.15276 |
url |
https://rsdjournal.org/index.php/rsd/article/view/15276 |
identifier_str_mv |
10.33448/rsd-v10i6.15276 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/15276/13998 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 6; e18110615276 Research, Society and Development; Vol. 10 Núm. 6; e18110615276 Research, Society and Development; v. 10 n. 6; e18110615276 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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UNIFEI |
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UNIFEI |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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rsd.articles@gmail.com |
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1797052676971692032 |