Evaluación del efecto farmacológico del extracto etanólico de Stryphnodendron adstringens peel sobre el peristalismo intestinal en Mus musculus

Detalhes bibliográficos
Autor(a) principal: Barros, Ádine Gabriely Teles de Sousa
Data de Publicação: 2020
Outros Autores: Moreira, Francisco Assis dos Santos, Branco, Alessandra Camillo da Silveira Castello, Sousa, Joubert Aires de, Meneses, Carlos Eduardo da Silva, Sousa, Carolina Francisca Alves de Jesus, Sousa, Ruy Gabriel Costa
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/2230
Resumo: The objective of this work is to analyze the pharmacological activity of the ethanolic extract of the Barbatimão-verdadeiro in the intestinal peristalsis of mice (Mus Musculus). The study is characterized as a quantitative, exploratory and experimental research, in which two pharmacological tests were performed. The animals (n = 35) were treated with a dose of 500mg / kg Stryphnodendron adstringens ethanolic extract and intestinal motility was evaluated following the intestinal transit models (n = 15) and castor oil-induced diarrhea (n = 20). Statistical analysis with one-way ANOVA and Tukey test for significance analysis showed that the group treated with the plant showed significance in relation to the group treated with loperamide (p <0.05). In the induced diarrhea test, the extract showed significance (P = 0.0002) compared with the loperamide treated group and the control group. Therefore, Stryphnodendron adstringens ethanolic extract was effective in reducing intestinal motility.
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spelling Evaluación del efecto farmacológico del extracto etanólico de Stryphnodendron adstringens peel sobre el peristalismo intestinal en Mus musculusEvaluación del efecto farmacológico del extracto etanólico de Stryphnodendron adstringens peel sobre el peristalismo intestinal en Mus musculusAvaliação do efeito farmacológico do extrato etanólico da casca de Stryphnodendron adstringens sobre o peristaltismo intestinal em Mus musculusBarbatimão-verdadeiroGastrointestinal tractAntidiarrheal effect.Barbatimão-verdadeiroTracto gastrointestinalEfecto antidiarreico.Barbatimão-verdadeiroTrato GastrointestinalEfeito Antidiarreico.The objective of this work is to analyze the pharmacological activity of the ethanolic extract of the Barbatimão-verdadeiro in the intestinal peristalsis of mice (Mus Musculus). The study is characterized as a quantitative, exploratory and experimental research, in which two pharmacological tests were performed. The animals (n = 35) were treated with a dose of 500mg / kg Stryphnodendron adstringens ethanolic extract and intestinal motility was evaluated following the intestinal transit models (n = 15) and castor oil-induced diarrhea (n = 20). Statistical analysis with one-way ANOVA and Tukey test for significance analysis showed that the group treated with the plant showed significance in relation to the group treated with loperamide (p <0.05). In the induced diarrhea test, the extract showed significance (P = 0.0002) compared with the loperamide treated group and the control group. Therefore, Stryphnodendron adstringens ethanolic extract was effective in reducing intestinal motility.Este artículo tiene como objetivo analizar la actividad farmacológica del extracto de corteza etanólica de Barbatimão-verdadeiro en la peristalsis intestinal de ratones (Mus Musculus). El estudio se caracteriza por ser una investigación cuantitativa, exploratoria y experimental, en la que se realizaron dos pruebas farmacológicas. Los animales (n = 35) fueron tratados con una dosis de 500 mg / kg de extracto etanólico de Stryphnodendron adstringens y se evaluó la motilidad intestinal siguiendo modelos de tránsito intestinal (n = 15) y diarrea inducida por aceite de ricino (n = 20). El análisis estadístico con ANOVA unidireccional y la prueba de Tukey para el análisis de significación mostró que el grupo tratado con la planta mostró significación en relación con el grupo tratado con loperamida (p <0.05). En la prueba de diarrea inducida, el extracto mostró significación (P = 0,0002) en comparación con el grupo tratado con loperamida y el grupo control. Por lo tanto, el extracto etanólico de Stryphnodendron adstringens fue eficaz para reducir la motilidad intestinal.Este trabalho tem como objetivo analisar a atividade farmacológica do extrato etanólico da casca do Barbatimão-verdadeiro no peristaltismo intestinal de camundongos (Mus Musculus). O estudo caracteriza-se como uma pesquisa quantitativa, de caráter exploratório e experimental, no qual foram realizados dois testes farmacológicos. Os animais (n=35) foram tratados com a dose de 500mg/kg de extrato etanólico de Stryphnodendron adstringens e a motilidade intestinal foi avaliada seguindo os modelos de trânsito intestinal (n=15) e diarreia induzida por óleo de rícino (n=20). Através de análises estatísticas com o teste de variância ANOVA (one-way) e teste Tukey na análise de significância, observou-se que o grupo tratado com a planta demonstrou significância em relação ao grupo tratado com loperamida (p<0,05). No teste de diarreia induzida, o extrato mostrou significância (P = 0,0002) comparado com o grupo tratado com loperamida e o grupo controle. Portanto o extrato etanólico de Stryphnodendron adstringens mostrou-se eficaz na redução da motilidade intestinal.Research, Society and Development2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/223010.33448/rsd-v9i2.2230Research, Society and Development; Vol. 9 No. 2; e142922230Research, Society and Development; Vol. 9 Núm. 2; e142922230Research, Society and Development; v. 9 n. 2; e1429222302525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/2230/2408Copyright (c) 2020 Ádine Gabriely Teles de Sousa Barros, Francisco Assis dos Santos Moreira, Alessandra Camillo da Silveira Castello Branco, Carlos Eduardo da Silva Meneses, Joubert Aires de Sousa, Carolina Francisca Alves de Jesus Sousa, Ruy Gabriel Costa Sousainfo:eu-repo/semantics/openAccessBarros, Ádine Gabriely Teles de SousaMoreira, Francisco Assis dos SantosBranco, Alessandra Camillo da Silveira CastelloSousa, Joubert Aires deMeneses, Carlos Eduardo da SilvaSousa, Carolina Francisca Alves de JesusSousa, Ruy Gabriel Costa2020-08-20T18:08:48Zoai:ojs.pkp.sfu.ca:article/2230Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:26:56.863540Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Evaluación del efecto farmacológico del extracto etanólico de Stryphnodendron adstringens peel sobre el peristalismo intestinal en Mus musculus
Evaluación del efecto farmacológico del extracto etanólico de Stryphnodendron adstringens peel sobre el peristalismo intestinal en Mus musculus
Avaliação do efeito farmacológico do extrato etanólico da casca de Stryphnodendron adstringens sobre o peristaltismo intestinal em Mus musculus
title Evaluación del efecto farmacológico del extracto etanólico de Stryphnodendron adstringens peel sobre el peristalismo intestinal en Mus musculus
spellingShingle Evaluación del efecto farmacológico del extracto etanólico de Stryphnodendron adstringens peel sobre el peristalismo intestinal en Mus musculus
Barros, Ádine Gabriely Teles de Sousa
Barbatimão-verdadeiro
Gastrointestinal tract
Antidiarrheal effect.
Barbatimão-verdadeiro
Tracto gastrointestinal
Efecto antidiarreico.
Barbatimão-verdadeiro
Trato Gastrointestinal
Efeito Antidiarreico.
title_short Evaluación del efecto farmacológico del extracto etanólico de Stryphnodendron adstringens peel sobre el peristalismo intestinal en Mus musculus
title_full Evaluación del efecto farmacológico del extracto etanólico de Stryphnodendron adstringens peel sobre el peristalismo intestinal en Mus musculus
title_fullStr Evaluación del efecto farmacológico del extracto etanólico de Stryphnodendron adstringens peel sobre el peristalismo intestinal en Mus musculus
title_full_unstemmed Evaluación del efecto farmacológico del extracto etanólico de Stryphnodendron adstringens peel sobre el peristalismo intestinal en Mus musculus
title_sort Evaluación del efecto farmacológico del extracto etanólico de Stryphnodendron adstringens peel sobre el peristalismo intestinal en Mus musculus
author Barros, Ádine Gabriely Teles de Sousa
author_facet Barros, Ádine Gabriely Teles de Sousa
Moreira, Francisco Assis dos Santos
Branco, Alessandra Camillo da Silveira Castello
Sousa, Joubert Aires de
Meneses, Carlos Eduardo da Silva
Sousa, Carolina Francisca Alves de Jesus
Sousa, Ruy Gabriel Costa
author_role author
author2 Moreira, Francisco Assis dos Santos
Branco, Alessandra Camillo da Silveira Castello
Sousa, Joubert Aires de
Meneses, Carlos Eduardo da Silva
Sousa, Carolina Francisca Alves de Jesus
Sousa, Ruy Gabriel Costa
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barros, Ádine Gabriely Teles de Sousa
Moreira, Francisco Assis dos Santos
Branco, Alessandra Camillo da Silveira Castello
Sousa, Joubert Aires de
Meneses, Carlos Eduardo da Silva
Sousa, Carolina Francisca Alves de Jesus
Sousa, Ruy Gabriel Costa
dc.subject.por.fl_str_mv Barbatimão-verdadeiro
Gastrointestinal tract
Antidiarrheal effect.
Barbatimão-verdadeiro
Tracto gastrointestinal
Efecto antidiarreico.
Barbatimão-verdadeiro
Trato Gastrointestinal
Efeito Antidiarreico.
topic Barbatimão-verdadeiro
Gastrointestinal tract
Antidiarrheal effect.
Barbatimão-verdadeiro
Tracto gastrointestinal
Efecto antidiarreico.
Barbatimão-verdadeiro
Trato Gastrointestinal
Efeito Antidiarreico.
description The objective of this work is to analyze the pharmacological activity of the ethanolic extract of the Barbatimão-verdadeiro in the intestinal peristalsis of mice (Mus Musculus). The study is characterized as a quantitative, exploratory and experimental research, in which two pharmacological tests were performed. The animals (n = 35) were treated with a dose of 500mg / kg Stryphnodendron adstringens ethanolic extract and intestinal motility was evaluated following the intestinal transit models (n = 15) and castor oil-induced diarrhea (n = 20). Statistical analysis with one-way ANOVA and Tukey test for significance analysis showed that the group treated with the plant showed significance in relation to the group treated with loperamide (p <0.05). In the induced diarrhea test, the extract showed significance (P = 0.0002) compared with the loperamide treated group and the control group. Therefore, Stryphnodendron adstringens ethanolic extract was effective in reducing intestinal motility.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/2230
10.33448/rsd-v9i2.2230
url https://rsdjournal.org/index.php/rsd/article/view/2230
identifier_str_mv 10.33448/rsd-v9i2.2230
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/2230/2408
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 9 No. 2; e142922230
Research, Society and Development; Vol. 9 Núm. 2; e142922230
Research, Society and Development; v. 9 n. 2; e142922230
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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