Association between brain-derived neurotrophic factor (BDNF) and depressive disorder: a literature review
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/19139 |
Resumo: | Objectives: This study aimed to gather and systematize the main available studies, which would clarify the close relationship between the levels of Brain Derived Neurotrophic Factor (BDNF) with depressive disorder. Methodology: 30 articles related to BDNF and depressive disorder from indexing platforms, published between 2017 and 2021, were selected, and the focus was on articles that presented contributions to the theme by associating the two conditions. Results and Discussion: Several studies linking BDNF to depressive disorder demonstrate a relationship between decreased levels of this polypeptide in patients with the pathology when compared to healthy individuals, even serving as a biomarker of the disease, in addition, there was an increase in the levels of this factor when performed specific treatments for depression. Other authors relate the increase in BDNF levels with the performance of physical activities and caloric restriction and suggest the possibility of such activity being considered as an adjuvant treatment to the conventional one. Finally, other studies focus on genetic and epigenetic alterations traceable through genomic analysis that can interfere with BDNF expression and serve as increased risk factors for the development of neuropsychiatric disorders. Conclusion: There is enough evidence to support the statement that BDNF is related and may be a promising tool for the diagnosis and future approaches to the pathology, but further studies are needed to consolidate the findings already demonstrated above, as well as to determine the levels of BDNF to be considered as predictors of disease. |
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Association between brain-derived neurotrophic factor (BDNF) and depressive disorder: a literature reviewAsociación entre el factor neurotrófico derivado del encéfalo (BDNF) y el trastorno depresivo: una revisión de la literaturaAssociação entre o fator neurotrófico derivado do encéfalo (BDNF) e o transtorno depressivo: uma revisão de literaturaFator neurotrófico derivado do encéfaloTranstorno depressivoPlasticidade neuronalAntidepressivos.Factor neurotrófico derivado del encéfaloTrastorno depresivoPlasticidad neuronalAntidepresivos.Brain-derived neurotrophic factorNeuronal plasticityDepressive disorderAntidepressive agents.Objectives: This study aimed to gather and systematize the main available studies, which would clarify the close relationship between the levels of Brain Derived Neurotrophic Factor (BDNF) with depressive disorder. Methodology: 30 articles related to BDNF and depressive disorder from indexing platforms, published between 2017 and 2021, were selected, and the focus was on articles that presented contributions to the theme by associating the two conditions. Results and Discussion: Several studies linking BDNF to depressive disorder demonstrate a relationship between decreased levels of this polypeptide in patients with the pathology when compared to healthy individuals, even serving as a biomarker of the disease, in addition, there was an increase in the levels of this factor when performed specific treatments for depression. Other authors relate the increase in BDNF levels with the performance of physical activities and caloric restriction and suggest the possibility of such activity being considered as an adjuvant treatment to the conventional one. Finally, other studies focus on genetic and epigenetic alterations traceable through genomic analysis that can interfere with BDNF expression and serve as increased risk factors for the development of neuropsychiatric disorders. Conclusion: There is enough evidence to support the statement that BDNF is related and may be a promising tool for the diagnosis and future approaches to the pathology, but further studies are needed to consolidate the findings already demonstrated above, as well as to determine the levels of BDNF to be considered as predictors of disease.Objetivos: Este trabajo tuvo como objetivo recopilar y sistematizar los principales estudios disponibles en el área de la salud y que evidencian la estrecha relación entre los niveles de Factor Neurotrófico Derivado del Cerebro (BDNF) con el trastorno depresivo. Metodología: Se seleccionaron 30 artículos relacionados con el BDNF y el trastorno depresivo de plataformas de indexación, publicados entre 2017 y 2021, y el foco estuvo en los artículos que presentaban contribuciones al tema asociando las dos condiciones. Resultados y Discusión: Varios estudios que relacionan el BDNF con el trastorno depresivo demuestran una relación entre la disminución de los niveles de este polipéptido en pacientes con la patología, en comparación con individuos sanos, sirviendo incluso como biomarcador de la enfermedad. Además, se percibe un aumento en los niveles de este factor cuando se realizan tratamientos específicos para la depresión. Otros autores relacionan el aumento de los niveles de BDNF con la realización de actividades físicas y restricción calórica y sugieren la posibilidad de que dicha actividad sea considerada como un tratamiento adyuvante al convencional. Finalmente, otros estudios se centran en alteraciones genéticas y epigenéticas rastreables a través del análisis genómico que pueden interferir con la expresión de BDNF y operar como factores de riesgo incrementados para el desarrollo de trastornos neuropsiquiátricos. Conclusión: Existe evidencia suficiente para apoyar la afirmación de que el BDNF está relacionado y puede ser una herramienta prometedora para el diagnóstico y tratamiento del trastorno depresivo. Sin embargo, continuar el camino de la investigación permitirá consolidar los hallazgos realizados y referidos en este trabajo destacando que la determinación de los niveles de BDNF resultan relevantes al momento de considerar los eventuales predictores del trastorno depresivo.Objetivos: O presente trabalho teve por objetivo, reunir e sistematizar os principais estudos disponíveis, que esclarecessem a íntima relação entre os níveis de Fator Neurotrófico Derivado do Encéfalo (BDNF) com o transtorno depressivo. Metodologia: Foram selecionados 30 trabalhos relacionados com o BDNF e transtorno depressivo de plataformas intexadoras, publicadod entre os anos de 2017 – 2021, sendo que, o foco foram artigos que apresentassem contribuições para o tema associando as duas condições. Resultados e Discussão: Diversos trabalhos que relacionam o BDNF ao transtorno depressivo demonstram uma relação entre níveis diminuídos desse polipeptídeo em pacientes com a patologia quando comparado com indivíduos saudáveis, servindo mesmo como biomarcador da doença, ademais, houve aumento dos níveis do citado fator quando realizados os tratamentso específicos para a depressão. Outros autores relacionam o aumento dos níveis do BDNF com a realização de atividades físicas e restrição calórica e aventam a possibilidade de tal atividade ser considerada como tratamento adjuvante ao convencional. Por fim, outros trabalhos se detêm nas alterações genéticas e epigenéticas rastreáveis através de análise genômica podem interferir na expressão do BDNF e servir como fatores de risco aumentado para desenvolvimento de desordens neuropsiquiátricas. Conclusão: Há evidêcias suficientes para embasar a fala de que o BDNF está relacionado e pode ser uma ferramenta promissora para o diagnóstico e futuras abordagens da patologia, porém são necessários novos estudos para consolidar os achados já demonstrados anteriormente, bem como determinar os níveis de BDNF a serem considerados como preditores de doença.Research, Society and Development2021-08-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1913910.33448/rsd-v10i10.19139Research, Society and Development; Vol. 10 No. 10; e461101019139Research, Society and Development; Vol. 10 Núm. 10; e461101019139Research, Society and Development; v. 10 n. 10; e4611010191392525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/19139/17025Copyright (c) 2021 Thayná Bertolini dos Santos; Vytor Hugo Staut de Souza; Noéli Cristina Gouveia Lopes; Flávia Albuquerque Ferreira; Cleber Queiroz Leite; Messias Genézio Santana da Silva; Brian França dos Santoshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos, Thayná Bertolini dos Souza, Vytor Hugo Staut de Lopes, Noéli Cristina Gouveia Ferreira, Flávia Albuquerque Leite, Cleber Queiroz Silva, Messias Genézio Santana daSantos, Brian França dos 2021-10-02T21:49:16Zoai:ojs.pkp.sfu.ca:article/19139Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:39:06.664698Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Association between brain-derived neurotrophic factor (BDNF) and depressive disorder: a literature review Asociación entre el factor neurotrófico derivado del encéfalo (BDNF) y el trastorno depresivo: una revisión de la literatura Associação entre o fator neurotrófico derivado do encéfalo (BDNF) e o transtorno depressivo: uma revisão de literatura |
title |
Association between brain-derived neurotrophic factor (BDNF) and depressive disorder: a literature review |
spellingShingle |
Association between brain-derived neurotrophic factor (BDNF) and depressive disorder: a literature review Santos, Thayná Bertolini dos Fator neurotrófico derivado do encéfalo Transtorno depressivo Plasticidade neuronal Antidepressivos. Factor neurotrófico derivado del encéfalo Trastorno depresivo Plasticidad neuronal Antidepresivos. Brain-derived neurotrophic factor Neuronal plasticity Depressive disorder Antidepressive agents. |
title_short |
Association between brain-derived neurotrophic factor (BDNF) and depressive disorder: a literature review |
title_full |
Association between brain-derived neurotrophic factor (BDNF) and depressive disorder: a literature review |
title_fullStr |
Association between brain-derived neurotrophic factor (BDNF) and depressive disorder: a literature review |
title_full_unstemmed |
Association between brain-derived neurotrophic factor (BDNF) and depressive disorder: a literature review |
title_sort |
Association between brain-derived neurotrophic factor (BDNF) and depressive disorder: a literature review |
author |
Santos, Thayná Bertolini dos |
author_facet |
Santos, Thayná Bertolini dos Souza, Vytor Hugo Staut de Lopes, Noéli Cristina Gouveia Ferreira, Flávia Albuquerque Leite, Cleber Queiroz Silva, Messias Genézio Santana da Santos, Brian França dos |
author_role |
author |
author2 |
Souza, Vytor Hugo Staut de Lopes, Noéli Cristina Gouveia Ferreira, Flávia Albuquerque Leite, Cleber Queiroz Silva, Messias Genézio Santana da Santos, Brian França dos |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Thayná Bertolini dos Souza, Vytor Hugo Staut de Lopes, Noéli Cristina Gouveia Ferreira, Flávia Albuquerque Leite, Cleber Queiroz Silva, Messias Genézio Santana da Santos, Brian França dos |
dc.subject.por.fl_str_mv |
Fator neurotrófico derivado do encéfalo Transtorno depressivo Plasticidade neuronal Antidepressivos. Factor neurotrófico derivado del encéfalo Trastorno depresivo Plasticidad neuronal Antidepresivos. Brain-derived neurotrophic factor Neuronal plasticity Depressive disorder Antidepressive agents. |
topic |
Fator neurotrófico derivado do encéfalo Transtorno depressivo Plasticidade neuronal Antidepressivos. Factor neurotrófico derivado del encéfalo Trastorno depresivo Plasticidad neuronal Antidepresivos. Brain-derived neurotrophic factor Neuronal plasticity Depressive disorder Antidepressive agents. |
description |
Objectives: This study aimed to gather and systematize the main available studies, which would clarify the close relationship between the levels of Brain Derived Neurotrophic Factor (BDNF) with depressive disorder. Methodology: 30 articles related to BDNF and depressive disorder from indexing platforms, published between 2017 and 2021, were selected, and the focus was on articles that presented contributions to the theme by associating the two conditions. Results and Discussion: Several studies linking BDNF to depressive disorder demonstrate a relationship between decreased levels of this polypeptide in patients with the pathology when compared to healthy individuals, even serving as a biomarker of the disease, in addition, there was an increase in the levels of this factor when performed specific treatments for depression. Other authors relate the increase in BDNF levels with the performance of physical activities and caloric restriction and suggest the possibility of such activity being considered as an adjuvant treatment to the conventional one. Finally, other studies focus on genetic and epigenetic alterations traceable through genomic analysis that can interfere with BDNF expression and serve as increased risk factors for the development of neuropsychiatric disorders. Conclusion: There is enough evidence to support the statement that BDNF is related and may be a promising tool for the diagnosis and future approaches to the pathology, but further studies are needed to consolidate the findings already demonstrated above, as well as to determine the levels of BDNF to be considered as predictors of disease. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/19139 10.33448/rsd-v10i10.19139 |
url |
https://rsdjournal.org/index.php/rsd/article/view/19139 |
identifier_str_mv |
10.33448/rsd-v10i10.19139 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/19139/17025 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 10; e461101019139 Research, Society and Development; Vol. 10 Núm. 10; e461101019139 Research, Society and Development; v. 10 n. 10; e461101019139 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052686832500736 |