Synthesis of Ni(II), Cu(II) and Zn(II) coumarin-3-carboxilic acid derivates and their and their physical-chemical properties
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/13430 |
Resumo: | In the search for new drugs, coumarins are an important class of compounds due to their chemical and biological properties, such as their potential to reduce cancer, diabetes, and cardiovascular diseases. They are heterocyclic compounds that contain oxygen in their structure and are found in plants.To improve the chemical and biological properties of the coumarin-3-carboxilic acid, were prepared metal transition complexes of Cu(II), Ni(II) and Zn(II) of coumarin-3-carboxilic acid by a new synthetic route. All complexes were characterized by Ultraviolet (UV), Infrared (FTIR), and Raman spectroscopy; Scanning electronic microscopy (SEM); X-Ray diffraction (XRD), as well as conductivity and elemental analysis. Electron microscopy and X-ray analysis showed that the degree of crystallinity of the complexes changes when compared with the precursor, 3-carboxy-coumarin acid, and the degree of crystallinity depends on the nature of the metal ion attached to coumarin. In addition, the antioxidant action of the complexes was evaluated by the DPPH method, and the results showed a higher activity of the complexes when compared with the precursor, suggesting that these complexes may present biological properties of interest. |
id |
UNIFEI_723e5e17f377582334ceed9fdbe9b144 |
---|---|
oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/13430 |
network_acronym_str |
UNIFEI |
network_name_str |
Research, Society and Development |
repository_id_str |
|
spelling |
Synthesis of Ni(II), Cu(II) and Zn(II) coumarin-3-carboxilic acid derivates and their and their physical-chemical propertiesSíntesis de derivados del ácido cumarina-3-carboxílico de Ni(II), Cu(II) y Zn(II) y sus propiedades físico-químicasSíntese de derivados de ácido cumarina-3-carboxílico de Ni(II), Cu(II) e Zn(II) e suas propriedades físico-químicasCoumarinSynthesisComplexesAntioxidantCoordination.CumarinaSínteseComplexosAntioxidanteCoordenação.CumarinaSíntesisComplejosAntioxidanteCoordinación.In the search for new drugs, coumarins are an important class of compounds due to their chemical and biological properties, such as their potential to reduce cancer, diabetes, and cardiovascular diseases. They are heterocyclic compounds that contain oxygen in their structure and are found in plants.To improve the chemical and biological properties of the coumarin-3-carboxilic acid, were prepared metal transition complexes of Cu(II), Ni(II) and Zn(II) of coumarin-3-carboxilic acid by a new synthetic route. All complexes were characterized by Ultraviolet (UV), Infrared (FTIR), and Raman spectroscopy; Scanning electronic microscopy (SEM); X-Ray diffraction (XRD), as well as conductivity and elemental analysis. Electron microscopy and X-ray analysis showed that the degree of crystallinity of the complexes changes when compared with the precursor, 3-carboxy-coumarin acid, and the degree of crystallinity depends on the nature of the metal ion attached to coumarin. In addition, the antioxidant action of the complexes was evaluated by the DPPH method, and the results showed a higher activity of the complexes when compared with the precursor, suggesting that these complexes may present biological properties of interest.En la búsqueda de nuevos fármacos, las cumarinas son una clase importante de compuestos debido a sus propiedades químicas y biológicas, como la reducción potencial de las enfermedades cancerosas, la diabetes y las enfermedades cardiovasculares. Son compuestos heterocíclicos que contienen oxígeno en su estructura y se encuentran en las plantas. Para mejorar las propiedades químicas y biológicas del ácido cumarínico-3-carboxílico, se prepararon complejos de transición de Cu(II), Ni(II), Zn(II), utilizando el ácido cumarínico-3-carboxílico como precursor utilizando una nueva ruta sintética. Todos los complejos se caracterizaron mediante espectroscopia Ultravioleta (UV), Infrarroja (FTIR) y Raman; Microscopía electrónica de barrido (MEB); Difracción de rayos X (DRX), así como conductividad y análisis elemental. Los análisis de microscopía electrónica y de rayos X mostraron que el grado de cristalinidad de los complejos cambia al compararlos con el precursor, el ácido 3-carboxi-cumarínico, y su cristalinidad depende de la naturaleza del ion metálico unido a la cumarina. Además, se evaluó la acción antioxidante de los complejos mediante el método DPPH, cuyos resultados indicaron una mayor actividad de los complejos en comparación con el precursor, lo que sugiere que estos complejos pueden tener potenciales propiedades biológicas de interés.Na busca por novos medicamentos, as cumarinas são uma classe importante de compostos devido suas propriedades químicas e biológicas como, potencial de redução de doenças cancerígenas, diabetes e doenças cardiovasculares. São compostos heterocíclicos que contém oxigênio em sua estrutura e são encontrados em plantas. Com objetivo de melhorar as propriedades químicas e biológicas do ácido cumarino-3-carboxilico foram preparados complexos de transição de Cu(II), Ni(II), Zn(II), utilizando o ácido cumarina-3-carboxílico como precursor utilizando-se uma nova rota sintética. Todos os complexos foram caracterizados por espectroscopia de Ultravioleta (UV), Infravermelho (IV) e Raman; Microscopia eletrônica de varredura (MEV); Difratometria de raios-X (DRX), bem como condutividade e análise elementar. A microscopia eletrônica e as análises de raios-X mostraram que o grau de cristalinidade dos complexos muda quando comparado com o precurso, ácido 3- carboxi-cumarina, e sua cristalinidade depende da natureza do íon metálico ligado à cumarina. Além disso, avaliou-se a ação antioxidante dos complexos pelo método DPPH, cujos resultados indicaram uma maior atividade dos complexos quando comparados com o precursor, sugerindo que esses complexos podem ter potenciais propriedades biológicas de interesse.Research, Society and Development2021-03-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1343010.33448/rsd-v10i3.13430Research, Society and Development; Vol. 10 No. 3; e47910313430Research, Society and Development; Vol. 10 Núm. 3; e47910313430Research, Society and Development; v. 10 n. 3; e479103134302525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/13430/12596Copyright (c) 2021 Dirceu Aparecido Gonçalves de Souza; Ricardo Luis Tranquilin; Marcio Luiz dos Santos; Regina Mara Silva Pereirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSouza, Dirceu Aparecido Gonçalves de Tranquilin, Ricardo LuisSantos, Marcio Luiz dos Pereira, Regina Mara Silva 2021-03-28T12:03:35Zoai:ojs.pkp.sfu.ca:article/13430Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:34:46.463399Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Synthesis of Ni(II), Cu(II) and Zn(II) coumarin-3-carboxilic acid derivates and their and their physical-chemical properties Síntesis de derivados del ácido cumarina-3-carboxílico de Ni(II), Cu(II) y Zn(II) y sus propiedades físico-químicas Síntese de derivados de ácido cumarina-3-carboxílico de Ni(II), Cu(II) e Zn(II) e suas propriedades físico-químicas |
title |
Synthesis of Ni(II), Cu(II) and Zn(II) coumarin-3-carboxilic acid derivates and their and their physical-chemical properties |
spellingShingle |
Synthesis of Ni(II), Cu(II) and Zn(II) coumarin-3-carboxilic acid derivates and their and their physical-chemical properties Souza, Dirceu Aparecido Gonçalves de Coumarin Synthesis Complexes Antioxidant Coordination. Cumarina Síntese Complexos Antioxidante Coordenação. Cumarina Síntesis Complejos Antioxidante Coordinación. |
title_short |
Synthesis of Ni(II), Cu(II) and Zn(II) coumarin-3-carboxilic acid derivates and their and their physical-chemical properties |
title_full |
Synthesis of Ni(II), Cu(II) and Zn(II) coumarin-3-carboxilic acid derivates and their and their physical-chemical properties |
title_fullStr |
Synthesis of Ni(II), Cu(II) and Zn(II) coumarin-3-carboxilic acid derivates and their and their physical-chemical properties |
title_full_unstemmed |
Synthesis of Ni(II), Cu(II) and Zn(II) coumarin-3-carboxilic acid derivates and their and their physical-chemical properties |
title_sort |
Synthesis of Ni(II), Cu(II) and Zn(II) coumarin-3-carboxilic acid derivates and their and their physical-chemical properties |
author |
Souza, Dirceu Aparecido Gonçalves de |
author_facet |
Souza, Dirceu Aparecido Gonçalves de Tranquilin, Ricardo Luis Santos, Marcio Luiz dos Pereira, Regina Mara Silva |
author_role |
author |
author2 |
Tranquilin, Ricardo Luis Santos, Marcio Luiz dos Pereira, Regina Mara Silva |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Souza, Dirceu Aparecido Gonçalves de Tranquilin, Ricardo Luis Santos, Marcio Luiz dos Pereira, Regina Mara Silva |
dc.subject.por.fl_str_mv |
Coumarin Synthesis Complexes Antioxidant Coordination. Cumarina Síntese Complexos Antioxidante Coordenação. Cumarina Síntesis Complejos Antioxidante Coordinación. |
topic |
Coumarin Synthesis Complexes Antioxidant Coordination. Cumarina Síntese Complexos Antioxidante Coordenação. Cumarina Síntesis Complejos Antioxidante Coordinación. |
description |
In the search for new drugs, coumarins are an important class of compounds due to their chemical and biological properties, such as their potential to reduce cancer, diabetes, and cardiovascular diseases. They are heterocyclic compounds that contain oxygen in their structure and are found in plants.To improve the chemical and biological properties of the coumarin-3-carboxilic acid, were prepared metal transition complexes of Cu(II), Ni(II) and Zn(II) of coumarin-3-carboxilic acid by a new synthetic route. All complexes were characterized by Ultraviolet (UV), Infrared (FTIR), and Raman spectroscopy; Scanning electronic microscopy (SEM); X-Ray diffraction (XRD), as well as conductivity and elemental analysis. Electron microscopy and X-ray analysis showed that the degree of crystallinity of the complexes changes when compared with the precursor, 3-carboxy-coumarin acid, and the degree of crystallinity depends on the nature of the metal ion attached to coumarin. In addition, the antioxidant action of the complexes was evaluated by the DPPH method, and the results showed a higher activity of the complexes when compared with the precursor, suggesting that these complexes may present biological properties of interest. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-22 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/13430 10.33448/rsd-v10i3.13430 |
url |
https://rsdjournal.org/index.php/rsd/article/view/13430 |
identifier_str_mv |
10.33448/rsd-v10i3.13430 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/13430/12596 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 3; e47910313430 Research, Society and Development; Vol. 10 Núm. 3; e47910313430 Research, Society and Development; v. 10 n. 3; e47910313430 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052672464912384 |