The importance of pharmacogenetics in the treatment of breast cancer - a literature review

Detalhes bibliográficos
Autor(a) principal: Corrêa, Caroline Cardoso
Data de Publicação: 2021
Outros Autores: Ortiz, Jessica Vanina
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/23162
Resumo: In view of the reports on the use of germline genetic information in preventive and treating this type of carcinoma, as well as their potential as patterns of genetic markers analogous to expression profiles obtained from tumor tissue, allowing a more powerful prediction who will respond best to a specific treatment or regimen. Thus, this study aims to assess the importance of pharmacogenetics in the treatment of breast cancer. This is a literature review, where the following databases were used: MEDLINE, LILACS and Scielo, in which publications in Portuguese and English were selected between 2016 and 2021. Through the results obtained, it was observed that the introduction of pharmacogenetics in oncology has enabled the development of a new generation of pharmacological agents capable of being selective against neoplastic cells, enabling a significant improvement in the risk/benefit ratio of numerous types of cancer, particularly breast cancer. Thus, the role of the pharmacist becomes essential in Pharmacogenetics when associated with clinical practice, as he is a health professional who has a full understanding of the phenomena that occur in this category, contributing to the assistance of other components of the functional health group , performing a plausible interpretation of the analysis results and their subsequent applicability.
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spelling The importance of pharmacogenetics in the treatment of breast cancer - a literature reviewLa importancia de la farmacogenética en el tratamiento del cáncer de mama: revisión de la literaturaA importância da farmacogenética no tratamento do câncer de mama - uma revisão de literaturaOncologyGenéticaIn view of the reports on the use of germline genetic information in preventive and treating this type of carcinoma, as well as their potential as patterns of genetic markers analogous to expression profiles obtained from tumor tissue, allowing a more powerful prediction who will respond best to a specific treatment or regimen. Thus, this study aims to assess the importance of pharmacogenetics in the treatment of breast cancer. This is a literature review, where the following databases were used: MEDLINE, LILACS and Scielo, in which publications in Portuguese and English were selected between 2016 and 2021. Through the results obtained, it was observed that the introduction of pharmacogenetics in oncology has enabled the development of a new generation of pharmacological agents capable of being selective against neoplastic cells, enabling a significant improvement in the risk/benefit ratio of numerous types of cancer, particularly breast cancer. Thus, the role of the pharmacist becomes essential in Pharmacogenetics when associated with clinical practice, as he is a health professional who has a full understanding of the phenomena that occur in this category, contributing to the assistance of other components of the functional health group , performing a plausible interpretation of the analysis results and their subsequent applicability.A la vista de los reportes sobre el uso de información genética germinal de forma preventiva y en el tratamiento de este tipo de carcinoma, así como su potencial como patrones de marcadores genéticos análogos a los perfiles de expresión obtenidos del tejido tumoral, permitiendo una mayor poderosa predicción de quién responderá mejor a un tratamiento o régimen específico. Por tanto, este estudio tiene como objetivo evaluar la importancia de la farmacogenética en el tratamiento del cáncer de mama. Se trata de una revisión de la literatura, donde se utilizaron las siguientes bases de datos: MEDLINE, LILACS y Scielo, en las que se seleccionaron publicaciones en portugués e inglés entre 2016 y 2021. A través de los resultados obtenidos, se observó que la introducción de la farmacogenética en oncología ha permitido el desarrollo de una nueva generación de agentes farmacológicos capaces de ser selectivos frente a las células neoplásicas, permitiendo una mejora significativa en la relación riesgo / beneficio de numerosos tipos de cáncer, en particular el cáncer de mama. Así, el rol del farmacéutico se torna fundamental en Farmacogenética cuando se asocia a la práctica clínica, por ser un profesional de la salud que tiene un conocimiento pleno de los fenómenos que ocurren en esta categoría, contribuyendo a la asistencia de otros componentes del grupo funcional de la salud, realizar una interpretación plausible de los resultados del análisis y su posterior aplicabilidad.Tendo em vista os relatos sobre o uso de informações genéticas germinativas na forma preventiva e no tratar desse tipo de carcinoma, bem como o seu potencial como padrões de marcadores genéticos análogos aos perfis de expressão obtidos a partir do tecido tumoral, permitindo uma previsão mais poderosa de quem responderá melhor a um tratamento ou regime específico. Com isso, este estudo tem como objetivo avaliar a importância da farmacogenética no tratamento do câncer de mama. Trata-se de uma revisão de literatura, onde foram utilizadas as bases de dados: MEDLINE, LILACS e Scielo, em que publicações em português e inglês foram selecionadas entre os anos de 2016 e 2021. Por meio dos resultados obtidos observou-se que a introdução da farmacogenética na oncologia tem possibilitado o desenvolvimento de uma nova geração de agentes farmacológicos capazes de serem seletivos contra células neoplásicas, possibilitando uma melhora significativa na relação risco/benefício de inúmeros tipos de câncer, em particular ao câncer de mama. Dessa forma, a função do farmacêutico torna-se essencial na Farmacogenética quando associado à prática clínica, já que é um profissional da saúde que detém de toda uma compreensão dos fenômenos que ocorrem nessa categoria, contribuindo no auxílio dos demais componentes do grupo funcional de saúde, realizando uma interpretação plausível dos resultados das análises e de sua posterior aplicabilidade.Research, Society and Development2021-11-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2316210.33448/rsd-v10i15.23162Research, Society and Development; Vol. 10 No. 15; e501101523162Research, Society and Development; Vol. 10 Núm. 15; e501101523162Research, Society and Development; v. 10 n. 15; e5011015231622525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/23162/20233Copyright (c) 2021 Caroline Cardoso Corrêa; Jessica Vanina Ortizhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCorrêa, Caroline CardosoOrtiz, Jessica Vanina2021-12-06T10:13:53Zoai:ojs.pkp.sfu.ca:article/23162Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:42:06.995169Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv The importance of pharmacogenetics in the treatment of breast cancer - a literature review
La importancia de la farmacogenética en el tratamiento del cáncer de mama: revisión de la literatura
A importância da farmacogenética no tratamento do câncer de mama - uma revisão de literatura
title The importance of pharmacogenetics in the treatment of breast cancer - a literature review
spellingShingle The importance of pharmacogenetics in the treatment of breast cancer - a literature review
Corrêa, Caroline Cardoso
Oncology
Genética
title_short The importance of pharmacogenetics in the treatment of breast cancer - a literature review
title_full The importance of pharmacogenetics in the treatment of breast cancer - a literature review
title_fullStr The importance of pharmacogenetics in the treatment of breast cancer - a literature review
title_full_unstemmed The importance of pharmacogenetics in the treatment of breast cancer - a literature review
title_sort The importance of pharmacogenetics in the treatment of breast cancer - a literature review
author Corrêa, Caroline Cardoso
author_facet Corrêa, Caroline Cardoso
Ortiz, Jessica Vanina
author_role author
author2 Ortiz, Jessica Vanina
author2_role author
dc.contributor.author.fl_str_mv Corrêa, Caroline Cardoso
Ortiz, Jessica Vanina
dc.subject.por.fl_str_mv Oncology
Genética
topic Oncology
Genética
description In view of the reports on the use of germline genetic information in preventive and treating this type of carcinoma, as well as their potential as patterns of genetic markers analogous to expression profiles obtained from tumor tissue, allowing a more powerful prediction who will respond best to a specific treatment or regimen. Thus, this study aims to assess the importance of pharmacogenetics in the treatment of breast cancer. This is a literature review, where the following databases were used: MEDLINE, LILACS and Scielo, in which publications in Portuguese and English were selected between 2016 and 2021. Through the results obtained, it was observed that the introduction of pharmacogenetics in oncology has enabled the development of a new generation of pharmacological agents capable of being selective against neoplastic cells, enabling a significant improvement in the risk/benefit ratio of numerous types of cancer, particularly breast cancer. Thus, the role of the pharmacist becomes essential in Pharmacogenetics when associated with clinical practice, as he is a health professional who has a full understanding of the phenomena that occur in this category, contributing to the assistance of other components of the functional health group , performing a plausible interpretation of the analysis results and their subsequent applicability.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-24
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/23162
10.33448/rsd-v10i15.23162
url https://rsdjournal.org/index.php/rsd/article/view/23162
identifier_str_mv 10.33448/rsd-v10i15.23162
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/23162/20233
dc.rights.driver.fl_str_mv Copyright (c) 2021 Caroline Cardoso Corrêa; Jessica Vanina Ortiz
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Caroline Cardoso Corrêa; Jessica Vanina Ortiz
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 15; e501101523162
Research, Society and Development; Vol. 10 Núm. 15; e501101523162
Research, Society and Development; v. 10 n. 15; e501101523162
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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