Unsaturated fatty acid as functional food for the treatment of Diabetes mellitus type 2
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/17231 |
Resumo: | Several studies have been demonstrating to a relationship between unsaturated fatty acids, improvement of pancreatic function and insulin secretion. In this context, this review presents the most recent findings on the pathophysiology of type 2 diabetes mellitus, the action mechanism of unsaturated fatty acids on pancreatic function, and clinical studies in diabetic patients. We evaluated here articles from MedLine/PubMed and the Science direct database, published between 2014 and 2020. Of the 637 results, 13 were selected. From their analysis, we could observe that mono and polyunsaturated fatty acids can improve glycemic control as well as reduce cardiovascular risk. The most recurrent antidiabetic action regarding monounsaturated fatty acids is the ability to preserve insulin signaling, whereas polyunsaturated fatty acids action consists in the increasing expression of the type 4 glucose transporter. However, a complete understanding of the relationship between fatty acids, insulin and inflammation should be considered in future investigations. |
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Unsaturated fatty acid as functional food for the treatment of Diabetes mellitus type 2Ácidos grasos insaturados como alimento funcional para el tratamiento de la Diabetes mellitus tipo 2Ácidos graxos insaturados como alimento funcional para o tratamento de Diabetes mellitus Tipo 2Ácidos Graxos MonoinsaturadosCompostos bioativosPropriedades funcionaisResistencia à insulinaTransportador de glicose tipo 4.Bioactive compoundsFunctional propertiesInsulin resistanceMonounsaturated fatty acidsType 4 glucose transporter.Ácidos Grasos MonoinsaturadosCompuestos bioactivosPropiedades funcionalesResistencia a la insulinaTransportador de glucosa tipo 4.Several studies have been demonstrating to a relationship between unsaturated fatty acids, improvement of pancreatic function and insulin secretion. In this context, this review presents the most recent findings on the pathophysiology of type 2 diabetes mellitus, the action mechanism of unsaturated fatty acids on pancreatic function, and clinical studies in diabetic patients. We evaluated here articles from MedLine/PubMed and the Science direct database, published between 2014 and 2020. Of the 637 results, 13 were selected. From their analysis, we could observe that mono and polyunsaturated fatty acids can improve glycemic control as well as reduce cardiovascular risk. The most recurrent antidiabetic action regarding monounsaturated fatty acids is the ability to preserve insulin signaling, whereas polyunsaturated fatty acids action consists in the increasing expression of the type 4 glucose transporter. However, a complete understanding of the relationship between fatty acids, insulin and inflammation should be considered in future investigations.Varios estudios apuntan a una relación entre los ácidos grasos insaturados, la función pancreática mejorada y la secreción de insulina. En este contexto, esta revisión presenta los hallazgos más recientes sobre la fisiopatología de la diabetes mellitus tipo 2, el mecanismo de acción de los ácidos grasos insaturados sobre la función pancreática y los estudios clínicos en pacientes diabéticos. Aquí evaluamos artículos de MedLine/PubMed y la base de datos directa de Science, publicados entre 2014 y 2020. De los 637 resultados, se seleccionaron 13. A partir de su análisis, vemos evidencia de que los ácidos grasos mono y poliinsaturados pueden mejorar el control glucémico y reducir el riesgo cardiovascular. La acción antidiabética más citada en la literatura con respecto a los ácidos grasos monoinsaturados es la capacidad de preservar la señalización de la insulina; por otro lado, el de los ácidos grasos poliinsaturados consiste en un aumento de la expresión del transportador de glucosa tipo 4. Sin embargo, en futuras investigaciones se debe considerar una comprensión completa de la relación entre los ácidos grasos, la insulina y la inflamación.Diversas pesquisas apontam para uma relação entre ácidos graxos insaturados, melhora da função pancreática e secreção de insulina. Nesse contexto, esta revisão apresenta os achados mais recentes sobre a fisiopatologia do diabetes mellitus tipo 2, o mecanismo de ação dos ácidos graxos insaturados na função pancreática e os estudos clínicos em pacientes diabéticos. Avaliamos aqui artigos do MedLine/PubMed e da base de dados Science direct, publicados entre 2014 e 2020. Dos 637 resultados, 13 foram selecionados. A partir da sua análise, observamos evidências de que ácidos graxos mono e poliinsaturados podem melhorar o controle glicêmico, bem como reduzir o risco cardiovascular. A ação antidiabética mais citada na literatura quanto aos ácidos graxos monoinsaturados é a capacidade de preservação da sinalização da insulina; já a dos ácidos graxos poliinsaturados consiste no aumento da expressão do transportador de glicose tipo 4. Entretanto, a compreensão completa da relação entre ácidos graxos, insulina e inflamação deve ser considerada em investigações futuras.Research, Society and Development2021-07-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1723110.33448/rsd-v10i9.17231Research, Society and Development; Vol. 10 No. 9; e41410917231Research, Society and Development; Vol. 10 Núm. 9; e41410917231Research, Society and Development; v. 10 n. 9; e414109172312525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/17231/16299Copyright (c) 2021 Naiane Silva Cardoso; Julia Rosental de Souza Cruz; Ramon Alves de Oliveira Paula; Stella Maris da Silveira Duarte; Maria Rita Rodrigues; Fernanda Borges de Araújo Paulahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCardoso, Naiane SilvaCruz, Julia Rosental de SouzaPaula, Ramon Alves de OliveiraDuarte, Stella Maris da SilveiraRodrigues, Maria RitaPaula, Fernanda Borges de Araújo2021-09-12T14:28:06Zoai:ojs.pkp.sfu.ca:article/17231Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:37:36.994224Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Unsaturated fatty acid as functional food for the treatment of Diabetes mellitus type 2 Ácidos grasos insaturados como alimento funcional para el tratamiento de la Diabetes mellitus tipo 2 Ácidos graxos insaturados como alimento funcional para o tratamento de Diabetes mellitus Tipo 2 |
title |
Unsaturated fatty acid as functional food for the treatment of Diabetes mellitus type 2 |
spellingShingle |
Unsaturated fatty acid as functional food for the treatment of Diabetes mellitus type 2 Cardoso, Naiane Silva Ácidos Graxos Monoinsaturados Compostos bioativos Propriedades funcionais Resistencia à insulina Transportador de glicose tipo 4. Bioactive compounds Functional properties Insulin resistance Monounsaturated fatty acids Type 4 glucose transporter. Ácidos Grasos Monoinsaturados Compuestos bioactivos Propiedades funcionales Resistencia a la insulina Transportador de glucosa tipo 4. |
title_short |
Unsaturated fatty acid as functional food for the treatment of Diabetes mellitus type 2 |
title_full |
Unsaturated fatty acid as functional food for the treatment of Diabetes mellitus type 2 |
title_fullStr |
Unsaturated fatty acid as functional food for the treatment of Diabetes mellitus type 2 |
title_full_unstemmed |
Unsaturated fatty acid as functional food for the treatment of Diabetes mellitus type 2 |
title_sort |
Unsaturated fatty acid as functional food for the treatment of Diabetes mellitus type 2 |
author |
Cardoso, Naiane Silva |
author_facet |
Cardoso, Naiane Silva Cruz, Julia Rosental de Souza Paula, Ramon Alves de Oliveira Duarte, Stella Maris da Silveira Rodrigues, Maria Rita Paula, Fernanda Borges de Araújo |
author_role |
author |
author2 |
Cruz, Julia Rosental de Souza Paula, Ramon Alves de Oliveira Duarte, Stella Maris da Silveira Rodrigues, Maria Rita Paula, Fernanda Borges de Araújo |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Cardoso, Naiane Silva Cruz, Julia Rosental de Souza Paula, Ramon Alves de Oliveira Duarte, Stella Maris da Silveira Rodrigues, Maria Rita Paula, Fernanda Borges de Araújo |
dc.subject.por.fl_str_mv |
Ácidos Graxos Monoinsaturados Compostos bioativos Propriedades funcionais Resistencia à insulina Transportador de glicose tipo 4. Bioactive compounds Functional properties Insulin resistance Monounsaturated fatty acids Type 4 glucose transporter. Ácidos Grasos Monoinsaturados Compuestos bioactivos Propiedades funcionales Resistencia a la insulina Transportador de glucosa tipo 4. |
topic |
Ácidos Graxos Monoinsaturados Compostos bioativos Propriedades funcionais Resistencia à insulina Transportador de glicose tipo 4. Bioactive compounds Functional properties Insulin resistance Monounsaturated fatty acids Type 4 glucose transporter. Ácidos Grasos Monoinsaturados Compuestos bioactivos Propiedades funcionales Resistencia a la insulina Transportador de glucosa tipo 4. |
description |
Several studies have been demonstrating to a relationship between unsaturated fatty acids, improvement of pancreatic function and insulin secretion. In this context, this review presents the most recent findings on the pathophysiology of type 2 diabetes mellitus, the action mechanism of unsaturated fatty acids on pancreatic function, and clinical studies in diabetic patients. We evaluated here articles from MedLine/PubMed and the Science direct database, published between 2014 and 2020. Of the 637 results, 13 were selected. From their analysis, we could observe that mono and polyunsaturated fatty acids can improve glycemic control as well as reduce cardiovascular risk. The most recurrent antidiabetic action regarding monounsaturated fatty acids is the ability to preserve insulin signaling, whereas polyunsaturated fatty acids action consists in the increasing expression of the type 4 glucose transporter. However, a complete understanding of the relationship between fatty acids, insulin and inflammation should be considered in future investigations. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-29 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/17231 10.33448/rsd-v10i9.17231 |
url |
https://rsdjournal.org/index.php/rsd/article/view/17231 |
identifier_str_mv |
10.33448/rsd-v10i9.17231 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/17231/16299 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 9; e41410917231 Research, Society and Development; Vol. 10 Núm. 9; e41410917231 Research, Society and Development; v. 10 n. 9; e41410917231 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052807478509568 |